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https://read.qxmd.com/read/30827004/gymnopodium-floribundum-fodder-as-a-model-for-the-in-vivo-evaluation-of-nutraceutical-value-against-haemonchus-contortus
#1
F A Méndez-Ortiz, C A Sandoval-Castro, J Ventura-Cordero, L A Sarmiento-Franco, R H Santos-Ricalde, J F J Torres-Acosta
This study validated a protocol to identify the nutraceutical value of Gymnopodium floribundum (GF) foliage based on its effects on sheep nutrition, production and health and its impact on adult Haemonchus contortus. Thirty animals (17.8 ± 3.44 kg BW) were distributed into five experimental groups (n = 6). Groups T1-T3 received feed including 20%, 30% and 40% GF content, respectively, and group T4 received feed with 0% GF. Groups T1-T4 were all infected with 6000 H. contortus infective larvae (L3 )...
March 2, 2019: Tropical Animal Health and Production
https://read.qxmd.com/read/30797849/cutaneous-presentations-of-omphalomesenteric-duct-remnant-a-systematic-review-of-the-literature
#2
Efrat Solomon Cohen, Moshe Lapidoth, Igor Snast, Dan Ben-Amitai, Omri Zidan, Rivka Friedland, Michael Moshe, Daniel Mimouni, Yael Ann Leshem, Emmilia Hodak, Assi Levi
BACKGROUND: Disorders of the umbilicus are commonly seen in infancy including: hernias, infections, anomalies, granulomas and malignancies. Meticulous inspection of the umbilicus at birth may reveal a persisting embryonic remnant such as omphalomesenteric duct (OMD), manifested by a variety of cutaneous signs such as: an umbilical mass, granulation tissue or discharge. OBJECTIVE: To systematically review the available data regarding the presence and management of OMD remnant with cutaneous involvement, in order to suggest a practical approach for diagnosis and treatment...
February 21, 2019: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/30742027/molecular-signature-of-human-bone-marrow-derived-mesenchymal-stromal-cell-subsets
#3
Selim Kuçi, Zyrafete Kuçi, Richard Schäfer, Gabriele Spohn, Stefan Winter, Matthias Schwab, Emilia Salzmann-Manrique, Thomas Klingebiel, Peter Bader
In the current study we compared the molecular signature of expanded mesenchymal stromal cells (MSCs) derived from selected CD271+ bone marrow mononuclear cells (CD271-MSCs) and MSCs derived from non-selected bone marrow mononuclear cells by plastic adherence (PA-MSCs). Transcriptome analysis demonstrated for the first time the upregulation of 115 and downregulation of 131 genes in CD271-MSCs. Functional enrichment analysis showed that the upregulated genes in CD271-MSCs are significantly enriched for extracellular matrix (tenascin XB, elastin, ABI family, member 3 (NESH) binding protein, carboxypeptidase Z, laminin alpha 2 and nephroblastoma overexpressed) and cell adhesion (CXCR7, GPNMB, MYBPH, SVEP1, ARHGAP6, TSPEAR, PIK3CG, ABL2 and NCAM1)...
February 11, 2019: Scientific Reports
https://read.qxmd.com/read/30670012/the-role-of-osteomodulin-on-osteo-odontogenic-differentiation-in-human-dental-pulp-stem-cells
#4
Wenzhen Lin, Li Gao, Wenxin Jiang, Chenguang Niu, Keyong Yuan, Xuchen Hu, Rui Ma, Zhengwei Huang
BACKGROUND: Extracellular matrix secretion and odontoblastic differentiation in human dental pulp stem cells (hDPSCs) are the cellular bases for reparative dentinogenesis. Osteomodulin (OMD) is a member of the small leucine-rich proteoglycan family distributed in the extracellular matrix but little is known about its role in osteo/odontogenic differentiation. The objective of this study was to investigate the role of OMD during osteo/odontoblastic differentiation of hDPSCs. METHODS: hDPSCs were selected using immune-magnetic beads and their capability of multi-differentiation was identified...
January 22, 2019: BMC Oral Health
https://read.qxmd.com/read/30664806/oromandibular-dystonia-mental-distress-and-oro-facial-dysfunction-a-follow-up-8-10-years-after-start-of-treatment-with-botulinum-toxin
#5
Merete Bakke, Sara Baram, Torben Dalager, Heidi Bryde Biernat, Eigild Møller
BACKGROUND: Oromandibular dystonia (OMD) with involuntary jaw and tongue movements may be misdiagnosed as temporomandibular disorders (TMD) and because of the complex muscle activity and involvement of several small muscles, OMD is also considered difficult to treat. OBJECTIVES: The aim was to evaluate OMD in patients 8-10 years after start of treatment with botulinum toxin (BoNT) by self-reported and standardised global scales and questionnaires. METHODS: Of 21 previously reported patients with OMD, 14 responded to a mail health questionnaire to describe the disease course and treatment effect as well as the overall impact of OMD by a visual analogue scale (VAS), the Patient Health Questionnaire (PHQ) for depression and anxiety, and the Jaw Functional Limitation Scale (JFLS)...
January 21, 2019: Journal of Oral Rehabilitation
https://read.qxmd.com/read/30654984/quality-of-life-in-functional-movement-disorders-is-as-altered-as-in-organic-movement-disorders
#6
Thierry Gendre, Guilhem Carle, Francine Mesrati, Cécile Hubsch, Thomas Mauras, Emmanuel Roze, Marion Houot, Bertrand Degos, Béatrice Garcin
OBJECTIVE: Patients with functional movement disorders (FMD) often report a disability and psychiatric comorbidities. However, few studies have compared these aspects in FMD and in organic movement disorders (OMD). The objectives were to compare QoL and psychiatric comorbidities of FMD and OMD patients. METHODS: Twenty-one and 30 FMD patients were compared to 21 and 30 sex- and age-matched dystonia and Parkinson patients respectively. QoL was assessed using the Parkinson's Disease Summary Index (PDSI)...
January 2019: Journal of Psychosomatic Research
https://read.qxmd.com/read/30642265/transcription-factors-stat-4-stat-6-and-creb-regulate-th1-th2-response-in-leprosy-patients-effect-of-m-leprae-antigens
#7
Rajni Upadhyay, Bhavyata Dua, Bhawna Sharma, Mohan Natrajan, Ajai Kumar Jain, Balaji Kithiganahalli Narayanaswamy, Beenu Joshi
BACKGROUND: Leprosy is an ideal human disease to study T cell regulation as patients show correlation between cytokine skewed Th1-Th2 responses and clinical forms of the disease. The Role of transcription factors on the modulation of Th1 and Th2 responses by M. leprae antigens has not been adequately studied. In the present study, we studied the effect of M. leprae antigens on transcription factors STAT-4, STAT-6 and CREB and their correlation with Th1/Th2 cell mediated immune responses in leprosy...
January 14, 2019: BMC Infectious Diseases
https://read.qxmd.com/read/30616057/facial-grimacing-and-clinical-correlates-in-spinocerebellar-ataxia-type-3
#8
Flávio Moura de Rezende Filho, Thiago Cardoso Vale, José Luiz Pedroso, Pedro Braga-Neto, Orlando G Barsottini
INTRODUCTION: Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease, is the most common spinocerebellar ataxia (SCA) worldwide. SCA3 presents with cerebellar ataxia in association with pyramidal signs, peripheral amyotrophy, nystagmus, ophthalmoparesis, fasciculations of the face and tongue, dystonia and parkinsonism. Oromandibular dystonia (OMD) with facial grimacing (FG) in SCA3 has seldom been reported in the literature and in series of SCA3 patients. METHODS: We evaluated 104 patients with SCA (59 patients with SCA3, 20 with SCA2, 20 with SCA7 and 5 with SCA6) and assessed dystonia frequency and types...
January 2, 2019: Journal of the Neurological Sciences
https://read.qxmd.com/read/30604200/botulinum-neurotoxin-a-therapy-efficacy-and-safety-for-oromandibular-dystonia-a-meta-analysis
#9
Pariessa D Dadgardoust, Raymond L Rosales, Ria Monica Asuncion, Dirk Dressler
Oromandibular dystonia (OMD) is a focal dystonia involving the mouth, jaw, and tongue. Botulinum neurotoxin (BoNT) therapy might be one form of treatment in OMD. Systematic pooling of BoNT studies in OMD remains wanting, as the derived data could provide useful information in regard to efficacy and safety issues. This meta-analysis determined the effects of botulinum neurotoxin type A (BoNT/A) on the reduction of dystonic movement and its safety among patients with OMD. A systematic search of the literature that met the following eligibility criteria were done: (1) patients treated with BoNT/A for OMD, (2) studies of high methodological quality and (3) outcome criteria specified as regard to efficacy...
January 2, 2019: Journal of Neural Transmission
https://read.qxmd.com/read/30597820/immediate-and-legacy-effects-of-urban-pollution-on-river-ecosystem-functioning-a-mesocosm-experiment
#10
Olatz Pereda, Vicenç Acuña, Daniel von Schiller, Sergi Sabater, Arturo Elosegi
Effluents from urban wastewater treatment plants (WWTP) consist of complex mixtures of substances that can affect processes in the receiving ecosystems. Some of these substances (toxic contaminants) stress biological activity at all concentrations, while others (e.g., nutrients) subsidize it at low concentrations and stress it above a threshold, causing subsidy-stress responses. Thus, the overall effects of WWTP effluents depend mostly on their composition and the dilution capacity of the receiving water bodies...
March 2019: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/30597797/immediate-and-legacy-effects-of-urban-pollution-on-river-ecosystem-functioning-a-mesocosm-experiment
#11
Olatz Pereda, Vicenç Acuña, Daniel von Schiller, Sergi Sabater, Arturo Elosegi
Effluents from urban wastewater treatment plants (WWTP) consist of complex mixtures of substances that can affect processes in the receiving ecosystems. Some of these substances (toxic contaminants) stress biological activity at all concentrations, while others (e.g., nutrients) subsidize it at low concentrations and stress it above a threshold, causing subsidy-stress responses. Thus, the overall effects of WWTP effluents depend mostly on their composition and the dilution capacity of the receiving water bodies...
March 2019: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/30578492/occult-macular-dystrophy
#12
Stephen H Tsang, Tarun Sharma
Patients with occult macular dystrophy (OMD) are usually middle-aged and have progressive loss of central vision or notice central scotoma, but no significant abnormality is seen in the fundus or fluorescein angiography. Optical coherence tomography (OCT) shows loss of the ellipsoid band in the central area (Fig. 19.1). Full-field electroretinography (ERG) is normal or may show diminished cone response; multifocal ERG reveals diminished amplitude in the central retina.
2018: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/30565183/effect-of-dried-sesbania-sesban-leaves-supplementation-on-milk-yield-feed-intake-and-digestibility-of-holstein-friesian-x-zebu-arado-crossbred-dairy-cows
#13
Solomon Gebreyowhans, Tsadkan Zegeye
This experiment was conducted to investigate effect of dried Sesbania sesban leaves supplementation on milk yield, feed intake and digestibility of Holstein Frisian X Zebu (Arado) crossbred dairy cows. Twelve cows at midlactation (155.83 ± 4.49 days of lactation), second parity, and 442.21 ± 3.40 kg average live body weight were randomly assigned to one of four dietary treatments according to a randomized complete block design. Cows were blocked according to their daily milk yield into three blocks of four animals each...
December 18, 2018: Tropical Animal Health and Production
https://read.qxmd.com/read/30553465/primary-aneurysmal-bone-cyst-with-a-novel-sparc-usp6-translocation-identified-by-next-generation-sequencing
#14
Daja Šekoranja, Emanuela Boštjančič, Vladka Salapura, Blaž Mavčič, Jože Pižem
Aneurysmal bone cyst (ABC) is a benign but locally aggressive, mostly pediatric neoplasm, with characteristic USP6 gene rearrangement that distinguishes it from a secondary ABC and other primary bone tumors. With the advent of next-generation sequencing (NGS) technology, several hitherto unknown USP6 fusion partners have been identified in ABC. Accordingly, we present a case of an 18-year-old male with a solid sub-periosteal primary ABC in the diaphysis of the left femur. Using an NGS-based assay, we identified SPARC-USP6 fusion, which has not previously been described in ABC...
December 2018: Cancer Genetics
https://read.qxmd.com/read/30429016/local-ablative-treatment-for-synchronous-single-organ-oligometastatic-lung-cancer-a-propensity-score-analysis-of-180-patients
#15
Nikolaj Frost, Antje Tessmer, Alexander Schmittel, Vincent van Laak, Matthias Raspe, Christoph Ruwwe-Glösenkamp, Matthias Brunn, Carolin Senger, Dirk Böhmer, Sebastian Ochsenreither, Bettina Temmesfeld-Wollbrück, Christian Furth, Bernd Schmidt, Jens Neudecker, Jens-Carsten Rückert, Norbert Suttorp, Martin Witzenrath, Christian Grohé
INTRODUCTION: Local ablative treatment (LAT) improves outcome in lung cancer with oligometastatic disease (OMD) and potentially leads to long term survival. The aim of this retrospective study was to evaluate and quantify the additional benefit of LAT in synchronous OMD and to further identify prognostic factors for survival. PATIENTS AND METHODS: A propensity score-matched pairs analysis was performed on a set of patient and disease variables in 180 patients, treated for synchronous single organ OMD including non small-cell and neuroendocrine lung cancer with ≤4 metastases between 2000 and 2016 in 3 lung cancer centers in Berlin, Germany...
November 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/30417098/the-optimal-mating-distance-resulting-from-heterosis-and-genetic-incompatibility
#16
Xinzhu Wei, Jianzhi Zhang
Theory predicts that the fitness of an individual is maximized when the genetic distance between its parents (i.e., mating distance) is neither too small nor too large. However, decades of research have generally failed to validate this prediction or identify the optimal mating distance (OMD). Respectively analyzing large numbers of crosses of fungal, plant, and animal model organisms, we indeed find the hybrid phenotypic value a humped quadratic polynomial function of the mating distance for the vast majority of fitness-related traits examined, with different traits of the same species exhibiting similar OMDs...
November 2018: Science Advances
https://read.qxmd.com/read/30271919/molecular-basis-for-governing-the-morphology-of-type-i-collagen-fibrils-by-osteomodulin
#17
Takumi Tashima, Satoru Nagatoishi, Jose M M Caaveiro, Makoto Nakakido, Hiroshi Sagara, Osamu Kusano-Arai, Hiroko Iwanari, Hitomi Mimuro, Takao Hamakubo, Shin-Ichi Ohnuma, Kouhei Tsumoto
Small leucine-rich repeat proteoglycan (SLRP) proteins have an important role in the organization of the extracellular matrix, especially in the formation of collagen fibrils. However, the mechanism governing the shape of collagen fibrils is poorly understood. Here, we report that the protein Osteomodulin (OMD) of the SLRP family is a monomeric protein in solution that interacts with type-I collagen. This interaction is dominated by weak electrostatic forces employing negatively charged residues of OMD, in particular Glu284 and Glu303, and controlled by entropic factors...
2018: Communications Biology
https://read.qxmd.com/read/30266553/administration-of-cinnamaldehyde-promotes-osteogenesis-in-ovariectomized-rats-and-differentiation-of-osteoblast-in-vitro
#18
Zongyi Wu, Sheji Weng, Deyi Yan, Zhongjie Xie, Qiang Zhou, Hang Li, Bingli Bai, Viraj Boodhun, Zijian Shen, Jiahao Tang, Lingling Zhou, Zhoushan Tao, Lei Yang
To explore the effect of cinnamaldehyde on the distal femur in ovariectomized rats and its influence on osteoblast in vitro. Female Sprague-Dawley rats which underwent either bilateral ovariectomy or sham operation were divided into five groups randomly: group OVX (OVX, N = 10) and group sham (SHAM, N = 10) received normal saline (NS) by gavage at a dose of 50 ml/kg·d; group low dose, group middle dose and group high dose received cinnamaldehyde by gavage at a dose of 25 mg/kg·d (OLD, N = 10), 50 mg/kg·d (OMD, N = 10), and 75 mg/kg·d (OHD, N = 10) respectively...
September 11, 2018: Journal of Pharmacological Sciences
https://read.qxmd.com/read/30248766/-the-correlation-of-occupational-musculoskeletal-disorders-and-occupational-safety-behaviors-in-assembly-line-workers
#19
Y C Zhou, H Y Zheng, H Z Liu, W N Pan, J Q Feng, X X Liu
Objective: To study the correlation of occupation musculoskeletal disease (OMD) and safety behavior in assembly line workers. Methods: Selected assembly line workers of 3 manufacturing factory in Pacity as the objects of this study by judgement sampling. Questionnaires were used for messages collection including the general sociodemographic characteristic, OMD condition, occupational safety behaviors. Results: This study shows that, 826 OMD workers were found that the annual prevalence was 38.03%. The scores of work posture, handling habits, health habit in OMD group was lower than non-OMD group ( P <0...
July 20, 2018: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://read.qxmd.com/read/30242630/feeding-difficulties-and-orofacial-myofunctional-disorder-in-patients-with-hepatic-glycogen-storage-diseases
#20
Chenia Caldeira Martinez, Tássia Tonon, Tatiéle Nalin, Lilia Farret Refosco, Carolina Fischinger Moura de Souza, Ida Vanessa Doederlein Schwartz
Hepatic glycogen storage diseases (GSDs) are inborn errors of metabolism whose dietary treatment involves uncooked cornstarch administration and restriction of simple carbohydrate intake. The prevalence of feeding difficulties (FDs) and orofacial myofunctional disorders (OMDs) in these patients is unknown. OBJECTIVE: To ascertain the prevalence of FDs and OMDs in GSD. METHODS: This was a cross-sectional, prospective study of 36 patients (19 males; median age, 12...
September 22, 2018: JIMD Reports
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