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Rheumatoid arthrits

Xiao-Yi Jia, Yan Chang, Xiao-Jing Sun, Fang Wei, Yu-Jing Wu, Xing Dai, Shu Xu, Hua-Xun Wu, Chun Wang, Xue-Zhi Yang, Wei Wei
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease. Dendritic cells (DCs) are one of the most powerful antigen-presenting cells, and they play an important role in RA pathogenesis. Prostaglandin E2 (PGE2) is a potent lipid mediator that can regulate the maturation and activation of DCs, but the molecular mechanisms have not been elucidated. In this study, both in vitro and in an RA rat model, we investigated the mechanisms involved by focusing on PGE2-mediated signaling and using a novel anti-inflammatory compound, paeoniflorin-6'-O-benzene sulfonate (CP-25)...
February 15, 2019: Inflammopharmacology
Yuta Shimizu, Masako Kohyama, Hideki Yorifuji, Hui Jin, Noriko Arase, Tadahiro Suenaga, Hisashi Arase
Natural killer (NK) cells are a major FcγRIIIA-expressing lymphocyte population that mediate antibody-dependent cellular cytotoxicity. Although NK cells are critical for immunity against viruses and tumors, they are also activated in the joints of patients with rheumatoid arthritis (RA) and may be involved in disease progression. We previously found that HLA class II molecules transport misfolded cellular proteins, such as immunoglobulin G heavy chain (IgGH), to the cell surface via association with their peptide-binding grooves...
February 5, 2019: International Immunology
Somaiya Mateen, Sumayya Shahzad, Shafeeque Ahmad, Syed Shariq Naeem, Saifullah Khalid, Kafil Akhtar, Waseem Rizvi, Shagufta Moin
BACKGROUND: Rheumatoid arthritis (RA) is an inflammatory autoimmune disease which leads to bone and cartilage erosion. Oxidative stress and pro-inflammatory cytokines plays crucial role in the pathophysiology of RA. Cinnamaldehyde and eugenol have a long history of medical use in various inflammatory disorders. PURPOSE: The drugs available for the treatment of RA are associated with various side effects. The present study was conducted to evaluate the anti-arthritic effects of cinnamaldehyde and eugenol in rat model of arthritis...
September 5, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Shirui Tan, Jian Xu, Aiyun Lai, Ruomei Cui, Ru Bai, Shu Li, Wei Liang, Guofang Zhang, Shaoquan Jiang, Shuang Liu, Mai Zheng, Wei Wang
The present study aimed to investigate the anti‑arthritic effects of curculigoside isolated from the rhizome of Curculigo orchioides Gaertn in vivo and in vitro, as well as to determine the potential underlying mechanisms. A rat model of arthritis was induced with type II collagen. Arthritic rats were treated with curculigoside (50 mg/kg) and blood samples were collected to determine serum levels of tumor necrosis factor (TNF)‑α, interleukin (IL)‑1β, IL‑6, IL‑10, IL‑12 and IL‑17A. Furthermore, indices of the thymus and spleen were determined...
January 14, 2019: Molecular Medicine Reports
Aswathy I S, Santhi Krishnan, Jasmine Peter, Vidya Sabu, A Helen
BACKGROUND: Toll-like receptor-4 (TLR-4) mediates activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) resulting in induction of proinflammatory genes such as that encoding tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) which played a significant role in cartilage destruction of rheumatoid arthritis (RA). Low risk and better efficacy made herbal drugs more reliable than nonsteroid anti-inflammatory drugs (NSAIDS) in RA treatment. Gugguluthiktam Kashayam (GuK), Punarnavadi Kashayam (PuK) and Balaguluchiadi Kashayam (BgK) are ayurvedic polyherbal formulations prescribed in classical ayurvedic texts Sahasrayogam and Ashtangahridayam as medicines for the treatment of RA...
January 16, 2019: Journal of Ayurveda and Integrative Medicine
Mathilde Lorscheider, Nicolas Tsapis, Mujeeb Ur-Rehman, Françoise Gaudin, Ivana Stolfa, Sonia Abreu, Simona Mura, Pierre Chaminade, Marion Espeli, Elias Fattal
Rheumatoid arthritis (RA) is a prevalent autoimmune disease characterized by joint inflammation, bone and cartilage erosion. The use of glucocorticoids in the treatment of RA is hampered by significant side effects induced by their unfavorable pharmacokinetics. Delivering glucocorticoids by means of nanotechnologies is promising but the encapsulation of highly crystalline and poorly water-soluble drugs results in poor loading and low stability. We report here the design of 130 nm nanoparticles made of solely dexamethasone palmitate, stabilized by polyethylene glycol-linked phospholipids displaying a negative zeta potential (-55 mV), high entrapment efficiency and stability over 21 days under storage at 4 °C...
January 16, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
Hyelin Jeon, Weon-Jong Yoon, Young-Min Ham, Seon-A Yoon, Se Chan Kang
(1) Background : Rheumatoid arthritis is a chronic autoimmune disease that causes progressive articular damage and functional loss. It is characterized by synovial inflammation that leads to progressive cartilage destruction. For this reason, research on functional foods that reduce the inflammatory response are under progress. (2) Methods : We focused on the anti-inflammatory effects of Sargassum muticum , and confirmed the effect of the extract on the collagen-induced arthritis (CIA) DBA/1J mice model. (3) Results : The extract was given at concentrations of 50, 100, and 200 mg/kg, and the arthritis score and edema volume of the experimental group were significantly different from the CIA group...
January 13, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Huanyu Guan, Xiaomei Luo, Xiaoyan Chang, Meifeng Su, Zhuangzhuang Li, Pengfei Li, Xiaoming Wang, Yue Shi
Wen Luo Yin (WLY), a well-known traditional Chinese medicine formulation, has been used as a complementary therapy for the treatment of rheumatoid arthritis in clinical settings. However, the chemical constituents of WLY remain unclear. In this study, a high-performance liquid chromatography coupled with tandem mass spectrometry method was established to separate and comprehensively identify the chemical constituents of WLY. The analytes were eluted with a mobile phase of acetonitrile and 0.1% aqueous acetic acid...
January 10, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Lyall Ashberg, Leslie C Yuen, Mary R Close, Itay Perets, Mitchell R Mohr, Edwin O Chaharbakhshi, Benjamin G Domb
PURPOSE: This study analyzed minimum 2-year hip arthroscopy outcomes in rheumatoid arthritis (RA) patients and non-RA control patients. It also examined whether disease-modifying antirheumatic drugs (DMARDs) affected RA patient outcomes. We hypothesized that patients with RA undergoing hip arthroscopy would have lower reported outcome scores. METHODS: Data were prospectively collected on all hip arthroscopies performed from 2009-2013. The indications for surgery were patients with hip pain and with physical examination and imaging studies confirming intra-articular pathology in whom conservative management had failed...
January 3, 2019: Arthroscopy: the Journal of Arthroscopic & related Surgery
Muhammed A Saad, Ayman E El-Sahhar, Hany H Arab, Muhammad Y Al-Shorbagy
BACKGROUND AND PURPOSE: Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory disease which poses a need to explore effective yet safe pharmacotherapeutic options. The current work aimed to study the therapeutic role of nicorandil in controlling RA. EXPERIMENTAL APPROACH: Complete Freund's adjuvant (CFA)-induced arthritis model was applied by injecting 400 μL of CFA in the right hind paw at day 0 and day 7. Four groups of rats were used as follows: normal-control (CTRL), CFA-induced arthritis (ART), CFA-induced arthritis treated with diclofenac (DIC) and CFA-induced arthritis treated with nicorandil (NIC)...
January 3, 2019: Life Sciences
Hung-Bo Hsiao, Jin-Bin Wu, Wen-Chuan Lin
BACKGROUND: (-)-Epicatechin-3-O-β-d-allopyranoside (ECAP) is isolated from the popular Chinese herbal medicine Davallia formosana, which has been used to treat bone diseases including bone fracture, arthritis, and osteoporosis. PURPOSE: To investigate the antiarthritic and the anti-inflammatory effect of ECAP on a mouse model of collagen-induced arthritis (CIA) and in vitro. METHODS: Male DBA/1 J mice were immunized by administering an intradermal injection of 100 µg of type II collagen in Freund's complete adjuvant...
January 2019: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Jian-Ping Bi, Ping Li, Xi-Xi Xu, Ting Wang, Fei Li
Notopterygium incisum (QH) has been used for the treatment of rheumatoid arthritis (RA), and volatile oils may be its mainly bioactive constituents. The present study was designed to analyze the volatile compounds in QH and to determine the anti-arthritic capacity of Notopterygium volatile oils and the potential mechanism of action. The volatile compounds analysis was conducted by GC-MS. The anti-arthritic capacity test of the volatile oils was conducted on adjuvant-induced arthritis (AIA) rats. The anti-inflammatory property was tested in NO release model in RAW 264...
December 2018: Chinese Journal of Natural Medicines
Mariana M N Wendt, Monique Cristine de Oliveira, Gabriela B Franco-Sala, Lorena Santos Castro, Ângela V Parizotto, Francielli M Souza Silva, Maria R M Natali, Ciomar A Bersani-Amado, Adelar Bracht, Jurandir F Comar
Severe rheumatoid cachexia is associated with pronounced loss of muscle and fat mass in patients with advanced rheumatoid arthritis. This condition is associated with dyslipidemia and predisposition to cardiovascular diseases. Circulating levels of triglycerides (TG) and free fatty acids (FFA) have not yet been consistently defined in severe arthritis. Similarly, the metabolism of these lipids in the arthritic liver has not yet been clarified. Aiming at filling these gaps this study presents a characterization of the circulating lipid profile and of the fatty acids uptake and metabolism in perfused livers of rats with adjuvant-induced arthritis...
December 26, 2018: Biochimica et biophysica acta. Molecular basis of disease
Himanshu Sharma, Prerna Chauhan, Surender Singh
Background: Cinnamomum cassia iswidely used as a traditional medicinal plant for the treatment of rheumatoid arthritis. Objective: The present study aimed to assess the anti-arthritic activity of C. cassia bark hydroalcoholic extract (CCHE) in different arthritic animal models. Methods: In formaldehyde model, sub-plantar administration of 0.1 ml of formaldehyde (2% v/v) into the right hind paws of Wistar albino rats on days 0 and 3. The rats were divided into six groups as follows: normal control, disease control, indomethacin group (3 mg/kg, p...
December 2018: Integrative Medicine Research
Qiaoding Dai, Di Zhou, Liping Xu, Xinwei Song
Purpose: Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease characterized by aggressive and symmetric polyarthritis. Mammalian target of rapamycin (mTOR) was reported to be a new target for RA therapy and its inhibitor rapamycin can significantly reduce the invasive force of fibroblast-like synoviocytes. Here, we determined the effect of curcumin to alleviate inflammation and synovial hyperplasia for the therapy of RA. Materials and methods: Collagen-induced arthritis (CIA) was developed in Wistar rats and used as a model resembling RA in humans...
2018: Drug Design, Development and Therapy
Ahmed H Eid, Amany M Gad, Ebtehal Mohammed Fikry, Hany H Arab
Testicular impairment has been commonly described in long-standing RA patients. Since depression and cardiovascular disorders are the most disturbing co-morbidities of RA, investigating the efficacy of the anti-depressant venlafaxine or the beta-blocker carvedilol in RA-associated testicular dysfunction may add to their clinical utility for RA patients. Previously, both agents have demonstrated significant in vivo anti-oxidant and anti-inflammatory actions. In the current study, venlafaxine (50 mg/kg/day) and carvedilol (10 mg/kg/day) were orally administered to adjuvant arthritic rats for 20 days...
December 19, 2018: Toxicology and Applied Pharmacology
Omnia Ahmed Mohamed Abdel El-Gaphar, Amira Mourad Abo-Youssef, Ali Ahmed Abo-Saif
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease characterized by joint infiltration and bone damage. The aim of the present study was to evaluate the beneficial effects of losartan in adjuvant-induced arthritis (AIA). Arthritis was induced in rats by subcutaneous injection of 0.2 mL of Complete Freund's adjuvant (CFA) in the planter surface of the hind paw. Arthritic rats were allocated into three groups (n = 10), the first group (arthritis control), received 1% of tween 80, the second and the third groups received prednisolone (10 mg/kg/day; p...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Hiba Hasan, Hanan Ismail, Youmna El-Orfali, Ghada Khawaja
BACKGROUND: Rheumatoid arthritis (RA) being an incapacitating disease requires early effective intervention. Considering Methotrexate (MTX)- the first line of treatment for RA- intoxicates the liver; therefore, alternative therapies with similar efficacy yet lower cytotoxicity are desired. Indole-3-Carbinol (I3C) which is found in cruciferous vegetables was examined for its possible therapeutic potentials in comparison with MTX by investigating its anti-inflammatory, anti-arthritic, anti-oxidant, and hepatoprotective potentials in adjuvant-induced arthritis (AIA) rat model...
December 19, 2018: BMC Complementary and Alternative Medicine
Min Li, Dongwei Zhu, Tingting Wang, Xueli Xia, Jie Tian, Shengjun Wang
Emerging evidence suggests the promise of the use of myeloid-derived suppressor cells (MDSCs) in inflammatory disorders based on their unique immune-intervention properties. However, the roles of MDSCs in autoimmune arthritis are not completely understood. Indeed, their immunosuppressive functions in arthritic conditions remain controversial, with heterogeneity among MDSCs and differential effects among subpopulations receiving much attention. As a result, it is necessary to determine the roles of MDSC subpopulations in autoimmune arthritis to clarify their diagnostic and therapeutic potential...
2018: Frontiers in Immunology
Ebtehal Mohammad Fikry, Amany M Gad, Ahmed H Eid, Hany H Arab
Rheumatoid arthritis (RA) is a chronic inflammatory arthropathy that principally attacks the joints. The present study aimed to explore the potential anti-arthritic effects of caffeic acid and ellagic acid in adjuvant-induced arthritis, compared to celecoxib. The current study also explored the underlying molecular mechanisms e.g., pro-inflammatory signals including chitinase-3-like protein-1 (CHI3L1); a glycoprotein that correlates with RA joint destruction besides angiogenesis, oxidative stres and apoptosis...
February 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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