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lung cancer vitamin D

Alice Barros Câmara, Igor Augusto Brandãob
BACKGROUND: Vitamin D (VD) deficiency affects individuals of different ages in many countries. VD deficiency may be related to several diseases, including cancer. OBJECTIVE: This study aimed to review the relationship between VD deficiency and cancer. METHOD: We describe the proteins involved in cancer pathogenesis and how those proteins can be influenced by VD deficiency. We also investigated a relationship between cancer death rate and solar radiation...
March 12, 2019: Anti-cancer Agents in Medicinal Chemistry
Yumie Takata, Xiao-Ou Shu, Maciej S Buchowski, Heather M Munro, Wanqing Wen, Mark D Steinwandel, Margaret K Hargreaves, William J Blot, Qiuyin Cai
PURPOSE: We prospectively examined associations of lung cancer risk with food intake of B vitamins involved in one-carbon metabolism and the use of folic acid-containing supplements among a low-income population of black and white adults in the Southeastern US. METHODS: Within the Southern Community Cohort Study, we included 1064 incident lung cancer cases among 68,236 participants aged 40-79 years at study enrollment. Food intake and the use of folic acid-containing supplements were assessed using a validated food frequency questionnaire at study enrollment...
March 5, 2019: European Journal of Nutrition
Jing Zhang, Suzhen Yang, Bing Xu, Ting Wang, Ying Zheng, Fei Liu, Fenggang Ren, Jiong Jiang, Haitao Shi, Baicang Zou, Xiaolan Lu, Shemin Lu, Lei Dong
OBJECTIVES: The role of p62 in cancer is controversial. Evidence has shown that p62 is upregulated in different cancers and promotes tumour growth, such as in liver cancer and lung cancer. However, a recent study showed that the downregulation of p62 in hepatic stellate cells (HSCs) promotes hepatocellular carcinoma (HCC) development. How p62 is regulated in colorectal cancer (CRC) remains largely unknown. In this study, we aimed to investigate the roles and molecular mechanisms of p62 in CRC...
February 22, 2019: Cell Proliferation
C Ferrándiz-Pulido, I B Torres, C Juárez-Dobjanschi, I Zarzoso-Muñoz, C Berastegui, L Castells, V García-Patos, F Moreso
BACKGROUND: Solid-organ transplant recipients (SOTRs) are at risk of developing vitamin D deficiency, mainly caused by reduced sunlight exposure with subsequent low vitamin D synthesis in the skin. AIM: To analyse whether SOTRs from a Spanish Mediterranean region were vitamin D-deficient. METHODS: This was a cross-sectional, descriptive and observational study in a transplantation-specialized Dermatological Unit from a Mediterranean area to determine the calcidiol levels of a cohort of 78 consecutively attending patients not receiving vitamin D supplements...
January 30, 2019: Clinical and Experimental Dermatology
Shasha Tao, Hong Zhang, Lian Xue, Xiaoyan Jiang, Hongyan Wang, Bingyan Li, Hailin Tian, Zengli Zhang
Fine particulate matter is a well-known air pollutant threatening public health. Studies have confirmed long-term exposure to the particles could decrease the pulmonary function, induce asthma exacerbation, and chronic obstructive pulmonary disease, as well as increase the incidence and mortality of lung cancer. A clinical study has explored that the prevalence and risks of vitamin D (VD) deficiency in various chronic disease and toxins induced tissue damage. Our current study aimed to explore the mechanism and further therapeutic potential of VD administration to ameliorate fine particles exposure induced pulmonary damage in vivo and in vitro...
January 30, 2019: Environmental Toxicology
H Zuo, P M Ueland, Ø Midttun, G S Tell, A Fanidi, W Zheng, X Shu, Y Xiang, J Wu, R Prentice, M Pettinger, C A Thomson, G G Giles, A Hodge, Q Cai, W J Blot, M Johansson, J Hultdin, K Grankvist, V L Stevens, M L McCullough, S J Weinstein, D Albanes, R G Ziegler, N D Freedman, N E Caporaso, A Langhammer, K Hveem, M Næss, J E Buring, I Lee, J M Gaziano, G Severi, X Zhang, M J Stampfer, J Han, A Zeleniuch-Jacquotte, L L Marchand, J Yuan, R Wang, W Koh, Y Gao, U Ericson, K Visvanathan, M R Jones, C Relton, P Brennan, M Johansson, A Ulvik
Background: Increased vitamin B6 catabolism related to inflammation, as measured by the PAr index (the ratio of 4-pyridoxic acid over the sum of pyridoxal and pyridoxal -5'-phosphate), has been positively associated with lung cancer risk in two prospective European studies. However, the extent to which this association translates to more diverse populations is not known. Materials and methods: For this study, we included 5,323 incident lung cancer cases and 5,323 controls individually matched by age, sex, and smoking status within each of 20 prospective cohorts from the Lung Cancer Cohort Consortium...
January 30, 2019: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Zhi-Hong Yu, Miao Chen, Qing-Qian Zhang, Xun Hu
The association between vitamin D receptor (VDR) genetic polymorphism and lung cancer risk has been evaluated by previous meta-analyses. Due to emergence of novel studies and inappropriate inclusion of overlapping populations, an update meta-analysis on recent evidences is necessarily needed. We comprehensively searched databases of PubMed, Web of Science and Chinese National Knowledge Infrastructure and finally obtained 7 eligible studies according to the inclusion criteria. Four positions on VDR gene, namely ApaI (rs7975232), BsmI (rs1544410), FokI (rs10735810) and TaqI (rs731236), were considered in this investigation...
January 25, 2019: Combinatorial Chemistry & High Throughput Screening
Jessica Cusato, Carlo Genova, Cristina Tomasello, Paolo Carrega, Selene Ottonello, Gabriella Pietra, Maria Cristina Mingari, Irene Cossu, Erika Rijavec, Anna Leggieri, Giovanni Di Perri, Maria Giovanna Dal Bello, Simona Coco, Simona Boccardo, Guido Ferlazzo, Francesco Grossi, Antonio D'Avolio
Nivolumab is one of the most commonly used monoclonal antibodies for advanced non-small cell lung cancer treatment, to the extent that the presence of its anti-antibody is considered a negative prognostic factor. Vitamin D (VD) modulates expression of the genes involved in drug metabolism and elimination. Immune system regulation and immunodeficiency is frequent in non-small cell lung cancer patients. To date, no data have been reported about the relationship between nivolumab and VD. The aim of this study was to quantify plasma 25-hydroxyVD (25-VD) and 1,25-VD, nivolumab, and its anti-antibody before starting treatment (baseline) and at 15, 45 and 60 days of therapy...
January 21, 2019: Cancers
Kathryn T Hall, Julie E Buring, Kenneth J Mukamal, M Vinayaga Moorthy, Peter M Wayne, Ted J Kaptchuk, Elisabeth M Battinelli, Paul M Ridker, Howard D Sesso, Stephanie J Weinstein, Demetrius Albanes, Nancy R Cook, Daniel I Chasman
Background: Vitamins are among the most frequently used supplements (48% of US adults). However, little is known about contributions of genetic variation to their efficacy and safety. Multiple pathways link catechol-O-methyltransferase (COMT) to the vitamin E supplement, alpha-tocopherol, and cancer. Methods: Here we determined if COMT exerted pharmacogenetic effects on cancer prevention in two randomized trials of alpha-tocopherol supplementation. Pharmacogenetic effects of common COMT rs4680 (val158met), which encodes a nonsynonymous valine-to-methionine substitution, were examined in the trial plus a 10-year post-trial follow-up (overall) period of The Women's Genome Health Study (WGHS, N = 23 294), a 10-year alpha-tocopherol and aspirin trial with 10 years post-trial follow-up...
January 8, 2019: Journal of the National Cancer Institute
Fie Juhl Vojdeman, Christian Medom Madsen, Kirsten Frederiksen, Darshana Durup, Anja Olsen, Louise Hansen, Anne-Marie Heegaard, Bent Lind, Anne Tjønneland, Henrik Løvendahl Jørgensen, Peter Schwarz
Vitamin D has been linked to cancer development in both pre-clinical and epidemiological studies. This study examines the association between serum levels of vitamin D and cancer incidence in the Capital Region of Denmark. Individuals who had vitamin D analyzed at The Copenhagen General Practitioners Laboratory between April 2004 and January 2010 were linked to Danish registries with end of follow-up date at Dec 31st 2014, excluding individuals with pre-existing cancer. Cox regression models adjusted for age in one-year intervals, sex, month of sampling, and Charlson Comorbidity Index were applied...
January 7, 2019: International Journal of Cancer. Journal International du Cancer
Arthur R Galbraith, Donna E Seabloom, Beverly R Wuertz, Jennifer D Antonides, Vernon E Steele, Lee W Wattenberg, Frank G Ondrey
Nicotinamide, the amide form of vitamin B3, and budesonide, a synthetic glucocorticoid used in the treatment of asthma, were evaluated to determine their individual and combinational chemopreventive efficacy on benzo(a)pyrene induced lung tumors in female A/J mice. Nicotinamide fed at a dietary concentration of 0.75% significantly inhibited tumor multiplicity. Nicotinamide by aerosol inhalation at doses up to 15 mg/kg/day did not result in a statistically significant reduction in tumor multiplicity. Finally, dietary nicotinamide was administered with aerosol budesonide and tumor multiplicity reduced by 90% at 1 week and 49% at 8 weeks post last carcinogen dose...
January 3, 2019: Cancer Prevention Research
Jue-Sheng Ong, Puya Gharahkhani, Jiyuan An, Matthew H Law, David C Whiteman, Rachel E Neale, Stuart MacGregor
There is considerable debate regarding the role that 25-hydroxyvitamin D [25(OH)D] concentrations play in cancer risk or mortality, with earlier studies drawing mixed conclusions. Using data from the UK Biobank (UKB), we evaluate whether genetically predicted 25(OH)D concentrations are associated with overall cancer susceptibility and cancer mortality using five 25(OH)D genetic markers. Data comprised 438 870 white British UKB participants aged 37-73, including 46 155 cancer cases and 6998 cancer-specific deaths...
December 15, 2018: Human Molecular Genetics
Anouar Fanidi, Robert Carreras-Torres, Tricia L Larose, Jian-Min Yuan, Victoria L Stevens, Stephanie J Weinstein, Demetrius Albanes, Ross Prentice, Mary Pettinger, Qiuyin Cai, William J Blot, Alan A Arslan, Anne Zeleniuch-Jacquotte, Marjorie L McCullough, Loic Le Marchand, Lynne R Wilkens, Christopher A Haiman, Xuehong Zhang, Meir J Stampfer, Stephanie A Smith-Warner, Edward Giovannucci, Graham G Giles, Allison M Hodge, Gianluca Severi, Mikael Johansson, Kjell Grankvist, Arnulf Langhammer, Ben M Brumpton, Renwei Wang, Yu-Tang Gao, Ulrika Ericson, Stig E Bojesen, Susanne M Arnold, Woon-Puay Koh, Xiao-Ou Shu, Yong-Bing Xiang, Honglan Li, Wei Zheng, Qing Lan, Kala Visvanathan, Judith Hoffman-Bolton, Per M Ueland, Øivind Midttun, Neil E Caporaso, Mark Purdue, Neal D Freedman, Julie E Buring, I-Min Lee, Howard D Sesso, J Michael Gaziano, Jonas Manjer, Caroline L Relton, Rayjean J Hung, Chris I Amos, Mattias Johansson, Paul Brennan
Vitamin B supplementation can have side effects for human health, including cancer risk. We aimed to elucidate the role of vitamin B12 in lung cancer etiology via direct measurements of pre-diagnostic circulating vitamin B12 concentrations in a nested case-control study, complemented with a Mendelian randomization (MR) approach in an independent case-control sample. We used pre-diagnostic biomarker data from 5183 case-control pairs nested within 20 prospective cohorts, and genetic data from 29,266 cases and 56,450 controls...
November 29, 2018: International Journal of Cancer. Journal International du Cancer
Hu Wei, Hu Jing, Qian Wei, Guo Wei, Zhou Heng
The associations of the risk of lung cancer with the vitamin D intake and serum level are controversial. We performed a comprehensive dose-response meta-analysis to evaluate the precise relationships between the above mentioned parameters.We performed a web search of the PubMed, Medline, and Embase databases to identify potential studies that evaluated the relationships between vitamin D intake or serum 25-hydroxyvitamin D (25([OH]D) levels and the risk of lung cancer on December 5, 2017. According to the inclusion and exclusive criteria, 16 studies were included in this meta-analysis...
September 2018: Medicine (Baltimore)
Imadeldin Elfaki, Rashid Mir, Fahad M Almutairi, Faisel M Abu Duhier
Cytochromes P450s (CYPs) constitute a superfamily of enzymes that catalyze the metabolism of drugs and other substances. Endogenous substrates of CYPs include eicosanoids, estradiol, arachidonic acids, cholesterol, vitamin D and neurotransmitters. Exogenous substrates of CYPs include the polycyclic aromatic hydrocarbons and about 80% of currently used drugs. Some isoforms can activate procarcinogens to ultimate carcinogens. Genetic polymorphisms of CYPs may affect the enzyme catalytic activity and have been reported among different populations to be associated with various diseases and adverse drug reactions...
August 24, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Robyn M Lucas, Rachael M Rodney Harris
If environmental exposures are shown to cause an adverse health outcome, reducing exposure should reduce the disease risk. Links between exposures and outcomes are typically based on 'associations' derived from observational studies, and causality may not be clear. Randomized controlled trials to 'prove' causality are often not feasible or ethical. Here the history of evidence that tobacco smoking causes lung cancer-from observational studies-is compared to that of low sun exposure and/or low vitamin D status as causal risk factors for the autoimmune disease, multiple sclerosis (MS)...
August 12, 2018: International Journal of Environmental Research and Public Health
Lichchavi D Rajasinghe, Rohini H Pindiprolu, Smiti Vaid Gupta
Background: Delta-tocotrienol (δT), an isomer of vitamin E, exhibits anticancer properties in different cancer types including non-small-cell lung cancer (NSCLC). Yet, anti-invasive effects of δT and its underlying cellular mechanism in NSCLC have not been fully explored. Matrix metalloproteinase 9 (MMP-9)-based cell migration and invasion are critical cellular mechanisms in cancer development. The current evidence indicates that MMP-9 is upregulated in most patients, and the inhibition of MMPs is involved in decreasing invasion and metastasis in NSCLC...
2018: OncoTargets and Therapy
Stephanie J Weinstein, Alison M Mondul, Kai Yu, Tracy M Layne, Christian C Abnet, Neal D Freedman, Racheal Z Stolzenberg-Solomon, Unhee Lim, Mitchell H Gail, Demetrius Albanes
While vitamin D has been associated with improved overall cancer survival in some investigations, few have prospectively evaluated organ-specific survival. We examined the accepted biomarker of vitamin D status, serum 25-hydroxyvitamin D [25(OH)D], and cancer survival in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Of 4616 cancer cases with measured serum 25(OH)D, 2884 died of their cancer during 28 years of follow-up and 1732 survived or died of other causes. Proportional hazards regression estimated hazard ratios (HR) and 95% confidence intervals (CI) for the association between pre-diagnostic 25(OH)D and overall and site-specific survival...
November 2018: European Journal of Epidemiology
Brandon L Pierce, Peter Kraft, Chenan Zhang
Purpose of review: In this paper, we summarize prior studies that have used Mendelian Randomization (MR) methods to study the effects of exposures, lifestyle factors, physical traits, and/or biomarkers on cancer risk in humans. Many such risk factors have been associated with cancer risk in observational studies, and the MR approach can be used to provide evidence as to whether these associations represent causal relationships. MR methods require a risk factor of interest to have known genetic determinants that can be used as proxies for the risk factor (i...
June 2018: Current Epidemiology Reports
Tadashi Akiba, Toshiaki Morikawa, Makoto Odaka, Takeo Nakada, Noriki Kamiya, Makoto Yamashita, Mitsuo Yabe, Takuya Inagaki, Hisatoshi Asano, Shohei Mori, Yo Tsukamoto, Mitsuyoshi Urashima
Purpose: Higher serum 25-hydroxyvitamin D (25(OH)D) levels are reportedly associated with better survival in early-stage non-small cell lung cancer (NSCLC). Therefore, whether vitamin D supplementation can improve the prognosis of patients with NSCLC was examined (UMIN000001869). Patients and Methods: A randomized, double-blind trial comparing vitamin D supplements (1,200 IU/day) with placebo for 1 year after operation was conducted. The primary and secondary outcomes were relapse-free survival (RFS) and overall survival (OS), respectively...
September 1, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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