Ana María García-Marín, Irving Cancino-Muñoz, Manuela Torres-Puente, Luis M Villamayor, Rafael Borrás, María Borrás-Máñez, Montserrat Bosque, Juan J Camarena, Ester Colomer-Roig, Javier Colomina, Isabel Escribano, Oscar Esparcia-Rodríguez, Ana Gil-Brusola, Concepción Gimeno, Adelina Gimeno-Gascón, Bárbara Gomila-Sard, Damiana González-Granda, Nieves Gonzalo-Jiménez, María Remedio Guna-Serrano, José Luis López-Hontangas, Coral Martín-González, Rosario Moreno-Muñoz, David Navarro, María Navarro, Nieves Orta, Elvira Pérez, Josep Prat, Juan Carlos Rodríguez, María Montserrat Ruiz-García, Hermelinda Vanaclocha, Fernando González-Candelas, Victoria Furió, Iñaki Comas
BACKGROUND: In June, 2021, WHO published the most complete catalogue to date of resistance-conferring mutations in Mycobacterium tuberculosis. Here, we aimed to assess the performance of genome-based antimicrobial resistance prediction using the catalogue and its potential for improving diagnostics in a real low-burden setting. METHODS: In this retrospective population-based genomic study M tuberculosis isolates were collected from 25 clinical laboratories in the low-burden setting of the Valencia Region, Spain...
December 4, 2023: The Lancet. Microbe