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https://read.qxmd.com/read/30754721/selecting-near-native-protein-structures-from-predicted-decoy-sets-using-ordered-graphlet-degree-similarity
#1
Xu Han, Li Li, Yonggang Lu
Effective prediction of protein tertiary structure from sequence is an important and challenging problem in computational structural biology. Ab initio protein structure prediction is based on amino acid sequence alone, thus, it has a wide application area. With the ab initio method, a large number of candidate protein structures called decoy set can be predicted, however, it is a difficult problem to select a good near-native structure from the predicted decoy set. In this work we propose a new method for selecting the near-native structure from the decoy set based on both contact map overlap (CMO) and graphlets...
February 11, 2019: Genes
https://read.qxmd.com/read/30737240/cmo-report-is-unable-to-shed-light-on-impact-of-screen-time-and-social-media-on-children-s-health
#2
Nigel Hawkes
No abstract text is available yet for this article.
February 8, 2019: BMJ: British Medical Journal
https://read.qxmd.com/read/30641285/exploring-the-contribution-of-social-enterprise-to-health-and-social-care-a-realist-evaluation
#3
Francesca Caló, Michael James Roy, Cam Donaldson, Simon Teasdale, Simone Baglioni
Since the late 1990s social enterprises have been increasingly utilised as a means of delivering of health and social care services. However, there is little evidence on if, and how, provision by social enterprise might achieve positive health outcomes, particularly in comparison to other modes of delivery. In this paper, we draw upon the multiple perspectives offered by stakeholders involved in a rural social enterprise initiative based in Scotland, UK, and in a nearby comparator public sector organisation...
January 7, 2019: Social Science & Medicine
https://read.qxmd.com/read/30633712/realist-synthesis-for-public-health-building-an-ontologically-deep-understanding-of-how-programs-work-for-whom-and-in-which-contexts
#4
Justin Jagosh
Realist synthesis is a literature review methodology for understanding how, for whom, and under what circumstances complex interventions function in complex environments. Using a heuristic called the context-mechanism-outcome (CMO) configuration, realist synthesis produces evidence-informed theories about the interactions between intervention mechanisms and their implementation contexts. Public health interventions and their effects unfold over time and develop differently in different contexts. Much of what causes programs to function remains in a realm beyond empirical measurement...
January 11, 2019: Annual Review of Public Health
https://read.qxmd.com/read/30578941/dealing-with-context-in-logic-model-development-reflections-from-a-realist-evaluation-of-a-community-health-worker-programme-in-nigeria
#5
Bassey Ebenso, Ana Manzano, Benjamin Uzochukwu, Enyi Etiaba, Reinhard Huss, Tim Ensor, James Newell, Obinna Onwujekwe, Nkoli Ezumah, Joe Hicks, Tolib Mirzoev
Logic models (LMs) have been used in programme evaluation for over four decades. Current debate questions the ability of logic modelling techniques to incorporate contextual factors into logic models. We share experience of developing a logic model within an ongoing realist evaluation which assesses the extent to which, and under what circumstances a community health workers (CHW) programme promotes access to maternity services in Nigeria. The article contributes to logic modelling debate by: i) reflecting on how other scholars captured context during LM development in theory-driven evaluations; and ii) explaining how we explored context during logic model development for realist evaluation of the CHW programme in Nigeria...
December 7, 2018: Evaluation and Program Planning
https://read.qxmd.com/read/30578293/tax-foods-high-in-sugar-and-salt-to-improve-nation-s-health-cmo-urges
#6
Gareth Iacobucci
No abstract text is available yet for this article.
December 21, 2018: BMJ: British Medical Journal
https://read.qxmd.com/read/30569694/influence-of-pharmacist-intervention-based-on-cmo-model-to-improve-activation-in-hiv-patients
#7
R Morillo-Verdugo, M A Robustillo-Cortés, M Manzano García, C V Almeida-González
OBJECTIVE: The aim of study was to evaluate the influence of pharmacist intervention based on "CMO model", to improve activation in HIV-patients. METHODS: Longitudinal, prospective, single-center study. Eligible patients were HIV-infected, taking antiretroviral treatment. The collected data included demographic characteristics, clinical and HIV-related and pharmacotherapeutic variables. The primary outcome was the variation of patient activation measured by Spanish adapted patient activation measure questionnaire...
December 18, 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://read.qxmd.com/read/30522457/intravitreal-dexamethasone-implant-therapy-for-the-treatment-of-cystoid-macular-oedema-due-to-hydroxychloroquine-retinopathy-a-case-report-and-literature-review
#8
Seong Joon Ahn, Jooyoung Joung, Sang Hyup Lee, Byung Ro Lee
BACKGROUND: Cystoid macular oedema (CMO) is an uncommon complication associated with hydroxychloroquine (HCQ) retinopathy threatening central vision. We report a patient with HCQ retinopathy and CMO, for which an intravitreal dexamethasone implant was used, which led to complete resolution of oedema. CASE PRESENTATION: A 57-year-old woman with systemic lupus erythematosus (SLE) complaining of blurred vision in both eyes was diagnosed with bilateral HCQ retinopathy and CMO based on characteristic photoreceptor defects and cystoid spaces on optical coherence tomography, hypo-autofluorescence on fundus autofluorescence, and corresponding visual field defects...
December 6, 2018: BMC Ophthalmology
https://read.qxmd.com/read/30485923/effect-of-a-cereal-and-milk-meal-with-or-without-fruits-and-nuts-on-the-postprandial-glycemic-response-in-indian-men
#9
Sulagna Bandyopadhyay, Srishti Sinha, Sumithra Selvam, Anura V Kurpad, Rebecca Kuriyan
BACKGROUND AND OBJECTIVES: Some cereals, consumed at breakfast, have shown lower glycemic responses. Limited data exist in the Indian context, where the effect could be modified due to genetic or racial differences. This study aimed to investigate the effect of cereal and milk, with or without fruits/nuts, on the glycemic response in healthy Indian men. METHODS AND STUDY DESIGN: A randomized cross-over study was carried out on 16 men (18 - 45 years), with 3 interventions providing equal amounts of glycemic carbohydrate: a glucose drink (Reference), cereal and milk (CM), and cereal, milk, fruits and nuts (CMO), on separate days...
2018: Asia Pacific Journal of Clinical Nutrition
https://read.qxmd.com/read/30466447/antinuclear-antibody-and-rheumatoid-factor-positivity-in-temporomandibular-disorders
#10
Ji Rak Kim, Jung Hwan Jo, Jin Woo Chung, Ji Woon Park
BACKGROUND: To investigate the differences in clinical characteristics and long-term treatment outcomes according to antinuclear antibody(ANA) and rheumatoid factor(RF) positivity and the correlation between pain-related and hematological indices in temporomandibular disorders(TMD) patients. METHODS: Clinical examinations were done following the Research Diagnostic Criteria for TMD in 257 patients. Comprehensive screening along with psychological and hematological evaluations (ANA, RF, complete blood cell count, C-reactive protein[CRP] and erythrocyte sedimentation rate[ESR]) were conducted...
November 22, 2018: Head & Face Medicine
https://read.qxmd.com/read/30369936/glycinebetaine-biosynthesis-in-response-to-osmotic-stress-depends-on-jasmonate-signaling-in-watermelon-suspension-cells
#11
Zijian Xu, Mengli Sun, Xuefei Jiang, Huapeng Sun, Xuanmin Dang, Hanqing Cong, Fei Qiao
Glycinebetaine is an important non-toxic osmoprotectant, which is accumulated in higher plants under various stresses. The biosynthesis of glycinebetaine achieved via is a two-step oxidation from choline and betaine aldehyde, catalyzed by choline monooxygenase (CMO) and betaine aldehyde dehydrogenase (BADH), respectively. Up-regulated gene expression of BADH and CMO induced by stress is clearly observed, but the signal transduction is poorly understood. Here, glycinebetaine accumulation in response to osmotic stress and growth recovery induced by exogenous glycinebetaine were observed in a watermelon cell line...
2018: Frontiers in Plant Science
https://read.qxmd.com/read/30369628/seasonal-forecasting-of-green-water-components-and-crop-yields-of-winter-wheat-in-serbia-and-austria
#12
B Lalić, A Firanj Sremac, L Dekić, J Eitzinger, D Perišić
A probabilistic crop forecast based on ensembles of crop model output (CMO) estimates offers a myriad of possible realizations and probabilistic forecasts of green water components (precipitation and evapotranspiration), crop yields and green water footprints (GWFs) on monthly or seasonal scales. The present paper presents part of the results of an ongoing study related to the application of ensemble forecasting concepts for agricultural production. The methodology used to produce the ensemble CMO using the ensemble seasonal weather forecasts as the crop model input meteorological data without the perturbation of initial soil or crop conditions is presented and tested for accuracy, as are its results...
July 2018: Journal of Agricultural Science
https://read.qxmd.com/read/30351064/first-principles-and-thermodynamics-study-of-compositionally-tuned-complex-metal-oxides-cation-release-from-the-001-surface-of-mn-rich-lithium-nickel-manganese-cobalt-oxide
#13
Joseph W Bennett, Diamond T Jones, Robert J Hamers, Sara E Mason
Compositional tuning of nanoscale complex metal oxides (CMOs) can lead to enhanced performance and favorable properties for a variety of energy-related applications. However, investigations of the nanoscale CMOs used in energy storage technologies demonstrate that these nanomaterials may have an adverse biological impact, highlighting a fundamental knowledge gap between nanomaterial design and the structure and properties at the end of life. CMO nanomaterials can enter the environment due to improper disposal, where they undergo subsequent (as of yet poorly understood) nanoscale transformations that may affect biological response and, ultimately, environmental fate...
November 5, 2018: Inorganic Chemistry
https://read.qxmd.com/read/30295225/hungarian-managed-care-initiatives-between-2000-and-2007-regional-health-outcomes-of-the-hungarian-care-organizations
#14
Csaba Móczár, Imre Rurik
BACKGROUND: In Hungary, since 1990, each government has tried to transform and rationalize the structure of health care. One of the reforms was the Care Managing Organization (CMO) programme introduced in 1999. OBJECTIVES: The aim of this paper is to describe the regional, environmental, structural and preliminary health related outcomes of the CMO in Bács-Kiskun County (Central-Eastern Hungary). METHODS: First, cardiovascular screening programmes were organized for pre-screened and randomly selected populations of a total of 4462 persons...
October 8, 2018: Primary Health Care Research & Development
https://read.qxmd.com/read/30256846/bona-fide-choline-monoxygenases-evolved-in-amaranthaceae-plants-from-oxygenases-of-unknown-function-evidence-from-phylogenetics-homology-modeling-and-docking-studies
#15
Javier Carrillo-Campos, Héctor Riveros-Rosas, Rogelio Rodríguez-Sotres, Rosario A Muñoz-Clares
Few land plants can synthesize and accumulate the osmoprotectant glycine betaine (GB) even though this metabolic trait has major adaptive importance given the prevalence of drought, hypersaline soils or cold. GB is synthesized from choline in two reactions catalyzed by choline monooxygenases (CMOs) and enzymes of the family 10 of aldehyde dehydrogenases (ALDH10s) that gained betaine aldehyde dehydrogenase activity (BADH). Homolog genes encoding CMO and ALDH10 enzymes are present in all known land plant genomes, but since GB-non-accumulators plants lack the BADH-type ALDH10 isozyme, they would be expected to also lack the CMO activity to avoid accumulation of the toxic betaine aldehyde...
2018: PloS One
https://read.qxmd.com/read/30190362/death-certificates-should-record-antimicrobial-resistance-as-cause-of-deaths-says-cmo
#16
Adrian O'Dowd
No abstract text is available yet for this article.
September 6, 2018: BMJ: British Medical Journal
https://read.qxmd.com/read/30176410/simplistic-synthesis-of-ultrafine-comno-3-nanosheets-an-excellent-electrocatalyst-for-highly-sensitive-detection-of-toxic-4-nitrophenol-in-environmental-water-samples
#17
Paramasivam Balasubramanian, T S T Balamurugan, Shen-Ming Chen, Tse-Wei Chen
Design and fabrication of cost effective analytical tools to monitor toxic organic emissions in eco system is of a great necessity. Nitrophenols are a class of widespread toxic organic pollutant lead to serious adverse effects in biosphere on its consumption. This article reports a high sensitive, cost effective, robust electrochemical sensor for 4-nitrophenol (4-NP) in environmental water samples. A novel sheet like CoMnO3 (CMO Ns) nanocatalyst was synthesized via oxalic acid assisted co-precipitation technique and employed as electrocatalyst for the high sensitive detection of 4-NP...
January 5, 2019: Journal of Hazardous Materials
https://read.qxmd.com/read/30130755/a-novel-biomarker-in-diabetic-macular-edema-with-serous-retinal-detachment-serum-chitinase-3-like-protein-1
#18
Mahmut Kaya, Derya Kaya, Egemen Idiman, Nilufer Kocak, Taylan Ozturk, Ziya Ayhan, Zekiye Altun, Suleyman Kaynak
PURPOSE: To determine whether serum chitinase-3-like protein 1 (CHI3L1) and interleukin-6 (IL-6) levels correlate with serous retinal detachment (SRD) in diabetic macular edema (DME) using spectral-domain optical coherence tomography (SD-OCT). METHODS: In this cross-sectional case-control study, 394 patients (treatment-naive DME patients, n = 218; diabetic patients without DME, n = 96; nondiabetic controls, n = 80) were included in the study. Eyes were classified according to SD-OCT features of DME: SRD, cystoid macular edema (CMO), and diffuse retinal thickness (DRT)...
August 21, 2018: Ophthalmologica. Journal International D'ophtalmologie
https://read.qxmd.com/read/30087892/technoeconomic-modeling-of-plant-based-griffithsin-manufacturing
#19
Aatif Alam, Linda Jiang, Gregory A Kittleson, Kenneth D Steadman, Somen Nandi, Joshua L Fuqua, Kenneth E Palmer, Daniel Tusé, Karen A McDonald
Griffithsin is a marine algal lectin that exhibits broad-spectrum antiviral activity by binding oligomannose glycans on viral envelope glycoproteins, including those found in HIV-1, HSV-2, SARS, HCV and other enveloped viruses. An efficient, scalable and cost-effective manufacturing process for Griffithsin is essential for the adoption of this drug in human antiviral prophylaxis and therapy, particularly in cost-sensitive indications such as topical microbicides for HIV-1 prevention. The production of certain classes of recombinant biologics in plants can offer scalability, cost and environmental impact advantages over traditional biomanufacturing platforms...
2018: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/30041532/operationalization-of-the-transition-to-comfort-measures-only-in-the-neurocritical-care-unit-a-quality-improvement-project
#20
Abhijit Lele, Chong Cheever, Larry Healey, Kellie Hurley, Louis J Kim, Claire J Creutzfeldt
INTRODUCTION: Transition to comfort measures only (CMO) is common in the neurocritical care unit, and close communication between interdisciplinary health-care teams is vital to a smooth transition. We developed and implemented a CMO huddle in an effort to reduce inconsistencies during the process of CMO transition. METHODS: The CMO huddle was a multiphase quality improvement project in a neurocritical care unit of a level-1 trauma and comprehensive stroke center...
July 24, 2018: American Journal of Hospice & Palliative Care
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