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Iran Prevalence Helicobacter

Azizollah Yousefi, Shahryar Eslami, Samileh Noorbakhsh, Morteza Haghighi, Leila TaheriNia, Fahimeh Ehsanipour
BACKGROUND: High resistance to common antibiotics has become a huge global dilemma in eradicating Helicobacter Pylori infection in both children and adults. The great concern is about the resistance to different classes of antibiotics especially Clarithromycin because of its widespread use. The present survey aimed to assess the resistance rate to Clarithromycin in Helicobacter Pylori isolated in patients aged less than 15 years as compared to patients older than 15 years of age. METHODS: In this cross-sectional study, total 72 patients with upper gastrointestinal symptoms requiring diagnostic endoscopy referred to Rasoul-e-Akram Hospital in Tehran during one year (August 2015 to August 2016)...
October 12, 2018: Infectious Disorders Drug Targets
Fatemeh Ahmadi-Motamayel, Samaneh Vaziri-Amjad, Poorandokht Davoodi, Mohammad Taghi Goodarzi, Jalal Poorolajal
BACKGROUND: High resistance to common antibiotics has become a huge global dilemma in eradicating Helicobacter Pylori infection in both children and adults. The great concern is about the resistance to different classes of antibiotics especially Clarithromycin because of its widespread use. The present survey aimed to assess the resistance rate to Clarithromycin in Helicobacter Pylori isolated in patients aged less than 15 years as compared to patients older than 15 years of age. METHODS: In this cross-sectional study, total 72 patients with upper gastrointestinal symptoms requiring diagnostic endoscopy referred to Rasoul-e-Akram Hospital in Tehran during one year (August 2015 to August 2016)...
October 5, 2018: Infectious Disorders Drug Targets
Saba Fakhrieh Asl, Mehrnaz Pourvahedi, Ali Mojtahedi, Mohammad Shenagari
OBJECTIVE: Helicobacter pylori is a Gram-negative bacterium which has a serious effect on the up to half of the world's population and has been related to different gastric diseases. The goal of this study was to assess the frequency of babA, cagE and cagA genotypes among H. pylori strains isolated from gastric biopsies of endoscopic patients in the north of Iran. METHODS: The present study was performed on 90 strains of H. pylori isolated from patients with gastric diseases (Gastric ulcer (GU), Duodenal ulcer (DU), Gastritis (G), Non-ulcer dyspepsia (NUD) and Gastric adenocarcinoma (GC))...
May 14, 2018: Infectious Disorders Drug Targets
Hafez Fakheri, Mehdi Saberi Firoozi, Zohreh Bari
Helicobacter pylori (H. pylori) infection is one of the most common bacterial infections, affecting almost half of the world's population. It is associated with peptic ulcer disease, gastric adenocarcinoma, and lymphoma. In Iran, the prevalence of H. pylori infection has been reported to be between 36% and 90% in different geographic regions. Several studies have assessed the efficacy of different therapeutic options for firstline and second-line H. pylori eradication in Iran; however, the results are conflicting...
January 2018: Middle East Journal of Digestive Diseases
Kourosh Sayehmiri, Ghobad Abangah, Gholamreza Kalvandi, Hamed Tavan, Sanaz Aazami
Background: Peptic ulcer is a prevalent problem and symptoms include epigastria pain and heartburn. This study aimed at investigating the prevalence and causes of peptic ulcers in Iran using systematic review and meta-analysis. Materials and Methods: Eleven Iranian papers published from 2002 to 2016 are selected using valid keywords in the SID, Goggle scholar, PubMed and Elsevier databases. Results of studies pooled using random effects model in meta-analysis. The heterogeneity of the sample was checked using Q test and I 2 index...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Mohammad Zamani, Amin Vahedi, Ahmad Tamaddoni, Ali Bijani, Mojgan Bagherzade, Javad Shokri-Shirvani
Background: Until now, no study has been reported investigating the association between β-thalassemia minor and Helicobacter pylori ( H. pylori) infection. This study was designed to compare H. pylori infection rate between β-thalassemia minor patients and healthy controls. Methods: A number of 100 β-thalassemia minor patients (50 males, 50 females) and 100 gender-matched healthy controls were prospectively recruited in this study in a period of 3 months. The study population consisted of the people who referred to a health center in Babol, North of Iran, for premarital counseling...
2018: Caspian Journal of Internal Medicine
Yousef Rahmani, Sareh Mohammadi, Mehran Babanejad, Alireza Rai, Bahar Zalei, Afshar Shahmohammadi
Background: Over the past decade, cardiovascular diseases have been recognized as the leading cause of mortality worldwide. Myocardial infarction (MI) is one of the most prevalent types of cardiovascular diseases that is caused by the closure of coronary arteries and ischemic heart muscle. Numerous studies have analyzed the role of H. pylori as a possible risk factor for coronary artery diseases, in most of which the role of infection in coronary artery disease is not statistically significant...
July 2017: Ethiopian Journal of Health Sciences
Aref Shavalipour, Habib Malekpour, Hossein Dabiri, Hossein Kazemian, Homayon Zojaji, Mahboube Bahroudi
Aim: Since the impact of H. pylori and its virulence is not clear in GERD, this study aimed to evaluate the prevalence of cag A and cag E gens of H. pylori among Iranian GERD patients. Background: Gastroesophageal reflux disease (GERD) is defined as a condition of reflux the stomach juice by low pH causes tissue damage. Helicobacter pylori may or may not influence the GERD; however, it is unclear. Methods: This study was a case-control study performed on patients with GERD who underwent upper gastrointestinal endoscopy at Taleghani Hospital of Tehran, Iran...
2017: Gastroenterology and Hepatology From Bed to Bench
Shahla Afrasiabian, Behzad Mohsenpour, Ebrahim Ghaderi, Sara Nadri, Katayon Hajibagheri
Brucellosis is endemic in Iran. Several studies have shown that brucellosis is associated with other infectious diseases. This study aimed to determine the relationship between Helicobacter pylori (HP) and brucellosis. In this case-control study, 100 patients with brucellosis as cases and 200 participants without brucellosis as controls were evaluated. To compare the prevalence of HP in the 2 groups, odds ratios and confidence intervals for every variable were analyzed using logistic regression models after adjustment for confounding factors...
November 22, 2017: Japanese Journal of Infectious Diseases
Farzad Khademi, Amir Hossein Sahebkar, Hamid Vaez, Mohsen Arzanlou, Hadi Peeridogaheh
BACKGROUND: The high prevalence of clarithromycin-resistant strains of Helicobacter pylori is a main challenge for the successful treatment of gastrointestinal infections. Point mutations in the 23S rRNA gene are one of the main mechanisms leading to the resistance to clarithromycin in Iran. The purpose of the present review was to evaluate the prevalence of clarithromycin-resistant H. pylori strains in Iran and to identify the major molecular mechanisms of resistance in the resistant isolates...
September 2017: Journal of Global Antimicrobial Resistance
Ali Bahadori, Mohammad Hossein Somi, Figen Doran, Amirtaher Eftekharsadat, Suna Kizilyildirim, Mahsa Esmaeillou, Maryam Yaasi, Başak Bedir, Fatih Köksal
BACKGROUND/AIM: Helicobacter pylori is a pathogen that colonizes a majority of the world's population. Genetic diversity within the virulence genes of bacteria such as cag PAI and vac A may have a modified effect on the pathogenic potential of the bacteria. This study aimed to investigate which genes can be suggested as potentially related virulence factors for H. pylori -associated active chronic gastritis and stomach adenocarcinoma in the northwest of Iran and south of Turkey. MATERIALS AND METHODS: Formalin-fixed, paraffin-embedded stomach biopsy tissue samples were obtained from Iranian and Turkish patients from selected geographical regions...
June 12, 2017: Turkish Journal of Medical Sciences
Ali Gilani, Vadood Razavilar, Nordahr Rokni, Ebrahim Rahimi
Foods with animal origins play a substantial role in the transmission of Helicobacter pylori. The present investigation was carried out to study the vacA and cagA genotypes status of H. pylori isolated from various types of meat samples. Two hundred and twenty meat samples were collected and cultured. H. pylori-positive strains were analyzed for the presence of vacA and cagA genotypes. Eleven out of 220 (5.00%) samples were positive for H. pylori. Findings were confirmed by nested PCR. Prevalence of H. pylori in the meat samples of slaughterhouses and butcheries were 72...
2017: Veterinary Research Forum
Hossein Dabiri, Fereshteh Jafari, Kaveh Baghaei, Leila Shokrzadeh, Saeed Abdi, Mohamad Amin Pourhoseingholi, Alireza Mohammadzadeh
There is diversity in clinical outcome of Helicobacter pylori infection in different regions. Microbial, host and environmental factors seem to be reason of such variation. Considering microbial factors, we studied H. pylori genotypes and their association with clinical feature of the infection. Overall 160 H. pylori-positive patients were enrolled in this study. Clinical information and biopsy were collected from each patient. The presence of the major virulence genes were determined by PCR. Regardless to clinical outcomes, vacA, cagA, cagE, oipA, iceA1, babA2 and babB genes was positive in 100%, 69%, 51%, 55%, 26%,78% and 28% of 160 strains respectively...
April 2017: Microbial Pathogenesis
H Alimohammadi, N Fouladi, F Salehzadeh, S A Alipour, M S Javadi
We examined the role of Helicobacter pylori infection as a cause of recurrent abdominal pain (RAP) among Iranian children in a population-based case-control study to determine the association between H. pylori infection and RAP among schoolchildren. A total of 1558 children aged 6-13 years were examined. Children with RAP confirmed by the Apley and Naish criteria were selected; 145 cases were selected for inclusion and were compared with 145 healthy children recruited from the same area. Both groups underwent stool antigen testing...
February 1, 2017: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
Nader Bagheri, Fatemeh Azadegan-Dehkordi, Mahmoud Rafieian-Kopaei, Ghorbanali Rahimian, Majid Asadi-Samani, Hedaytollah Shirzad
Helicobacter pylori (H. pylori) usually colonizes the gastric mucosa of more than 50% of the human population, causing an infection that may appear in early childhood and can persist for life. H. pylori is suggested as the main cause of peptic ulcer and chronic gastritis. It is also associated with gastric cancer. Its severity and symptoms depend on environmental factors, host susceptibility and bacterial components, which allow H. pylori to switch between commensalism and pathogenicity. H. pylori is genetically highly variable, and the variability which affects H...
November 2016: Microbial Pathogenesis
Mehdi Goudarzi, Sima Sadat Seyedjavadi, Maryam Fazeli, Maryam Roshani, Mehdi Azad, Mohsen Heidary, Masoumeh Navidinia, Hossein Goudarzi
Helicobacter pylori as the second most common cause of gastric cancer in the world infects approximately half of the developed countries population and 80% of the population living in developing countries. Integrons as genetic reservoirs play major roles in dissemination of antimicrobial resistance genes. To the best of our knowledge, this is the first study to report carriage of class 1 and 2 integrons and associated gene cassettes in H. pylori isolates from Iran. This crosssectional study was conducted in Tehran among 110 patients with H...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Hassan Bazmamoun, Mandana Rafeey, Maryam Nikpouri, Robabeh Ghergherehchi
BACKGROUND: Helicobacter pylori infection is one of the most common chronic bacterial infections. There is challenge on the real rate of prevalence of H. pylori in diabetic patients. This study was done to assess the prevalence of H. pylori infection in children suffering from type 1 insulin-dependent diabetes mellitus. METHODS: In this case-control study, 80 diabetic patients (as the target group) refer to the Endocrinology Clinic of Tabriz Educational and Treatment Center, Tabriz northwestern Iran and 80 non-diabetic patients (as the control group) from the group of children referring to the GI Clinic of the same center  were enrolled in 2012 and 2013...
2016: Journal of Research in Health Sciences
Reza Ranjbar, Faham Khamesipour, Nematollah Jonaidi-Jafari, Ebrahim Rahimi
Despite the clinical importance of Helicobacter pylori in human gastric disorders, its exact route of transmission is still uncertain. Based on the contentious hypothesis and findings of previous investigations, water may play an important role in the transmission of H. pylori to humans. This study was carried out to investigate the vacA, cagA, oipA, iceA and babA2 genotype status and antimicrobial resistance properties of H. pylori strains isolated from the drinking water samples of four major provinces in Iran...
May 2016: FEBS Open Bio
Zaruni Leila, Seyed Alimohammad Arabzadeh, Reza Malekpour Afshar, Abbas Aghaei Afshar, Hamid Reza Mollaei
Gastric cancer (GC) is a multifactorial disease with different factors having roles in its genesis. Helicobacter pylori and Epstein-Barr virus (EBV) are known infectious agents that could contribute. In addition, there is evidence of a relationship with cytomegalovirus (CMV). Since data on CMV prevalence in gastric cancer are limited, we here evaluated the frequency of EBV and CMV in Iranian patients. Ninety paraffin blocks of GC tissues from patients in Kerman were evaluated for the presence of EBV and CMV genomes by real-time polymerase chain reaction...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Mahmood Moosazadeh, Kamran B Lankarani, Mahdi Afshari
Helicobacter pylori infection is a common health problem related to many gastrointestinal disorders. This study aims to estimate the total and age specific prevalence of Helicobacter Pylori infection in Iran. We systematically reviewed all national and international databases and finally identified 21 studies were eligible for meta-analysis. Each of them were assigned a quality score using STROBE checklist. Due to significant heterogeneity of the results, random effects model was used to estimate the pooled prevalence and 95% confidence interval of Helicobacter Pylori infection...
2016: International Journal of Preventive Medicine
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