Nandini Chatterjee, Ravi K Komaravolu, Christopher P Durant, Runpei Wu, Chantel McSkimming, Fabrizio Drago, Sunil Kumar, Gabriel Valentin-Guillama, Yury I Miller, Coleen A McNamara, Klaus Ley, Angela Taylor, Ahmad Alimadadi, Catherine C Hedrick
Monocytes are associated with human cardiovascular disease progression. Monocytes are segregated into three major subsets: classical (cMo), intermediate (iMo), and nonclassical (nMo). Recent studies have identified heterogeneity within each of these main monocyte classes, yet the extent to which these subsets contribute to heart disease progression is not known. Peripheral blood mononuclear cells (PBMC) were obtained from 61 human subjects within the Coronary Assessment of Virginia (CAVA) Cohort. Coronary atherosclerosis severity was quantified using the Gensini Score (GS)...
March 1, 2024: International Journal of Molecular Sciences