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Keywords Vasculitis and mixed connectiv...

Vasculitis and mixed connective disease

https://read.qxmd.com/read/35430254/collapsing-glomerulopathy-in-a-patient-with-mixed-connective-tissue-disease
#21
REVIEW
Mohammad Atari, Josephine M Ambruzs, Osaid Saqqa, Eric E Simon
Collapsing glomerulopathy (CG) is a form of podocytopathy that is challenging to manage. CG can be idiopathic or associated with other conditions including autoimmune connective tissue diseases. In the setting of autoimmune connective tissue diseases, there are no current guidelines to guide therapy. Here we report a unique and challenging case of CG with mixed connective tissue disease (MCTD) that responded to steroids followed by mycophenolate. In PubMed, we identified three previously reported cases of CG with MCTD in addition to other forms of autoimmune diseases, including Sjogren syndrome, adult-onset still's disease, and vasculitis, etc...
July 2022: American Journal of the Medical Sciences
https://read.qxmd.com/read/35338032/outcomes-of-sars-cov-2-infection-among-children-and-young-people-with-pre-existing-rheumatic-and-musculoskeletal-diseases
#22
JOURNAL ARTICLE
Lianne Kearsley-Fleet, Min-Lee Chang, Saskia Lawson-Tovey, Ruth Costello, Šárka Fingerhutová, Natálie Švestková, Alexandre Belot, Florence A Aeschlimann, Isabelle Melki, Isabelle Koné-Paut, Sascha Eulert, Tilmann Kallinich, Yackov Berkun, Yosef Uziel, Bernd Raffeiner, Filipa Oliveira Ramos, Daniel Clemente, Christina Dackhammar, Nico M Wulffraat, Helen Waite, Anja Strangfeld, Elsa F Mateus, Pedro M Machado, Marc Natter, Kimme L Hyrich
OBJECTIVES: Some adults with rheumatic and musculoskeletal diseases (RMDs) are at increased risk of COVID-19-related death. Excluding post-COVID-19 multisystem inflammatory syndrome of children, children and young people (CYP) are overall less prone to severe COVID-19 and most experience a mild or asymptomatic course. However, it is unknown if CYP with RMDs are more likely to have more severe COVID-19. This analysis aims to describe outcomes among CYP with underlying RMDs with COVID-19...
July 2022: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/35145871/mixed-connective-tissue-disease-and-idiopathic-retroperitoneal-fibrosis-a-rare-but-important-association
#23
Thomas Neerhut, Alexander Mills, Samuel Davies, Handoo Rhee
Idiopathic Retroperitoneal fibrosis (RPF) is a fibro-inflammatory disease. In patients with known mixed connective tissue disease (MCTD) it has rarely been described. Our case illustrates a unique presentation of RPF in a patient with MCTD. We emphasise possible links between the two disease processes and the high level of clinical suspicion required to make a diagnosis.
May 2022: Urology Case Reports
https://read.qxmd.com/read/35110331/eular-recommendations-for-cardiovascular-risk-management-in-rheumatic-and-musculoskeletal-diseases-including-systemic-lupus-erythematosus-and-antiphospholipid-syndrome
#24
JOURNAL ARTICLE
George C Drosos, Daisy Vedder, Eline Houben, Laura Boekel, Fabiola Atzeni, Sara Badreh, Dimitrios T Boumpas, Nina Brodin, Ian N Bruce, Miguel Ángel González-Gay, Søren Jacobsen, György Kerekes, Francesca Marchiori, Chetan Mukhtyar, Manuel Ramos-Casals, Naveed Sattar, Karen Schreiber, Savino Sciascia, Elisabet Svenungsson, Zoltan Szekanecz, Anne-Kathrin Tausche, Alan Tyndall, Vokko van Halm, Alexandre Voskuyl, Gary J Macfarlane, Michael M Ward, Michael T Nurmohamed, Maria G Tektonidou
OBJECTIVE: To develop recommendations for cardiovascular risk (CVR) management in gout, vasculitis, systemic sclerosis (SSc), myositis, mixed connective tissue disease (MCTD), Sjögren's syndrome (SS), systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). METHODS: Following European League against Rheumatism (EULAR) standardised procedures, a multidisciplinary task force formulated recommendations for CVR prediction and management based on systematic literature reviews and expert opinion...
June 2022: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/35106243/the-role-of-cardiac-imaging-in-the-evaluation-of-cardiac-involvement-in-systemic-diseases
#25
REVIEW
Kelash Kumar, Karthik Seetharam, Fnu Poonam, Amit Gulati, Adnan Sadiq, Vijay Shetty
For systemic diseases like rheumatoid arthritis, systemic lupus erythematosus (SLE), systemic sclerosis, systemic vasculitis, myopathies, and mixed connective tissue diseases, cardiac disease is a major contributing factor for morbidity and mortality. The cardiovascular manifestations are the result of various pathophysiological components, which complicate management. Furthermore, the signs and symptoms can be subtle and missed due to the complex nature of the underlying condition. As a result, various imaging approaches play an imperative role in diagnosis and prognosis...
December 2021: Curēus
https://read.qxmd.com/read/34915182/fc-receptors-gone-wrong-a-comprehensive-review-of-their-roles-in-autoimmune-and-inflammatory-diseases
#26
REVIEW
Emilie Chalayer, Baptiste Gramont, Franck Zekre, Roman Goguyer-Deschaumes, Louis Waeckel, Lucile Grange, Stéphane Paul, Amy W Chung, Martin Killian
Systemic autoimmune and inflammatory diseases have a complex and only partially known pathophysiology with various abnormalities involving all the components of the immune system. Among these components, antibodies, and especially autoantibodies are key elements contributing to autoimmunity. The interaction of antibody fragment crystallisable (Fc) and several distinct receptors, namely Fc receptors (FcRs), have gained much attention during the recent years, with possible major therapeutic perspectives for the future...
March 2022: Autoimmunity Reviews
https://read.qxmd.com/read/34745681/a-rare-case-of-fatal-hemorrhagic-stroke-in-a-young-female-with-early-mixed-connective-tissue-disease
#27
James R Agapoff Iv
Mixed connective tissue disease (MCTD) often presents as a slow progressive illness with low morbidity and mortality. Serious central nervous system disease is uncommon, and fatal outcomes are rarely seen. Here, we report a rare case of fatal hemorrhagic stroke in a 43-year-old female with a rapidly progressive MCTD. She presented to primary care with a history of headaches, visual disturbances, and unprovoked lower extremity swelling and pain. A rheumatological workup showed positive antinuclear (ANA) and ribonucleoprotein (RNP) antibodies...
2021: Case Reports in Rheumatology
https://read.qxmd.com/read/34409510/protracted-severe-covid-19-pneumonia-following-rituximab-treatment-caution-needed
#28
REVIEW
Dimitrios Daoussis, Lydia Leonidou, Christina Kalogeropoulou, Fotini Paliogianni, Argyrios Tzouvelekis
The outcomes of COVID-19 in patients treated with biologic agents are a subject of intense investigation. Recent data indicated that patients under rituximab (RTX) may carry an increased risk of serious disease. We performed an electronic search in Medline and Scopus using the keywords rituximab and COVID-19. We present a rare case of severe, protracted COVID-19 pneumonia in a patient with mixed connective tissue disease (MCTD) who was infected a few days following RTX treatment. In a relevant literature search, we identified 18 cases of patients with rheumatic diseases (6 RA, 8 ANCA vasculitis, 3 systemic sclerosis and 1 polymyositis) treated with RTX who experienced an atypical and/or prolonged course of COVID-19 pneumonia with no evidence of cytokine storm...
August 19, 2021: Rheumatology International
https://read.qxmd.com/read/34217479/chronic-cytomegalovirus-necrotizing-retinitis-in-a-patient-with-scleroderma-and-mixed-connective-tissue-disease
#29
F López-Herrero, J L Sánchez-Vicente, M A Espiñeira-Periñán, J de Las Morenas-Iglesias, C Franco-Ruedas, T Rueda-Rueda
The case is presented of a 52-year-old woman with scleroderma, mixed connective tissue disease, and interstitial lung disease, who developed chronic cytomegalovirus necrotizing retinitis while on treatment with prednisone, mycophenolate, and hydroxychloroquine. Initially diagnosed as macular hole, the patient underwent a pars plana vitrectomy. Two months after surgery, due to progressive worsening, the diagnosis was made and treatment started (intravenous and intravitreal ganciclovir). The patient developed severe macular atrophy with final visual acuity of counting fingers...
July 2021: Archivos de la Sociedad Española de Oftalmología
https://read.qxmd.com/read/34010670/the-emerging-roles-of-exosomes-in-autoimmune-diseases-with-special-emphasis-on-micrornas-in-exosomes
#30
REVIEW
Chenggui Miao, Xiao Wang, Wanwan Zhou, Jinling Huang
Autoimmune diseases include rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic vasculitis, dermatomyositis, systemic sclerosis (SSc), mixed connective tissue disease, autoimmune hemolytic anemia, autoimmune thyroiditis (AITD) and ulcerative colitis. Exosomes exist in body fluids, including blood, saliva, urine, cerebrospinal fluid and milk. They are mainly derived from the invagination of intracellular lysosomal particles, which are released into the extracellular matrix after fusion of the outer membrane of the exosomes with the cell membrane...
July 2021: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/33717064/renal-involvement-and-hbv-infection-are-common-in-chinese-patients-with-cryoglobulinemia
#31
JOURNAL ARTICLE
Wei Bai, Lixia Zhang, Jiuliang Zhao, Shangzhu Zhang, Jiaxin Zhou, Xiaomei Leng, Zhengyin Liu, Wenling Ye, Bing Han, Xinping Tian, Mengtao Li, Yan Zhao, Xiaofeng Zeng
Objectives: This study aimed to describe the main characteristics of Chinese patients with cryoglobulinemia, especially the characteristics of patients with different causes of cryoglobulinemia. Methods: Eighty inpatients diagnosed with cryoglobulinemia from different wards in Peking Union Medical College Hospital were included in this study. Demographic, clinical, biological, and renal pathological data were collected. We analyzed the characteristics of 61 patients with different causes of cryoglobulinemia...
2021: Frontiers in Immunology
https://read.qxmd.com/read/33506759/flare-of-a-mixed-cryoglobulinaemic-vasculitis-after-obinutuzumab-infusion
#32
JOURNAL ARTICLE
Gregoire Martin de Fremont, Andrada Chiron, Roman Krzysiek, Salima Hacein-Bey-Abina, Xavier Mariette, Gaetane Nocturne
OBJECTIVES: Obinutuzumab (OBZ) is a new humanised type II anti-CD20 monoclonal antibody (mAb) approved in onco-haematology. Its use as an alternative to rituximab (RTX) in case of immunisation in autoimmune diseases has not been fully assessed yet. Here we report the case of a patient suffering from a refractory cryoglobulinaemic vasculitis (CV) associated to Sjögren's syndrome (SS) and treated with OBZ. METHODS: Since the patient was immunised against RTX, she was treated with OBZ at relapse...
March 2021: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/33054944/programmed-cell-death-protein-1-inhibitor-induced-recalcitrant-mixed-small-and-medium-vessel-vasculitis
#33
JOURNAL ARTICLE
Sara A Kullberg, Hollis Krug, Kevin Gaddis, Noah Goldfarb
Pembrolizumab, a programmed cell death protein 1 (PD1) inhibitor, has been known to be associated with several adverse reactions, including immune related adverse events. In less than one percent of patients, PD1 inhibitors have been linked to the development of connective tissue disease. Patients with previously known connective tissue disease are hypothesized to be at increased risk of flares in as many as 40% of cases. A 70-year-old man with a past medical history significant for rheumatoid arthritis in remission and stage IV lung adenocarcinoma presented to the dermatology clinic after one cycle of nivolumab and eight cycles of pembrolizumab exhibiting worsening, painful bilateral lower extremity ulcers for approximately one month...
September 15, 2020: Dermatology Online Journal
https://read.qxmd.com/read/32654826/chronic-cytomegalovirus-necrotising-retinitis-in-a-patient-with-scleroderma-and-mixed-connective-tissue-disease
#34
JOURNAL ARTICLE
F López-Herrero, J L Sánchez-Vicente, M A Espiñeira-Periñán, J de Las Morenas-Iglesias, C Franco-Ruedas, T Rueda-Rueda
The case is presented of a 52-year-old woman with scleroderma, mixed connective tissue disease, and interstitial lung disease, who developed chronic cytomegalovirus necrotising retinitis while on treatment with prednisone, mycophenolate, and hydroxychloroquine. Initially diagnosed as macular hole, the patient underwent a pars plana vitrectomy. Two months after surgery, due to progressive worsening, the diagnosis was made and treatment started (intravenous and intravitreal ganciclovir). The patient developed severe macular atrophy with final visual acuity of counting fingers...
July 9, 2020: Archivos de la Sociedad Española de Oftalmología
https://read.qxmd.com/read/32234406/worldwide-trends-in-all-cause-mortality-of-auto-immune-systemic-diseases-between-2001-and-2014
#35
REVIEW
Marc Scherlinger, Philippe Mertz, Flora Sagez, Alain Meyer, Renaud Felten, Emmanuel Chatelus, Rose-Marie Javier, Christelle Sordet, Thierry Martin, Anne-Sophie Korganow, Aurélien Guffroy, Vincent Poindron, Christophe Richez, Marie-Elise Truchetet, Patrick Blanco, Thierry Schaeverbeke, Jean Sibilia, Hervé Devillers, Laurent Arnaud
AIM: To describe changes in the 2001-2014 mortality of 6 autoimmune systemic diseases (AISDs), namely Systemic Lupus Erythematosus (SLE), Systemic Sclerosis (SSc), Idiopathic Inflammatory Myopathies (IIM), Sjögren's Syndrome (SS), Mixed Connective Tissue Disease (MCTD) and ANCA-associated vasculitis (AAV) at the country-, continent-, and world-levels. METHODS: Mortality data were retrieved from the World Health Organization (WHO) mortality database for each disease, based on ICD-10 codes...
June 2020: Autoimmunity Reviews
https://read.qxmd.com/read/31745825/congestive-hepatopathy-and-acute-pancreatitis-as-severe-complications-of-mixed-connective-tissue-disease
#36
JOURNAL ARTICLE
Shigekazu Kurihara, Takefumi Kimura, Naoki Tanaka, Takumi Yanagisawa, Hiroyuki Kobayashi, Keita Kanai, Takeji Umemura, Mamoru Kobayashi, Hiromitsu Mori, Shuichi Wada
Mixed connective tissue disease (MCTD) causes multiple organ dysfunctions, such as joint swelling, pulmonary fibrosis and hypertension, and serositis, but hepatopancreatic complications are rare. Here, we report a case of young man who exhibited acute severe liver dysfunction. He also had impaired cardiac function: both ventriculi were hypokinetic, but pulmonary hypertension and pericarditis were not observed. Since his liver and cardiac function markedly improved after commencing furosemide and carperitide, we considered congestive hepatopathy due to MCTD and accompanying heart failure...
November 19, 2019: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/31620606/pathological-interpretation-of-connective-tissue-disease-associated-lung-diseases
#37
REVIEW
Kun Young Kwon
Connective tissue diseases (CTDs) can affect all compartments of the lungs, including airways, alveoli, interstitium, vessels, and pleura. CTD-associated lung diseases (CTD-LDs) may present as diffuse lung disease or as focal lesions, and there is significant heterogeneity between the individual CTDs in their clinical and pathological manifestations. CTD-LDs may presage the clinical diagnosis a primary CTD, or it may develop in the context of an established CTD diagnosis. CTD-LDs reveal acute, chronic or mixed pattern of lung and pleural manifestations...
January 2019: Yeungnam University journal of medicine
https://read.qxmd.com/read/31585842/suspected-inflammatory-rheumatic-diseases-in-patients-presenting-with-skin-rashes
#38
REVIEW
Francisca Alves, Margarida Gonçalo
Skin lesions occur, often at very early stages, in many of the most frequent inflammatory rheumatic diseases such as in systemic lupus erythematosus (SLE), dermatomyositis (DM), systemic sclerosis (SSc), Sjögren's syndrome, rheumatoid arthritis (RA), and psoriatic arthritis. It is important to recognize the different specific cutaneous lesions in SLE (e.g., "butterfly" rash in acute, annular or psoriasiform photosensitive lesions in the subacute form, and discoid lesions in the chronic form) for an early diagnosis and to estimate the associated risks of internal disease, whereas nonspecific lesions (exanthema, vasculitis, and alopecia) can be part of SLE flares...
August 2019: Best Practice & Research. Clinical Rheumatology
https://read.qxmd.com/read/31238745/safety-of-fertility-treatments-in-women-with-systemic-autoimmune-diseases-sads
#39
REVIEW
V S Vanni, R De Lorenzo, L Privitera, V Canti, P Viganò, P Rovere-Querini
Introduction : Systemic Autoimmune Diseases (SADs) include systemic lupus erythematosus, antiphospholipid antibody syndrome, rheumatoid arthritis, systemic sclerosis, Sjogren's syndrome, mixed connective tissue disease, idiopathic inflammatory myopathies and vasculitis. SADs often occur in women of childbearing age and can affect fertility. Both infertility treatments and fertility preservation techniques are thus often indicated. Areas covered : The literature regarding the safety of fertility-related drugs for both fertility preservation and infertility treatment in patients affected by SADs was reviewed...
September 2019: Expert Opinion on Drug Safety
https://read.qxmd.com/read/31062611/clinical-manifestations-and-mechanisms-of-autoimmune-disease-related-multiple-cerebral-infarcts
#40
JOURNAL ARTICLE
Li-Li Sun, Wen-Xiong Tang, Min Tian, Lu Zhang, Zun-Jing Liu
It is important to investigate the clinical characteristics and identify the stroke mechanisms of patients with autoimmune disease-related stroke, which are necessary for early etiology diagnosis, accurate treatment and preventive strategies. In this article we retrospectively studied eight cases of acute ischemic stroke associated with autoimmune diseases, and without competing conventional stroke etiologies. The characteristics of stroke (clinical and radiological features), the laboratory tests especially serum D-dimer levels (as a marker of hypercoagulable state), and embolic signals on transcranial Doppler were evaluated for all eight patients...
August 2019: Cell Transplantation
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