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https://read.qxmd.com/read/30906635/epithelial-ovarian-cancer-feasibility-of-image-guided-intratumoral-radiofrequency-hyperthermia-enhanced-direct-gene-therapy
#1
Guangxin Jin, Yaying Li, Feng Zhang, Peicheng Li, Liangcai Zhao, Yiming Zhou, Hongxiu Ji, Sean Pietrini, Bo Zhai, Xiaoming Yang
The aim of this study was to develop an interventional oncologic technique, "Image-guided intratumoral radiofrequency hyperthermia (RFH)-enhanced herpes simplex virus-thymidine kinase (HSV-TK) gene therapy of ovarian cancer. This study consisted of three portions: (1) serial in-vitro experiments to establish "proof-of-principle" of this novel technique using human ovarian cancer cells; (2) serial in-vivo experiments to validate technical feasibility using animal models with the same orthotopic ovarian cancers; and (3) serial investigations into the underlying bio-molecular mechanisms of this technique...
2019: American Journal of Cancer Research
https://read.qxmd.com/read/30905999/growing-without-pain-the-noninvasive-expandable-prosthesis-is-boon-for-children-with-bone-cancer-as-well-as-their-surgeons
#2
Manit K Gundavda, Manish G Agarwal
Background: Orthopedic oncology has evolved over the past few decades to favor limb salvage over amputations. The noninvasive expandable prosthesis can be lengthened with an externally applied magnetic field eliminating the pain, stiffness, as well as the risk of infection. We present the largest series in Indian experience with this implant over the last 8 years while analyzing its benefit to the surgeons and the patients, but are we able to justify the cost effectiveness? Materials and Methods: Eighteen implants were used in 16 patients with nonmetastatic primary bone sarcoma from May 2006 to June 2015...
January 2019: Indian Journal of Orthopaedics
https://read.qxmd.com/read/30905598/implementation-of-intraoperative-frozen-section-during-radical-prostatectomy-short-term-results-from-a-german-tertiary-care-center
#3
Felix Preisser, Lena Theissen, Peter Wild, Katharina Bartelt, Luis Kluth, Jens Köllermann, Markus Graefen, Thomas Steuber, Hartwig Huland, Derya Tilki, Frederik Roos, Andreas Becker, Felix K-H Chun, Philipp Mandel
BACKGROUND: Neurovascular bundle (NVB) preservation (NVBP) and surgical margin status are the main intraoperative factors influencing functional and oncologic outcomes in patients with prostate cancer undergoing radical prostatectomy (RP). OBJECTIVE: To test the impact of implementing the intraoperative frozen section technique (IFST) during NVBP on the frequency of NVB procedures and its effect on positive surgical margins (PSMs). DESIGN, SETTING, AND PARTICIPANTS: We relied on an institutional tertiary-care center database to identify patients who underwent RP (January 2014-October 2018)...
March 21, 2019: European Urology Focus
https://read.qxmd.com/read/30905510/external-validation-of-the-updated-leibovich-prognostic-models-for-clear-cell-and-papillary-renal-cell-carcinoma-in-an-asian-population
#4
Han Jie Lee, Alvin Lee, Hong Hong Huang, Weber Kam On Lau
PURPOSE: The Leibovich model was updated to prognosticate oncological outcomes in postnephrectomy nonmetastatic renal cell carcinoma (RCC) for each major histological subtype including clear cell (ccRCC), papillary (papRCC), and chromophobe RCC. We evaluated its performance in an independent population of predominantly Asian patients from Singapore. MATERIALS AND METHODS: Nine hundred and forty two binephric patients with nonmetastatic unilateral RCC treated with radical/partial nephrectomy from 1990 to 2015 from Singapore were retrospectively reviewed...
March 22, 2019: Urologic Oncology
https://read.qxmd.com/read/30905435/shaping-the-standard-of-care-in-ovarian-cancer-management-a-review-of-gynecologic-oncology-group-gog-nrg-oncology-clinical-trials-of-the-past-twenty-years
#5
Paul A DiSilvestro
The Gynecologic Oncology Group (GOG), now part of the NRG Oncology network since the re-alignment of the National Clinical Trials Network in 2014, has played a fundamental role in creating the standard of care for women with ovarian cancer. GOG/NRG Oncology has had a series of achievements that have contributed to how we treat this disease; the approval of bevacizumab in frontline therapy, defining the role of intraperitoneal chemotherapy, optimal chemotherapy for early stage disease and the role of surgery in primary and recurrent disease management...
March 22, 2019: Gynecologic Oncology
https://read.qxmd.com/read/30905200/triple-drug-chemotherapy-regimens-in-combination-with-an-anti-egfr-agent-in-metastatic-colorectal-cancer-prospects-from-phase-ii-clinical-trials
#6
Ignacio Matos, Alba Noguerido, Javier Ros, Nuria Mulet, Guillem Argilés, Élena Elez, Josep Tabernero
The addition of monoclonal antibody (mAb) epidermal growth factor receptor (EGFR) inhibitors to classic chemotherapy doublet backbones has improved survival of metastatic colorectal cancer (mCRC). However, the role of triple-drug chemotherapy regimens in combination with an anti-EGFR mAb inhibitor is not yet clear. Areas covered: The activity of triple-drug chemotherapy regimens when combined with an anti-EGFR mAb in mCRC patients is examined. We describe the overall safety and tolerability profiles based on a literature review of all published phase I and II clinical trials in this setting...
March 25, 2019: Expert Opinion on Investigational Drugs
https://read.qxmd.com/read/30905173/a-randomized-assessor-blinded-wait-list-controlled-trial-to-assess-the-effectiveness-of-acupuncture-in-the-management-of-chemotherapy-induced-peripheral-neuropathy
#7
Alexander Molassiotis, Lorna K P Suen, Hui Lin Cheng, T S K Mok, Sara C Y Lee, C H Wang, Paul Lee, Howan Leung, V Chan, T K H Lau, Winnie Yeo
PURPOSE: Chemotherapy-induced peripheral neuropathy is a complex side effect with few available treatment options. The aim of the study was to test the effectiveness of an 8-week course of acupuncture in the management of chemotherapy-induced peripheral neuropathy in cancer patients who were receiving or had received neurotoxic chemotherapy. METHODS: Randomized assessor-blinded controlled trial with 2 arms; one arm received acupuncture twice weekly for 8 weeks, while the other arm was a wait-list control group receiving only standard care...
January 2019: Integrative Cancer Therapies
https://read.qxmd.com/read/30904965/nci-alliance-for-nanotechnology-in-cancer-from-academic-research-to-clinical-interventions
#8
Piotr Grodzinski, Christina H Liu, Christopher M Hartshorn, Stephanie A Morris, Luisa M Russell
The National Cancer Institute (NCI) of National Institutes of Health has funded and operated the NCI Alliance for Nanotechnology in Cancer - a large multi-disciplinary program which leverages research at the intersection of molecular biology, oncology, physics, chemistry, and engineering to develop innovative cancer interventions. The program has demonstrated that convergence of several scientific disciplines catalyzes innovation and progress in cancer nanotechnology and advances its clinical translation. This paper takes a look at last thirteen years of the Alliance program operations and delineates its outcomes, successes, and outlook for the future...
March 23, 2019: Biomedical Microdevices
https://read.qxmd.com/read/30904707/cost-of-acute-and-follow-up-care-in-patients-with-pre-existing-psychiatric-diagnoses-undergoing-radiation-therapy
#9
M R Waddle, S K Niazi, D Aljabri, L White, T A Kaleem, J M Naessens, A Spaulding, J Y Habboush, T Rummans, R C Miller
BACKGROUND: The impact of psychiatric comorbidities on the cost of cancer care in radiation-oncology practices is not well studied. We assessed the acute and 24-month follow-up costs for patients with and without pre-existing psychiatric comorbidities undergoing radiation therapy. MATERIALS AND METHODS: Cancer patients undergoing radiotherapy at Our Institution from 2009-2014 were denoted as having pre-existing psychiatric conditions (Psych-Group) if they had associated billing codes for any of the 422 ICD-9 psychiatric conditions during 12-months prior to their cancer diagnosis...
March 20, 2019: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/30904388/utilization-patterns-of-single-fraction-radiation-therapy-for-multiple-myeloma
#10
Lucas Resende Salgado, Sanders Chang, Meng Ru, Erin Moshier, Zahra Ghiassi-Nejad, Stanislav Lazarev, William Smith, Marcher Thompson, Kavita Dharmarajan
BACKGROUND: Patients with multiple myeloma (MM) are living longer than ever before thanks to new therapies. As a consequence, radiation therapy (RT) is increasingly important in the management of bone lesions from MM. Current American Society for Radiation Oncology guidelines recommend greater usage of 8 Gy in 1 fraction for treatment of these lesions. The objective of this study is to analyze utilization of 8 Gy in 1 fraction for treatment of MM bone lesions in the United States utilizing the National Cancer Data Base (NCDB)...
February 22, 2019: Clinical Lymphoma, Myeloma & Leukemia
https://read.qxmd.com/read/30904357/robot-assisted-radical-prostatectomy-after-focal-therapy-oncological-functional-outcomes-and-predictors-of-recurrence
#11
Lorenzo Marconi, Thomas Stonier, Rafael Tourinho-Barbosa, Caroline Moore, Hashim U Ahmed, Xavier Cathelineau, Mark Emberton, Rafael Sanchez-Salas, Paul Cathcart
There are few data on the outcomes and toxicity of radical prostatectomy (RP) among men experiencing local recurrence of prostate cancer (PC) following focal therapy (FT). To characterise perioperative, oncological, and functional outcomes after salvage robot-assisted RP (S-RALP) and determine the risk factors for S-RALP failure, we conducted a multicentre cohort study of 82 patients undergoing S-RALP after FT. All had histological confirmation of PC recurrence, with metastatic disease excluded using pelvic magnetic resonance imaging, a bone scan, and/or positron emission tomography/computed tomography...
March 20, 2019: European Urology
https://read.qxmd.com/read/30904235/association-between-early-nutritional-risk-and-overall-survival-in-patients-with-advanced-pancreatic-cancer-a-single-center-retrospective-study
#12
Joung Soon Park, Hyung-Mi Kim, Hei-Cheul Jeung, Soon Ah Kang
BACKGROUND & AIMS: We investigated the predictors of overall survival (OS) among Korean patients with advanced pancreatic cancer (PC) according to their baseline nutritional status. METHODS: We retrospectively reviewed the data of 412 inpatients with PC between January 2007 and February 2015 at the Department of Oncology of the Gangnam Severance Hospital, Korea. Data on demographic and clinical parameters were collected from electronic medical records, and OS was estimated using the Kaplan-Meier method...
April 2019: Clinical Nutrition ESPEN
https://read.qxmd.com/read/30904031/cardio-oncology-a-tale-of-two-cities-the-art-of-preventing-broken-hearts-in-women-with-breast-cancer
#13
Davinder S Jassal
2018 CSCI Henry Friesen Award recipient.
March 23, 2019: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://read.qxmd.com/read/30903913/low-doses-of-bisphenol-a-have-pro-inflammatory-and-pro-oxidant-effects-stimulate-lipid-peroxidation-and-increase-the-cardiotoxicity-of-doxorubicin-in-cardiomyoblasts
#14
V Quagliariello, C Coppola, D G Mita, G Piscopo, R V Iaffaioli, G Botti, N Maurea
Endocrine disrupters are strictly associated to cancer and several cardiovascular risk factors. Bisphenol A (BPA) is an endocrine disrupter commonly used in the manufacturing of plastics based on polycarbonate, polyvinyl chloride and resins. Our study aims to investigate whether BPA may cause pro-oxidative and pro-inflammatory effects on cardiomyoblasts, thus exacerbating the Doxorubicin (DOXO)-induced cardiotoxicity phenomena. We tested the metabolic effects of BPA at low doses analyzing its affections on the intracellular calcium uptake, oxidative stress, lipid peroxidation and production of nitric oxide and interleukins...
March 7, 2019: Environmental Toxicology and Pharmacology
https://read.qxmd.com/read/30903516/association-of-neurologic-manifestations-and-cea-levels-with-the-diagnosis-of-brain-metastases-in-lung-cancer-patients
#15
B Cacho-Díaz, H Spínola-Maroño, L G Mendoza-Olivas, A Monroy-Sosa, G Reyes-Soto, O Arrieta
PURPOSE: Lung cancer (LC) is the most common source of brain metastases (BM). Because of the difficulty in predicting LC patients who will develop BM, we aimed to identify the clinical and serologic markers that could predict the presence of BM in LC patients. METHODS: We analyzed a cohort of LC patients sent for neurooncological consultation for any neurologic symptom at a cancer center from June 2013 to July 2017. INCLUSION CRITERIA: histologically confirmed LC, age ≥ 18 years and complete clinical records...
March 22, 2019: Clinical & Translational Oncology
https://read.qxmd.com/read/30903367/cancer-related-fatigue-and-sleep-deficiency-in-cancer-care-continuum-concepts-assessment-clusters-and-management
#16
Andreas Charalambous, Ann M Berger, Ellyn Matthews, Dave D Balachandran, Evridiki Papastavrou, Oxana Palesh
Throughout the cancer continuum, patients are faced with the cancer- and treatment-related side effects that can have a negative impact on their overall quality of life. Cancer-related fatigue (CRF) and sleep deficiency are among the symptoms that patients and their caregivers most often experience. An increasing body of literature suggests that a strong correlation between CRF and sleep deficiency exists, indicating that they may be reciprocally related and that they may have similar underlying etiology. This paper aims at bringing together the opinions of leading cancer control (i...
March 22, 2019: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://read.qxmd.com/read/30903162/pet-imaging-and-glioblastoma
#17
Katharina Weigel
INTRODUCTION: Patients who present with Glioblastoma have a median survival of around 15 mo, even when treated with the most aggressive methods available. Imaging of glial cell tumours is faced with multiple challenges, including the accurate delineation of abnormal tissue and the identification of low-grade gliomas.PET imaging depicts aspects of tissue activity in Vivo and thus, helps us improve our understanding of the tumor's size and behavior. While functional imaging is already an established modality in other fields of oncology, the appropriate tracer for the imaging of glial cancers remains under investigation since FDG, the traditional oncological tracer, proves suboptimal due to the high physiological glucose uptake of the cerebral grey matter...
March 23, 2019: Neurosurgery
https://read.qxmd.com/read/30903015/correction-genomic-profiling-reveals-spatial-intra-tumor-heterogeneity-in-follicular-lymphoma
#18
Shamzah Araf, Jun Wang, Koorosh Korfi, Celine Pangault, Eleni Kotsiou, Ana Rio-Machin, Tahrima Rahim, James Heward, Andrew Clear, Sameena Iqbal, Jeff K Davies, Peter Johnson, Maria Calaminici, Silvia Montoto, Rebecca Auer, Claude Chelala, John G Gribben, Trevor A Graham, Thierry Fest, Jude Fitzgibbon, Jessica Okosun
In the original version of this article the authors noted an omission in the author affiliations where the university details: Queen Mary University of London was not included in the original affiliation for the majority of the authors. The correct affiliations are as follows1. Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK3. Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK6. Evolution and Cancer Laboratory, Barts Cancer Institute, Queen Mary University of London, London, UK...
March 23, 2019: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://read.qxmd.com/read/30902914/attitudes-and-barriers-to-research-among-oncology-trainees-in-east-africa
#19
Fidel Rubagumya, Sarah K Nyagabona, Khadija H Msami, Achille Manirakiza, Ahuka N Longombe, Theoneste Maniragaba, Hilary Chan, Alan Paciorek, Li Zhang, Emmanuel Balandya, Leyna H Germana, Elia J Mmbaga, Nazima Dharsee, Katherine Van Loon
BACKGROUND: East Africa is one of the fastest growing regions in the world and faces a rising burden of cancer; however, few people are equipped to effectively conduct research in this area. MATERIALS AND METHODS: A 31-item questionnaire was distributed to current trainees and recent graduates of the Master in Medicine in Clinical Oncology Program at Muhimbili University of Health and Allied Sciences in Tanzania. Areas that were assessed included (a) demographic information, (b) prior research training, (c) prior and current research activities, (d) attitudes toward the importance of research, and (e) supports and barriers to inclusion of research in an oncology career path...
March 22, 2019: Oncologist
https://read.qxmd.com/read/30902881/ciap1-promotes-proliferation-and-migration-and-prevents-apoptosis-in-gallbladder-cancer-in-vitro
#20
Wei Su, Xiaojie Jiang, Mingyuan Chen, Maotuan Huang, Nanhong Tang, Xiaoqian Wang, Xiujin Li, Feifei She, Yanlin Chen
Gallbladder cancer (GBC) is a demanding fatal disease with no ideal treatment for inoperable patients. Recent reports have determined TNF-α associated lymphatic metastasis in GBC, while its resistance to TNF-α-killing remains largely unexplored. In this assay, we firstly find Cellular inhibitor of apoptosis (cIAP1) overexpressed in GBC tissues and the roles in promoting the proliferation and migration of GBC in vitro as its homology cIAP2 does. Then how GBC cell survives TNF-α toxicity and TNF-α-induced apoptosis firstly prevail as follows...
March 22, 2019: Bioscience Reports
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