keyword
https://read.qxmd.com/read/38275678/late-complications-in-long-term-childhood-cancer-survivors-what-the-oral-health-professional-needs-to-know
#21
REVIEW
Sali Al-Ansari, Juliette Stolze, Dorine Bresters, Alan Henry Brook, Alexa M G A Laheij, Henk S Brand, Göran Dahllöf, Frederik R Rozema, Judith E Raber-Durlacher
With diagnostic and therapeutic advances, over 80% of children diagnosed with cancer become long-term survivors. As the number of childhood cancer survivors (CCS) continues to increase, dental practitioners become more likely to have CCS among their patients. CCS may develop late complications from damage caused by their cancer treatment to endocrine, cardiovascular, musculoskeletal, and other organ systems. These complications may surface decades after the completion of treatment. Adverse outcomes of childhood cancer treatment frequently involve oral and craniofacial structures including the dentition...
January 19, 2024: Dentistry Journal
https://read.qxmd.com/read/38271115/late-mortality-among-5-year-survivors-of-childhood-cancer-a-systematic-review-and-meta-analysis
#22
JOURNAL ARTICLE
Alexandra Moskalewicz, Benjamin Martinez, Elizabeth M Uleryk, Petros Pechlivanoglou, Sumit Gupta, Paul C Nathan
BACKGROUND: Childhood cancer survivors are at increased risk of late mortality (death ≥5 years after diagnosis) from cancer recurrence and treatment-related late effects. The authors conducted a systematic review and meta-analysis to provide comprehensive estimates of late mortality risk among survivors internationally and to investigate differences in risk across world regions. METHODS: Health sciences databases were searched for cohort studies comprised of 5-year childhood cancer survivors in which the risk of mortality was evaluated across multiple cancer types...
January 25, 2024: Cancer
https://read.qxmd.com/read/38270745/late-effects-of-high-dose-methotrexate-in-childhood-cancer-survivors-a-swiss-single-centre-observational-study
#23
JOURNAL ARTICLE
Kevin Brunold, Maria Otth, Katrin Scheinemann
IMPORTANCE: Childhood cancer survivors (CCS) are at risk for late effects of different organ systems. The currently available screening recommendations for those treated with high-dose methotrexate (HD-MTX) are not uniform and the available literature is limited. OBJECTIVE: We aim to assess the prevalence and severity of late effects in CCS treated with HD-MTX at a single centre in Switzerland. We focus on organ systems defined at risk by the long-term follow-up care guidelines of the children's oncology group (COG), because this guideline has a holistic approach, is evidence based, and up to date...
January 25, 2024: Discover. Oncology
https://read.qxmd.com/read/38267891/a-software-tool-to-support-follow-up-care-in-a-french-childhood-cancer-cohort-construction-and-feasibility
#24
JOURNAL ARTICLE
Charlotte Demoor-Goldschmidt, Pascal Veillon, Maxime Esvan, Mathilde Leonard, Sophie Chauvet, Amandine Bertrand, Liana Carausu, Fanny Delehaye, Julien Lejeune, Jérémie Rouger, Pascale Schneider, Caroline Thomas, Frédéric Millot, Line Claude, Julie Leseur, Fernand Missohou, Stéphane Supiot, Nathalie Bihannic, Isabelle Debroise, Carole Jeanneaud, Esther Lebreton, Marianne Roumy, Les Aguerris, Jean-Marie Chrétien, Virginie Gandemer, Isabelle Pellier
BACKGROUND: Treatment summaries and a personalized survivorship care plans based on internationally approved, organ-specific follow-up care recommendations are essential in preserving the health and quality of life for cancer survivors. Cohorts made up of survivors of childhood cancer have made significant contributions to the understanding of early mortality, somatic late complications, and psychosocial outcomes among former patients. New treatment protocols are needed to enhance survival and reduce the potential risk and severity of late effects, and working with treatment databases is crucial in doing so...
January 25, 2024: BMC Cancer
https://read.qxmd.com/read/38247061/-current-status-and-challenges-in-oncofertility-for-pediatric-cancer-patients
#25
JOURNAL ARTICLE
Naoko Maeda
Infertility is a frequent late effect of cancer treatment that significantly affects cancer survivors' quality of life. In recent years, with advances in oncofertility, the number of children with cancer receiving fertility preservation therapy has increased. However, specific challenges exist in pediatric cancer patients. First, fertility preservation therapy for children with cancer relies significantly on their age and sex. Ovarian tissue cryopreservation is possible until puberty in females, and after menarche, the ovarian tissues and oocytes can be preserved...
December 2023: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38246972/pulmonary-metastatectomy-in-pediatric-cancer-patients-at-national-cancer-institute-egypt-prognostic-factors-and-outcome
#26
JOURNAL ARTICLE
Asmaa Hamoda, Inas Elattar, Heba Mahmoud, Mohamed Abdelrahman, Emad Ebied
BACKGROUND: Metastatic tumors account for 80% of all lung tumors in children. Wilms tumour and osteosarcoma are the most tumors of childhood that produce lung metastases. The aim of the current study is to assess the prognostic factors of pulmonary metastatectomy in pediatric solid tumours as age, number, size, site,laterality, resectability of pulmonary nodules, and number of Thoracotomies. Calculate overall survival among patients who underwent pulmonary metastatectomy. METHODS: It is a retrospective study including all pediatric patients with metastatic solid tumors to lungs treated at pediatric oncology department, National Cancer Institute, Cairo University from 2008 to 2014...
January 22, 2024: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/38241048/late-cardiac-toxic-effects-associated-with-treatment-protocols-for-hodgkin-lymphoma-in-children
#27
JOURNAL ARTICLE
Andrea C Lo, Amy Liu, Qi Liu, Yutaka Yasui, Sharon M Castellino, Kara M Kelly, Alex F Hererra, Jonathan W Friedberg, Debra L Friedman, Cindy L Schwartz, Qinglin Pei, Sandy Kessel, Samuel Bergeron-Gravel, Hitesh Dama, Kenneth Roberts, Louis S Constine, David C Hodgson
IMPORTANCE: Contemporary North American trials for children with Hodgkin lymphoma (HL) have decreased radiation therapy (RT) use and increased pharmacologic cardioprotection but also increased the cumulative doxorubicin dose, making overall treatment consequences for late cardiac toxic effects uncertain. OBJECTIVE: To estimate the risk of cardiac toxic effects associated with treatments used in modern pediatric HL clinical trials. DESIGN, SETTING, AND PARTICIPANTS: For this cohort study, Fine and Gray models were fitted using survivors in the Childhood Cancer Survivor Study who were diagnosed with HL between January 1, 1970, and December 31, 1999, and were followed for a median of 23...
January 2, 2024: JAMA Network Open
https://read.qxmd.com/read/38240104/neurocognitive-and-psychosocial-outcomes-in-survivors-of-childhood-leukemia-with-down-syndrome
#28
JOURNAL ARTICLE
Kellen Gandy, Lacey Hall, Kevin R Krull, Anna J Esbensen, Jeffrey Rubnitz, Lisa M Jacola
OBJECTIVE: The primary aim of this study was to assess the feasibility of a developmentally tailored neurocognitive assessment in survivors of childhood acute leukemia with Down syndrome (DS-leukemia). A secondary aim was to compare outcomes in the DS-leukemia group to a historical comparison group of individuals with DS and no history of childhood cancer. METHODS: Survivors of DS-leukemia (n = 43; 56% male, mean [SD] age at diagnosis = 4...
January 19, 2024: Cancer Medicine
https://read.qxmd.com/read/38225859/serum-adipokines-as-biomarkers-for-surveillance-of-metabolic-syndrome-in-childhood-acute-lymphoblastic-leukemia-survivors-in-low-middle-income-countries
#29
JOURNAL ARTICLE
Gargi Das, Kritika Setlur, Manisha Jana, Lakshmy Ramakrishnan, Vandana Jain, Jagdish Prasad Meena, Aditya Kumar Gupta, Sada Nand Dwivedi, Rachna Seth
BACKGROUND: Serum adipokines (leptin and adiponectin) are dysregulated before the onset of metabolic syndrome and hence may be useful biomarkers for screening of cardiometabolic late effects in childhood Acute Lymphoblastic Leukemia (cALL) survivors. METHODS: We compared serum adipokine levels between 40 cALL survivors (aged 10-18 years, >2 years from treatment completion) with similar controls. A multivariable logistic regression analysis was then done to assess the association of metabolic syndrome in cALL survivors with variables including adipokines and other metabolic parameters, demographic and treatment details, and Dual-energy X-ray absorptiometry scan-derived variables...
January 15, 2024: Nutrition and Cancer
https://read.qxmd.com/read/38205003/increased-cardiac-risk-after-a-second-malignant-neoplasm-among-childhood-cancer-survivors-a-fccss-study
#30
JOURNAL ARTICLE
Thibaud Charrier, Nadia Haddy, Boris Schwartz, Neige Journy, Brice Fresneau, Charlotte Demoor-Goldschmidt, Ibrahima Diallo, Aurore Surun, Isabelle Aerts, François Doz, Vincent Souchard, Giao Vu-Bezin, Anne Laprie, Sarah Lemler, Véronique Letort, Carole Rubino, Stéfania Chounta, Florent de Vathaire, Aurélien Latouche, Rodrigue S Allodji
BACKGROUND: Childhood cancer survivors (CCS) are at an elevated risk of developing both a second malignant neoplasm (SMN) and cardiac disease. OBJECTIVES: This study sought to assess the excess of occurrence of cardiac disease after a SMN among CCS. METHODS: Analyses included 7,670 CCS from the French Childhood Cancer Survivors Study cohort diagnosed between 1945 and 2000. To account for the time dependence of the occurrence of a SMN, we employed a landmark approach, considering an additive regression model for the cumulative incidence of cardiac disease...
December 2023: JACC CardioOncology
https://read.qxmd.com/read/38204211/anthracycline-induced-cardiotoxicity-on-regional-myocardial-work-and-left-ventricular-mechanical-dispersion-in-adolescents-and-young-adults-in-post-lymphoma-remission
#31
JOURNAL ARTICLE
Mohamed Jaber, Alexandre Armand, Emmanuelle Rochette, Severine Monzy, Victoria Greze, Justyna Kanold, Etienne Merlin, Justine Paysal, Stéphane Nottin
BACKGROUND: Myocardial work (MW) is a new echocardiographic tool with a high sensitivity to detect early and subtle alterations of myocardial function. We aimed to evaluate the late effects of anthracyclines by assessing the global and segmental MW and intraventricular mechanical dispersion from speckle tracking echocardiography in childhood lymphoma survivors (CLS). METHODS: Thirty-one young adults including CLS and age-matched healthy controls were enrolled. All underwent echocardiography including an evaluation of left ventricular (LV) morphology and regional function...
January 10, 2024: Cancer Medicine
https://read.qxmd.com/read/38201538/chemotherapy-and-radiotherapy-long-term-adverse-effects-on-oral-health-of-childhood-cancer-survivors-a-systematic-review-and-meta-analysis
#32
REVIEW
Joana Pombo Lopes, Inês Rodrigues, Vanessa Machado, João Botelho, Luísa Bandeira Lopes
The survival rate for pediatric cancer has increased over the past few decades, short- and long-term complications have been detected and studied, and oral complications have emerged as an important topic of research. Here, we aimed to highlight the importance of oral manifestations that may only become apparent years or even decades after cancer treatment. This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis. We searched articles using PubMed via the MEDLINE, Web of Science, and LILACS databases until October 2023...
December 25, 2023: Cancers
https://read.qxmd.com/read/38195683/evaluation-of-late-effects-during-a-21-year-follow-up-of-pediatric-hodgkin-lymphoma-survivors-experience-of-a-pediatric-cancer-center-in-turkey-as-a-developing-country-model
#33
JOURNAL ARTICLE
Nurdan Tacyildiz, Hatice M Cakmak, Emel Unal, Handan Dincaslan, Gulsah Tanyıldız, Sonay I Özdemir, Ömer Kartal, Yasin Yılmaz, Gulsan Yavuz, Işınsu Kuzu
BACKGROUND: Long-term survivors of Hodgkin lymphoma (HL) are at risk of developing a range of late effects, with a second malignant neoplasm and cardiovascular diseases being the leading causes of death in these patients. The present study aims to evaluate the late side effects in children with HL. MATERIALS AND METHODS: Out of 53 HL patients, we assessed the long-term effects of childhood HL survivors (HLSs; n = 50) diagnosed between 1998 and 2019. Patient data related to chronic health conditions, and sociodemographic characteristics were compared with their siblings (n = 56)...
January 9, 2024: Indian Journal of Cancer
https://read.qxmd.com/read/38183576/physical-late-effects-of-treatment-among-survivors-of-childhood-cancer-in-low-and-middle-income-countries-a-systematic-review
#34
REVIEW
Kevin A Wong, Alexandra Moskalewicz, Paul C Nathan, Sumit Gupta, Avram Denburg
PURPOSE: Physical late effects of treatment are well-documented among childhood cancer survivors in high-income countries, but whether prevalence and risk factors are comparable in low- and middle-income countries (LMICs) is unclear. We conducted a systematic review to assess physical late effect outcomes among childhood cancer survivors in LMICs. METHODS: Five health sciences databases were searched from inception to November 2022 in all languages. We included observational studies conducted in LMICs that evaluated physical late effects of treatment in childhood cancer survivors...
January 6, 2024: Journal of Cancer Survivorship: Research and Practice
https://read.qxmd.com/read/38174736/association-of-european-paediatric-and-congenital-cardiology-practical-recommendations-for-surveillance-and-prevention-of-cardiac-disease-in-childhood-cancer-survivors-the-importance-of-physical-activity-and-lifestyle-changes-from-the-association-of-european
#35
REVIEW
Sabine Kesting, Ugo Giordano, Jochen Weil, Colin J McMahon, Dimpna C Albert, Claire Berger, Werner Budts, Peter Fritsch, Erzsébet V Hidvégi, Renate Oberhoffer-Fritz, Giuseppe M Milano, Annette Wacker-Gußmann, Vesna Herceg-Čavrak
BACKGROUND: Childhood cancer survivors are at increased risk of developing cardiovascular diseases, presenting as the main causes of morbidity and mortality within this group. Besides the usual primary and secondary prevention in combination with screening during follow-up, the modifiable lifestyle factors of physical activity, nutrition, and body weight have not yet gained enough attention regarding potential cardiovascular risk reduction. OBJECTIVE: These practical recommendations aim to provide summarised information and practical implications to paediatricians and health professionals treating childhood cancer survivors to reduce the risk of cardiovascular late effects...
February 2024: Cardiology in the Young
https://read.qxmd.com/read/38149843/longitudinal-assessment-of-leydig-cell-function-in-male-survivors-of-childhood-cancer
#36
JOURNAL ARTICLE
Alexandra Thrope, Linda M Gerber, Charlene Thomas, Zoltan Antal
BACKGROUND: As the number and longevity of childhood cancer survivors increases, assessing treatment-associated late effects remains crucial. We longitudinally examined the incidence of and associated risk factors for Leydig cell dysfunction (LCD) and Leydig cell failure (LCF) in men treated for pediatric cancers at our institution. PROCEDURE: We performed a retrospective longitudinal cohort study of adult male survivors treated for various childhood cancers who are at risk for LCD...
December 27, 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/38116579/editorial-acute-toxicities-and-late-effects-of-childhood-cancer-treatment
#37
EDITORIAL
Małgorzata Czogała, Katarzyna Muszyńska-Rosłan
No abstract text is available yet for this article.
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38100618/the-cumulative-burden-of-self-reported-clinically-relevant-outcomes-in-long-term-childhood-cancer-survivors-and-implications-for-survivorship-care-a-dccss-later-study
#38
JOURNAL ARTICLE
Nina Streefkerk, Jop C Teepen, Elizabeth A M Feijen, Katarzyna Jóźwiak, Helena J H van der Pal, Cecile M Ronckers, Andrica C H De Vries, Margriet Van der Heiden-van Der Loo, Nynke Hollema, Marleen van den Berg, Jacqueline Loonen, Martha A Grootenhuis, Dorine Bresters, A Brigitta Versluys, Eline van Dulmen-den Broeder, Marry M van den Heuvel-Eibrink, Flora E van Leeuwen, Sebastian J C M M Neggers, Hanneke M Van Santen, Mike Hawkins, Michael Hauptmann, Daisuke Yoneoka, Joke C Korevaar, Wim J E Tissing, Leontien C M Kremer
BACKGROUND: The aim of this study is to evaluate how cumulative burden of clinically relevant, self-reported outcomes in childhood cancer survivors (CCSs) compares to a sibling control group and to explore how the burden corresponds to levels of care proposed by existing risk stratifications. METHODS: The authors invited 5925 5-year survivors from the Dutch Childhood Cancer Survivor Study (DCCSS LATER) cohort and their 1066 siblings to complete a questionnaire on health outcomes...
December 15, 2023: Cancer
https://read.qxmd.com/read/38091040/primary-care-utilization-and-cardiovascular-screening-in-adult-survivors-of-childhood-cancer
#39
JOURNAL ARTICLE
Timothy J D Ohlsen, Yan Chen, Laura-Mae Baldwin, Melissa M Hudson, Paul C Nathan, Claire Snyder, Karen L Syrjala, Emily S Tonorezos, Yutaka Yasui, Gregory T Armstrong, Kevin C Oeffinger, Eric J Chow
IMPORTANCE: Cardiovascular disease is the leading noncancer cause of premature death among survivors of childhood cancer. Adult survivors of childhood cancer are largely managed by primary care practitioners (PCPs), and health care utilization patterns related to cardiovascular screening are not well described. OBJECTIVE: To examine screening and health care utilization among survivors of childhood cancer at high risk for cardiovascular complications. DESIGN, SETTING, AND PARTICIPANTS: This multicenter cross-sectional study included participants enrolled in a randomized clinical trial from 2017 to 2021...
December 1, 2023: JAMA Network Open
https://read.qxmd.com/read/38088465/association-analysis-of-self-reported-outcomes-with-a-validated-subset
#40
JOURNAL ARTICLE
Sedigheh Mirzaei, José M Martínez, Eric J Chow, Kirsten K Ness, Melissa M Hudson, Gregory T Armstrong, Yutaka Yasui
In health-science research, outcomes ascertained through surveys and interviews are subject to potential bias with respect to the true outcome status, which is only ascertainable with clinical and laboratory assessment. This measurement error may lead to biased inference when evaluating associations between exposures and outcomes of interest. Here, we consider a cohort study in which the outcome of interest is ascertained via questionnaire, subject to imperfect ascertainment, but where a subset of participants also have a clinically assessed, validated outcome available...
December 13, 2023: Statistics in Medicine
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