Hongzhu Li, Can Wei, Jun Gao, Shuzhi Bai, Hongxia Li, Yajun Zhao, Hong Li, Liping Han, Ye Tian, Guangdong Yang, Rui Wang, Lingyun Wu, Changqing Xu
The physiological and pathological roles of dopamine D2 receptors (DR2) in the regulation of cardiovacular functions have been recognized. DR2 activation protects hypoxia/reoxygenation (H/R)-induced cardiomyocyte injury and apoptosis, and ischemic post-conditioning (PC) plays a critical role in cardioprotection as well; however the involvement of the DR2 activation in the PC-induced cardioprotection is unknown. In the present study, we found that the H/R increased the expressions of DR2 mRNA and protein in cardiomyocytes, which were significantly enhanced by PC...
April 15, 2014: Experimental Cell Research