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V I Ershov, I Yu Gadaev, F G Perina, V L Surin, V V Salomashkina, O S Pshenichnikova, N I Zozulya
The article provides review of possible mechanisms of inhibitor coagulopathies, in particular of acquired hemophilia A. This pathology is an extremely rare disease occurring in 1-2 cases in 1 million per year. In the present study we provide data for two clinical cases of hemophilia A in women. These cases had different development mechanisms, although both women have a newly discovered missense mutation His2026Arg in the VIII factor gene. The matter of main interest is the description of the disease development in the patient with an acquired idiopathic hemophilia A with a possible disease occurrence due to an asymmetric X-chromosome inactivation (lyonization)...
August 17, 2018: Terapevticheskiĭ Arkhiv
Ekaterina A Perina, Vladimir V Ivanov, Alexandra G Pershina, Natalya A Perekucha, Anna N Dzyuman, Ilya P Kaminskii, Irina V Saltykova, Alexey E Sazonov, Ludmila M Ogorodova
Although data on oxidative stress during liver fluke infection have been previously presented, a comprehensive study of the glutathione system that plays a crucial role in scavenging of reactive oxygen species (ROS) and detoxification of primary and secondary oxidation products has not been addressed yet. In the present study, the hepatic glutathione system was investigated in a hamster model of experimental opisthorchiasis infection. It was shown that chronic oxidative stress in an Opisthorchis felineus infected liver, evidenced by abundant hydroperoxide accumulation, leads to strong imbalance in the hepatic glutathione system, namely the depletion of reduced form of glutathione (GSH), lowering of the GSH/GSSG ratio, and a decrease in the glutathione peroxidase and glyoxalase 1 activity...
January 23, 2019: Acta Tropica
Inés González-Castellano, Alejandra Perina, Ana M González-Tizón, Zeltia Torrecilla, Andrés Martínez-Lage
The rockpool shrimp Palaemon elegans is considered an important crustacean species within the European coastline fauna. This species is experiencing an ongoing geographical expansion beyond its native distribution range due to unintentional human introductions. A better knowledge of the genetic diversity, geographic structure and connectivity of its populations is necessary. In the present study, microsatellite loci were isolated using the Illumina MiSeq platform. The microsatellite-enriched library sequencing produced 3...
November 21, 2018: Scientific Reports
Jan Peřina
Properties of intense twin beams generated in parametric down-conversion in periodically poled LiNbO3 crystals and their chirped variants by intense pump fields are analyzed along the model of intense parametric down-conversion that allows for pump depletion and uses the dual spatio-spectral Schmidt modes. Spectral and spatial intensity auto- and cross-correlation functions are determined as they depend on the pump power. Temporal correlations in intense twin beams at the fs time scale are investigated using the Hong-Ou-Mandel interferometer and the process of sum-frequency generation...
October 18, 2018: Scientific Reports
Denis M S Abessa, Heitor C Albuquerque, Lucas G Morais, Giuliana S Araújo, Tainá G Fonseca, Ana C F Cruz, Bruno G Campos, Julia B D A Camargo, Paloma K Gusso-Choueri, Fernando C Perina, Rodrigo B Choueri, Lucas M Buruaem
Chemical pollution is considered a factor that may threaten marine protected areas (MPAs), and recent studies have found contamination and associated biological effects in some MPAs. However, organized data on this topic are lacking. This study reviewed the literature on pollution in MPAs in order to compile data, determine whether MPAs are influenced by pollution and, whenever possible, describe how they are being affected by contaminants. The results show that the pollution status is unknown in most MPAs worldwide...
December 2018: Environmental Pollution
Peter E Fischer, Debra G Perina, Theodore R Delbridge, Mary E Fallat, Jeffrey P Salomone, Jimm Dodd, Eileen M Bulger, Mark L Gestring
The American College of Surgeons Committee on Trauma (ACS-COT), American College of Emergency Physicians (ACEP), and the National Association of EMS Physicians (NAEMSP) have previously offered varied guidance on the role of backboards and spinal immobilization in out-of-hospital situations. This updated consensus statement on spinal motion restriction in the trauma patient represents the collective positions of the ACS-COT, ACEP and NAEMSP. It has further been formally endorsed by a number of national stakeholder organizations...
November 2018: Prehospital Emergency Care
Lauren E-A Eyssen, Perina Vather, Laurelle Jackson, Phindile Ximba, Nicolas Biteau, Théo Baltz, Alain Boulangé, Philippe Büscher, Theresa H T Coetzer
African animal trypanosomosis (nagana) is caused by tsetse-transmitted protozoan parasites. Their cysteine proteases are potential chemotherapeutic and diagnostic targets. The N-glycosylated catalytic domain of Trypanosoma vivax cathepsin L-like cysteine protease, rTviCATLcat , was recombinantly expressed and purified from culture supernatants while native TviCATL was purified from T. vivax Y486 parasite lysates. Typical of Clan CA, family C1 proteases, TviCATL activity is sensitive to E-64 and cystatin and substrate specificity is defined by the S2 pocket...
July 2018: Molecular and Biochemical Parasitology
Baochang Zhang, Shangzhen Luan, Chen Chen, Jungong Han, Wei Wang, Alessandro Perina, Ling Shao
Correlation filters are special classifiers designed for shift-invariant object recognition, which are robust to pattern distortions. The recent literature shows that combining a set of sub-filters trained based on a single or a small group of images obtains the best performance. The idea is equivalent to estimating variable distribution based on the data sampling (bagging), which can be interpreted as finding solutions (variable distribution approximation) directly from sampled data space. However, this methodology fails to account for the variations existed in the data...
November 17, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
Robert J Winchell, Brian J Eastridge, Margaret M Moore, Dennis W Ashley, Barbara A Gaines, Dia Gainor, A Alex Jahangir, James C Krieg, Carole A Mays, Holly N Michaels, Nicholas Namias, Debra G Perina, Eileen M Bulger, Ronald M Stewart
No abstract text is available yet for this article.
September 2018: Journal of Trauma and Acute Care Surgery
Debra G Perina, Christopher S Kang, Eileen M Bulger, Ronald M Stewart, Robert J Winchell, Megan Brenner, Sharon Henry, Leonard J Weireter, Michael C Chang, Michael F Rotondo
No abstract text is available yet for this article.
2018: Trauma surgery & acute care open
Megan Brenner, Debra G Perina, Eileen M Bulger, Robert J Winchell, Christopher S Kang, Sharon Henry, Ronald M Stewart, Leonard J Weireter, Michael C Chang, Michael F Rotondo
No abstract text is available yet for this article.
2018: Trauma surgery & acute care open
Megan Brenner, Eileen M Bulger, Debra G Perina, Sharon Henry, Christopher S Kang, Michael F Rotondo, Michael C Chang, Leonard J Weireter, Michael Coburn, Robert J Winchell, Ronald M Stewart
No abstract text is available yet for this article.
2018: Trauma surgery & acute care open
Debra G Perina, Catherine A Marco, Rebecca Smith-Coggins, Terry Kowalenko, Mary M Johnston, Anne Harvey
BACKGROUND: The Longitudinal Study of Emergency Medicine Residents (LSEMR) conducted by the American Board of Emergency Medicine queries a randomized cohort of emergency medicine (EM) residents. It is designed to identify residents' perceptions of their training, sources of stress, well-being level, and career choice satisfaction over time. OBJECTIVES: This study utilizes LSEMR to identify resident well-being levels, career satisfaction, factors producing stress, and whether a specific cohort is more stressed than the overall respondent group...
July 2018: Journal of Emergency Medicine
Ievgen I Arkhipov, Jan Peřina
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
April 30, 2018: Scientific Reports
Helena Ćetković, Maja Herak Bosnar, Drago Perina, Andreja Mikoč, Martina Deželjin, Robert Belužić, Helena Bilandžija, Iñaki Ruiz-Trillo, Matija Harcet
Nucleoside diphosphate kinases are enzymes present in all domains of life. In animals, they are called Nme or Nm23 proteins, and are divided into group I and II. Human Nme1 was the first protein identified as a metastasis suppressor. Because of its medical importance, it has been extensively studied. In spite of the large research effort, the exact mechanism of metastasis suppression remains unclear. It is unknown which of the biochemical properties or biological functions are responsible for the antimetastatic role of the mammalian Nme1...
March 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
Ievgen I Arkhipov, Jan Peřina
Different non-classicality criteria expressed in the form of inequalities among intensity moments and elements of photon-number distributions are applied to noisy twin beams and other two-mode states obtained from a twin beam by using a beam splitter. Their performance in revealing the non-classicality is judged in comparison with the exact results provided by suitable entanglement and local non-classicality quantifiers. Whereas the non-classicality of noisy twin beams is always revealed by these criteria, not all the nonclassical states obtained at the output of the beam splitter can be identified by these experimentally easily reachable criteria...
January 23, 2018: Scientific Reports
Elizabeth Fearon, Richard D Wiggins, Audrey E Pettifor, Catherine MacPhail, Kathleen Kahn, Amanda Selin, F Xavier Gómez-Olivé, Sinéad Delany-Moretlwe, Estelle Piwowar-Manning, Oliver Laeyendecker, James R Hargreaves
INTRODUCTION: Prevalence of HIV among young women in South Africa remains extremely high. Adolescent peer groups have been found to be an important influence on a range of health behaviours. The characteristics of young women's friendships might influence their sexual health and HIV risk via connections to sexual partners, norms around sexual initiation and condom use, or provision of social support. We investigated associations between young women's friendships and their Herpes Simplex Virus Type 2 (HSV-2) and HIV infection status in rural South Africa...
December 2017: Journal of the International AIDS Society
Frederico José Ribeiro Teixeira, Sergio Dias do Couto Netto, André Luis de Freitas Perina, Fabio C M Torricelli, Luciana Ragazzo Teixeira, Antonio Eduardo Zerati, Fabio de Oliveira Ferreira, Eduardo Hiroshi Akaishi, William Carlos Nahas, Edivaldo Massazo Utiyama
Leiomyosarcoma (LMS) of inferior vena cava (IVC) is a rare neoplasm affecting approximately 1/100,000 people. The prognosis is poor and potential curative intent occurs through challenging operations, such as vena cava resection, occasionally multivisceral when required, and vascular reconstruction. There are few retrospective series regarding this retroperitoneal neoplasm, and the aim of the present study was to discuss the experience at the São Paulo Cancer Institute and Clinics Hospital of University of São Paulo Medical School, São Paulo, Brazil...
October 2017: Oncology Letters
Daria A Kokova, Sarantos Kostidis, Judit Morello, Nataly Dementeva, Ekaterina A Perina, Vladimir V Ivanov, Ludmila M Ogorodova, Aleksey E Sazonov, Irina V Saltykova, Oleg A Mayboroda
BACKGROUND: Opisthorchiasis is a parasitic infection caused by the liver flukes of the Opisthorchiidae family. Both experimental and epidemiological data strongly support a role of these parasites in the etiology of the hepatobiliary pathologies and an increased risk of intrahepatic cholangiocarcinoma. Understanding a functional link between the infection and hepatobiliary pathologies requires a detailed description a host-parasite interaction on different levels of biological regulation including the metabolic response on the infection...
October 2017: PLoS Neglected Tropical Diseases
Rodrigo Salim, Fabricio Fogagnolo, Mauricio Martins Perina, Ugo Messas Rubio, Mauricio Kfuri Junior
OBJECTIVE: Opening-wedge osteotomy of the proximal tibia is a widely performed procedure for treating medial gonarthrosis in active patients and in the presence of varus malalignment of the lower limb. The fixation method is controversial, and the use of conventional implants has been abandoned in favor of implants with more modern locking screws. The aim of the present clinical study was to assess the maintenance of the correction achieved in cases wherein fixation was performed using conventional implants...
September 2017: Revista Brasileira de Ortopedia
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