Makoto Sano, Ryota Takahashi, Hideaki Ijichi, Kazunaga Ishigaki, Tomoharu Yamada, Koji Miyabayashi, Gen Kimura, Suguru Mizuno, Hiroyuki Kato, Hiroaki Fujiwara, Takuma Nakatsuka, Yasuo Tanaka, Jinsuk Kim, Yohei Masugi, Yasuyuki Morishita, Mariko Tanaka, Tetsuo Ushiku, Yousuke Nakai, Keisuke Tateishi, Yukimoto Ishii, Hiroyuki Isayama, Harold L Moses, Kazuhiko Koike
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is the deadliest cancer. Cancer-associated thrombosis/thromboembolism (CAT), frequently observed in PDAC, is known as a poor prognostic factor. Here, we investigated the underlying mechanisms between PDAC and CAT, and performed a trial of therapeutic approach for PDAC using a genetically engineered mouse model, PKF ( Ptf1acre/+ ;LSL-KrasG12D/+ ;Tgfbr2flox/flox ). DESIGN: Presence of CAT in PKF mice was detected by systemic autopsy...
October 21, 2020: Gut