Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
James K Chow, Akshay Bagai, Mary K Tan, Bryan J Har, Amelia M C Yip, Mario Paniagua, Basem Elbarouni, Kevin R Bainey, Jean-Michel Paradis, Robert Maranda, Warren J Cantor, Mark J Eisenberg, Jean-Pierre Dery, Mina Madan, Tomas Cieza, Alexis Matteau, Sherryn Roth, Shahar Lavi, Anthony Glanz, Dongsheng Gao, Ravi Tahiliani, Robert C Welsh, Hahn Hoe Kim, Simon D Robinson, Benoit Daneault, Aun-Yeong Chong, Michel R Le May, Vineeta Ahooja, Jean C Gregoire, Pierre-Louis Nadeau, Zachary Laksman, Brett Heilbron, Derek Yung, Kunal Minhas, Ronald Bourgeois, Christopher B Overgaard, Hamid Bonakdar, Giridhar Logsetty, Andrea J Lavoie, Robert De LaRochelliere, Samer Mansour, Caroline Spindler, Andrew T Yan, Shaun G Goodman
BACKGROUND: Selecting the appropriate antithrombotic regimen for patients with atrial fibrillation (AF) who have undergone percutaneous coronary intervention (PCI) or have had medically managed acute coronary syndrome (ACS) remains complex. This multi-centre observational study evaluated patterns of antithrombotic therapies utilized among Canadian patients with AF post-PCI or ACS. METHODS AND RESULTS: By retrospective chart audit, 611 non-valvular AF patients [median (interquartile range) age 76 (69-83) years, CHADS2 score 2 (1-3)] who underwent PCI or had medically managed ACS between August 2018 and December 2020 were identified by 68 cardiologists across eight provinces in Canada...
March 15, 2023: Journal of Cardiology
#22
JOURNAL ARTICLE
Rui-Bin Li, Xiao-Hong Yang, Ji-Dong Zhang, Wei Cui
BACKGROUND: Stroke attributable to atrial fibrillation (AF related stroke, AFST) accounts for 13 ~ 26% of ischemic stroke. It has been found that AFST patients have a higher risk of disability and mortality than those without AF. Additionally, it's still a great challenge to treat AFST patients because its exact mechanism at the molecular level remains unclear. Thus, it's vital to investigate the mechanism of AFST and search for molecular targets of treatment. Long non-coding RNAs (lncRNAs) are related to the pathogenesis of various diseases...
March 9, 2023: BMC Medical Genomics
#23
JOURNAL ARTICLE
Noel Chan, Matt Wheeler, Vinai Bhagirath, Jacqueline Bosch, Jutta Heinrich-Nols, Debbie Sloane, Joanne van Ryn, Linda Jefferies, Jacqueline Wilkinson, Qilong Yi, John Eikelboom
BACKGROUND: Dabigatran is effective and safe for stroke prevention in patients with atrial fibrillation and for venous thromboembolism prevention and treatment. In Canada, APO-dabigatran, a generic formulation, has been approved based on a bioequivalence study, but its bioavailability in settings of reduced gastric acidity has not been examined. METHODS: Treatment With A PO- D abigatran A bsorption (TADA) was an open-label crossover study in 46 healthy male volunteers, comparing the absorption of APO-dabigatran (150 mg) with vs without rabeprazole...
January 2023: CJC open
#24
JOURNAL ARTICLE
Bixiao Wei, Xiaofang Huang, Yiming Lu, Delong Xie, Guangji Wei, Wangrong Wen
BACKGROUND: Study have shown that atrial fibrillation (AF) is a disease with genetic risk, and its pathogenesis is still unclear. This study sought to screen the gene microarray data of AF patients and to perform a bioinformatics analysis to identify AF signature diagnostic genes. METHODS: The AF gene sets from the Gene Expression Omnibus (GEO) database were screened, and the differentially expressed genes (DEGs) were identified after the normalization of the data set by R software...
December 2022: Journal of Thoracic Disease
#25
JOURNAL ARTICLE
Zefu Li, Pengxu Kong, Bin Wen, Shouzheng Wang, Fengwen Zhang, Wenbin Ouyang, Xiangbin Pan
BACKGROUND: Mitral regurgitation (MR) is one of the most prevalent valvular diseases. Degenerated MR-induced volume overload leads to left atrial enlargement and eventually, atrial fibrillation (AF). AF has a negative effect on patient prognosis despite recent advances in minimal invasive transcatheter devices for valve surgery. However, more effective strategies aimed at precisely treating from pathophysiology and genetic perspective are scarce. METHODS: The gene expression datasets, GSE109744 and GSE79768, were obtained from the Gene Expression Omnibus database and analyzed to identify the differentially expressed genes (DEGs) in patients with mitral value prolapse (MVP) and AF...
November 2022: Annals of Translational Medicine
#26
JOURNAL ARTICLE
Jeffry Samuel, Akash Batta, Parag Barwad, Yash Paul Sharma, Prashant Panda, Navjyot Kaur, Shrimanth Y S, Pruthvi Cr, Bharat Sambyal
Atrial high rate episodes (AHRE) confers increased morbidity and mortality amongst patients with permanent pacemaker implantation (PPI). The incidence of AHREs and it's clinical predictors in Indian patients without prior history of atrial fibrillation (AF) are not well understood. A total of 100 dual-chamber PPI patients, who had no prior history of AF, underwent pacemaker interrogation starting from a minimum of 1 month after implantation to detect any AHREs. The incidence of AHREs was 17% at a mean follow up 15...
November 29, 2022: Indian Heart Journal
#27
JOURNAL ARTICLE
Identification of the Potential Molecular Mechanism of TGFBI Gene in Persistent Atrial Fibrillation.
Yao-Zong Guan, Hao Liu, Huan-Jie Huang, Dong-Yan Liang, Si-Ying Wu, Tang Zhang
Background: Transforming growth factor beta-induced protein (TGFBI, encoded by TGFBI gene), is an extracellular matrix protein, widely expressed in variety of tissues. It binds to collagens type I, II, and IV and plays important roles in the interactions of cell with cell, collagen, and matrix. It has been reported to be associated with myocardial fibrosis, and the latter is an important pathophysiologyical basis of atrial fibrillation (AF). However, the mechanism of TGFBI in AF remains unclear...
2022: Computational and Mathematical Methods in Medicine
#28
JOURNAL ARTICLE
Yang Lu, Ning Zhao, Yimei Du
Objectives: Atrial fibrillation (AF) is the most common arrhythmia in coronary virus disease 2019 (COVID-19) patients, especially in severe patients. A history of AF can exacerbate COVID-19 symptoms. COVID-19 Patients with new-onset AF have prolonged hospital stays and increased death risk. However, the mechanisms and targets of the interaction between COVID-19 and AF have not been elucidated. Materials and methods: We used a series of bioinformatics analyses to understand biological pathways, protein-protein interaction (PPI) networks, gene regulatory networks (GRNs), and protein-chemical interactions between COVID-19 and AF and constructed an AF-related gene signature to assess COVID-19 severity and prognosis...
2022: Frontiers in Cardiovascular Medicine
#29
JOURNAL ARTICLE
Yufei Zhou, Qianyun Wu, Gehui Ni, Yulu Hong, Shengjue Xiao, Chunjiang Liu, Zongliang Yu
Background: Atrial fibrillation (AF) is the most common arrhythmia. Previous studies mainly focused on identifying potential diagnostic biomarkers and treatment strategies for AF, while few studies concentrated on post-operative AF (POAF), particularly using bioinformatics analysis and machine learning algorithms. Therefore, our study aimed to identify immune-associated genes and provide the competing endogenous RNA (ceRNA) network for POAF. Methods: Three GSE datasets were downloaded from the GEO database, and we used a variety of bioinformatics strategies and machine learning algorithms to discover candidate hub genes...
2022: Frontiers in Immunology
#30
JOURNAL ARTICLE
Joshua Sink, Kiran Nimmagadda, Manyun Zhao, Adin-Cristian Andrei, Hawkins Gay, Rachel M Kaplan, Xu Gao, Anna Pfenniger, Kaustubha D Patil, Rishi Arora, Susan S Kim, Alexandru B Chicos, Albert C Lin, Rod S Passman, Bradley P Knight, Nishant Verma
BACKGROUND: Esophageal thermal injury (ETI) is a well-recognized complication of atrial fibrillation (AF) ablation. Previous studies have demonstrated that direct esophageal cooling reduces ETI during radiofrequency AF ablation. OBJECTIVE: The purpose of this study was to evaluate the use of an esophageal warming device to prevent ETI during cryoballoon ablation (CBA) for AF. METHODS: This prospective, double-blinded study enrolled 42 patients with symptomatic AF undergoing CBA...
November 1, 2022: Journal of Cardiovascular Electrophysiology
#31
JOURNAL ARTICLE
Gaetano Pinnacchio, Eleonora Ruscio, Erica Rocco, Carlo Trani, Francesco Burzotta, Cristina Aurigemma, Enrico Romagnoli, Roberto Scacciavillani, Maria Lucia Narducci, Gianluigi Bencardino, Francesco Perna, Francesco Raffaele Spera, Gianluca Comerci, Antonio Bisignani, Gemma Pelargonio
Permanent pacemaker implantation (PPI) represents a frequent complication after transcatheter aortic valve implantation (TAVI) due to atrio-ventricular (AV) node injury. Predictors of early AV function recovery were investigated. We analyzed 50 consecutive patients (82 ± 6 years, 58% males, EuroSCORE: 7.8 ± 3.3%, STS mortality score: 5 ± 2.8%). Pacemaker interrogations within 4-6 weeks from PPI were performed to collect data on AV conduction. The most common indication of PPI was persistent third-degree (44%)/high-degree (20%) AV block/atrial fibrillation (AF) with slow ventricular conduction (16%) after TAVI...
September 24, 2022: Journal of Cardiovascular Development and Disease
#32
JOURNAL ARTICLE
Simon Schoechlin, Martin Eichenlaub, Björn Müller-Edenborn, Franz-Josef Neumann, Thomas Arentz, Dirk Westermann, Amir Jadidi
BACKGROUND: Permanent pacemaker implantation (PPI) after transcatheter valve implantation (TAVI) is a common complication. Pre-existing right bundle branch block (RBBB) is a strong risk factor for PPI after TAVI. However, a patient-specific approach for risk stratification in this subgroup has not yet been established. METHODS: We investigated TAVI patients with pre-existing RBBB to stratify risk factors for PPI and 1-year-mortality by detailed analysis of ECG data, RBBB morphology and degree of calcification in the implantation area assessed by computed tomography angiography...
September 22, 2022: Journal of Clinical Medicine
#33
JOURNAL ARTICLE
Fan Zou, Tiantian Chen, Xiuying Xiang, Chengjiang Peng, Shuai Huang, Shaohong Ma
Purpose: We apply the bioinformatics method to excavate the potential genes and therapeutic targets associated with valvular atrial fibrillation (VAF). Methods: The downloaded gene expression files from the gene expression omnibus (GEO) included patients with primary severe mitral regurgitation complicated with sinus or atrial fibrillation rhythm. Subsequently, the differential gene expression in left and right atrium was analyzed by R software. Additionally, weighted correlation network analysis (WGCNA), principal component analysis (PCA), and linear model for microarray data (LIMMA) algorithm were used to determine hub genes...
2022: Computational and Mathematical Methods in Medicine
#34
JOURNAL ARTICLE
Rong Wang, Emre Bektik, Phraew Sakon, Xiaowei Wang, Shanying Huang, Xiangbin Meng, Mo Chen, Wenqiang Han, Jie Chen, Yanhong Wang, Jingquan Zhong
Atrial fibrillation (AF) is a form of sustained cardiac arrhythmia and microRNAs (miRs) play crucial roles in the pathophysiology of AF. To identify novel miR-mRNA pairs, we performed RNA-seq from atrial biopsies of persistent AF patients and non-AF patients with normal sinus rhythm (SR). Differentially expressed miRs (11 down and 9 up) and mRNAs (95 up and 82 down) were identified and hierarchically clustered in a heat map. Subsequently, GO, KEGG, and GSEA analyses were run to identify deregulated pathways...
August 24, 2022: Cells
#35
JOURNAL ARTICLE
Xing Liu, Yiqian Zeng, Zhao Liu, Wenbin Li, Lei Wang, Mingxing Wu
Atrial fibrillation (AF) is a chronic and progressive disease, with advancing age, the morbidity of which will increase exponentially. Circular ribonucleic acids (RNAs; circRNAs) have gained a growing attention in the development of AF in recent years. The purpose of this study is to explore the mechanism of circRNA regulation in AF, in particular, the intricate interactions among circRNA, microRNA (miRNA), and messenger RNA (mRNA). Three datasets (GSE129409, GSE68475, and GSE79768) were obtained from the Gene Expression Omnibus database to screen differentially expressed (DE) circRNAs, DE miRNAs, and DE mRNAs in AF, respectively...
August 26, 2022: Medicine (Baltimore)
#36
JOURNAL ARTICLE
Xing Liu, Ke Peng, Guoqiang Zhong, Mingxing Wu, Lei Wang
Background: There is still no clear understanding of the pathogenesis of atrial fibrillation (AF). For this purpose, we used integrated analysis to uncover immune infiltration characteristics and investigated their relationship with competing endogenous RNA (ceRNA) network in AF. Methods: Three AF mRNA data sets (GSE14975, GSE79768, and GSE41177) were integrated using the SVA method from Gene Expression Omnibus (GEO). Together with AF circRNA data set (GSE129409) and miRNA data set (GSE70887) from GEO database, we built a ceRNA network...
2022: Genetics Research
#37
JOURNAL ARTICLE
Juan Martínez-Milla, Álvaro Aceña, Ana Pello, Marta López-Castillo, Hans Paul Gaebelt, Óscar González-Lorenzo, Nieves Tarín, Carmen Cristóbal, Luis M Blanco-Colio, José Luis Martín-Ventura, Ana Huelmos, Andrea Kallmeyer, Joaquín Alonso, Carlos Gutiérrez-Landaluce, Lorenzo López Bescós, Jesús Egido, Ignacio Mahíllo-Fernández, Óscar Lorenzo, María Luisa González-Casaus, José Tuñón
Background. Mineral metabolism (MM) system and N-terminal pro-brain natriuretic peptide (NT-ProBNP) have been shown to add prognostic value in patients with stable coronary artery disease (SCAD). However, the influence of NT-ProBNP on the prognostic role of MM in patients with SCAD has not been shown yet. The objective of this study is to assess the influence of NT-ProBNP on the prognostic role of MM markers in patients with SCAD. Methods: We analyzed the prognostic value of MM markers (parathormone (PTH), klotho, phosphate, calcidiol (25-hydroxyvitamin D3), and fibroblast growth factor-23) in 964 patients with SCAD and NT-ProBNP > 125 pg/mL vs...
July 17, 2022: Journal of Clinical Medicine
#38
JOURNAL ARTICLE
Anja Schade, Lisa Costello-Boerrigter, Thomas Deneke, Frank Steinborn, Mykhaylo Chapran, Koroush Vathie, Nemanja Milisavljevic, Marcus Franz, Ralf Surber, Mohamad Assani, Hussam Hamo, Muhammed Khshfeh, Alexander Lauten, Violeta Mattea
AIMS: Left atrial ablation using radiofrequency (RF) is associated with endoscopically detected thermal oesophageal lesions (EDELs). The aim of this study was to compare EDEL occurrence after conventional contact force-guided (CFG) RF ablation vs. an ablation index-guided (AIG) approach in clinical routine of voltage-guided ablation (VGA). Predictors of EDEL were also assessed. METHODS AND RESULTS: This study compared CFG (n = 100) with AIG (n = 100) in consecutive atrial fibrillation ablation procedures, in which both pulmonary vein isolation and VGA were performed...
July 19, 2022: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#39
JOURNAL ARTICLE
Woldesellassie M Bezabhe, Jan Radford, Barbara C Wimmer, Mohammed S Salahudeen, Ivan Bindoff, Tristan Ling, Gregory M Peterson
BACKGROUND: We aimed to compare the risk of developing osteoporosis in patients prescribed warfarin or direct-acting oral anticoagulants (DOACs) with those with no therapy. RESEARCH DESIGN AND METHODS: We included 37,632 patients aged between 18 and 111 years with a recorded diagnosis of AF between 1 January 2013 and 31 December 2017. Patients were followed until the diagnosis of osteoporosis, switch or discontinuation of the OAC, last clinical visit, or end of the study period, whichever occurred first...
August 2022: Expert Review of Clinical Pharmacology
#40
JOURNAL ARTICLE
Yanan Chu, Fangcong Yu, Yakui Wu, Jinxiu Yang, Jiaran Shi, Tianxin Ye, Deheng Han, Xingxiang Wang
BACKGROUND: Atrial fibrillation (AF) is one of the most prevalent sustained cardiac arrhythmias. The latest studies have revealed a tight correlation between nonalcoholic fatty liver disease (NAFLD) and AF. However, the exact molecular mechanisms underlying the association between NAFLD and AF remain unclear. The current research aimed to expound the genes and signaling pathways that are related to the mechanisms underlying the association between these two diseases. MATERIALS AND METHODS: NAFLD- and AF- related differentially expressed genes (DEGs) were identified via bioinformatic analysis of the Gene Expression Omnibus (GEO) datasets GSE63067 and GSE79768, respectively...
July 5, 2022: BMC Medical Genomics
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
