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gene environment interaction

Kiron Bhakat, Arindam Chakraborty, Ekramul Islam
Arsenic (As) is often found naturally as the co-contaminant in the uranium (U)-contaminated area, obstructing the bioremediation process. Although the U-contaminated environment harbors microorganisms capable of interacting with U which could be exploited in bioremediation. However, they might be unable to perform with their full potential due to As toxicity. Therefore, potential in arsenic resistance and oxidation is greatly desired among the microorganisms for a continued bioremediation process. In this study, arsenic-resistant bacteria were isolated from U ore collected from Bundugurang U mine, characterized and their As oxidation and U removal potentials were determined...
March 19, 2019: Environmental Science and Pollution Research International
Fernando Cázarez-Márquez, Sebastien Milesi, Marie-Pierre Laran-Chich, Paul Klosen, Andries Kalsbeek, Valérie Simonneaux
Many animals exhibit remarkable metabolic and reproductive adaptations to seasonal changes in their environment. When day length shortens, Djungarian hamsters (Phodopus sungorus) reduce their body weight and inhibit their reproductive activity, while the opposite occurs in springtime. These physiological adaptations are thought to depend on photoperiodic changes in hypothalamic genes encoding the peptides kisspeptin and RFRP3 for the control of reproduction, and pro-opiomelanocortin and somatostatin for metabolic regulation...
March 19, 2019: Journal of Neuroendocrinology
François Tessier, Bénédicte Fontaine-Bisson, Jean-François Lefebvre, Ahmed El-Sohemy, Marie-Hélène Roy-Gagnon
Introduction: Animal studies suggested that NFKB1 , IKBKB , and SOCS3 genes could be involved in the association between overnutrition and obesity. This study aims to investigate interactions involving these genes and macronutrient intakes affecting obesity-related phenotypes. Methods: We used a traditional statistical method, logistic regression, and compared it to alternative statistical method, multifactor dimensionality reduction (MDR) and penalized logistic regression (PLR), to better detect genes/environment interactions in the Toronto Nutrigenomics and Health Study ( n = 1639) using dichotomized body mass index (BMI) and waist circumference as obesity-related phenotypes...
2019: Frontiers in Genetics
Guiping Ren, Yingchun Yan, Yong Nie, Anhuai Lu, Xiaolei Wu, Yan Li, Changqiu Wang, Hongrui Ding
Rock varnish is a thin coating enriched with manganese (Mn) and iron (Fe) oxides. The mineral composition and formation of rock varnish elicit considerable attention from geologists and microbiologists. However, limited research has been devoted to the semiconducting properties of these Fe/Mn oxides in varnish and relatively little attention is paid to the mineral-microbe interaction under sunlight. In this study, the mineral composition and the bacterial communities on varnish from the Gobi Desert in Xinjiang, China were analyzed...
2019: Frontiers in Microbiology
Paolo Abondio, Marco Sazzini, Paolo Garagnani, Alessio Boattini, Daniela Monti, Claudio Franceschi, Donata Luiselli, Cristina Giuliani
Human longevity is a complex phenotype resulting from the combinations of context-dependent gene-environment interactions that require analysis as a dynamic process in a cohesive ecological and evolutionary framework. Genome-wide association (GWAS) and whole-genome sequencing (WGS) studies on centenarians pointed toward the inclusion of the apolipoprotein E ( APOE ) polymorphisms ε2 and ε4, as implicated in the attainment of extreme longevity, which refers to their effect in age-related Alzheimer's disease (AD) and cardiovascular disease (CVD)...
March 15, 2019: Genes
Laura Bordoni, Rosita Gabbianelli
Understanding the relationship between genotype and phenotype is a central goal not just for genetics but also for medicine and biological sciences. Despite outstanding technological progresses, genetics alone is not able to completely explain phenotypes, in particular for complex diseases. Given the existence of a "missing heritability", growing attention has been given to non-mendelian mechanisms of inheritance and to the role of the environment. The study of interaction between gene and environment represents a challenging but also a promising field with high potential for health prevention, and epigenetics has been suggested as one of the best candidate to mediate environmental effects on the genome...
March 13, 2019: Biochimie
Mauricio Macossay-Castillo, Giulio Marvelli, Mainak Guharoy, Aashish Jain, Daisuke Kihara, Peter Tompa, Shoshana J Wodak
Intrinsically disordered proteins (IDPs) or regions (IDRs) perform diverse cellular functions, but are also prone to forming promiscuous and potentially deleterious interactions. We investigate the extent to which the properties of, and content in, IDRs have adapted to enable functional diversity while limiting interference from promiscuous interactions in the crowded cellular environment. Information on protein sequences, their predicted intrinsic disorder and 3D structure contents, is related to data on protein cellular concentrations, gene co-expression, and protein-protein interactions (PPI) in the well-studied yeast S...
March 13, 2019: Journal of Molecular Biology
Chibuisi Gideon Alimba, Caterina Faggio
The global plastics production has increased from 1.5 million tons in the 1950s to 335 million tons in 2016, with plastics discharged into virtually all components of the environment. Plastics rarely biodegrade but through different processes they fragment into microplastics and nanoplastics, which have been reported as ubiquitous pollutants in all marine environments worldwide. This study is a review of trend in marine plastic pollution with focus on the current toxicological consequences. Microplastics are capable of absorbing organic contaminants, metals and pathogens from the environment into organisms...
March 8, 2019: Environmental Toxicology and Pharmacology
Jan Bocianowski, Tomasz Warzecha, Kamila Nowosad, Roman Bathelt
The objective of this study was to assess genotype by environment interaction for 1000-kernel weight in spring barley lines grown in South Poland by the additive main effects and multiplicative interaction model. The study comprised of 32 spring barley (Hordeum vulgare L.) genotypes (two parental genotypes-breeding line 1 N86 and doubled haploid (DH) line RK63/1, and 30 DH lines derived from F1 hybrids), evaluated at six locations in a randomized complete block design, with three replicates. 1000-kernel weight ranged from 24...
March 15, 2019: Journal of Applied Genetics
Gabriel L Lozano, Hyun Bong Park, Juan I Bravo, Eric A Armstrong, John M Denu, Eric V Stabb, Nichole A Broderick, Jason M Crawford, Jo Handelsman
Plants expend significant resources to select and maintain rhizosphere communities that benefit their growth and protect them from pathogens. A better understanding of assembly and function of rhizosphere microbial communities will provide new avenues for improving crop production. Secretion of antibiotics is one means by which bacteria interact with neighboring microbes and sometimes change community composition. In our analysis of a taxonomically diverse consortium from the soybean rhizosphere, we found that Pseudomonas koreensis selectively inhibits growth of Flavobacterium johnsoniae and other members of the Bacteroidetes grown in soybean root exudate...
March 15, 2019: Applied and Environmental Microbiology
Aseel Eid, Isha Mhatre, Jason R Richardson
Alzheimer's disease (AD) is the leading cause of dementia in the United States and afflicts greater than 5.7 million Americans in 2018. Therapeutic options remain extremely limited to those that are symptom targeting, while no drugs have been approved for the modification or reversal of the disease itself. Risk factors for AD including aging, the female sex, as well as carrying an APOE4 genotype. These risk factors have been extensively examined in the literature, while less attention has been paid to modifiable risk factors, including lifestyle, and environmental risk factors such as exposures to air pollution and pesticides...
March 12, 2019: Pharmacology & Therapeutics
Rinku Sharma, Shashankaditya Upadhyay, Basharat Bhat, Garima Singh, Sudeepto Bhattacharya, Ashutosh Singh
MicroRNAs (miRNAs) and transcription factors (TFs) are the largest families of trans-acting gene regulatory species, which are pivotal players in a complex regulatory network. Recently, extensive research on miRNAs and TFs in agriculture has identified these trans-acting regulatory species, as an effective tool for engineering new crop cultivars to increase yield and quality as well tolerance to environmental stresses but our knowledge of regulatory network is still not sufficient to decipher the exact mechanism...
March 12, 2019: Genomics
M A Sanabrais-Jiménez, C E Sotelo-Ramirez, B Ordoñez-Martinez, J Jiménez-Pavón, G Ahumada-Curiel, S Piana-Diaz, G Flores-Flores, M Flores-Ramos, A Jiménez-Anguiano, B Camarena
Family, twin, and adoption studies have suggested that genetic factors might be involved in suicidal behavior. Corticotropin-releasing receptor type 1 (CRHR1) and 2 (CRHR2) genes play a key role in the activation and modulation of the hypothalamic-pituitary-adrenal (HPA) axis, which is considered a major stress regulator. Childhood trauma is an environmental risk factor associated with suicide attempt (SA) and it has been related to HPA axis dysregulation. This study aimed at analyzing the relationship of CRHR1 and CRHR2 genes with childhood trauma concerning the development of SA...
March 14, 2019: Journal of Neural Transmission
Jared R Bagley, Karen K Szumlinski, Tod E Kippin
BACKGROUND AND PURPOSE: Addiction vulnerability involves complex gene X environment interactions leading to a pathological response to drugs. Identification of the genes mediating these interactions is an important step in understanding the underlying neurobiology and rarely have such analyses examined sex-specific influences. To dissect this interaction, we examined the impact of prenatal stress (PNS) on cocaine responsiveness in male and female mice of the BXD recombinant inbred panel...
March 15, 2019: British Journal of Pharmacology
Erika J Wolf, Filomene G Morrison, Danielle R Sullivan, Mark W Logue, Rachel E Guetta, Annjanette Stone, Steven A Schichman, Regina E McGlinchey, William P Milberg, Mark W Miller
BACKGROUND: Longevity gene klotho (KL) is associated with age-related phenotypes but has not been evaluated against a direct human biomarker of cellular aging. We examined KL and psychiatric stress, including posttraumatic stress disorder (PTSD), which is thought to potentiate accelerated aging, in association with biomarkers of cellular aging. METHODS: 309 white, non-Hispanic genotyped veterans with measures of epigenetic age (DNA methylation age), telomere length (n = 252), inflammation (C-reactive protein), psychiatric symptoms, metabolic function, and white matter neural integrity (diffusion tensor imaging; n = 185)...
March 11, 2019: Brain, Behavior, and Immunity
D Katharine Coykendall, Robert Scott Cornman, Nancy G Prouty, Sandra Brooke, Amanda W J Demopoulos, Cheryl L Morrison
Mussels of the genus Bathymodiolus are among the most widespread colonizers of hydrothermal vent and cold seep environments, sustained by endosymbiosis with chemosynthetic bacteria. Presumed species of Bathymodiolus are abundant at newly discovered cold seeps on the Mid-Atlantic continental slope, however morphological taxonomy is challenging, and their phylogenetic affinities remain unestablished. Here we used mitochondrial sequence to classify species found at three seep sites (Baltimore Canyon seep (BCS; ~400m); Norfolk Canyon seep (NCS; ~1520m); and Chincoteague Island seep (CTS; ~1000m))...
2019: PloS One
Dominika Bartnicka, Justyna Karkowska-Kuleta, Marcin Zawrotniak, Dorota Satała, Kinga Michalik, Gabriela Zielinska, Oliwia Bochenska, Andrzej Kozik, Izabela Ciaston, Joanna Koziel, Lindsay C Dutton, Angela H Nobbs, Barbara Potempa, Zbigniew Baster, Zenon Rajfur, Jan Potempa, Maria Rapala-Kozik
The oral cavity contains different types of microbial species that colonize human host via extensive cell-to-cell interactions and biofilm formation. Candida albicans-a yeast-like fungus that inhabits mucosal surfaces-is also a significant colonizer of subgingival sites in patients with chronic periodontitis. It is notable however that one of the main infectious agents that causes periodontal disease is an anaerobic bacterium-Porphyromonas gingivalis. In our study, we evaluated the different strategies of both pathogens in the mutual colonization of an artificial surface and confirmed that a protective environment existed for P...
March 13, 2019: Scientific Reports
Priyanka Mishra, Jessica Ngo, Jahanshah Ashkani, Frederic Pio
The genetic model organism, Caenorhabditis elegans (C. elegans), shares many genes with humans and is the best-annotated of the eukaryotic genome. Therefore, the identification of new genes and pathways is unlikely. Nevertheless, host-pathogen interaction studies from viruses, recently discovered in the environment, has created new opportunity to discover these pathways. For example, the exogenous RNAi response in C. elegans by the Orsay virus as seen in plants and other eukaryotes is not systemic and transgenerational, suggesting different RNAi pathways between these organisms...
March 13, 2019: Scientific Reports
Jialing Fan, Wuhai Tao, Xin Li, He Li, Junying Zhang, Dongfeng Wei, Yaojing Chen, Zhanjun Zhang
Alzheimer's disease (AD) is a progressive neurodegenerative disease. Although it has been studied for years, the pathogenesis of AD is still controversial. Genetic factors may play an important role in pathogenesis, with the apolipoprotein E ( APOE ) gene among the greatest risk factors for AD. In this review, we focus on the influence of genetic factors, including the APOE gene, the interaction between APOE and other genes, and the polygenic risk factors for cognitive function and dementia. The presence of the APOE ε4 allele is associated with increased AD risk and reduced age of AD onset...
March 7, 2019: International Journal of Molecular Sciences
Marica Franzago, Federica Fraticelli, Liborio Stuppia, Ester Vitacolonna
Gestational Diabetes Mellitus (GDM) is the most common metabolic condition during pregnancy and may result in short- and long-term complications for both mother and offspring. The complexity of phenotypic outcomes seems influenced by genetic susceptibility, nutrient-gene interactions and lifestyle interacting with clinical factors. There are strong evidences that not only the adverse genetic background but also the epigenetic modifications in response to nutritional and environmental factors could influence the maternal hyperglycemia in pregnancy and the foetal metabolic programming...
March 13, 2019: Epigenetics: Official Journal of the DNA Methylation Society
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