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Renal hypertension

Hilmi Erdem Sumbul, Ayse Selcan Koc, Derya Demirtas, Hasan Koca, Burcak Cakir Pekoz, Feride Fatma Gorgulu, Yurdaer Donmez, Abdullah Orhan Demirtas, Mevlut Koc, Yahya Kemal Icen
PURPOSE: We aimed to investigate the relation between renal cortical stiffness (CS) obtained by shear-wave elastography (SWE) and contrast-induced nephropathy (CIN) development in interventional treatment-planned acute coronary syndrome (ACS) patients. METHODS: Our study group consisted of 465 ACS patients. Routine laboratory assessments, B-mode, Doppler, and SWE renal ultrasonography (USG) evaluations were performed. Renal resistive index (RRI), renal pulsatility index (RPI), and acceleration time (AT) and CS were measured...
March 14, 2019: Journal of Ultrasound
Qiongjing Yuan, Jinwei Wang, Zhangzhe Peng, Qiaoling Zhou, Xiangcheng Xiao, Yanyun Xie, Wei Wang, Ling Huang, Wenbin Tang, Danni Sun, Luxia Zhang, Fang Wang, Ming-Hui Zhao, Lijian Tao, Kevin He, Hui Xu
BACKGROUND: Chronic kidney disease (CKD) leads to end-stage renal failure and cardiovascular events. An attribute to these progressions is abnormalities in inflammation, which can be evaluated using the neutrophil-to-lymphocyte ratio (NLR). We aimed to investigate the association of NLR with the progression of end stage of renal disease (ESRD), cardiovascular disease (CVD) and all-cause mortality in Chinese patients with stages 1-4 CKD. METHODS: Patients with stages 1-4 CKD (18-74 years of age) were recruited at 39 centers in 28 cities across 22 provinces in China since 2011...
March 15, 2019: Journal of Translational Medicine
Jasvinder A Singh, John D Cleveland
BACKGROUND: Hyperuricemia and gout have been linked to chronic kidney disease (CKD). Whether the increased risk of CKD in gout is due to shared risk factors such as hypertension, diabetes or heart disease, or due to gout itself is not known. Studies in older adults, who tend to have a high incidence of CKD, are limited. Our objective was to assess whether gout was associated with incident CKD in older adults. METHODS: Using the 5% random sample of Medicare claims, we assessed whether gout is associated with higher risk of incident (new) CKD in adults 65 years or older, using multivariable-adjusted Cox regression analyses, adjusting for demographics (age, gender, race), medical comorbidity and common medications...
March 15, 2019: BMC Nephrology
Kateir Mariel Contreras Villamizar, Diana Carolina Afanador Rubio, Camilo Alberto González González, Paola Karina García Padilla, Martha Patricia Rodríguez Sánchez
INTRODUCTION: Morbid obesity in chronic kidney disease patients on hemodialysis limits access to renal transplantation. We report here a case of a surgical procedure for weight reduction in a hemodialysis patient and adjustment of dry weight through bioelectrical impedance. CASE PRESENTATION: A 44-year-old male with CKD on hemodialysis for 26 years. After 3 years on dialysis, he underwent a cadaveric kidney transplant. However, after 8 years of transplant, he loses the kidney graft and returns to dialysis treatment...
March 5, 2019: International Journal of Surgery Case Reports
Jocelyn S Gandelman, Omair A Khan, Megan M Shuey, Jacquelyn E Neal, Elizabeth McNeer, Alyson Dickson, April Barnado, Li Wang, Prathima Anandi, William D Dupont, C Michael Stein, Cecilia P Chung
OBJECTIVES: To compare the risk of resistant hypertension (RHTN) in systemic lupus erythematosus (SLE) patients and controls without SLE; to define factors associated with RHTN in SLE patients. METHODS: We studied 1,044 SLE patients and 5,241 control subjects using de-identified electronic health records from a tertiary care center. SLE was defined as ≥ 4 ICD codes for SLE and ANA ≥ 1:160. RHTN was defined as uncontrolled blood pressure on three anti-hypertensive medications or requiring four or more anti-hypertensives to attain control...
March 15, 2019: Arthritis Care & Research
Christian Reynolds, Donal S O'Leary, Cheng Ly, Scott A Smith, Zeljka Minic
Autonomic dysreflexia (AD) often occurs in individuals living with spinal cord injury (SCI) and is characterized by uncontrolled hypertension in response to otherwise innocuous stimuli originating below the level of the spinal lesion. Visceral stimulation is a predominate cause of AD in humans, and effectively replicates the phenotype in rodent models of SCI. Direct assessment of sympathetic responses to viscerosensory stimulation in spinalized animals is challenging and requires invasive surgical procedures necessitating the use of anesthesia...
March 15, 2019: American Journal of Physiology. Heart and Circulatory Physiology
Malamo E Countouris, Jill R Demirci, Arun Jeyabalan, Janet M Catov, Eleanor B Schwarz
BACKGROUND: Women with hypertensive disorders of pregnancy are at increased risk of cardiovascular disease in later life. We sought to determine the association between lactation and markers of maternal cardiovascular health among postpartum women with and without hypertensive disorders of pregnancy via measures of inflammation (high-sensitivity C-reactive protein [hsCRP]) and renal function (cystatin C). METHODS: This prospective cohort study enrolled primarily overweight and obese women during early pregnancy...
March 15, 2019: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
Monika Kubacka, Monika Zadrożna, Barbara Nowak, Magdalena Kotańska, Barbara Filipek, Anna Maria Waszkielewicz, Henryk Marona, Szczepan Mogilski
We investigated the therapeutic effect of MH-76 and MH-79, which are non-quinazoline α1-adrenoceptor antagonists with an additional ability to stimulate the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP)/K + pathway, on deoxycorticosterone acetate (DOCA)-salt induced hypertension in rats. Prazosin was used as a reference compound, as quinazoline-based α1-adrenolytics may potentially exert unfavorable proapoptotic and necrotic effects. DOCA-salt hypertension was induced by DOCA (20 mg/kg s.c...
March 12, 2019: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Thomas A Marciniak, Victor Serebruany
BACKGROUND: Ranolazine is an anti-angina agent with many metabolites creating the potential for off-target effects. FDA reviews sometimes contain clinically relevant data not found in other sources. METHODS: We reanalyzed data in an FDA review of the placebo-controlled MERLIN trial of ranolazine to display differences in adverse event rates graphically. RESULTS: Rates of ACE inhibitor (ACEI) or angiotensin receptor blocker (ARB)-related adverse events (angioedema, dry cough, renal impairment, hypotension, anemia, and serum potassium >5...
March 11, 2019: American Journal of Medicine
Stefan Büttner, Alexander Koch, Josef Pfeilschifter
The treatment of generalized edema includes primarily the treatment of the underlying disease as well as the sodium restriction. Often, however, the volume balance alone can not be controlled satisfactorily. Commonly, diuretics are used for the treatment of chronic heart failure, liver cirrhosis, nephrotic syndrome and renal failure. Diuretics are well documented effective and necessary drugs for the treatment of hypervolemia. From a symptomatic point of view, they are indispensable for cardiac decompensation and they have a firm place in the treatment of hypertension...
March 2019: Deutsche Medizinische Wochenschrift
Sjoerd A M E G Timmermans, Pieter van Paassen
Severe hypertension can lead to irreversible kidney failure and end-stage renal disease (ESRD) and vice versa. Patients are often classified as hypertensive ESRD with no confirmative proof and the true cause of disease can therefore be missed, affecting outcomes. We present a case of chronic thrombotic microangiopathy (TMA) after kidney transplantation in a recipient who had been classified as hypertensive ESRD and found to have a genetic defect in CD46, a transmembrane protein that regulates complement activation, indicating atypical hemolytic uremic syndrome (HUS)...
March 14, 2019: Nephron
Vivek Nagaraja
PURPOSE OF REVIEW: Scleroderma renal crisis (SRC) is a life-threatening manifestation in systemic sclerosis (SSc) and is usually presented by an acute onset of severe hypertension together with an acute kidney injury. We can conceptualize SRC as a systemic syndrome with features that extend beyond the involvement of the kidney. The goal of this review is to inform clinicians about the risk factors for SRC in patients with SSc and to emphasize the importance of early identification and initiation of treatment...
March 5, 2019: Current Opinion in Rheumatology
Sebastian Völz, Linda C Lundblad, Bert Andersson, Jonas Multing, Bengt Rundqvist, Mikael Elam
BACKGROUND: The impact of renal denervation (RDN) on muscle sympathetic nerve activity (MSNA) at rest remains controversial. Mental stress (MS) induces transient changes in sympathetic nerve activity, heart rate (HR) and blood pressure (BP). It is not known whether RDN modifies these changes. PURPOSE: The main objective was to assess the effect of RDN on MSNA and BP alterations during MS. METHODS: In 14 patients (11 included in analysis) with resistant hypertension multi-unit MSNA, BP (Finometer ®) and HR were assessed at rest and during forced arithmetics at baseline and 6 months after RDN...
March 14, 2019: Clinical and Experimental Hypertension: CHE
Zaeem Lone, Shelby Hall, Tomoaki Terakawa, Ahmed Hussein, Youssef Ahmed, Ahmed S Elsayed, Naif A Aldhaam, Paul May, Austin Miller, Zhe Jing, Luciano Nunez Bagayrac, Hijab Khan, Jared Cohen, Adam Cole, Omer Rana, Renuka Kanapan, Christian Prechtl, Khurshid A Guru
INTRODUCTION: There is paucity of literature about the validation American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP®) surgical risk calculator for prediction of outcomes after robot-assisted radical cystectomy (RARC). We sought to evaluate the accuracy of the ACS NSQIP® surgical risk calculator in the patients who underwent RARC at our institute. METHODS: We retrospectively reviewed our prospectively maintained database for patients who underwent RARC between 2005 and 2017...
March 14, 2019: Journal of Endourology
Dominique Joly
Management of a patient with polycystic kidney disease. In patients with autosomal dominant polycystic kidney disease, the nephrologist is typically asked to treat hypertension, urological complications (pain, stones, infections), progressive renal failure and its consequences, and finally initiate renal replacement therapy (hemodialysis, peritoneal dialysis, kidney transplant) for those reaching end-stage renal failure, most often in the second part of their life. We should now consider a more modern vision: in at risk subjects, an early diagnosis (around 20 years of age) will help to provide dietary advice (water intake, salt and protein intake), detect hypertension, fight against cardiovascular risk factors, detect intracranial aneurysms; in women, to give advice on contraception, pregnancies, and to detect massive polycystic liver disease; finally, to discuss advances in cystic blocking research and to propose the first of these, tolvaptan, to eligible patients...
May 2018: La Revue du Praticien
Sarwat Abbasi, Nadia Haleem, Sara Jadoon, Amjad Farooq
BACKGROUND: Non-alcoholic fatty liver disorder is a clinicopathological condition, characterized by macro vesicular steatosis in hepatic cells and metabolic stress related disorders without other causes of chronic hepatic disease. Uric acid is basically a heterocyclic compound of hydrogen, carbon, oxygen and nitrogen. Uric acid is the metabolic end product of purine metabolism. Hyperuricemia is considered to be related with the causes responsible for the production of metabolic syndrome...
January 2019: Journal of Ayub Medical College, Abbottabad: JAMC
Ojas H Mehta, James D Cameron, Sam Mirzaee
Familial hypercholesterolemia (FH) is a common hereditary lipid disorder associated with substantial risk of premature atherosclerotic cardiovascular disease (ASCVD). We report an interesting newly diagnosed index case of FH in a 31 year old man who presented to the hospital with a ST-elevated myocardial infarction (STEMI). He had a background of inadequately treated hypertension and hypercholesterolemia. Further investigations raised the possibility of secondary hypertension after the identification of renal artery stenosis, in addition to other areas of mesenteric arterial stenoses...
March 14, 2019: American Journal of Hypertension
Jong Wook Choi, Chang Hwa Lee, Joon-Sung Park
Non-alcoholic fatty liver disease (NAFLD) is closely linked to insulin resistance and related adverse health outcomes. We investigated the non-invasive index of NAFLD that has the best performance in estimating the renal manifestations of metabolic disturbances. This nation-wide, cross-sectional study included 11,836 subjects, using various non-invasive assessments comprising routinely measured clinical and laboratory variables. The subjects were native Koreans aged 20 years or older and had no diabetes, history of liver or kidney disease...
2019: PeerJ
Leay Kiaw Er, Lung-An Hsu, Jyh-Ming Jimmy Juang, Fu-Tien Chiang, Ming-Sheng Teng, I-Shiang Tzeng, Semon Wu, Jeng-Feng Lin, Yu-Lin Ko
Chemerin, a novel adipokine, has been associated with metabolic, inflammatory, and atherosclerotic diseases. We aimed to determine the genetic basis of chemerin levels by conducting a genome-wide association study (GWAS) and to investigate the role of RARRES2 polymorphisms and circulating chemerin levels in the long-term outcome of coronary artery disease (CAD). A total of 2197 participants from the Taiwan Biobank (TWB) were recruited for the GWAS analysis, and 481 patients with angiographically confirmed CAD were enrolled for long-term outcome analysis...
March 7, 2019: International Journal of Molecular Sciences
Dragana Komnenov, Peter E Levanovich, Noreen F Rossi
Hypertension is a leading cause of cardiovascular and chronic renal disease. Despite multiple important strides that have been made in our understanding of the etiology of hypertension, the mechanisms remain complex due to multiple factors, including the environment, heredity and diet. This review focuses on dietary contributions, providing evidence for the involvement of elevated fructose and salt consumption that parallels the increased incidence of hypertension worldwide. High fructose loads potentiate salt reabsorption by the kidney, leading to elevation in blood pressure...
March 7, 2019: Nutrients
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