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https://read.qxmd.com/read/30868686/rapidly-progressive-miliary-brain-metastasis-of-lung-cancer-after-egfr-tyrosine-kinase-inhibitor-discontinuation-an-autopsy-report
#1
Masanori Kurihara, Hirotomo Koda, Hiromi Aono, Izumi Sugimoto, Yasuhisa Sakurai, Terunori Sano, Yuko Saito, Shigeo Murayama, Masaya Mori
Miliary brain metastasis is a rare type of brain metastasis, in which carcinoma cells disseminate to numerous foci confined to Virchow-Robin/subpial spaces. Symptoms usually progress within several months, and magnetic resonance imaging (MRI) shows multiple small contrast-enhancing lesions. We report an autopsy case of a patient who rapidly deteriorated within a week due to miliary brain metastasis after epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) discontinuation, without contrast-enhancing lesions on MRI...
March 13, 2019: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://read.qxmd.com/read/30863728/troisier-sign-and-virchow-node-the-anatomy-and-pathology-of-pulmonary-adenocarcinoma-metastasis-to-a-supraclavicular-lymph-node
#2
Matthew J Zdilla, Ali M Aldawood, Andrew Plata, Jeffrey A Vos, H Wayne Lambert
Metastatic spread of cancer via the thoracic duct may lead to an enlargement of the left supraclavicular node, known as the Virchow node (VN), leading to an appreciable mass that can be recognized clinically - a Troisier sign. The VN is of profound clinical importance; however, there have been few studies of its regional anatomical relationships. Our report presents a case of a Troisier sign/VN discovered during cadaveric dissection in an individual whose cause of death was, reportedly, chronic obstructive pulmonary disease...
January 2019: Autopsy & Case Reports
https://read.qxmd.com/read/30861135/sequential-transmission-of-salmonella-in-the-slaughtering-process-of-chicken-in-korea
#3
Hye-Jin Lee, So-Youn Youn, Ok-Mi Jeong, Jin-Hyun Kim, Dong-Wan Kim, Ji-Yeon Jeong, Yong-Kuk Kwon, Min-Su Kang
Salmonella is one of the most common foodborne pathogens worldwide. Salmonella infections in humans are mainly associated with consumption of poultry products contaminated with this foodborne pathogen. Therefore, strict sanitary measures are necessary to control Salmonella contamination during the slaughtering process of poultry. The objective of this study was to determine the occurrence and transmission of Salmonella at a series of steps in the slaughtering process of chicken. A total of 601 samples were collected from a series of slaughtering steps (10 sampling sites) of 26 chicken slaughterhouses throughout Korea...
March 12, 2019: Journal of Food Science
https://read.qxmd.com/read/30860156/dilated-virchow-robin-spaces-on-mri-differential-diagnosis-ranging-from-benign-to-pathological-entities
#4
Maria Maddalenas Sirufo, Lia Ginaldi, Massimo De Martinis
No abstract text is available yet for this article.
January 2019: Neurology India
https://read.qxmd.com/read/30781716/recently-discovered-interstitial-cell-population-of-telocytes-distinguishing-facts-from-fiction-regarding-their-role-in-the-pathogenesis-of-diverse-diseases-called-telocytopathies
#5
REVIEW
Ivan Varga, Štefan Polák, Ján Kyselovič, David Kachlík, Ľuboš Danišovič, Martin Klein
In recent years, the interstitial cells telocytes, formerly known as interstitial Cajal-like cells, have been described in almost all organs of the human body. Although telocytes were previously thought to be localized predominantly in the organs of the digestive system, as of 2018 they have also been described in the lymphoid tissue, skin, respiratory system, urinary system, meninges and the organs of the male and female genital tracts. Since the time of eminent German pathologist Rudolf Virchow, we have known that many pathological processes originate directly from cellular changes...
February 18, 2019: Medicina
https://read.qxmd.com/read/30774258/phenotypic-and-genotypic-drug-resistance-profile-of-salmonella-serovars-isolated-from-poultry-farm-and-processing-units-located-in-and-around-mumbai-city-india
#6
R N Waghamare, A M Paturkar, V M Vaidya, R J Zende, Z N Dubal, A Dwivedi, R V Gaikwad
Background and Aim: The extensive use of antimicrobials in poultry has led to an increase in bacterial multidrug resistance, and the emergence of multidrug-resistant nontyphoidal Salmonella is a global problem. This study was performed to detect antibiotic-resistant Salmonella serovars in poultry farming and processing environment. Materials and Methods: A total of 956 various samples, comprising 432 farm origin, 324 poultry processing stage wise and environmental, and 154 product processing stages and environmental samples, were collected from poultry farms and processing units located in and around Mumbai city...
December 2018: Veterinary World
https://read.qxmd.com/read/30743273/superior-vena-cava-cancerous-thrombus-due-to-squamous-cell-tongue-cancer-virchow-s-triad-at-its-worst-version
#7
John Papanikolaou, Triantafyllia Koukoubani, Epaminondas Zakynthinos
Superior vena cava (SVC) cancerous thrombosis is extremely sparse, especially in the setting of extrathoracic tumours. Herein, we present the case of a patient with a squamous cell carcinoma of the tongue, who presented with SVC syndrome possibly secondary to symptomatic metastatic pericardial effusion. In this unique patient, the disastrous concurrence of all the elements of Virchow's triad within the confined anatomical space of SVC may have precipitated extensive vessel thrombosis with catastrophic consequences...
February 11, 2019: Thrombosis and Haemostasis
https://read.qxmd.com/read/30692383/-long-term-survival-of-a-rectal-cancer-patient-with-virchow-lymph-node-metastasis-liver-metastasis-and-para-aortic-lymph-node-metastasis
#8
Ryuma Urahama, Takeshi Toyozumi, Toshiki Kamata, Tetsuro Isozaki, Tetsutaro Sazuka, Yo Asai, Mari Kuboshima, Kentaro Tasaki, Yuji Sugamoto, Toru Fukunaga, Masayuki Kimura, Hisahiro Matsubara
A 67-year-old female was diagnosed with Stage Ⅳ rectal cancer with paraaortic lymph node metastasis. The patient underwent Hartmann's operation with D3 lymph node and paraaortic lymph node dissection. Postoperative chemotherapy with FOLFIRI was then administered for 1 year. However, liver metastasis developed, for which partial hepatectomy was performed. Postoperative chemotherapy with S-1(20 courses)was then administered. Three years and 11 months following the first operation, lymph node metastases developed and resection of lymph nodes(No...
December 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/30691661/tumefactive-virchow-robin-spaces
#9
REVIEW
Robert M Kwee, Thomas C Kwee
OBJECTIVE: To systematically review the clinical manifestations, MRI appearance, and management of tumefactive Virchow-Robin spaces (VRs). METHODS: A systematic MEDLINE literature search was performed. Data were extracted per tumefactive VRs location (type 1: along lenticulostriate arteries entering the basal ganglia; type 2: along perforating medullary arteries; type 3: mesencephalothalamic region; and other locations). RESULTS: Ninety-nine articles were included, comprising 164 patients...
February 2019: European Journal of Radiology
https://read.qxmd.com/read/30635676/-immuno-oncology-of-head-and-neck-tumors
#10
Stefan Kasper, Timon Hussain, Isabel Virchow, Martin Stuschke, Stephan Lang
Treatment of patients with squamous cell carcinoma of the head and neck (SCCHN) is nowadays multidisciplinary. Therapeutic concepts include modern surgical and radiation techniques as well as systemic therapies. However, the prognosis of these patients is still poor for all stages. In the recurrent or metastatic situation after definitive therapy, there is an indication for palliative systemic treatment, whereby classical platinum-based chemotherapy and the monoclonal epidermal growth factor receptor (EGFR) antibody cetuximab are established, and immunotherapy (IO) has recently been proven a potent treatment option...
March 2019: HNO
https://read.qxmd.com/read/30628993/neuroimaging-biomarkers-at-baseline-predict-electroconvulsive-therapy-overall-clinical-response-in-depression-a-systematic-review
#11
Anna Levy, Simon Taib, Christophe Arbus, Patrice Péran, Anne Sauvaget, Laurent Schmitt, Antoine Yrondi
OBJECTIVE: Major depressive disorder is a frequent and disabling disease and can be treated with antidepressant drugs. When faced with severe or resistant major depressive disorder, however, psychiatrists may resort to electroconvulsive therapy (ECT). Although very effective, the response falls short of 100%. A recent meta-analysis established clinical and biological predictive factors of the response to ECT. We decided to explore neuroimaging biomarkers that could be predictors of the ECT response...
January 8, 2019: Journal of ECT
https://read.qxmd.com/read/30535173/characteristics-of-third-generation-cephalosporin-resistant-salmonella-from-retail-chicken-meat-produced-by-integrated-broiler-operations
#12
Hye Young Jeon, Kwang Won Seo, Yeong Bin Kim, Dong Kyu Kim, Shin Woo Kim, Young Ju Lee
Integrated broiler operations, which control and operate vertically through all phases of the chicken industry, have applied biosecurity and sanitation practices, housing technologies, feeding regimens, and antibiotic applications in different ways to improve food safety. The objective of this study was to compare the prevalence and antimicrobial resistance profiles of Salmonella isolates recovered from 6 different integrated broiler operations and to analyze the characteristics of extended-spectrum β-lactamase (ESBL)- and plasmid-mediated AmpC β-lactamase (pAmpC)-producing Salmonella isolates...
December 7, 2018: Poultry Science
https://read.qxmd.com/read/30533445/prevalence-and-antimicrobial-susceptibility-profile-of-salmonella-serovars-isolated-from-slaughtered-cattle-in-addis-ababa-ethiopia
#13
Lidya Ketema, Zerihun Ketema, Bitsu Kiflu, Haile Alemayehu, Yitagele Terefe, Mohammed Ibrahim, Tadesse Eguale
Salmonella is one of the top causes of foodborne bacterial illnesses in humans. The primary sources of human Salmonella infection are food producing animals such as cattle, poultry, and swine. A cross-sectional study was undertaken to estimate the prevalence and to determine the serovar distribution and antimicrobial susceptibility profiles of Salmonella spp. isolated from fecal (n=567) and carcass swab (n=159) samples of slaughtered cattle at Addis Ababa Abattoir Enterprise and Kara'alo PLC, Abattoirs, in Addis Ababa, Ethiopia between January 2014 and April 2015...
2018: BioMed Research International
https://read.qxmd.com/read/30498607/gastrointestinal-malignancy-presenting-with-a-virchow-s-node-in-a-patient-with-rothmund-thomson-syndrome
#14
Kara Nadeau, Michele Brule
Rothmund-Thomson syndrome is a genetic disorder with characteristic findings in childhood as well as a predisposition to osteosarcoma, skin cancer, and hematological malignancy. We present the first reported case of duodenal malignancy in a patient with Rothmund-Thompson syndrome. An enlarged Virchow's node was noted and an advanced duodenal adenocarcinoma was diagnosed shortly thereafter. The features of Rothmund-Thomson syndrome are discussed, as well as current management and screening guidelines for duodenal adenocarcinoma...
2018: Case Reports in Genetics
https://read.qxmd.com/read/30475435/gain-of-function-variants-in-the-odc1-gene-cause-a-syndromic-neurodevelopmental-disorder-associated-with-macrocephaly-alopecia-dysmorphic-features-and-neuroimaging-abnormalities
#15
Lance H Rodan, Kwame Anyane-Yeboa, Karen Chong, Jolien S Klein Wassink-Ruiter, Ashley Wilson, Lacey Smith, Sanjeev V Kothare, Farrah Rajabi, Susan Blaser, Min Ni, Ralph J DeBerardinis, Annapurna Poduri, Gerard T Berry
Polyamines serve a number of vital functions in humans, including regulation of cellular proliferation, intracellular signaling, and modulation of ion channels. Ornithine decarboxylase 1 (ODC1) is the rate-limiting enzyme in endogenous polyamine synthesis. In this report, we present four patients with a distinct neurometabolic disorder associated with de novo heterozygous, gain-of-function variants in the ODC1 gene. This disorder presents with global developmental delay, ectodermal abnormalities including alopecia, absolute or relative macrocephaly, and characteristic facial dysmorphisms...
November 26, 2018: American Journal of Medical Genetics. Part A
https://read.qxmd.com/read/30474266/brain-invasion-by-chronic-lymphocytic-leukemia
#16
Ryohei Otani, Takeo Uzuka, Hadzki Matsuda, Fumi Higuchi, Phyo Kim, Keisuke Ueki
Brain invasion by chronic lymphocytic leukemia (CLL) is very rare, and only a handful of cases have been reported. We here report a case of 61-year-old woman who had been treated for CLL for 14 years presenting with a progressive mental disturbance. Magnetic resonance imaging (MRI) showed discontinuous ring-enhancing lesions compatible with the "open ring" sign, which was considered a demyelinating disorder, in both the frontal lobes. However, on histological examination of the biopsied specimen, infiltration of small lymphocytes positive for CD5, CD20, and CD23, indicating brain invasion by CLL, was seen...
November 25, 2018: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://read.qxmd.com/read/30468321/role-of-fine-needle-aspiration-cytology-in-the-management-of-supraclavicular-lymph-node-metastasis-review-of-our-experience
#17
Mª Jesús Fernández Aceñero, Ana Caso Viesca, Cristina Díaz Del Arco
INTRODUCTION: In the 19th century Virchow described that metastasis to left supraclavicular lymph nodes (SLN) could originate in neoplasms located under the diaphragm. In the same way, right SLN metastasis are usually thought to arise from thoracic neoplasms. Our aims are to review our experience with metastatic SLN diagnosed by fine-needle aspiration cytology (FNAC) and to discuss the location of the primary in these cases. METHODS: We have reviewed all lymph node FNACs diagnosed in a single tertiary hospital between 2010 and 2017 and we have included all cases of metastatic SLN...
November 23, 2018: Diagnostic Cytopathology
https://read.qxmd.com/read/30459922/a-giant-tumefactive-perivascular-space-a-rare-cause-of-obstructive-hydrocephalus-and-monoparesis
#18
Peter Yat-Ming Woo, Eric Cheung, James Ting-Fong Zhuang, Hoi-Tung Wong, Kwong-Yau Chan
Cerebral perivascular spaces (PVSs), otherwise known as Virchow-Robin spaces, are interstitial fluid-filled channels, <2 mm in diameter that form around arterial perforators as they course from the cortex into the brain parenchyma. In contrast, a giant tumefactive PVS is a rare entity comprising of clusters of such channels larger than 15mm resembling a neoplastic process as the name suggests. We report a 55-year-old male who presented with unsteady gait, cognitive decline, and left lower limb weakness for 6 months...
October 2018: Asian Journal of Neurosurgery
https://read.qxmd.com/read/30433856/effects-of-dam-and-seqa-genes-on-biofilm-and-pellicle-formation-in-salmonella
#19
Sinem Uğur, Nefise Akçelik, Fatma Neslihan Yüksel, Neslihan Taşkale Karatuğ, Mustafa Akçelik
In this study, the effects of dam and seqA genes on the formation of pellicle and biofilm was determined using five different Salmonella serovars S. Group C1 (DMC2 encoded), S. Typhimurium (DMC4 encoded), S. Virchow (DMC11 encoded), S. Enteritidis (DMC22 encoded), and S. Montevideo (DMC89 encoded). dam and seqA mutants in Salmonella serovars were performed by the single step lambda red recombination method. The mutants obtained were examined according to the properties of biofilm on the polystyrene surfaces and the pellicle formation on the liquid medium...
November 15, 2018: Pathogens and Global Health
https://read.qxmd.com/read/30390492/intestinal-ischemia-secondary-to-superior-mesenteric-venous-thrombosis-a-case-report
#20
Jason Cui, Brian Kirkby
INTRODUCTION: Acute mesenteric venous thrombosis is a rare but potentially fatal condition with superior mesenteric vein being the most common site of thrombosis development [1]. It is more common in patients with underlying disorders which cause disruptions to Virchow's Triad of hypercoagulability, stasis and endothelial injury. The disease is often associated with intestinal ischemia in its acute form, further complicating its management. PRESENTATION OF CASE: We present a case of acute superior mesenteric venous thrombosis resulting in jejunal ischemia in a 60-year-old Caucasian male with possible ulcerative colitis...
October 29, 2018: International Journal of Surgery Case Reports
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