keyword
https://read.qxmd.com/read/38542424/micronutrients-at-supplemental-levels-tight-junctions-and-epithelial-barrier-function-a-narrative-review
#1
REVIEW
Katherine M DiGuilio, Elizabeth A Del Rio, Ronald N Harty, James M Mullin
Disease modifiers, whether from cancer, sepsis, systemic inflammation, or microbial pathogens, all appear to induce epithelial barrier leak, with induced changes of the Tight Junctional (TJ) complex being pivotal to the process. This leak-and the ensuant breakdown of compartmentation-plays a central role in disease morbidity on many levels. Accumulation of lung water in the luminal compartment of airways was a major driver of morbidity and mortality in COVID-19 and is an excellent example of the phenomenon...
March 19, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38482381/revealing-the-association-between-vitamin-d-metabolic-pathway-gene-variants-and-lung-cancer-risk-a-systematic-review-and-meta-analysis
#2
Mohamed I Elsalahaty, Samar Sami Alkafaas, Aya O Bashir, Khaled A El-Tarabily, Mohamed T El-Saadony, Eman H Yousef
Lung cancer is a crucial global issue, with more than one million deaths annually. While smoking is considered the main etiology of the disease, several genetic variants are associated with it. Alterations in vitamin D pathway genes have also been studied in regards to lung cancer, but the findings have been inconclusive. We here present a systematic review and meta-analysis of seven genes in this pathway: CYP2R1 , CYP27B1 , CYP24A1 , CYP3A4 , CYP3A5 , GC , and VDR . Four databases (PubMed, Scopus, Cochrane Library, and Web of Science (WOS) databases) were searched...
2024: Frontiers in Genetics
https://read.qxmd.com/read/38467003/long-term-effect-of-randomization-to-calcium-and-vitamin-d-supplementation-on-health-in-older-women-postintervention-follow-up-of-a-randomized-clinical-trial
#3
JOURNAL ARTICLE
Cynthia A Thomson, Aaron K Aragaki, Ross L Prentice, Marcia L Stefanick, JoAnn E Manson, Jean Wactawski-Wende, Nelson B Watts, Linda Van Horn, James M Shikany, Thomas E Rohan, Dorothy S Lane, Robert A Wild, Rogelio Robles-Morales, Aladdin H Shadyab, Nazmus Saquib, Jane Cauley
BACKGROUND: Although calcium and vitamin D (CaD) supplementation may affect chronic disease in older women, evidence of long-term effects on health outcomes is limited. OBJECTIVE: To evaluate long-term health outcomes among postmenopausal women in the Women's Health Initiative CaD trial. DESIGN: Post hoc analysis of long-term postintervention follow-up of the 7-year randomized intervention trial of CaD. (ClinicalTrials.gov: NCT00000611). SETTING: A multicenter ( n = 40) trial across the United States...
March 12, 2024: Annals of Internal Medicine
https://read.qxmd.com/read/38388112/dietary-patterns-linked-to-lower-odds-of-malnutrition-are-associated-with-all-cause-and-cancer-mortality-in-adults-with-cancer
#4
JOURNAL ARTICLE
Annie R Curtis, Katherine M Livingstone, Robin M Daly, Gavin Abbott, Nicole Kiss
OBJECTIVES: Dietary patterns, characterised by protein, polyunsaturated fatty acids, and vitamin D, reduce the odds of malnutrition in cancer survivors. However, it is unclear whether these dietary patterns also improve prognosis. This study prospectively examined associations between dietary patterns linked to lower odds of malnutrition and the risk of all-cause and cancer mortality in adult cancer survivors from the UK Biobank cohort. DESIGN: Prospective observational study...
February 2024: Journal of Nutrition, Health & Aging
https://read.qxmd.com/read/38289488/vitamin-d-mediated-tsrna-07804-triggers-mitochondrial-dysfunction-and-suppresses-non-small-cell-lung-cancer-progression-by-targeting-crkl
#5
JOURNAL ARTICLE
Yonggang Liang, Xiaoqiang Zhang, Jinhua Peng, Jing Liu, He Chen, Shanxian Guo
OBJECTIVE: tRNA-derived small RNAs (tsRNAs) are novel non-coding RNAs with various functions in multiple cancers. Nevertheless, whether vitamin D executes its function in mitochondrial dysfunction and non-small cell lung cancer (NSCLC) progression through tsRNAs remains obscure. METHODS: Differentially expressed tsRNAs between control and vitamin D-treated H1299 cells were acquired by small RNA sequencing. Cell and animal experiments were implemented to elucidate the impacts of vitamin D and tsRNA on mitochondrial dysfunction and NSCLC progression...
January 30, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38257146/has-a-high-dose-of-vitamin-d3-impacted-health-conditions-in-older-adults-a-systematic-review-and-meta-analysis-focusing-on-dose-100-000-iu
#6
REVIEW
Barbara Owczarek, Anna Ziomkiewicz, Edyta Łukowska-Chojnacka
BACKGROUND: Older adults are prone to vitamin D3 (VD3) deficiency, which may impair their health. A high dose of VD3 (HDVD3 = 100,000 IU) could improve their 25-hydroxyvitamin D3 [25(OH)D] level and health outcomes. However, evidence for such a beneficial effect of HDVD3 in older adults coming from clinical trials is mixed. OBJECTIVE: To review the literature on the efficacy of a single dose of 100,000 IU of VD3 in older people. METHODS: We searched PubMed/Medline, Science Direct, and NIH's clinical trials registry for clinical studies on the effect of a single high dose of VD3 on various health outcomes in older people...
January 14, 2024: Nutrients
https://read.qxmd.com/read/38234882/vitamin-d-receptor-induces-oxidative-stress-to-promote-esophageal-squamous-cell-carcinoma-proliferation-via-the-p53-signaling-pathway
#7
JOURNAL ARTICLE
Qi-Xin Shang, Yu-Shang Yang, Han-Lu Zhang, Ya-Ping Cheng, Han Lu, Yong Yuan, Long-Qi Chen, Ai-Fang Ji
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is a common pathological esophageal cancer with poor prognosis. Vitamin D deficiency reportedly occurs in ESCC patients, and this is related to single nucleotide polymorphism of vitamin D receptor (VDR). OBJECTIVE: We investigated the effect of VDR on ESCC proliferation, invasion, and metastasis and its potential mechanism. METHODS: ESCC and normal tissues were collected from 20 ESCC patients...
January 15, 2024: Heliyon
https://read.qxmd.com/read/38203636/changes-in-dna-methylation-and-mrna-expression-in-lung-tissue-after-long-term-supplementation-with-an-increased-dose-of-cholecalciferol
#8
JOURNAL ARTICLE
Alicja Wierzbicka, Ewelina Semik-Gurgul, Małgorzata Świątkiewicz, Tomasz Szmatoła, Anna Steg, Maria Oczkowicz
Maintaining an appropriate concentration of vitamin D is essential for the proper functioning of the body, regardless of age. Nowadays, there are more and more indications that vitamin D supplementation at higher than standard doses may show protective and therapeutic effects. Our study identified differences in the body's response to long-term supplementation with cholecalciferol at an increased dose. Two groups of pigs were used in the experiment. The first group received a standard dose of cholecalciferol (grower, 2000 IU/kg feed, and finisher, 1500 IU/kg feed), and the second group received an increased dose (grower, 3000 IU/kg feed, and finisher, 2500 IU/kg feed)...
December 29, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38185349/antifibrotic-effects-of-vitamin-d3-on-human-lung-fibroblasts-derived-from-patients-with-idiopathic-pulmonary-fibrosis
#9
JOURNAL ARTICLE
Tom Voisin, Audrey Joannes, Claudie Morzadec, Dominique Lagadic-Gossmann, Cécile Le Naoures, Bertrand Richard De Latour, Simon Rouze, Stéphane Jouneau, Laurent Vernhet
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease. Up to now, no treatment can stop the progression of IPF. Vitamin D3 (VD) reduces experimental lung fibrosis in murine models and depletion of vitamin D3 might be associated with the reduced survival of patients with IPF. In this context, we determined if VD can prevent the pro-fibrotic functions of human lung fibroblasts (HLFs) isolated from patients with IPF. IPF and control HLFs were derived from surgical lung biopsies collected from patients with IPF or with primary lung cancer, respectively...
January 5, 2024: Journal of Nutritional Biochemistry
https://read.qxmd.com/read/38106156/ancestry-specific-polygenic-risk-score-dietary-patterns-physical-activity-and-cardiovascular-disease
#10
Dale S Hardy, Jane T Garvin, Tesfaye B Mersha
BACKGROUND: It is unknown whether the impact of high diet-quality and physical activity (PA) depends on the level of polygenic risk score (PRS) in different ancestries. OBJECTIVE: Determine the associations and interactions between high-risk PRSs, dietary patterns, and high PA with atherosclerotic cardiovascular disease (ASCVD) in European Americans (EAs) and African Americans (AAs). Another aim determined the molecular pathways of PRS-mapped genes and their relationships with dietary intake...
December 6, 2023: medRxiv
https://read.qxmd.com/read/38085380/changes-in-mirna-expression-in-the-lungs-of-pigs-supplemented-with-different-levels-and-forms-of-vitamin-d
#11
JOURNAL ARTICLE
Alicja Wierzbicka, Klaudia Pawlina-Tyszko, Małgorzata Świątkiewicz, Tomasz Szmatoła, Maria Oczkowicz
BACKGROUND: Vitamin D is an immunomodulator, and its effects have been linked to many diseases, including the pathogenesis of cancer. However, the effect of vitamin D supplementation on the regulation of gene expression of the lungs is not fully understood. This study aims to determine the effect of the increased dose of cholecalciferol and a combination of cholecalciferol + calcidiol, as well as the replacement of cholecalciferol with calcidiol, on the miRNA profile of healthy swine lungs...
December 12, 2023: Molecular Biology Reports
https://read.qxmd.com/read/38078646/the-association-between-edentulism-and-progress-of-multimorbidity-over-12-years-among-older-american-adults
#12
JOURNAL ARTICLE
R Mira, J T Newton, W Sabbah
OBJECTIVES: To examine the relationship between edentulism and the progress of multimorbidity, and the role of nutritional intake and behaviours among older Americans. METHODS: We used 7 waves (2006-2018) of the Health and Retirement Study, a longitudinal survey of older Americans (number included in analysis 2,224). Edentulism was assessed in 2006 and 2012. Multimorbidity was indicated by 5 self-reported conditions: diabetes, heart conditions, lung diseases, cancer, and stroke...
November 28, 2023: Community Dental Health
https://read.qxmd.com/read/38059187/calcitriol-induced-hypercalcemia-a-rare-phenomenon-in-lung-cancer-a-case-report
#13
Amulya Prakash, Farhan Khalid, Ahmad Alalwan, Husam Bader, Doantrang Du, Trishala Meghal
BACKGROUND: Calcitriol-induced hypercalcemia has been rarely reported in cases of lung cancer; however, it is frequently reported in cases of lymphoid malignancy and granulomatous disease. We present a rare case of hypercalcemia associated with squamous cell cancer of the lung with elevated calcitriol level. CASE SUMMARY: A 61-year-old Caucasian female with severe hypercalcemia of 15 mg/dL, which led to a new diagnosis of metastatic lung cancer. Since the parathyroid hormone-related peptide (PTHrP) level was minimally elevated at 2...
November 24, 2023: World Journal of Clinical Oncology
https://read.qxmd.com/read/37921568/1-25-oh-2-d-3-inhibits-lewis-lung-cancer-cell-migration-via-nhe1-sensitive-metabolic-reprograming
#14
JOURNAL ARTICLE
Hong Chen, Mei-Zhen Zhu, Xi-Ting Wang, Min Ai, Shuang-Shuang Li, Ming-Yu Wan, Pei-Yao Wang, Wei-Wei Cai, Bao Hou, Fei Xu, Florian Lang, Li-Ying Qiu, Yue-Tao Zhou
High prevalence and metastasis rates are characteristics of lung cancer. Glycolysis provides energy for the development and metastasis of cancer cells. The 1,25-dihydroxy vitamin D3 (1,25(OH)2 D3 ) has been linked to reducing cancer risk and regulates various physiological functions. We hypothesized that 1,25(OH)2 D3 could be associated with the expression and activity of Na+ /H+ exchanger isoform 1 (NHE1) of Lewis lung cancer cells, thus regulating glycolysis as well as migration by actin reorganization. Followed by online public data analysis, Vitamin D3 receptor, the receptor of 1,25(OH)2 D3 has been proved to be abundant in lung cancers...
November 3, 2023: IUBMB Life
https://read.qxmd.com/read/37768028/the-anticancer-cytotoxic-effect-of-a-novel-gallic-acid-derivative-in-non-small-cell-lung-carcinoma-a549-cells-and-peripheral-blood-mononuclear-cells-from-healthy-individuals-and-lung-cancer-patients
#15
JOURNAL ARTICLE
Shohreh Jafarinejad, William H C Martin, Bayan Abu Ras, Mohammad Isreb, Badie Jacob, Abid Aziz, Zahra Adoul, Ruby Lagnado, Richard D Bowen, Mojgan Najafzadeh
Gallic acid (GA) is a naturally occurring polyphenol with a strong antioxidant capacity. GA stimulates the apoptosis of cancer cells, thereby suppressing cancer cell invasion. However, the low oral permeability of GA limits its therapeutic use. In order to enhance the antioxidant capacity and oral permeability of GA, a series of compounds analogous to GA were synthesized: 4-methoxybenzenesulfonamide (MBS), 3,4-dimethoxybenzenesulfonamide (DMBS) and 3,4,5-trimethoxybenzenesulfonamide (TMBS). In the new compounds, hydroxyl groups were replaced with various numbers of methoxy groups (stronger electron-donating groups), to increase hydrophobicity and oral permeability compared to GA...
September 28, 2023: BioFactors
https://read.qxmd.com/read/37716341/a-metabolomic-investigation-of-serum-perfluorooctane-sulfonate-and-perfluorooctanoate
#16
JOURNAL ARTICLE
Jongeun Rhee, Erikka Loftfield, Demetrius Albanes, Tracy M Layne, Rachael Stolzenberg-Solomon, Linda M Liao, Mary C Playdon, Sonja I Berndt, Joshua N Sampson, Neal D Freedman, Steven C Moore, Mark P Purdue
BACKGROUND: Exposures to perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA), environmentally persistent chemicals detectable in the blood of most Americans, have been associated with several health outcomes. To offer insight into their possible biologic effects, we evaluated the metabolomic correlates of circulating PFOS and PFOA among 3,647 participants in eight nested case-control serum metabolomic profiling studies from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial...
September 9, 2023: Environment International
https://read.qxmd.com/read/37569540/phytochemicals-and-vitamin-d-for-a-healthy-life-and-prevention-of-diseases
#17
REVIEW
Kazuki Santa, Kenji Watanabe, Yoshio Kumazawa, Isao Nagaoka
A variety of phytocompounds contained in medical plants have been used as medication, including Kampo (traditional Japanese) medicine. Phytochemicals are one category of the chemical compounds mainly known as antioxidants, and recently, their anti-inflammatory effects in preventing chronic inflammation have received much attention. Here, we present a narrative review of the health-promotion and disease-prevention effects of phytochemicals, including polyphenols, the latter of which are abundant in onions, oranges, tea, soybeans, turmeric, cacao, and grapes, along with the synergetic effects of vitamin D...
July 29, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37549530/associations-of-25-hydroxyvitamin-d-status-and-vitamin-d-supplementation-use-with-mortality-due-to-18-frequent-cancer-types-in-the-uk-biobank-cohort
#18
JOURNAL ARTICLE
Sha Sha, Li-Ju Chen, Hermann Brenner, Ben Schöttker
BACKGROUND: Although the associations of serum 25-hydroxyvitamin D (25(OH)D) levels and vitamin D supplementation with total cancer mortality are well-known, evidence regarding the association of 25(OH)D and cancer site-specific mortality is predominantly limited to common cancer types, and most studies on vitamin D supplementation use have limitations on sample size and the adjustment of important confounding factors. METHODS: We used cause-specific Cox regression models adjusted for 48 covariates to assess the associations of vitamin D deficiency, insufficiency, and vitamin D supplementation use with mortality from any cancer and 18 specific cancers in 411,436 United Kingdom Biobank participants, aged 40-69 years...
July 17, 2023: European Journal of Cancer
https://read.qxmd.com/read/37468265/fgf23-related-hypophosphatemia-in-a-patient-with-small-cell-lung-cancer-a-case-report-and-literature-review
#19
JOURNAL ARTICLE
Hajime Kato, Soichiro Kimura, Maho Taguchi, Takashi Sunouchi, Yoshitomo Hoshino, Naoko Hidaka, Nadia Edvige Foligno, Minae Koga, Katsunori Manaka, Hiroyuki Tamiya, Masanori Kawakami, Hidenori Kage, Yoichi Yasunaga, Masaomi Nangaku, Noriko Makita, Nobuaki Ito
Although there are a few case reports of patients with small cell lung cancer developing hypophosphatemia, detailed information on this condition is scarce. A 52-year-old patient with advanced stage small cell lung cancer developed hypophosphatemia (1.1 mg/dL) during chemotherapy. A reduced level of the tubular reabsorption of phosphate concomitant with an inappropriately elevated level of fibroblast growth factor (FGF) 23 (48.4 pg/mL) was noted, leading to the diagnosis of FGF23-related hypophosphatemia. Laboratory data also showed hypercortisolemia with an elevated ACTH level and hyponatremia with an inappropriately unsuppressed level of antidiuretic hormone (ADH)...
July 20, 2023: Endocrine Journal
https://read.qxmd.com/read/37447163/metabolomic-analysis-of-vitamin-e-supplement-use-in-the-prostate-lung-colorectal-and-ovarian-cancer-screening-trial
#20
JOURNAL ARTICLE
Jungeun Lim, Hyokyoung G Hong, Stephanie J Weinstein, Mary C Playdon, Amanda J Cross, Rachael Stolzenberg-Solomon, Neal D Freedman, Jiaqi Huang, Demetrius Albanes
The effects of vitamin E supplementation on cancer and other chronic diseases are not clear. We compared the serum metabolomic profile of differing vitamin E dosages in order to re-examine the previously observed changes in a novel C22 lactone sulfate compound, androgenic steroids, and other metabolites. A total of 3409 women and men previously selected for metabolomics studies in the PLCO Cancer Screening Trial were included in this investigation. Serum metabolites were profiled using ultrahigh-performance liquid and gas chromatography/tandem mass spectrometry...
June 22, 2023: Nutrients
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