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PIDPs—(Potentially Inappropriate Drug Prescriptions)

Mamta Agiwal, Hu Jin
The millimeter-wave (mmWave) spectrum is one of the important propositions of 5G mobile networks due to its ability to accommodate massive traffic demands and an ever-increasing number of wireless devices. The beam-formed directional technique overcomes the propagation and path loss challenges of mmWave high frequencies. Though the directional convergence is expected to unleash new possibilities, it cannot be implemented with conventional power-saving solutions optimized over omnidirectional communications...
June 5, 2018: Sensors
Karin A Rosenblatt, Elaina F Osterbur, Jeffrey A Douglas
OBJECTIVE: To determine the association between Pap smear and pelvic examination screenings and the development of invasive cervical cancer in a Medicare population using a matched case-control design. METHODS: Matched case-control data sets were constructed from the SEER-Medicare database that links the Surveillance Epidemiology End Results (SEER) cancer registry data and Medicare enrollment and claims data of subjects who received care between the years 1991 and 1999 aged 65years or older...
September 2016: Gynecologic Oncology
Yan Wang, Shineng Luo, Jianguo Lin, Ling Qiu, Wen Cheng, Haozhen Zhai, Beibei Nan, Wanzhong Ye, Yongmei Xia
This study was to investigate the preparation and biodistribution of (99m)Tc-labeled novel zoledronic acid derivative 1-hydroxy-2-(2-isopropyl-1H-imidazole-1-yl) ethylidene-1,1-bisphosphonic ((99m)Tc-i-PIDP) as a potential bone imaging agent. Satisfactory labeling results (radiochemical purity over 95%) were obtained when the amount of i-PIDP, Na(99m)TcO(4), and SnCl(2)·2H(2)O, were 5 mg, 37 MBq, and 100 μg, respectively, the pH value was between 4.0 and 6.0, and the labeling reaction continued for 30 min...
September 2011: Applied Radiation and Isotopes
Yongxin Yang, Zhenghong Xu, Jingui Jiang, Yu Gao, Wangwen Gu, Lingli Chen, Xiaozheng Tang, Yaping Li
A new cationic derivate of polyphosphazene with imidazole and 2-dimethylaminoethylamino (DMAEA) as side groups, poly(imidazole/DMAEA)phosphazene (PIDP), was synthesized and investigated for gene delivery. The half-lives of PIDP degradation under neutral (pH 7.4) and acidic conditions (pH 5.0) were 22 and 3 days at 37 degrees C, respectively. The cytotoxicity of PIDP assayed by MTT was much lower than that of poly(2-dimethylaminoethylamino)phosphazene (PDAP) and PEI 25K. PIDP could condense DNA into nanoparticles with a size around 100 nm and zeta potential (+25 mV) at the ratio of 10:1 (PIDP/DNA, w/w)...
May 8, 2008: Journal of Controlled Release: Official Journal of the Controlled Release Society
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