keyword
Keywords STOPP - (Screening Tool of Old...

STOPP - (Screening Tool of Older Person's Prescriptions)

https://read.qxmd.com/read/38525745/deprescribing-in-older-poly-treated-patients-affected-with-dementia
#1
JOURNAL ARTICLE
Pietro Gareri, Luca Gallelli, Ilaria Gareri, Vincenzo Rania, Caterina Palleria, Giovambattista De Sarro
Polypharmacy is an important issue in older patients affected by dementia because they are very vulnerable to the side effects of drugs'. Between October 2021 and September 2022, we randomly assessed 205 old-aged outpatients. The study was carried out in a Center for Dementia in collaboration with a university center. The primary outcomes were: (1) deprescribing inappropriate drugs through the Beers and STOPP&START criteria; (2) assessing duplicate drugs and the risk of iatrogenic damage due to drug-drug and drug-disease interactions...
February 26, 2024: Geriatrics
https://read.qxmd.com/read/38519972/the-long-term-intercorrelation-between-post-burn-pain-anxiety-and-depression-a-post-hoc-analysis-of-the-re-energize-double-blind-randomized-multicenter-placebo-controlled-trial
#2
RANDOMIZED CONTROLLED TRIAL
Adriana C Panayi, Daren K Heyland, Christian Stoppe, Marc G Jeschke, Oliver Didzun, Dany Matar, Christian Tapking, Alen Palackic, Björn Bliesener, Leila Harhaus, Samuel Knoedler, Valentin Haug, Amir K Bigdeli, Ulrich Kneser, Dennis P Orgill, Gabriel Hundeshagen
BACKGROUND: Despite the growing prevalence of burn survivors, a gap persists in our understanding of the correlation between acute burn trauma and the long-term impact on psychosocial health. This study set out to investigate the prevalence of long-term pain and symptoms of anxiety and depression in survivors of extensive burns, comparing this to the general population, and identify injury and demographic-related factors predisposing individuals to psychosocial compromise. METHODS: RE-ENERGIZE was an international, double-blinded, randomized-controlled trial that enrolled 1200 patients with partial- or full-thickness burns that required surgical treatment...
March 22, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38450651/clinician-treatment-choices-for-post-traumatic-stress-disorder-ptsd-ambassadors-survey-of-psychiatrists-in-39-european-countries
#3
REVIEW
Martina Rojnic Kuzman, Frank Padberg, Benedikt L Amann, Meryam Schouler-Ocak, Zarko Bajic, Tarja Melartin, Adrian James, Julian Beezhold, Jordi Artigue Gómez, Celso Arango, Tihana Jendričko, Jamila Ismayilov, William Flannery, Egor Chumakov, Koray Başar, Simavi Vahip, Dominika Dudek, Jerzy Samochowiec, Goran Mihajlović, Fulvia Rota, Gabriela Stoppe, Geert Dom, Kirsten Catthoor, Eka Chkonia, Maria João Heitor Dos Santos, Diogo Telles, Peter Falkai, Philippe Courtet, Michal Patarák, Lubomira Izakova, Oleg Skugarevski, Stojan Barjaktarov, Dragan Babić, Goran Račetović, Andrea Fiorillo, Bernardo Carpiniello, Maris Taube, Yuval Melamed, Jana Chihai, Doina Constanta Maria Cozman, Pavel Mohr, György Szekeres, Mirjana Delic, Ramunė Mazaliauskienė, Aleksandar Tomcuk, Nataliya Maruta, Philip Gorwood
No abstract text is available yet for this article.
March 7, 2024: European Psychiatry: the Journal of the Association of European Psychiatrists
https://read.qxmd.com/read/38441190/micronutrients-as-therapy-in-critical-illness
#4
JOURNAL ARTICLE
Christian Stoppe, Ellen Dresen, Angelique de Man
PURPOSE OF REVIEW: Recent large-scale randomized controlled trials (RCTs) challenged current beliefs about the potential role of micronutrients to attenuate the inflammatory response and improve clinical outcomes of critically ill patients. The purpose of this narrative review is to provide an overview and critical discussion about most recent clinical trials, which evaluated the clinical significance of a vitamin C, vitamin D, or selenium administration in critically ill patients. RECENT FINDINGS: None of the most recent large-scale RCTs could demonstrate any clinical benefits for a micronutrient administration in ICU patients, whereas a recent RCT indicated harmful effects, if high dose vitamin C was administered in septic patients...
January 8, 2024: Current Opinion in Critical Care
https://read.qxmd.com/read/38441124/enteral-nutrition-in-septic-shock-a-call-for-a-paradigm-shift
#5
JOURNAL ARTICLE
Jayshil J Patel, Juan Carlos Lopez-Delgado, Christian Stoppe, Stephen A McClave
PURPOSE OF REVIEW: The purpose of this review is to identify contemporary evidence evaluating enteral nutrition in patients with septic shock, outline risk factors for enteral feeding intolerance (EFI), describe the conundrum of initiating enteral nutrition in patients with septic shock, appraise current EFI definitions, and identify bedside monitors for guiding enteral nutrition therapy. RECENT FINDINGS: The NUTRIREA-2 and NUTRIREA-3 trial results have better informed the dose of enteral nutrition in critically ill patients with circulatory shock...
January 15, 2024: Current Opinion in Critical Care
https://read.qxmd.com/read/38429302/bi-allelic-variants-in-celsr3-are-implicated-in-central-nervous-system-and-urinary-tract-anomalies
#6
JOURNAL ARTICLE
Jil D Stegmann, Jeshurun C Kalanithy, Gabriel C Dworschak, Nina Ishorst, Enrico Mingardo, Filipa M Lopes, Yee Mang Ho, Phillip Grote, Tobias T Lindenberg, Öznur Yilmaz, Khadija Channab, Steve Seltzsam, Shirlee Shril, Friedhelm Hildebrandt, Felix Boschann, André Heinen, Angad Jolly, Katherine Myers, Kim McBride, Mir Reza Bekheirnia, Nasim Bekheirnia, Marcello Scala, Manuela Morleo, Vincenzo Nigro, Annalaura Torella, Michele Pinelli, Valeria Capra, Andrea Accogli, Silvia Maitz, Alice Spano, Rory J Olson, Eric W Klee, Brendan C Lanpher, Se Song Jang, Jong-Hee Chae, Philipp Steinbauer, Dietmar Rieder, Andreas R Janecke, Julia Vodopiutz, Ida Vogel, Jenny Blechingberg, Jennifer L Cohen, Kacie Riley, Victoria Klee, Laurence E Walsh, Matthias Begemann, Miriam Elbracht, Thomas Eggermann, Arzu Stoppe, Kyra Stuurman, Marjon van Slegtenhorst, Tahsin Stefan Barakat, Maureen S Mulhern, Tristan T Sands, Cheryl Cytrynbaum, Rosanna Weksberg, Federica Isidori, Tommaso Pippucci, Giulia Severi, Francesca Montanari, Michael C Kruer, Somayeh Bakhtiari, Hossein Darvish, Heiko Reutter, Gregor Hagelueken, Matthias Geyer, Adrian S Woolf, Jennifer E Posey, James R Lupski, Benjamin Odermatt, Alina C Hilger
CELSR3 codes for a planar cell polarity protein. We describe twelve affected individuals from eleven independent families with bi-allelic variants in CELSR3. Affected individuals presented with an overlapping phenotypic spectrum comprising central nervous system (CNS) anomalies (7/12), combined CNS anomalies and congenital anomalies of the kidneys and urinary tract (CAKUT) (3/12) and CAKUT only (2/12). Computational simulation of the 3D protein structure suggests the position of the identified variants to be implicated in penetrance and phenotype expression...
March 1, 2024: NPJ Genomic Medicine
https://read.qxmd.com/read/38412995/-not-available
#7
JOURNAL ARTICLE
Dorothee Böhm, Björn Bliesener, Thorben Dieck, Marianne Kruse, Tobias Odenthal, Christian Stoppe, Stefan Trojan, Jochen Gille
Acute phase and resuscitation after burn trauma are challenging even for specialised burn centres due to the individual onset and differences compared with other forms of shock. The guidelines of the German Society of Burn Medicine (DGV) cover the scientific basis of modern burn treatment. Nevertheless, uncertainty remains regarding the detailed practical handling. This expert consensus focuses on best practices for the treatment of patients with major burns in specialised burn centres and by clinical first responders...
February 27, 2024: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://read.qxmd.com/read/38362229/potentially-inappropriate-medications-use-and-associated-factors-among-older-patients-on-follow-up-at-the-chronic-care-clinic-of-hiwot-fana-comprehensive-specialized-hospital-in-eastern-ethiopia
#8
JOURNAL ARTICLE
Shambel Nigussie, Fekade Demeke
BACKGROUND: Potentially inappropriate medications (PIMs) use often cause to poor health outcomes in older patients. There is a dearth of information on PIMS use in this population of patients seeking treatment at Hiwot Fana Comprehensive Specialized Hospital. OBJECTIVE: To assess PIMs use and associated factors among older patients receiving follow-up treatment at the chronic care clinic of Hiwot Fana Comprehensive Specialized Hospital in eastern Ethiopia. METHODS: A retrospective cross-sectional study using medical records of 419 older patients was conducted...
2024: Current Therapeutic Research, Clinical and Experimental
https://read.qxmd.com/read/38356344/immune-enhancing-treatment-among-acute-necrotizing-pancreatitis-patients-with-metabolic-abnormalities-a-post-hoc-analysis-of-a-randomized-clinical-trial
#9
JOURNAL ARTICLE
Xiaofei Huang, Wenjian Mao, Xingxing Hu, Fengxia Qin, Hui Zhao, Aiping Zhang, Xinyu Wang, Christian Stoppe, Dandan Zhou, Lu Ke, Haibin Ni
BACKGROUND/AIMS: : Metabolic syndrome is common in patients with acute pancreatitis and its components have been reported to be associated with infectious complications. In this post hoc analysis, we aimed to evaluate whether metabolic abnormalities impact the effect of immune-enhancing thymosin alpha-1 (Tα1) therapy in acute necrotizing pancreatitis (ANP) patients. METHODS: : All data were obtained from the database for a multicenter randomized clinical trial that evaluated the efficacy of Tα1 in ANP patients...
February 15, 2024: Gut and Liver
https://read.qxmd.com/read/38321367/appropriateness-of-direct-oral-anticoagulant-prescribing-in-older-subjects-with-atrial-fibrillation-discharged-from-acute-medical-wards
#10
JOURNAL ARTICLE
Antonio De Vincentis, Luca Soraci, Elena Arena, Angela Sciacqua, Giuseppe Armentaro, Francesco Aucella, Andrea Corsonello, Filippo Aucella, Raffaele Antonelli Incalzi
AIMS: Knowledge on the prescriptive practice of direct oral anticoagulants (DOACs) in older subjects with atrial fibrillation (AF) hospitalized in acute medical wards is limited. This study aimed to evaluate the prevalence and appropriateness of DOAC prescriptions in hospitalized older subjects with AF, discharged from acute medical wards. METHODS: We analysed a cohort of 609 subjects with AF, aged ≥65 years (mean age 85 years) enrolled from 39 geriatric and nephrology wards in Italy...
February 6, 2024: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/38317476/stopp-start-criteria-used-to-identify-the-elderly-population-prone-to-potentially-inadequate-prescribing-in-a-colombian-cohort
#11
JOURNAL ARTICLE
Loren Zambrano, Rosa-Helena Bustos, Edgar Beltran, Daniel Gomez, Sara Arias, Wilson Briceño
BACKGROUND: Elderly people have multiple comorbidities that often require treatment with multiple medications. Having strategies to lessen the risks associated with pharmacological interactions and potentially inadequate prescribing (PIP) is of major importance. The STOPP- START criteria are useful in identifying PIP along with other tools, such as LASA (look alike/sound alike) drugs and high-risk medications (HRM). OBJECTIVE: We aimed to clinically and sociodemographically characterize the population with PIP according to the STOPP-START criteria in hospitalized elderly patients over 6 months in a third-level hospital in Colombia, South America...
January 16, 2024: Current Aging Science
https://read.qxmd.com/read/38310478/highlights-in-the-clinical-nutrition-literature-a-critical-appraisal-of-current-research
#12
REVIEW
Christian Stoppe, Gunnar Elke, Simone Chaves de Miranda Silvstre, Matthew Kappus
Within the American Society for Parenteral and Enteral Nutrition (ASPEN), the Physician Engagement Committee (PEC) was created in 2017 by the ASPEN Board of Directors with the goal of growing the physician community both nationally and internationally. The PEC meets each month throughout the year to develop educational and research initiatives. In 2022, the PEC began an initiative to systematically review and evaluate practice-changing literature annually with the overall aim to highlight these studies at the annual ASPEN conferences and to critically discuss the potential clinical implications...
February 4, 2024: JPEN. Journal of Parenteral and Enteral Nutrition
https://read.qxmd.com/read/38299039/storage-duration-of-human-blood-samples-for-fatty-acid-concentration-analyses-how-long-is-too-long
#13
JOURNAL ARTICLE
Ghaith Mohsen, Helga Peisker, Katharina Gutbrod, Christian Stoppe, Georg Daniel Duerr, Markus Velten
Polyunsaturated fatty acids such as DHA have known anti-inflammatory properties. The therapeutic implication highlights the importance of accurate serum measurements. Sample preservation is challenging when performed parallel to the clinical obligations. Impact of time between sample collection and processing regarding concentration alterations of fatty acids in human blood remains to be elucidated. Therefore, more information is required with respect to the stability and storage options in the context of potential degradation and concentration changes...
June 2024: MethodsX
https://read.qxmd.com/read/38269564/-how-potentially-inapropriate-are-psychotropic-drugs-prescribing-in-acute-psychiatric-unit-for-the-elderly-results-from-a-large-multicentric-audit-in-france
#14
JOURNAL ARTICLE
Morgane Houix, Ilia Humbert, Guillaume Mabileau, Guillaume Chapelet, Anne Sauvaget, Bénédicte Gohier, Sophie Armand-Branger, Jean-François Huon, Fanny D'Acremont, Samuel Bulteau
Adverse drug reactions (ADRs) are a major public health issue, especially when it comes to the elderly. Potentially inappropriate prescribing (PIP) are one of the causes of ADRs in older people. A PIP can be defined as a prescription for which the benefit/risk ratio is unfavourable compared to other therapeutic alternatives. Psychotropic drugs are the second highest risk class for ADRs in the elderly. In order to reduce the prevalence of PIP, prescription assistance tools have been created. An inventory of PIP of psychotropic drugs in older patients hospitalized in psychiatry units was carried out in a French regional setting in 2019...
December 1, 2023: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://read.qxmd.com/read/38256457/potentially-inappropriate-prescribing-and-potential-prescribing-omissions-and-their-association-with-adverse-drug-reaction-related-hospital-admissions
#15
JOURNAL ARTICLE
Ross Brannigan, John E Hughes, Frank Moriarty, Emma Wallace, Ciara Kirke, David Williams, Kathleen Bennett, Caitriona Cahir
BACKGROUND: This study aimed to determine the prevalence of potentially inappropriate prescribing (PIP) and potential prescribing omissions (PPOs) and their association with ADR-related hospital admissions in patients aged ≥ 65 years admitted acutely to the hospital. METHODS: Information on medications and morbidities was extracted from the Adverse Drug Reactions in an Ageing Population (ADAPT) cohort (N = 798: N = 361 ADR-related admissions; 437 non-ADR-related admissions)...
January 6, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38247981/influence-of-potentially-inappropriate-medication-use-on-older-australians-admission-to-emergency-department-short-stay
#16
JOURNAL ARTICLE
Hoa T M Tran, Cristina Roman, Gary Yip, Michael Dooley, Mohammed S Salahudeen, Biswadev Mitra
Older people in the emergency department (ED) often pose complex medical challenges, with a significant prevalence of polypharmacy and potentially inappropriate medicines (PIMs) in Australia. A retrospective analysis of 200 consecutive patients aged over 65 years admitted to the emergency short stay unit (ESSU) aimed to identify polypharmacy (five or more regular medications), assess PIM prevalence, and explore the link between pre-admission PIMs and ESSU admissions. STOPP/START version 2 criteria were used for the PIM assessment, with an expert panel categorizing associated risks...
January 4, 2024: Geriatrics
https://read.qxmd.com/read/38245768/enhanced-exclusive-enteral-nutrition-delivery-during-the-first-7-days-is-associated-with-decreased-28-day-mortality-in-critically-ill-patients-with-normal-lactate-level-a-post-hoc-analysis-of-a-multicenter-randomized-trial
#17
JOURNAL ARTICLE
Yizhe Chen, Zirui Liu, Qiuhui Wang, Fei Gao, Hongyang Xu, Lu Ke, Zheng-Yii Lee, Christian Stoppe, Daren K Heyland, Fengming Liang, Jiajia Lin
BACKGROUND AND AIMS: Exclusive enteral nutrition (EN) is often observed during the first week of ICU admission because of the extra costs and safety considerations for early parenteral nutrition. This study aimed to assess the association between nutrition intake and 28-day mortality in critically ill patients receiving exclusive EN. METHODS: This is a post hoc analysis of a cluster-randomized clinical trial that assesses the effect of implementing a feeding protocol on mortality in critically ill patients...
January 20, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38234703/recommendations-of-apex-health-bodies-remain-localized-not-in-conformity-with-international-implementation-policy-for-urological-disorders
#18
REVIEW
Suresh Kumar Goyal, Renu Bansal, Vikas Gupta, Cherry Bansal, Parveen Bansal
In developing/underdeveloped countries there is still a great burden of adverse drug reaction (ADR), morbidity and mortality because of poor regulations and implementation of preventive measures. These countries try to copy/follow guidelines from international bodies like American Urology Association (AUA), European Association of Urology (EAU), AGS, UMC and WHO irrespective of their country of origin and success in implementation. Although recommendations of these organizations are obligatory, yet these are taken as the gold standard for good clinical practices...
January 2024: Lancet Reg Health Southeast Asia
https://read.qxmd.com/read/38220371/the-impact-of-high-versus-standard-enteral-protein-provision-on-functional-recovery-following-intensive-care-admission-protocol-for-a-pre-planned-secondary-bayesian-analysis-of-the-precise-trial
#19
JOURNAL ARTICLE
Samuel Heuts, Pieter de Heer, Andrea Gabrio, Julia L M Bels, Zheng-Yii Lee, Christian Stoppe, Sander van Kuijk, Albertus Beishuizen, Ashley de Bie-Dekker, Vincent Fraipont, Stoffel Lamote, Didier Ledoux, Clarissa Scheeren, Elisabeth De Waele, Arthur van Zanten, Dieter Mesotten, Marcel C G van de Poll
BACKGROUND: The PRECISe trial is a pragmatic, multicenter randomized controlled trial that evaluates the effect of high versus standard enteral protein provision on functional recovery in adult, mechanically ventilated critically ill patients. The current protocol presents the rationale and analysis plan for an evaluation of the primary and secondary outcomes under the Bayesian framework, with an emphasis on clinically important effect sizes. METHODS: This protocol was drafted in agreement with the ROBUST-statement, and is submitted for publication before database lock and primary data analysis...
February 2024: Clinical Nutrition ESPEN
https://read.qxmd.com/read/38214865/chronic-benzodiazepine-usage-among-older-people-prevalence-indications-and-treatment-modifications-in-patients-admitted-to-an-acute-geriatric-unit
#20
JOURNAL ARTICLE
C Corral-Tuesta, A Rodríguez Díaz-Pavón, B Montero-Errasquín, C G Álvarez-Pinheiro, V Lavilla-Gracia, A J Cruz-Jentoft
AIM: To investigate the prevalence and indications of benzodiazepines (BZD) usage among patients admitted to an acute geriatric unit and assess changes in prescriptions. METHODS: BZD indications were documented reviewing clinical records, with appropriateness assessed based on the STOPP-START criteria. Changes in BZD prescriptions were recorded at discharge and 3 months later. RESULTS: Among the 366 patients included (mean age: 92.8 years, 68% females), 91 (24...
January 12, 2024: European Geriatric Medicine
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