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Diastolic Dysfunction Or HFpEF

Veerle A B van den Bogaard, Peter van Luijk, Yoran M Hummel, Peter van der Meer, E Schuit, Liselotte M Boerman, Saskia W M C Maass, Jan F Nauta, Lars C Steggink, Jourik A Gietema, Geertruida H de Bock, Annette J Berendsen, Wilma G J M Smit, Nanna M Sijtsema, Roel G J Kierkels, Johannes A Langendijk, Anne P G Crijns, John H Maduro
PURPOSE: The main purpose of this study was to test the hypothesis that incidental cardiac irradiation is associated with changes in cardiac function in breast cancer (BC) survivors treated with radiotherapy (RT). METHODS AND MATERIALS: We conducted a cross-sectional study consisting of 109 BC survivors treated with RT between 2005 and 2011. The endpoint was cardiac function, assessed by echocardiography. Systolic function was assessed with the left ventricle ejection fraction (LVEF) (n=107) and the global longitudinal strain (GLS) of the left ventricle (LV) (n=52)...
February 11, 2019: International Journal of Radiation Oncology, Biology, Physics
Jessica C Garbern, Jason Williams, Amy C Kristl, Alyyah Malick, Inbal Rachmin, Benjamin Gaeta, Nafis Ahmed, Ana Vujic, Peter Libby, Richard T Lee
Microvascular dysfunction in the heart and its association with periarteriolar fibrosis may contribute to the diastolic dysfunction seen in heart failure with preserved ejection fraction. Interleukin-33 (IL-33) prevents global myocardial fibrosis in a pressure overloaded left ventricle by acting via its receptor, ST2 (encoded by the gene, Il1rl1); however, whether this cytokine can also modulate periarteriolar fibrosis remains unclear. We utilized two approaches to explore the role of IL-33/ST2 in periarteriolar fibrosis...
February 11, 2019: Journal of Molecular and Cellular Cardiology
Noha I Hussien, Hend S El-Wakeel, Safwa M Souror, Inas A Ahmed
Chronic stress is associated with oxidative stress and mitochondrial dysfunction. These mechanisms promote adverse cardiovascular events. Though many experimental studies have reported a protective effect of vitamin D (VitD) on cardiovascular system, its effect on cardiovascular system in case of chronic stress is not studied yet. The present study aimed to detect the effects of VitD treatment against chronic immobilization stress (CIS)-induced cardiac dysfunction, focusing mainly on mitochondrial function and oxidative stress in rats...
January 2019: General Physiology and Biophysics
Halil Kara, Uğur Nadir Karakulak, Meside Gündüzöz, Ceylan Bal, Murat Alışık, Murat Büyükşekerci, Servet Bilgin İritaş, Ömer Hınç Yılmaz, Lütfiye Tutkun
Background/aim: Lead can cause morphological and functional changes in heart, and inflammation and endothelial dysfunction in vasculature. Endocan, as a novel indicator of endothelial dysfunction, has been used for cardiovascular diseases. This study investigated the relationship between lead exposure, endocan levels, and diastolic functions. Materials and methods: A total of 51 lead-exposed workers without a known cardiovascular disease or risk factors and 54 healthy controls were enrolled...
February 11, 2019: Turkish Journal of Medical Sciences
June-Sung Kim, Muyeol Kim, Youn-Jung Kim, Seung Mok Ryoo, Chang Hwan Sohn, Shin Ahn, Won Young Kim
(1) Background: Myocardial dysfunction in patients with sepsis is not an uncommon phenomenon, yet reported results are conflicting and there is no objective definition. Measurement of troponin may reflect the state of the heart and may correlate with echocardiographically derived data. This study aimed to evaluate the role of admission and peak troponin-I testing for the identification of sepsis-induced myocardial dysfunction (SIMD) by transthoracic echocardiography (TTE). (2) Methods: This was a retrospective cohort study using a prospective registry of septic shock at an Emergency Department from January 2011 and April 2017...
February 12, 2019: Journal of Clinical Medicine
David J Cox, Wenjia Bai, Anthony N Price, A David Edwards, Daniel Rueckert, Alan M Groves
BACKGROUND: Premature birth is associated with ventricular remodeling, early heart failure, and altered left ventricular (LV) response to physiological stress. Using computational cardiac magnetic resonance (CMR) imaging, we aimed to quantify preterm ventricular remodeling in the neonatal period, and explore contributory clinical factors. METHODS: Seventy-three CMR scans (34 preterm infants, 10 term controls) were performed to assess in-utero development and preterm ex-utero growth...
November 19, 2018: Pediatric Research
U H Ferdaushi, M A Ali, N Islam, S Nabi, M Islam, M S Alom, G K Paul
Cardiac resynchronization therapy (CRT) reduces symptoms and improves left ventricular function in patients with heart failure due to left ventricular systolic dysfunction and cardiac dyssynchrony. We analyzed the clinical and echocardiographic outcome of CRT in heart failure patients. Thirty five (35) heart failure patients were included in this prospective observational study, conducted from February 2015 to February 2016 in the Department of cardiology, National Institute of Cardiology & Vascular Disease (NICVD) hospital, Dhaka, Bangladesh...
January 2019: Mymensingh Medical Journal: MMJ
Marilucy Lopez-Sublet, Nicolas Girerd, Erwan Bozec, Jean-Loup Machu, João Pedro Ferreira, Faiez Zannad, Jean-Jacques Mourad, Patrick Rossignol
Objective: The attenuation of physiological nocturnal decline of blood pressure (BP) - called nondipper pattern - has previously been reported to be associated with target organ damage in hypertensive subjects. However, this association remains debated and poorly studied in normotensive patients. The present study aimed to investigate the association between nondipper pattern and subclinical cardiovascular and renal damage in an initially healthy population-based cohort study. Methods: The STANISLAS Cohort is a single-center, familial longitudinal cohort comprised of 1006 families (4295 subjects) recruited in 1993-1995 for a 5-year periodic health examination...
February 7, 2019: American Journal of Hypertension
Jacentha Buggs, Madison Shramek, Ebonie Rogers, Ambuj Kumar, Nyingi Kemmer
No abstract text is available yet for this article.
November 1, 2018: American Surgeon
William R Miranda, Donald J Hagler, Guy S Reeder, Carole A Warnes, Heidi M Connolly, Alexander C Egbe, Nathaniel W Taggart
OBJECTIVE: To review our experience with balloon testing prior to atrial septal defect (ASD) closure in adults with left ventricular (LV) diastolic dysfunction. BACKGROUND: ASD closure in patients with LV diastolic dysfunction may precipitate LV failure. Temporary ASD occlusion has been used in this scenario but data are limited. METHODS: Retrospective review of 27 patients age ≥ 50 years undergoing temporary ASD balloon occlusion between 2000 and 2018 for suspected LV diastolic dysfunction or elevated LV end-diastolic pressure (LVEDP)...
February 12, 2019: Catheterization and Cardiovascular Interventions
Ahmad Kautsar, Najib Advani, Murti Andriastuti
Background: Iron-induced cardiomyopathy remains the leading cause of mortality in patients with β-thalassemia major. Iron overload cardiomyopathy, which may be reversible through iron chelation, is characterized by early diastolic dysfunction. Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is a sensitive biomarker of diastolic dysfunction. Aim: The aim of the study is to evaluate the diagnostic value of NT-proBNP as a surrogate marker of iron overload examined with magnetic resonance imaging T2-star (MRI T2*)...
January 2019: Annals of Pediatric Cardiology
Mohamed Abdelaziz El-Gamasy, Walid Ahmed El-Shehaby, Maaly M Mabrouk
Background: Cardiovascular morbidity (CVM) is the main etiology of mortality in children and adolescents with chronic kidney disease (CKD). CKD associated cardiovascular mortality is more common in children with diastolic cardiac dysfunction which was considered as an early indicator for death, while increased left ventricular mass (LVM) is a strong independent risk factor for these patients. Vitamin D deficiency was previously studied as one of the risk factors for CVM. Aim: The aim of the work was to investigate the relationship between biomarkers of mineral bone disorder including serum 25(OH) Vitamin D3 (25-OH D3), phosphorus and calcium × phosphorus (Ca×Po4) product with diastolic cardiac function and LVM in children and adolescents with CKD...
January 2019: Annals of Pediatric Cardiology
Nicole M Novielli-Kuntz, Meghan Jelen, Kevin Barr, Leon J Delailo, Qingping Feng, Brant E Isakson, Robert Gros, Dale W Laird
Connexins (Cxs) and pannexins (Panxs) are highly-regulated large-pore channel-forming proteins that participate in cellular communication via small molecular exchange with the extracellular microenvironment, or in the case of connexins, directly between cells. Given the putative functional overlap between single membrane-spanning connexin hemichannels and Panx channels, and cardiovascular system prevalence, we generated the first Cx40-/- Panx1-/- mouse with the anticipation that this genetic modification would lead to a severe cardiovascular phenotype...
February 11, 2019: Bioscience Reports
Woori Cho, Tae Yeon Hwang, Yoon Kyung Choi, Ji Hyun Yang, Myung-Gyu Kim, Sang-Kyung Jo, Won Yong Cho, Se Won Oh
Background: Femoral neck fracture is common in the elderly population. Acute kidney injury (AKI) is an important risk factor for mortality in patients who have had such fracture. We evaluated the incidence of AKI in patients who had femoral neck fracture and identified risk factors for AKI and mortality. Methods: This was an observational cohort study including 285 patients who were ≥ 65 years of age and who underwent femoral neck fracture surgery between 2013 and 2017...
February 11, 2019: Kidney Research and Clinical Practice
Jun Koyama, Masatoshi Minamisawa, Yoshiki Sekijima, Koichiro Kuwahara, Tsutomu Katsuyama, Kazutoshi Maruyama
Cardiac amyloidosis is a manifestation of one of several systemic amyloidoses, and is characterized by increased left-ventricular (LV) wall thickness and normal or decreased LV cavity size. Congestive heart failure in cardiac amyloidosis is characterized by a predominant diastolic LV dysfunction, and systolic dysfunction occurs only in late-stage disease. Echocardiography is a noninvasive, reproducible method for assessing cardiac morphology and function in cardiac amyloidosis, and some echocardiographic indices are prognostic for amyloidoses...
February 11, 2019: Journal of Echocardiography
Hyun Ju Yoon, Kye Hun Kim, Hyung Yoon Kim, Hyukjin Park, Jae Yeong Cho, Young Joon Hong, Hyung Wook Park, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park
OBJECTIVES: The impacts of non-recovery of trastuzumab-induced left ventricular dysfunction (LVD) on clinical outcomes in breast cancer have been poorly studied. We investigated the predictors of LV-functional non-recovery and its impacts on clinical outcomes in breast cancer patients with trastuzumab-induced LVD. METHODS AND RESULTS: A total of 243 patients with trastuzumab-induced LVD were divided into the recovered LVD group (n = 195) and non-recovered LVD group (n = 48)...
February 8, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Zahra Hoodbhoy, Lubaina Ehsan, Najveen Alvi, Fatimah Sajjad, Aleezay Asghar, Omair Nadeem, Asim Qidwai, Shabneez Hussain, Erum Hasan, Sadaf Altaf, Salman Kirmani, Babar S Hasan
OBJECTIVES: The aim of this study was to establish multidisciplinary care for patients with transfusion-dependent thalassaemia (TDT) by creating a TDT quality improvement (QI) collaborative in a resource-constrained setting. This study presents our initial experience of creating this collaborative, the baseline characteristics of the participants, the proposed QI interventions and the outcome metrics of the collaborative. DESIGN AND SETTING: TDT QI collaborative is a database comprising patients with TDT from four centres in Karachi, Pakistan...
February 8, 2019: Archives of Disease in Childhood
Mariann Bombicz, Daniel Priksz, Rudolf Gesztelyi, Rita Kiss, Nora Hollos, Balazs Varga, Jozsef Nemeth, Attila Toth, Zoltan Papp, Zoltan Szilvassy, Bela Juhasz
Background and Aims : Diabetic cardiomyopathy (DCM) is an emerging problem worldwide due to an increase in the incidence of type 2 diabetes. Animal studies have indicated that metformin and pioglitazone can prevent DCM partly by normalizing insulin resistance, and partly by other, pleiotropic mechanisms. One clinical study has evidenced the insulin-senzitizing effect of the drug candidate BGP-15, along with additional animal studies that have confirmed its beneficial effects in models of diabetes, muscular dystrophy and heart failure, with the drug affecting chaperones, contractile proteins and mitochondria...
February 7, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Grace Casaclang-Verzosa, Sirish Shrestha, Muhammad Jahanzeb Khalil, Jung Sun Cho, Márton Tokodi, Sudarshan Balla, Mohamad Alkhouli, Vinay Badhwar, Jagat Narula, Jordan D Miller, Partho P Sengupta
OBJECTIVES: This study sought to build a patient-patient similarity network using multiple features of left ventricular (LV) structure and function in patients with aortic stenosis (AS). The study further validated the observations in an experimental murine model of AS. BACKGROUND: The LV response in AS is variable and results in heterogeneous phenotypic presentations. METHODS: The patient similarity network was developed using topological data analysis (TDA) from cross-sectional echocardiographic data collected from 246 patients with AS...
February 2019: JACC. Cardiovascular Imaging
Miho Fukui, Aman Gupta, Islam Abdelkarim, Michael S Sharbaugh, Andrew D Althouse, Hesham Elzomor, Suresh Mulukutla, Joon S Lee, John T Schindler, Thomas G Gleason, João L Cavalcante
Importance: Severe aortic stenosis causes pressure overload of the left ventricle, resulting in progressive cardiac dysfunction that can extend beyond the left ventricle. A staging system for aortic stenosis has been recently proposed that quantifies the extent of structural and functional cardiac changes in aortic stenosis. Objectives: To confirm the reproducibility of a proposed staging system and expand the study findings by performing a survival analysis and to evaluate the association of aortic stenosis staging with both cardiac and noncardiac post-transcatheter aortic valve replacement (TAVR) readmissions...
February 6, 2019: JAMA Cardiology
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