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JOURNAL ARTICLE
Sung-Mok Jung, Sara L Loo, Emily Howerton, Lucie Contamin, Claire P Smith, Erica C Carcelén, Katie Yan, Samantha J Bents, John Levander, Jessi Espino, Joseph C Lemaitre, Koji Sato, Clifton D McKee, Alison L Hill, Matteo Chinazzi, Jessica T Davis, Kunpeng Mu, Alessandro Vespignani, Erik T Rosenstrom, Sebastian A Rodriguez-Cartes, Julie S Ivy, Maria E Mayorga, Julie L Swann, Guido España, Sean Cavany, Sean M Moore, T Alex Perkins, Shi Chen, Rajib Paul, Daniel Janies, Jean-Claude Thill, Ajitesh Srivastava, Majd Al Aawar, Kaiming Bi, Shraddha Ramdas Bandekar, Anass Bouchnita, Spencer J Fox, Lauren Ancel Meyers, Przemyslaw Porebski, Srini Venkatramanan, Aniruddha Adiga, Benjamin Hurt, Brian Klahn, Joseph Outten, Jiangzhuo Chen, Henning Mortveit, Amanda Wilson, Stefan Hoops, Parantapa Bhattacharya, Dustin Machi, Anil Vullikanti, Bryan Lewis, Madhav Marathe, Harry Hochheiser, Michael C Runge, Katriona Shea, Shaun Truelove, Cécile Viboud, Justin Lessler
BACKGROUND: Coronavirus Disease 2019 (COVID-19) continues to cause significant hospitalizations and deaths in the United States. Its continued burden and the impact of annually reformulated vaccines remain unclear. Here, we present projections of COVID-19 hospitalizations and deaths in the United States for the next 2 years under 2 plausible assumptions about immune escape (20% per year and 50% per year) and 3 possible CDC recommendations for the use of annually reformulated vaccines (no recommendation, vaccination for those aged 65 years and over, vaccination for all eligible age groups based on FDA approval)...
April 17, 2024: PLoS Medicine
#2
JOURNAL ARTICLE
Ursula Grazini, Aleksandra Markovets, Lucy Ireland, Daniel O'Neill, Benjamin Phillips, Man Xu, Matthias Pfeifer, Tereza Vaclova, Matthew J Martin, Ludovic Bigot, Luc Friboulet, Ryan Hartmaier, Maria Emanuela Cuomo, Simon T Barry, Paul D Smith, Nicolas Floc'h
PURPOSE: Osimertinib is an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) indicated for the treatment of EGFR mutated (EGFRm)-driven lung adenocarcinomas. Osimertinib significantly improves progression-free survival in first-line treated patients with EGFRm advanced NSCLC. Despite the durable disease control, the majority of patients receiving osimertinib eventually develop disease progression. EXPERIMENTAL DESIGN: ctDNA profiling analysis on-progression plasma samples from patients treated with osimertinib in both first (Phase 3, FLAURA trial) and second-line trials (Phase 3, AURA3 trial) revealed a high prevalence of PIK3CA/AKT/PTEN alterations...
April 17, 2024: Clinical Cancer Research
#3
JOURNAL ARTICLE
Lucy Gately, C Mesía, J M Sepúlveda, S Del Barco, E Pineda, R Gironés, J Fuster, M Dumas, S Gill, L M Navarro, A Herrero, A Dowling, R de Las Peñas, M A Vaz, M Alonso, Z Lwin, R Harrup, S Peralta, A Long, P Perez-Segura, E Ahern, C O Garate, M Wong, R Campbell, K Cuff, R Jennens, O Gallego, C Underhill, M Martinez-Garcia, M Covela, A Cooper, S Brown, M Rosenthal, J Torres, I M Collins, P Gibbs, C Balana
PURPOSE: The impact of age on optimal management of glioblastoma remains unclear. A recent combined analysis of two randomised trials, GEINO14-01 and EX-TEM, found no benefit from extending post-radiation temozolomide in newly diagnosed glioblastoma. Here, we explore the impact of age. METHODS: Relevant intergroup statistics were used to identify differences in tumour, treatment and outcome characteristics based on age with elderly patients (EP) defined as age 65 years and over...
April 17, 2024: Journal of Neuro-oncology
#4
JOURNAL ARTICLE
Ana Catalina Lara, Lucie Kotrbová, Moritz Keller, Imen Nouioui, Meina Neumann-Schaal, Yvonne Mast, Alica Chroňáková
The taxonomic position of three actinobacterial strains, BCCO 10_0061T , BCCO 10_0798T , and BCCO 10_0856T , recovered from bare soil in the Sokolov Coal Basin, Czech Republic, was established using a polyphasic approach. The multilocus sequence analysis based on 100 single-copy genes positioned BCCO 10_0061T in the same cluster as Lentzea waywayandensis , strain BCCO 10_0798T in the same cluster as Lentzea flaviverrucosa , Lentzea californiensis , Lentzea violacea , and Lentzea albidocapillata , and strain BCCO 10_0856T clustered together with Lentzea kentuckyensis and Lentzea alba ...
April 2024: International Journal of Systematic and Evolutionary Microbiology
#5
JOURNAL ARTICLE
Juliette Bougon, Eileigh Kadijk, Lucie Gallot-Lavallee, Bruce A Curtis, Matthew Landers, John M Archibald, Denys A Khaperskyy
Many viruses inhibit general host gene expression to limit innate immune responses and gain preferential access to the cellular translational apparatus for their protein synthesis. This process is known as host shutoff. Influenza A viruses (IAVs) encode two host shutoff proteins: nonstructural protein 1 (NS1) and polymerase acidic X (PA-X). NS1 inhibits host nuclear pre-messenger RNA maturation and export, and PA-X is an endoribonuclease that preferentially cleaves host spliced nuclear and cytoplasmic messenger RNAs...
April 17, 2024: Journal of Virology
#6
JOURNAL ARTICLE
Lucie Crhak Khaitova, Pavlina Mikulkova, Jana Pecinkova, Manikandan Kalidass, Stefan Heckmann, Inna Lermontova, Karel Riha
Heat stress is a major threat to global crop production, and understanding its impact on plant fertility is crucial for developing climate-resilient crops. Despite the known negative effects of heat stress on plant reproduction, the underlying molecular mechanisms remain poorly understood. Here, we investigated the impact of elevated temperature on centromere structure and chromosome segregation during meiosis in Arabidopsis thaliana . Consistent with previous studies, heat stress leads to a decline in fertility and micronuclei formation in pollen mother cells...
April 17, 2024: ELife
#7
JOURNAL ARTICLE
Jihyun Song, Lucie Lanikova, Soo Jin Kim, Nicolas Papadopoulos, Jessica Meznarich, Stefan N Constantinescu, Brynn Parsegov, Jaroslav F Prchal, Josef T Prchal
Polycythemia vera (PV) is a clonal disorder arising from the acquired somatic mutations of the JAK2 gene, including JAK2V617F or several others in exon 12. A 38-year-old female had a stroke at age 32 and found to have elevated hemoglobin, normal leukocytes, normal platelets, and tested negative for JAK2V617F and exon 12 mutations. Next generation sequencing revealed a novel mutation: JAK2R715T in the pseudokinase domain (JH2) at 47.5%. Its presence in her nail DNA confirmed a germline origin. Her mother and her son similarly had erythrocytosis and a JAK2R715T mutation...
April 17, 2024: American Journal of Hematology
#8
JOURNAL ARTICLE
Lucie Chastaingt, Marie Laure Toba, Carine Boulon, Loubna Dari, Joel Constans, Hela Daoud, Romain Chauvet, Caroline Adou, Julien Magne, Philippe Lacroix
<b/> Background: In the latest American Heart Association guidelines, influenza vaccination is recommended for patients with peripheral arterial disease (PAD). The vaccination coverage in this specific population is currently unknown. This study aims to determine the adherence to influenza vaccination in a PAD population and identify associated determinants. Patients and methods. Hospitalized patients and outpatients with PAD from two university departments of vascular medicine were prospectively included...
April 17, 2024: VASA. Zeitschrift Für Gefässkrankheiten
#9
JOURNAL ARTICLE
Stacy M Carter, Yves Saint James Aquino, Lucy Carolan, Emma Frost, Chris Degeling, Wendy A Rogers, Ian A Scott, Katy Jl Bell, Belinda Fabrianesi, Farah Magrabi
OBJECTIVE: To support a diverse sample of Australians to make recommendations about the use of artificial intelligence (AI) technology in health care. STUDY DESIGN: Citizens' jury, deliberating the question: "Under which circumstances, if any, should artificial intelligence be used in Australian health systems to detect or diagnose disease?" SETTING, PARTICIPANTS: Thirty Australian adults recruited by Sortition Foundation using random invitation and stratified selection to reflect population proportions by gender, age, ancestry, highest level of education, and residential location (state/territory; urban, regional, rural)...
April 17, 2024: Medical Journal of Australia
#10
JOURNAL ARTICLE
Ibrahim Aldoss, Jianying Zhang, Marjorie Robbins, Joo Song, Monzr M Al Malki, Salman Otoukesh, Karamjeet Sandhu, Vaibhav Agrawal, Alex F Herrera, Leslie L Popplewell, Lucy Ghoda, Anthony Stein, Guido Marcucci, Stephen Forman, Vinod Pullarkat
CD123 "expression" is common in hematological malignancies, including acute lymphoblastic leukemia (ALL). Flotetuzumab is a novel, investigational CD3/CD123 DART®. We conducted a phase 1 study evaluating safety and efficacy of flotetuzumab in relapsed/refractory ALL (Cohort A) and other advanced CD123-positive hematological malignancies (excluding myeloid malignancies) (cohort B). Thirteen patients (9 in Cohort A and 4 in Cohort B) were treated at dose level 1 (500 ng/kg/day) before early closure due to discontinuation of drug development by sponsor...
April 17, 2024: Leukemia & Lymphoma
#11
JOURNAL ARTICLE
Lucy W Maina, Gloria Chepngeno-Langat, Samuel M Mwangi
BACKGROUND AND OBJECTIVES: Policy and program interventions for older adults 60 years or older in Africa have consistently been undermined by a lack of vital data as they are usually excluded from nationally representative population surveys. The Health and Wellbeing of Older Persons in Kenya (HWOPs-1) study developed a standardized assessment questionnaire that can be used for periodic data generation. This study presents how the questionnaire was developed and examines its internal consistency and psychometric properties of the health module...
2024: Innovation in Aging
#12
JOURNAL ARTICLE
Lucie Troubat, Deniz Fettahoglu, Léo Henches, Hugues Aschard, Hanna Julienne
BACKGROUND: Approximately 95% of samples analyzed in univariate genome-wide association studies (GWAS) are of European ancestry. This bias toward European ancestry populations in association screening also exists for other analyses and methods that are often developed and tested on European ancestry only. However, existing data in non-European populations, which are often of modest sample size, could benefit from innovative approaches as recently illustrated in the context of polygenic risk scores...
April 17, 2024: BMC Genomics
#13
JOURNAL ARTICLE
Lucy J Martinez-Guerrero, Xiaohong Zhang, Stephen H Wright, Nathan J Cherrington
Organic anions (OA) are compounds including drugs or toxicants that are negatively charged at physiological pH and are typically transported by Organic Anion Transporters (OATs). Human OAT4 (SLC22A11) is expressed in the apical membrane of renal proximal tubules. Although there is no rodent ortholog of hOAT4, rodents express Oat5 (Slc22a19), an anion exchanger that is also localized to the apical membrane of renal proximal tubule cells. The purpose of this study was to determine the functional similarity between mouse Oat5 and human OAT4...
April 16, 2024: Journal of Pharmacology and Experimental Therapeutics
#14
JOURNAL ARTICLE
Courtney Sakolish, Haley L Moyer, Han-Hsuan D Tsai, Lucie C Ford, Allison N Dickey, Piyush Bajaj, Remi Villenave, Philip Hewitt, Stephen S Ferguson, Jason Stanko, Ivan Rusyn
In vitro models that can faithfully replicate critical aspects of kidney tubule function such as directional drug transport are in high demand in pharmacology and toxicology. Accordingly, development and validation of new models is underway. The objective of this study was to characterize physiological and transport functions of various sources of human renal proximal tubule epithelial cells (RPTECs). We tested TERT1-immortalized RPTEC, including OAT1-, OCT2- or OAT3-overexpressing variants, and primary RPTECs...
April 16, 2024: Drug Metabolism and Disposition: the Biological Fate of Chemicals
#15
JOURNAL ARTICLE
Matt Dawson, William Hage, Cristian Nita, Lucy Bell, Janice Gorman, Leon Jonker
PURPOSE: Investigate efficacy of reduced compression bandage for the control of pain after total knee arthroplasty. PATIENTS & METHODS: Prospective, single-centre, randomised controlled trial involving data for 56 out of 94 consented patients; 29 standard care versus 27 Andoflex TLC Calamine Lite. Comparison of standard care (non-compression bandage applied for up to one day) versus Andoflex TLC Calamine Lite (25-30 mmHg) two-layer compression bandage worn for five days...
April 5, 2024: International Journal of Orthopaedic and Trauma Nursing
#16
JOURNAL ARTICLE
Kelsey Julian, Lucy J Allbaugh
Objective: Drinking for emotion regulation may be a concern for college students who have experienced childhood maltreatment, due to high levels of shame and guilt. The present cross-sectional survey study tested how trait shame-proneness, trait guilt-proneness, and trauma-related guilt are differently related to drinking motives and how these pathways mediate the links between maltreatment severity and alcohol outcomes. Participants: Undergraduate student drinkers ( n = 464; M age = 19.50, SD = 2...
April 16, 2024: Journal of American College Health: J of ACH
#17
JOURNAL ARTICLE
Merran R Courtney, Ana Antonic-Baker, Zhibin Chen, Benjamin Sinclair, John-Paul Nicolo, Andrew Neal, Cassandra Marotta, Jacob Bunyamin, Meng Law, Patrick Kwan, Terence J O'Brien, Lucy Vivash
BACKGROUND AND OBJECTIVES: Although commonly used in the evaluation of patients for epilepsy surgery, the association between the detection of localizing 18 fluorine fluorodeoxyglucose PET (18 F-FDG-PET) hypometabolism and epilepsy surgery outcome is uncertain. We conducted a systematic review and meta-analysis to determine whether localizing 18 F-FDG-PET hypometabolism is associated with favorable outcome after epilepsy surgery. METHODS: A systematic literature search was undertaken...
May 14, 2024: Neurology
#18
JOURNAL ARTICLE
Autoimmunity Against Surfactant Protein B Is Associated with Pneumonitis During Checkpoint Blockade.
Nina Wyss, Fiamma Berner, Vincent Walter, Ann-Kristin Jochum, Mette T Purde, Marie-Therese Abdou, Tobias Sinnberg, Kathrin Hofmeister, Oltin T Pop, Omar Hasan Ali, Jens Bauer, Hung-Wei Cheng, Mechthild Lütge, Niklas Klümper, Stefan Diem, Zeynep Kosaloglu-Yalcin, Yizheng Zhang, Laura Sellmer, Boris Macek, Julia Karbach, David König, Heinz Läubli, Lars Zender, Britta S Meyer, Christoph Driessen, Christian M Schürch, Wolfram Jochum, Teresa Amaral, Lucie Heinzerling, Antonio Cozzio, Ahmed N Hegazy, Tino Schneider, Martin H Brutsche, Alessandro Sette, Tobias L Lenz, Juliane Walz, Hans-Georg Rammensee, Martin Früh, Elke Jäger, Burkhard Becher, Amanda Tufman, Nicolas Nuñez, Markus Joerger, Lukas Flatz
RATIONALE: Immune checkpoint inhibitor-related pneumonitis is a serious autoimmune event affecting up to 20% of patients with non-small cell lung cancer, yet the factors underpinning its development in some patients and not others are poorly understood. OBJECTIVES: To investigate the role of autoantibodies and autoreactive T cells against surfactant-related proteins in the development of pneumonitis. METHODS: The study cohort consisted of non-small cell lung cancer patients who gave blood samples before and during immune checkpoint inhibitor treatment...
April 16, 2024: American Journal of Respiratory and Critical Care Medicine
#19
JOURNAL ARTICLE
Lucy D'Agostino McGowan, Sarah C Lotspeich, Staci A Hepler
Missing data is a common challenge when analyzing epidemiological data, and imputation is often used to address this issue. Here, we investigate the scenario where a covariate used in an analysis has missingness and will be imputed. There are recommendations to include the outcome from the analysis model in the imputation model for missing covariates, but it is not necessarily clear if this recommendation always holds and why this is sometimes true. We examine deterministic imputation (i.e. single imputation with fixed values) and stochastic imputation (i...
April 16, 2024: Statistical Methods in Medical Research
#20
JOURNAL ARTICLE
Katerina Chudejova, Tsolaire Sourenian, Jana Palkovicova, Katarina Stredanska, Lucie Nechutna, Katerina Vlkova, Vendula Studentova, Jaroslav Hrabak, Costas C Papagiannitsis, Monika Dolejska, Ibrahim Bitar
A 2-year national genomic screening in the Czech Republic identified a notable prevalence of the New Delhi metallo-β-lactamase 5 (NDM-5)-producing Escherichia coli sequence type 38 (ST38) in the city of Brno. Forty-two ST38 E. coli isolates harbored the bla NDM-5 gene on the chromosome. Virulence factors confirmed the persistence of these isolates through biofilm formation. Single Nucleotide Polymorphisms (SNPs)-based phylogeny and CRISPR assay typing showed minimal genomic variations, implying a clonally driven outbreak...
April 16, 2024: Antimicrobial Agents and Chemotherapy
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