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Salvatore Caruso, Antonio Cianci, Stefano Cianci, Caterina Monaco, Valentina Fava, Vittorio Cavallari
BACKGROUND: The effects of phosphodiesterase-type 5 (PDE5) inhibitors on the in vivo clitoral structure of women with diabetes have never been investigated. AIM: To study the in vivo structural and hemodynamic changes of the clitoris in premenopausal women with type 1 diabetes on PDE5 inhibitors. METHODS: 38 premenopausal women with type 1 diabetes aged 36 -46 years. A randomized 1:1 study design was used: Study Group (group A) on Tadalafil 5 mg daily, and control group (group B)...
February 14, 2019: Journal of Sexual Medicine
Stephanie G Harshman, M Kyla Shea, Xueyan Fu, Michael A Grusak, Donald Smith, Stefania Lamon-Fava, Athan Kuliopulos, Andrew Greenberg, Sarah L Booth
Background: Menaquinone-4 (MK4), a vitamin K metabolite, is converted from phylloquinone through a process that requires intermediates of endogenous cholesterol production. Recent evidence suggests that MK4 is involved in kidney function. Objective: The purpose of this study was to determine the effect of atorvastatin treatment on MK4 formation in young and old male mice. Methods: C57BL/6 male mice (4-mo-old and 20-mo-old) were randomly assigned to either a diet containing 300 mg atorvastatin/kg with 3 mg phylloquinone/kg or a control diet containing 3 mg phylloquinone/kg for 8 wk...
February 8, 2019: Journal of Nutrition
Stephanie N DeCross, Amy H Farabaugh, Avram J Holmes, Maeve Ward, Emily A Boeke, Rick P F Wolthusen, Garth Coombs, Maren Nyer, Maurizio Fava, Randy L Buckner, Daphne J Holt
BACKGROUND: Subclinical delusional ideas, including persecutory beliefs, in otherwise healthy individuals are heritable symptoms associated with increased risk for psychotic illness, possibly representing an expression of one end of a continuum of psychosis severity. The identification of variation in brain function associated with these symptoms may provide insights about the neurobiology of delusions in clinical psychosis. METHODS: A resting-state functional magnetic resonance imaging scan was collected from 131 young adults with a wide range of severity of subclinical delusional beliefs, including persecutory ideas...
February 12, 2019: Psychological Medicine
Giada Pietrabissa, Alessandro Rossi, Susan Simpson, Andrea Tagliagambe, Venessa Bertuzzi, Clarissa Volpi, Giulia Fava, Gian Mauro Manzoni, Giovanni Gravina, Gianluca Castelnuovo
PURPOSE: To examine the psychometric properties and the factorial structure of the Italian version of the schema mode inventory for eating disorders-short form (SMI-ED-SF) for adults with dysfunctional eating patterns. METHODS: 649 participants (72.1% females) completed the 64-item Italian version of the SMI-ED-SF and the eating disorder examination questionnaire (EDE-Q) for measuring eating disorder symptoms. Psychometric testing included confirmatory factor analysis (CFA) and internal consistency...
February 7, 2019: Eating and Weight Disorders: EWD
Alexis E Whitton, Christian A Webb, Daniel G Dillon, Jürgen Kayser, Ashleigh Rutherford, Franziska Goer, Maurizio Fava, Patrick McGrath, Myrna Weissman, Ramin Parsey, Phil Adams, Joseph M Trombello, Crystal Cooper, Patricia Deldin, Maria A Oquendo, Melvin G McInnis, Thomas Carmody, Gerard Bruder, Madhukar H Trivedi, Diego A Pizzagalli
BACKGROUND: Baseline rostral anterior cingulate cortex (rACC) activity is a well-replicated nonspecific predictor of depression improvement. The rACC is a key hub of the default mode network, which prior studies indicate is hyperactive in major depressive disorder. Because default mode network downregulation is reliant on input from the salience network and frontoparietal network, an important question is whether rACC connectivity with these systems contributes to depression improvement...
December 19, 2018: Biological Psychiatry
Daniel A H Peach, Regine Gries, Nathan Young, Robyn Lakes, Erin Galloway, Santosh Kumar Alamsetti, Elton Ko, Amy Ly, Gerhard Gries
Plant sugar is an essential dietary constituent for mosquitoes, and hemipteran honeydew is one of the many forms of plant sugar that is important to mosquitoes. Many insects rely on volatile honeydew semiochemicals to locate aphids or honeydew itself. Mosquitoes exploit volatile semiochemicals to locate sources of plant sugar but their attraction to honeydew has not previously been investigated. Here, we report the attraction of female yellow fever mosquitoes, Aedes aegypti , to honeydew odorants from the green peach aphid, Myzus persicae , and the pea aphid, Acyrthosiphon pisum , feeding on fava bean, Vicia faba ...
February 1, 2019: Insects
Kwan Woo Choi, Eun Jin Na, Jin Pyo Hong, Maeng Je Cho, Maurizio Fava, David Mischoulon, Hong Jin Jeon
BACKGROUND: Subthreshold hypomania is defined as a distinct period of elevated, expansive or irritable mood lasting for at least four days, but insufficient to fulfill the criteria of hypomania. This study aimed to investigate the association between suicidality and subthreshold hypomania in subjects with and without major depressive disorder (MDD). METHODS: Face-to-face interviews were completed for 12,526 adults, randomly selected through a one-person-per-household method, using the Korean version of the Composite International Diagnostic Interview (K-CIDI) and a questionnaire relative to lifetime suicide attempts (LSA)...
January 26, 2019: Journal of Affective Disorders
Carol Cardona Attard, Stephen Fava
Adult-onset hypogonadism is used to define androgen deficiency and its associated symptoms commonly occurring in middle-aged and elderly men, who are unable to mount an adequate compensatory gonadotropin response but may also have an element of testicular failure. It often occurs in relation with chronic metabolic conditions such as diabetes and the metabolic syndrome. There is a growing demand from elderly men for testosterone therapy. The physician should therefore be well-informed so as the patient can make an informed decision...
January 28, 2019: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
Allen Liao, Robrina Walker, Thomas J Carmody, Crystal Cooper, Meredith A Shaw, Bruce D Grannemann, Phil Adams, Gerard E Bruder, Melvin G McInnis, Christian A Webb, Daniel G Dillon, Diego A Pizzagalli, Mary L Phillips, Benji T Kurian, Maurizio Fava, Ramin V Parsey, Patrick J McGrath, Myrna M Weissman, Madhukar H Trivedi
BACKGROUND: Despite the fact that higher levels of anxiety and anhedonia in Major Depressive Disorder (MDD) are linked to poorer treatment outcomes, mechanisms contributing to these clinical presentations remain unclear. Neuroticism, impaired cognitive control, and blunted reward learning may be critical processes involved in MDD and may help to explain symptoms of anxiety and anhedonia. METHODS: Using baseline data from patients with early-onset MDD (N = 296) in the Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care (EMBARC) trial, we conducted a path analysis to model relationships between neuroticism, cognitive control, and reward learning to levels of anxiety and anhedonia...
February 15, 2019: Journal of Affective Disorders
Mi Jin Park, Kwan Woo Choi, Eun Jin Na, Jin Pyo Hong, Maeng Je Cho, Maurizio Fava, David Mischoulon, Hong Jin Jeon
OBJECTIVE: Somatic pain is an important risk factor for suicide and suicidal behaviors. However, the association between the number of somatic pain conditions and lifetime suicide attempts (LSA) has not been well established yet. Therefore, the objective of this study was to examine associations between LSA and multiple somatic pain (MSP), singe pain, and no pain in a nationwide survey. METHODS: A total of 12,532 adults were randomly selected from the population using the one-person-per-household method...
December 19, 2018: Comprehensive Psychiatry
Giovanni A Fava, Fiammetta Cosci, Carmen Berrocal Montiel, Elena Tomba
No abstract text is available yet for this article.
January 24, 2019: Psychotherapy and Psychosomatics
B C Bock, H Thind, J L Fava, S Dunsiger, K M Guthrie, L Stroud, G Gopalakrishnan, M Sillice, W Wu
OBJECTIVES: This study:Healthy Active and in Control (HA1C), examined the feasibility and acceptability of yoga as a complementary therapy for adults with Type-2 Diabetes (T2DM). DESIGN: A 2-arm randomized clinical trial comparing Iyengar yoga with a supervised walking program. SETTING: Hospital based gym-type facility and conference rooms. INTERVENTIONS: Participants were randomized to a 12-week program of either; (1) a twice weekly Iyengar yoga, or (2) a twice-weekly program of standard exercise (SE)...
February 2019: Complementary Therapies in Medicine
A Tagetti, S Bonafini, T Ohlsson, G Engström, P Almgren, P Minuz, G Smith, O Melander, C Fava
A genetic risk score (GRS) based on 29 single nucleotide polymorpysms (SNPs) associated with high blood pressure (BP) was prospectively associated with development of hypertension, stroke and cardiovascular events. The aim of the present study was to evaluate the impact of this GRS on the incidence of aortic disease, including aortic dissection (AD), rupture or surgery of a thoracic (TAA) or abdominal (AAA) aortic aneurysm. More than 25,000 people from the Swedish Malmo Diet and Cancer Study had information on at least 24 SNPs and were followed up for a median ≥ 18 years...
January 18, 2019: Journal of Human Hypertension
Qiao Shi, Yaxi Hou, Yan Xu, Kristian B R Mørkeberg Krogh, Maija Tenkanen
Levans and inulins are fructans with mainly β-(2→6) and β-(2→1) linkages, respectively. Levans are produced by many lactic acid bacteria, e.g. during sourdough fermentation. Levans have shown prebiotic properties and may also function as in situ-produced hydrocolloids. So far, levan contents have been measured by acid hydrolysis, which cannot distinguish levans from e.g. inulins. In order to develop a specific analysis for levan in food matrices, a Paenibacillus amylolyticus endolevanase was combined with exoinulinase for levan hydrolysis...
March 15, 2019: Carbohydrate Polymers
Marlene P Freeman, George I Papakostas, Bettina Hoeppner, Erica Mazzone, Heidi Judge, Cristina Cusin, Sanjay Mathew, Gerard Sanacora, Dan Iosifescu, Charles DeBattista, Madhukar H Trivedi, Maurizio Fava
BACKGROUND: While ketamine has been increasingly studied for treatment resistant depression (TRD), the impact of sex differences on treatment outcomes has not been well studied. The objective was to ascertain whether there were differences in response to a single administration of ketamine for TRD between men and women, and between pre- and post-menopausal women. METHODS: A randomized, double-blind, placebo-controlled trial (N = 99; N = 50 male; N = 49 female) was conducted to investigate the efficacy of intravenous ketamine versus active placebo as augmentation of antidepressant therapy for TRD...
January 8, 2019: Journal of Psychiatric Research
Marcus Pickhardt, Michele Tassoni, Philip Denner, Birgit Kurkowsky, Ana Kitanovic, Christoph Möhl, Eugenio Fava, Eckhard Mandelkow
We have developed a cell-based phenotypic automated high-content screening approach for N2a cells expressing the pro-aggregant repeat domain of tau protein (tauRDΔK ), which allows analysis of a chemogenomic library of 1649 compounds for their effect on the inhibition or stimulation of intracellular tau aggregation. We identified several inhibitors and stimulators of aggregation and achieved a screening reproducibility >85% for all data. We identified 18 potential inhibitors (= 1.1% of the library) and 10 stimulators (= 0...
December 13, 2018: Neurobiology of Aging
Valentina Fava, Anne-Sophie Gremeau, Jean Luc Pouly, Pauline Chauvet, Krzysztof Gałczyński, Revaz Botchorishvili, Nicolas Bourdel
STUDY OBJECTIVE: Laparoscopic myomectomy has the advantages of a minimally invasive approach for the surgical treatment of myomas. The standardization and description of the technique are the main objectives of this video. We described laparoscopic myomectomy in 10 steps, which could help to make this procedure easier and safer [1]. DESIGN: Step-by-step video demonstration of the technique (Canadian Task Force III) SETTING: French university tertiary care hospital PATIENTS: Patients with indication for laparoscopic myomectomy...
January 10, 2019: Journal of Minimally Invasive Gynecology
Akilah J Dulin, Sannisha K Dale, Valerie A Earnshaw, Joseph L Fava, Michael J Mugavero, Sonia Napravnik, Joseph W Hogan, Michael P Carey, Chanelle J Howe
We use a socioecological model of health to define resilience, review the definition and study of resilience among persons living with human immunodeficiency virus (PLWH) in the existing peer-reviewed literature, and discuss the strengths and limitations of how resilience is defined and studied in HIV research. We conducted a review of resilience research for HIV-related behaviors/outcomes of antiretroviral therapy (ART) adherence, clinic attendance, CD4 cell count, viral load, viral suppression, and/or immune functioning among PLWH...
January 11, 2019: AIDS Care
G I Papakostas, K Johe, H Hand, A Drouillard, P Russo, G Kay, R Kashambwa, B Hoeppner, M Flynn, A Yeung, M A Martinson, M Fava
NSI-189 is a novel neurogenic compound independent of monoamine reuptake pathways. This trial evaluated oral NSI-189 as monotherapy in major depressive disorder. To improve signal detection, the sequential-parallel comparison design (SPCD) was chosen. Two hundred and twenty subjects were randomized to NSI-189 40 mg daily, 80 mg daily, or placebo for 12 weeks. The primary outcome measure was the Montogmery Asberg Depression Rating Scale (MADRS). Secondary subject-rated measures included the Symptoms of Depression Questionnaire (SDQ), the Cognitive and Physical Functioning Scale (CPFQ), the patient-rated version of the Quick Inventory of Depressive Symptomatology Scale (QIDS-SR), and subtests from the CogScreen and Cogstate cognitive tests...
January 9, 2019: Molecular Psychiatry
Fernando H Cincotto, Elson L Fava, Fernando C Moraes, Orlando Fatibello-Filho, Ronaldo C Faria
A new disposable microfluidic electrochemical paper-based device (ePAD) consisting of two spot sensors in the same working electrode for the simultaneous determination of uric acid and creatinine was developed. The spot 1 surface was modified with graphene quantum dots for direct uric acid oxidation and spot 2 surface modified with graphene quantum dots, creatininase and a ruthenium electrochemical mediator for creatinine oxidation. The ePAD was employed to construct an electrochemical sensor (based on square wave voltammetry analysis) for the simultaneous determination of uric acid and creatinine in the 0...
April 1, 2019: Talanta
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