Matteo Di Segni, Sebastian Luca D'Addario, Lucy Babicola, Donald Ielpo, Luisa Lo Iacono, Diego Andolina, Alessandra Accoto, Alessandra Luchetti, Camilla Mancini, Chiara Parisi, Mara D'Onofrio, Ivan Arisi, Rossella Brandi, Tiziana Pascucci, Carlo Cifani, Francesca R D'Amato, Rossella Ventura
Although several studies have been performed in rodents, non-human primates and humans, the biological basis of vulnerability to develop cocaine addiction remains largely unknown. Exposure to critical early events (as Repeated Cross Fostering (RCF)) has been reported to increase sensitivity to cocaine effects in adult C57BL/6J female mice. Using a microarray approach, here we report data showing a strong engagement of X-linked lymphocyte-regulated 4a and 4b (Xlr4) genes in cocaine effects. The expression of Xlr4, a gene involved in chromatin remodeling and dendritic spine morphology, was reduced into the Nucleus Accumbens (NAc) of adult RCF C57BL/6J female...
February 27, 2020: Neuropharmacology