David F Colón, Carlos W Wanderley, Walter M Turato, Vanessa F Borges, Marcelo Franchin, Fernanda V S Castanheira, Daniele Nascimento, Douglas Prado, Mikhael Haruo Fernandes de Lima, Leila C Volpon, Silvia K Kavaguti, Ana P Carlotti, Fabio Carmona, Bernardo S Franklin, Thiago M Cunha, Jose C Alves-Filho, Fernando Q Cunha
BACKGROUND AND PURPOSE: Sepsis-surviving adult individuals commonly develop immunosuppression and increased susceptibility to secondary infections, outcome mediated by the axis IL-33/ILC2s/M2 macrophages/Tregs. Nonetheless, the long-term immune consequences of pediatric sepsis are indeterminate. We sought to investigate the role of age in the genesis of immunosuppression following sepsis. EXPERIMENTAL APPROACH: Here, we compared the frequency of Tregs, the activation of the IL33/ILC2s axis in M2 macrophages, and the DNA methylation of epithelial lung cells from post-septic infant and adult mice...
November 22, 2023: British Journal of Pharmacology