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Chlamydia vaccine

Huirong Zhang, Sangeevan Vellappan, M Matt Tang, Xiaofeng Bao, Huizhou Fan
Chlamydia is a common pathogen that can causes serious complications in the reproductive system and eyes. Lack of vaccine and other effective prophylactic measures coupled with the largely asymptomatic nature and unrare clinical treatment failure calls for development of new antichlamydials, particularly selective antichlamydials without adverse effects on humans and the beneficial microbiota. We previously reported that benzal-N-acylhydrazones (BAH) can inhibit chlamydiae without detectable adverse effects on host cells and beneficial lactobacilli that dominate the human vaginal microbiota among reproductive-age women...
2019: PloS One
Taylor B Poston, De'Ashia E Lee, Toni Darville, Wujuan Zhong, Li Dong, Catherine M O'Connell, Harold C Wiesenfeld, Sharon L Hillier, Gregory D Sempowski, Xiaojing Zheng
BACKGROUND: Chlamydia trachomatis can cause reproductive morbidities after ascending to the upper genital tract of women, and repeated infection can lead to worse disease. Data related to protective immune responses at the cervical mucosa that could limit chlamydial infection to the cervix and/or prevent reinfection inform vaccine approaches and biomarkers of risk. METHODS: We measured forty-eight cytokines in cervical secretions from women having chlamydial cervical infection alone (N=92) or both cervical and endometrial infection (N=68)...
March 1, 2019: Journal of Infectious Diseases
Karin Erneholm, Emma Lorenzen, Sarah Bøje, Anja Weinreich Olsen, Gregers Jungersen, Henrik E Jensen, Joseph P Cassidy, Peter Andersen, Jørgen S Agerholm, Frank Follmann
The development of a vaccine against genital chlamydia in women is advancing, and the evaluation of in situ immune responses following vaccination and challenge infections is crucial for development of a safe and protective vaccine. This study employs the sexually mature minipig model to characterize the genital in situ immune response to Chlamydia trachomatis infection in pigs previously immunized intramuscularly with UV-inactivated C. trachomatis serovar D (UV-SvD) adjuvanted/formulated with CAF01 adjuvant compared to a CAF01-alone control group...
2019: Frontiers in Microbiology
Samuel Phillips, Bonnie L Quigley, Peter Timms
Chlamydia is a major bacterial pathogen that infects humans, as well as a wide range of animals, including marsupials, birds, cats, pigs, cattle, and sheep. Antibiotics are the only treatment currently available, however, with high rates of re-infection, there is mounting pressure to develop Chlamydia vaccines. In this review, we analyzed how Chlamydia vaccine trials have developed over the past 70 years and identified where future trials need to be focused. There has been a strong bias toward studies targeting C...
2019: Frontiers in Microbiology
Howa Yeung, Kevin M Luk, Suephy C Chen, Brian A Ginsberg, Kenneth A Katz
Lesbian, gay, bisexual, and transgender (LGBT) persons face important health issues relevant to dermatologists. Men who have sex with men (MSM) are at higher risk of certain infectious diseases, including HIV, syphilis and other sexually transmitted diseases (STDs), methicillin-resistant Staphylococcus aureus infections, and invasive meningococcal disease, and might be at higher risk of non-infectious conditions, including skin cancer. Recommendations for preventive health care, including screening for HIV and other STDs, sexual health-related vaccinations, and HIV pre-exposure prophylaxis, differ for MSM compared with non-MSM...
March 2019: Journal of the American Academy of Dermatology
Penelope Gray, Tapio Luostarinen, Simopekka Vänskä, Tiina Eriksson, Camilla Lagheden, Irene Man, Johanna Palmroth, Ville N Pimenoff, Anna Söderlund-Strand, Joakim Dillner, Matti Lehtinen
Oncogenic non-vaccine human papillomavirus (HPV) types may conceivably fill the vacated ecological niche of the vaccine types. The likelihood of this may differ by the risk of acquiring HPV infections. We examined occurrence of HPV types among vaccinated and unvaccinated subgroups of 1992-1994 birth cohorts with differing acquisition risks up to 9 years post-implementation of HPV vaccination in 33 Finnish communities randomized to: Arm A (gender-neutral HPV16/18 vaccination), Arm B (girls-only HPV16/18 vaccination and hepatitis B-virus (HBV) vaccination of boys), and Arm C (gender-neutral HBV vaccination)...
February 5, 2019: International Journal of Cancer. Journal International du Cancer
Noussa R El Basha, Hala H Shaaban, Hassan A El Atroush, May M Sherif, Amani A El Kholy
Background: Atypical pathogen infections played an important role in community-acquired pneumonia (CAP) in children. Pathogen-specific clinical symptoms are often lacking, and it is difficult to detect atypical pathogens by culture methods. The use of multiplex polymerase chain reaction (PCR) methods enables testing for many pathogens simultaneously in a single analysis. Aim: To determine the role of atypical pathogens in children hospitalized with CAP. Patients and methods: This cross-sectional study was conducted throughout a 2-year period from August 2015 to September 2017...
2019: Journal of the Egyptian Public Health Association
Nakia S Clemmons, Nikki N Jordan, Alfonza D Brown, Erin M Kough, Laura A Pacha, Susan M Varner, Anthony W Hawksworth, Christopher A Myers, Joel C Gaydos
Introduction: Chlamydia pneumoniae (Cp) is a bacterium that causes pneumonia and other respiratory diseases. Fever may be present early but absent by time of presentation to clinic. Increases in X-ray-confirmed pneumonia (XCP) and laboratory-confirmed Cp infections were observed in new soldiers in training at Fort Leonard Wood (FLW), Missouri, early in 2014. These findings prompted a site assistance visit from the U.S. Army Public Health Command, Aberdeen Proving Ground, Maryland, with a review of available data and information to describe the outbreak, and inspections of barracks and training facilities and review of training practices to identify opportunities for interventions to reduce the risk of respiratory disease agent transmission...
January 23, 2019: Military Medicine
Sharon Nyari, Rosemary Booth, Bonnie L Quigley, Courtney A Waugh, Peter Timms
Chlamydia pecorum is responsible for causing ocular infection and disease which can lead to blindness in koalas (Phascolarctos cinereus). Antibiotics are the current treatment for chlamydial infection and disease in koalas, however, they can be detrimental for the koala's gastrointestinal tract microbiota and in severe cases, can lead to dysbiosis and death. In this study, we evaluated the therapeutic effects provided by a recombinant chlamydial major outer membrane protein (MOMP) vaccine on ocular disease in koalas...
2019: PloS One
Xiuli Luan, Bo Peng, Zhongyu Li, Lingli Tang, Chaoqun Chen, Lili Chen, Haiying Wu, Zhenjie Sun, Chunxue Lu
Previously we reported that recombinant Chlamydia muridarum macrophage infectivity potentiator (MIP) provided partial protection against C. muridarum genital tract infection in mice. On the other hand, Chlamydia trachomatis plasmid encoded Pgp3could induce the protection against C. muridarum air way infection. This study aimed to evaluate the immunogenicity of MIP and Pgp3 from C. trachomatis serovar D and further investigate whether MIP and Pgp3 provide cross-serovar protection against C. muridarum genital tract infection in mice...
December 5, 2018: Immunobiology
Malik Siddique Mahmood, Muhammad Asad Ullah, Hina Batool, Sana Batool, Naeem Mehmood Ashraf
Gonorrheal infections are the second most prevalent sexually transmitted diseases STDs in the USA populations after Chlamydia. These infections have now become an urgent problem to address because Neisseria gonorrhoeae is capable of developing resistance to multiple antibiotic classes. Infection with these antibiotic-resistant strains has become the major public health concern. Although extensive researches are ongoing to control its transmission and to develop the productive treatments against this pathogen, no effective vaccine could develop till now...
November 28, 2018: Molecular and Cellular Probes
Yumeng Li, Kang Zheng, Yuan Tan, Yating Wen, Chuan Wang, Qian Chen, Jian Yu, Man Xu, Manyi Tan, Yimou Wu
Chlamydia psittaci is an obligate intracellular pathogen with a broad host range that can lead to severe infectious disease by transferring from birds to humans. Vaccination has been considered the best way to prevent chlamydial infection; nevertheless, there is currently still no commercially available vaccine that can inhibit the spread of C. psittaci. In previous study, major outer membrane protein (MOMP) of C. psittaci was confirmed to be an appropriate candidate antigen for limiting C. psittaci respiratory infections in a murine model, and plasmid-encoded CPSIT_p6 also has functions similar to those of MOMP in our study...
November 23, 2018: Applied Microbiology and Biotechnology
P Spornraft-Ragaller, D Varwig-Janßen
BACKGROUND: Sexually transmitted infections (STI) are common worldwide and can cause impairment of fertility. In women pelvic inflammatory disease with subsequent tubal sterility is well-documented but the influence of STI on male fertility is still controversely discussed OBJECTIVE: The effects of various bacterial and viral STI on male fertility are discussed. MATERIAL AND METHODS: An evaluation of the international literature up to 30 April 2018 was carried out including studies on larger collectives from the Asiatic region...
December 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
Samik Datta, Catherine H Mercer, Matt J Keeling
BACKGROUND: Understanding the spread of sexually transmitted infections (STIs) in a population is of great importance to the planning and delivery of health services globally. The worldwide rise of HIV since the 1980's, and the recent increase in common STIs (including HPV and Chlamydia) in many countries, means that there is an urgent need to understand transmission dynamics in order to better predict the spread of such infections in the population. Unlike many other infections which can be captured by assumptions of random mixing, STI transmission is intimately linked to the number and pattern of sexual contacts...
2018: PloS One
K Laroucau, R Aaziz, F Vorimore, M F Menard, D Longbottom, G Denis
Chlamydia abortus is responsible for enzootic abortion (known as ovine enzootic abortion (OEA) and enzootic abortion of ewes (EAE)) in both sheep and goats and has major economic implications for the farming industry worldwide. A virulence-attenuated mutant strain of C. abortus (strain 1B) is currently commercially available as a live attenuated vaccine for immunization of sheep and goats in several European countries. Following an abortion storm in a French flock of 200 ewes that occurred two years after vaccination of 36 replacement ewes with the commercial 1B vaccine strain, the vaginal swabs of 3 vaccinated and 7 unvaccinated aborted ewes and 12 of the 13 dead fetuses were found to be positive for C...
November 2018: Veterinary Microbiology
Kathryn M Frietze, Rebeccah Lijek, Bryce Chackerian
Chlamydia trachomatis (Ct), the most common bacterial sexually transmitted infection (STI), leads to pelvic inflammatory disease, infertility, and ectopic pregnancy in women. In this Perspective, we discuss the successful human papillomavirus (HPV) vaccine as a case study to inform Ct vaccine efforts. Areas covered: The immunological basis of HPV vaccine-elicited protection is high-titer, long-lasting antibody responses in the genital tract which provides sterilizing immunity. These antibodies are elicited through parenteral administration of a subunit vaccine based on virus-like particles (VLPs) of HPV...
November 2018: Expert Review of Vaccines
Thomas M Lietman, Michael S Deiner, Catherine E Oldenburg, Scott D Nash, Jeremy D Keenan, Travis C Porco
BACKGROUND: In many infectious diseases, a core group of individuals plays a disproportionate role in transmission. If these individuals were effectively prevented from transmitting infection, for example with a perfect vaccine, then the disease would disappear in the remainder of the community. No vaccine has yet proven effective against the ocular strains of chlamydia that cause trachoma. However, repeated treatment with oral azithromycin may be able to prevent individuals from effectively transmitting trachoma...
October 2018: PLoS Neglected Tropical Diseases
Delia F Tifrea, Sukumar Pal, Christel Le Bon, Fabrice Giusti, Jean-Luc Popot, Melanie J Cocco, Manuela Zoonens, Luis M de la Maza
INTRODUCTION: Chlamydial infections are spread worldwide and a vaccine is needed to control this pathogen. The goals of this study were to determine if the delivery of an adjuvant associated to the antigen, via a derivatized amphipol, and adjuvant combinations improve vaccine protection. METHODS: A novel approach, trapping the Chlamydia muridarum (Cm) native MOMP (nMOMP) with amphipols (A8-35), bearing a covalently conjugated peptide (EP67), was used. Adjuvants incorporated were: EP67 either conjugated to A8-35, which was used to trap nMOMP (nMOMP/EP67-A8-35), or free as a control, added to nMOMP/A8-35 complexes (nMOMP/A8-35+EP67); Montanide ISA 720 to enhance humoral responses, and CpG-1826 to elicit robust cell-mediated immunity (CMI)...
October 29, 2018: Vaccine
Ryosuke Omori, Hiam Chemaitelly, Christian L Althaus, Laith J Abu-Raddad
OBJECTIVES: To explore whether existence of long-lasting partial immunity against reinfection with Chlamydia trachomatis is necessary to explain C. trachomatis prevalence patterns by age and sexual risk, and to provide a plausible estimate for the effect size, defined here as a reduction in susceptibility to reinfection. METHODS: A population-based mathematical model was constructed to describe C. trachomatis natural history and transmission dynamics by age and sexual risk...
September 4, 2018: Sexually Transmitted Infections
Jasmine C Labuda, Stephen J McSorley
Chlamydia trachomatis is responsible for an increasing number of sexually transmitted infections in the United States and is a common cause of serious pathology in the female reproductive tract (FRT). Given the impact and incidence of these infections, the production of an effective Chlamydia vaccine is a public health priority. Mouse models of Chlamydia infection have been utilized to develop a detailed and mechanistic understanding of protective immunity in the FRT. These studies reveal that MHC class-II restricted Chlamydia-specific CD4 T cells are critical for primary bacterial clearance and provide effective protection against secondary infection in the FRT...
October 2018: Immunology Letters
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