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PIP—(Potentially Inappropriate Prescriptions)

Chen Qu, Joel M Bowman
We describe and apply a method to extend permutationally invariant polynomial (PIP) potential energy surface (PES) fitting to molecules with more than 10 atoms. The method creates a compact basis of PIPs as the union of PIPs obtained from fragments of the molecule. An application is reported for trans-N-methyl acetamide, where B3LYP/cc-pVDZ electronic energies and gradients are used to develop a full-dimensional potential for this prototype peptide molecule. The performance of several fragmented bases is verified against a benchmark PES using all (66) Morse variables...
April 14, 2019: Journal of Chemical Physics
V A Cazares, G Rodriguez, R Parent, L Ouillette, K M Glanowska, S J Moore, G G Murphy
Fear conditioning is an associative learning process by which organisms learn to avoid environmental stimuli that are predictive of aversive outcomes. Fear extinction learning is a process by which avoidance of fear-conditioned stimuli is attenuated when the environmental stimuli is no longer predictive of the aversive outcome. Aberrant fear conditioning and extinction learning are key elements in the development of several anxiety disorders. The 129S1 inbred strain of mice is used as an animal model for maladaptive fear learning because this strain has been shown to generalize fear to other non-aversive stimuli and is less capable of extinguishing fear responses relative to other mouse strains, such as the C57BL/6...
April 11, 2019: Genes, Brain, and Behavior
Jihui Ju, Lei Li, Ruixing Hou
Background: This study aimed to evaluate a novel surgical method for the acute reconstruction of defects in the thumb and other fingers by transplanting a free vascularized joint flap from the second toe and to determine its clinical curative effects. Materials and Methods: A free vascularized joint flap from the second toe was transplanted to reconstruct a complete defect of the thumb and other fingers accompanied by the loss of the proximal finger in 10 patients...
March 2019: Indian Journal of Orthopaedics
Jacopo P Mortola
During the last days of incubation vocalization is a form of communication between the avian embryo and the incubating parent. Commonly, embryonic calls increase when ambient temperature (Ta) deviates from the optimal range, but no information is available on whether the characteristics of the calls differ between warming and cooling. Rate of calls, power spectra (distribution of the call's energy among its frequency components) and spectrograms (time-frequency plots) were obtained in chicken embryos during the external pipping phase, in normothermia (38 °C), during progressive cooling to Ta = 27 °C (C) or progressive warming to Ta = 43 °C (W) over a short (30 min) or a long (150 min) period...
April 6, 2019: Behavioural Processes
Wil Ratzan, Vamseedhar Rayaprolu, Scott E Killian, Roger Bradley, Susy C Kohout
Voltage-sensing phosphatases (VSPs) are transmembrane proteins that couple changes in membrane potential to hydrolysis of inositol signaling lipids. VSPs catalyze the dephosphorylation of phosphatidylinositol phosphates (PIPs) that regulate diverse aspects of cell membrane physiology including cell division, growth and migration. VSPs are highly conserved among chordates, and their RNA transcripts have been detected in the adult and embryonic stages of frogs, fish, chickens, mice and humans. However, the subcellular localization and biological function of VSP remains unknown...
2019: PloS One
Shino Oikawa, Yuko Kai, Asuka Mano, Shigeo Nakamura, Yoshihiko Kakinuma
BACKGROUND/AIMS: In a previous study, we reported that cardiomyocytes were equipped with non-neuronal cardiac cholinergic system (NNCCS) to synthesize acetylcholine (ACh), which is indispensable for maintaining the basic physiological cardiac functions. The aim of this study was to identify and characterize a pharmacological inducer of NNCCS. METHODS: To identify a pharmacological inducer of NNCCS, we screened several chemical compounds with chemical structures similar to the structure of S-nitroso-N-acetyl-DL-penicillamine (SNAP)...
2019: Cellular Physiology and Biochemistry
Francesca Boldrin, Saber Anoosheh, Agnese Serafini, Laura Cioetto Mazzabò, Giorgio Palù, Roberta Provvedi, Riccardo Manganelli
Tightly regulated gene expression systems are powerful tools to study essential genes and characterize potential drug targets. In a past work we reported the construction of a very stringent and versatile repressible promoter system for Mycobacterium tuberculosis based on two different repressors (TetR/Pip-OFF system). This system, causing the repression of the target gene in response to anhydrotetracycline (ATc), has been successfully used in several laboratories to characterize essential genes in different mycobacterial species both in vitro and in vivo...
April 8, 2019: Scientific Reports
Chigozie Jesse Uneke, Etienne V Langlois, Henry C Uro-Chukwu, Jeremiah Chukwu, Abdul Ghaffar
BACKGROUND: Contextualising evidence to inform policy-making is increasingly recognised as key to developing and implementing effective health policies. Creating a one-stop shop for evidence is an approach that can facilitate timely access to the best evidence to inform policy decisions. We report outcomes after implementation of the Policy Information Platform (PIP), a pilot one-stop evidence repository in Nigeria designed to alleviate barriers to accessing policy-relevant knowledge...
April 8, 2019: Health Research Policy and Systems
Norio Matsushima, Hiroki Miyashita, Shinsuke Tamaki, Robert H Kretsinger
Plant peptide hormones play a crucial role in plant growth and development. A group of these peptide hormones are signaling peptides with 5 ⎼ 23 amino acids. Flagellin peptide (flg22) also elicits an immune response in plants. The functions are expressed through recognition of the peptide hormones and flg22. This recognition relies on membrane localized receptor kinases with extracellular leucine rich repeats (LRR⎼RKs). The structures of plant peptide hormones ⎼ AtPep1, IDA, IDL1, RGFs 1⎼ 3, TDIF/CLE41 ⎼ and of flg22 complexed with LRR domains of corresponding LRR⎼RKs and co-receptors SERKs have been determined...
April 8, 2019: Protein and Peptide Letters
Veronika van der Wardt, Jennie Hancox, Kristian Pollock, Pip Logan, Kavita Vedhara, Rowan H Harwood
OBJECTIVE: This focus group study aimed to explore how to motivate people with mild cognitive impairment (MCI) or dementia and their carers to engage in exercise and physical activity. METHODS: Four focus groups were conducted with six people with MCI or dementia, three carers and four clinicians (nurse, occupational therapist, physiotherapists). A thematic analysis of the data was undertaken. RESULTS: Five main themes were identified: 'memory problems', 'self-motivation', 'external motivation', 'design of activities' and 'barriers'...
April 7, 2019: Aging & Mental Health
Y M Shi, L J Wu, W J Wang, C N Luo, Y J Chen
Objective: To investigate the value of musculoskeletal ultrasound (MSUS) in assessing the disease activity of rheumatoid arthritis (RA). Methods: As a retrospective study, clinical data, laboratory test results and MSUS results of 22 joints (2 wrist joints, 10 metacarpophalangeal joints, 2 thumb interphalangeal joints, 8 proximal interphalangeal joints) were collected from 403 hospitalized RA patients (including Han and Uygur patients) in the People's Hospital of the Xinjiang Uygur Autonomous Region from January 2016 to December 2016...
April 2, 2019: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Li He, Chengla Yi, Zhiyong Hou, David J Hak
BACKGROUND: Limited data exist regarding intraabdominal hypertension/abdominal compartment syndrome (IAH/ACS) after pelvic fractures. We aimed to explore risk factors for IAH/ACS in pelvic fracture patients, assess the physiological effects of decompressive laparotomy (DL) on IAH/ACS, and generate an algorithm to manage IAH/ACS after pelvic fracture. MATERIALS AND METHODS: Pelvic fracture patients were included based on the presence of IAH/ACS. Intraabdominal pressure (IAP) was measured through a Foley catheter...
March 28, 2019: Injury
Ahren Ward Jasper, Michael J Davis
The accuracy of separable strategies for constructing full-dimensional potential energy surfaces for collisional energy transfer and collision rate calculations is studied systematically for three alcohols (A = methanol, ethanol, and butanol) and three bath gases (M = Ar, N2, and H2O). The fitting efficiency (defined as the number of ab initio data required to achieve parameterizations of a desired accuracy) is quantified for both pairwise (Buckingham or "exp6") and nonpairwise (permutationally invariant polynomials, PIPs, of Morse variables) functional forms, for four sampling strategies, and as a function of the complexity and anisotropy of the interaction potential...
April 5, 2019: Journal of Physical Chemistry. A
Mengge Shan, Zachary D Anderson, Brian D Gregory
Two major components of posttranscriptional regulation are RNA-protein interactions and RNA secondary structure. While noncoding RNAs are far more abundant than messenger RNAs in eukaryotic systems, their functions remain largely unstudied. Evidence suggests that RNA-protein interactions and RNA secondary structure also regulate the function of long noncoding RNAs (lncRNAs), which are noncoding RNAs over 200 nucleotides (nt) in length. Protein interaction profile sequencing (PIP-seq) allows researchers to perform an unbiased screen of protein-bound regions and secondary structure of RNAs throughout a transcriptome of interest...
2019: Methods in Molecular Biology
Marianne C Kramer, Brian D Gregory
From the moment of transcription, RNA molecules are continuously bound by RNA-binding proteins (RBPs). While the majority of research has focused on how these RBPs regulate posttranscriptional gene regulation of messenger RNAs (mRNAs), the majority of cellular RNAs do not code for proteins, such as ribosomal RNAs, transfer RNAs, and microRNAs. Since these RNAs do not code for protein, their function is mainly determined by their interactions with RBPs as well as their intramolecular base pairing, or RNA secondary structure...
2019: Methods in Molecular Biology
Clarissa Romez, David Zaritzky, Joshua W Brown
A male infant at two weeks of age was hospitalized vomiting forcefully. He had a pyloromyotomy. He did not improve with medical therapy. The diagnosis of gastroparesis was made after a nuclear medicine gastric emptying study and intestinal manometry. He required a gastrostomy tube (g-tube) and a jejunostomy tube (j-tube) for feeding. At 11 months of age, the j-tube was converted into a feeding jejunostomy with Roux-en-Y limb. For 16 years he was completely dependent on j-tube feeding. In November 2011, he experienced proximal-intercessory-prayer (PIP) at a church and felt an electric shock starting from his shoulder and going through his stomach...
April 2019: Complementary Therapies in Medicine
Diarmuid Denneny, Annina Frijdal Nee Klapper, Nadia Bianchi-Berthouze, Jim Greenwood, Rebecca McLoughlin, Katrine Petersen, Aneesha Singh, Amanda C de C Williams
OBJECTIVES: Psychologically informed practice (PIP) is advocated for physiotherapists to help people with chronic pain. There is little research observing how PIP is delivered in clinical practice. This study describes behaviours and techniques used by experienced physiotherapists working with groups of people with chronic pain. SETTING AND PARTICIPANTS: Experienced physiotherapists (n=4) were observed working with groups of people with chronic pain in out-patient pain management, and physiotherapy departments, in a large UK city centre teaching hospital...
February 4, 2019: Physiotherapy
A Galván Ruiz, I Díaz-Cano Carmona, M O González Oria, E Carvajal Ramos, V Álamo Vera
INTRODUCTION: To evaluate the effectiveness of early capsular ultrasound-guided hydrodilatation (HD) of the proximal interphalangeal or metacarpophalangeal joints in reducing joint stiffness and shortening kinesitherapy, as well as in improving hand functionality. MATERIAL AND METHODS: We performed a one-year quasi-experimental pretest-posttest study with a control group in patients with proximal interphalangeal or metacarpophalangeal capsulitis in complex regional pain syndrome stages 2 or 3...
January 2019: Rehabilitación
Zihui Chi, Lin Huang, Shaoli Ge, Huabei Jiang
PURPOSE: Thermoacoustic tomography (TAT) has been studied to image joints. While several joint tissues could be thermoacoustically imaged, tendons and bone could not be recovered completely or clearly. The purpose of this study was to overcome this limitation. METHODS: We developed a novel TAT system based on anti-phase microwave illumination method to image the proximal interphalangeal joint and middle phalanx of a right middle finger from a healthy volunteer. The performance of this new system for imaging joints and tendons was compared with that by in-phase microwave illumination and a conventional pyramidal horn antenna...
March 28, 2019: Medical Physics
Benjamin E Smith, Paul Hendrick, Marcus Bateman, Fiona Moffatt, Michael Skovdal Rathleff, James Selfe, Toby O Smith, Pip Logan
BACKGROUND: A novel loaded self-managed exercise programme that includes pain education and self-management strategies may result in better outcomes for people with patellofemoral pain (PFP). However, establishing program feasibility is an essential first step before testing efficacy. The purpose of this study was to evaluate the feasibility and acceptability of conducting a definitive RCT which will evaluate the clinical and cost-effectiveness of a loaded self-managed exercise programme for people with PFP compared with usual physiotherapy...
March 27, 2019: BMC Musculoskeletal Disorders
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