Katharina Feige, Janine Rubbert, Annika Raupach, Martin Stroethoff, André Heinen, Markus W Hollmann, Ragnar Huhn, Carolin Torregroza
Cardiac preconditioning (PC) and postconditioning (PoC) are powerful measures against the consequences of myocardial ischemia and reperfusion (I/R) injury. Mannitol-a hyperosmolar solution-is clinically used for treatment of intracranial and intraocular pressure or promotion of diuresis in renal failure. Next to these clinical indications, different organ-protective properties-e.g., perioperative neuroprotection-are described. However, whether Mannitol also confers cardioprotection via a pre- and/or postconditioning stimulus, possibly reducing consequences of I/R injury, remains to be seen...
February 27, 2021: International Journal of Molecular Sciences