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Catuaba Bark

Nadini Oliveira Martins, Isabella Modelli de Brito, Sandra Syomara O Araújo, Giuseppina Negri, Elisaldo de Araújo Carlini, Fúlvio Rieli Mendes
BACKGROUND: Trichilia catigua A. Juss. (Meliaceae) is a species known as catuaba and used in folk medicine for the treatment of fatigue, stress, impotence and memory deficit. The main phytochemical compounds identified in the barks of T. catigua are flavalignans, flavan-3-ols and flavonoids which are associated with its antioxidant activity. Pre-clinical studies with T. catigua extracts have identified many pharmacological properties, such as anti-inflammatory, antidepressant, antinociceptive, pro-memory and neuroprotective against ischemia and oxidative stress...
June 5, 2018: BMC Complementary and Alternative Medicine
João Bernardo, Federico Ferreres, Ángel Gil-Izquierdo, Romeu António Videira, Patrícia Valentão, Francisco Veiga, Paula B Andrade
ETHNOPHARMACOLOGICAL RELEVANCE: The bark of Trichilia catigua A. Juss. (Meliaceae), popularly known as "big catuaba", is traditionally used in Brazilian folk medicine for its neuroactive potential as memory stimulant, and antinociceptive and antidepressant effects. AIM OF THE STUDY: To study the aqueous extract of T. catigua bark as dual inhibitor of monoamine oxidase A (MAO-A) and acetylcholinesterase (AChE). To explore its antioxidant potential through interaction with xanthine/xanthine oxidase (X/XO) pathway, and to attempt a relationship between its phenolic profile and effects displayed...
January 30, 2018: Journal of Ethnopharmacology
Emerson F Queiroz, Boris Zanolari, Andrew Marston, David Guilet, Leila Burgener, Marçal de Queiroz Paulo, Kurt Hostettmann
Two new tropane alkaloid N-oxides substituted by a methylpyrrole moiety were isolated from the bark of Erythroxylum vacciniifolium Mart. (Erythroxylaceae), a Brazilian indigenous plant, locally known as catuaba and used in traditional medicine as an aphrodisiac. The alkaloid structures were determined by a combination of high resolution mass spectrometry and multi-dimensional NMR spectroscopy.
October 2009: Natural Product Communications
Cristina Daolio, Flávio L Beltrame, Antonio G Ferreira, Quezia B Cass, Diógenes Aparício Garcia Cortez, Márcia M C Ferreira
For over a century, Catuaba has been used in Brazilian folk medicine as an aphrodisiac even though the identity of the plant material employed is often uncertain. The species recommended by the Brazilian Pharmacopeia is Anemopaegma arvense (Bignoniaceae), but many other plants, regionally known as Catuaba, are commercialised. Frequently, the quality control of such a complex system is based on chemical markers that do not supply a general idea of the system. With the advent of the metabolomics approach, a global analysis of samples becomes possible...
May 2008: Phytochemical Analysis: PCA
Nurhayat Tabanca, Rahul S Pawar, Daneel Ferreira, Jannie P Marais, Shabana I Khan, Vaishali Joshi, David E Wedge, Ikhlas A Khan
One of the species of commercially available catuaba was identified as Anemopaegma arvense by comparison of its micromorphological characteristics and TLC profile with six species of authenticated plants that are commonly referred to as catuaba. The bioactivity-guided fractionation of the ethyl acetate extract of the stem bark of this catuaba sample resulted in the isolation of one new (1, catuabin A) and three known flavan-3-ol type phenylpropanoids, cinchonain Ia (2), cinchonain IIa (3), and kandelin A1 (4) with antioxidant activities...
August 2007: Planta Medica
Flávio Luís Beltrame, Edson Rodrigues Filho, Fabio A Proença Barros, Diógenes Aparíciogarcia Cortez, Quezia Bezerra Cass
The hydroalcoholic extract, prepared from authentic chopped barks of Trichilia catigua, was evaluated by high-performance liquid chromatography using a diode array detector (200-400 mn). The crude extract was purified by rotation locular counter-current chromatography and the chloroform fraction obtained was clean-up by solid-phase extraction. With the aim of getting preliminary structure information on-line, the methanol fraction thus obtained was analyzed by gradient elution using the diode array detector coupled to a mass spectrometer...
June 30, 2006: Journal of Chromatography. A
Boris Zanolari, David Guilet, Andrew Marston, Emerson F Queiroz, Marçal de Queiroz Paulo, Kurt Hostettmann
Nine new tropane alkaloids substituted by a methylpyrrole moiety were isolated from the bark of Erythroxylum vacciniifolium, a Brazilian endemic plant used in traditional medicine and locally known as catuaba. All compounds were elucidated as tropanediol or -triol alkaloids esterified by at least one 1-methyl-1H-pyrrole-2-carboxylic acid. One of the isolated compounds was identified as a tropane alkaloid N-oxide. Their structures were determined by high-resolution mass spectrometry and multidimensional NMR spectroscopy...
August 2005: Journal of Natural Products
Christa Kletter, Sabine Glasl, Armin Presser, Ingrid Werner, Gottfried Reznicek, Samdan Narantuya, Selim Cellek, Ernst Haslinger, Johann Jurenitsch
Fourteen commercial samples of the popular Brazilian aphrodisiac Catuaba specified as bark drugs of Anemopaegma, Erythroxylum and Trichilia species were examined for identity and purity. Only a minority of the examined Catuaba samples contained the crude drugs claimed on the labels. More than half of the products were adulterated with different crude drugs. The majority of the samples contained a bark originating from Trichilia catigua. The TLC fingerprints confirmed the heterogeneity, in 50% of the samples tropane alkaloids of various concentrations were detected...
October 2004: Planta Medica
B Zanolari, J L Wolfender, D Guilet, A Marston, E F Queiroz, M Q Paulo, K Hostettmann
The bark of catuaba (Erythroxylum vacciniifolium Martius, Erythroxylaceae), a tree native to the northern part of Brazil, was investigated for its alkaloid content. With the aim of obtaining preliminary structure information on-line, the alkaloid extract was analysed by high-performance liquid chromatography coupled to diode array UV detection, to mass spectrometry and to nuclear magnetic resonance. Interpretation of on-line spectroscopic data obtained from this extract led to structural elucidation of six new alkaloids and partial identification of 18 potentially original alkaloids bearing the same tropane skeleton esterified in positions 3 and 6 by 1-methyl-1H-pyrrol-2-carboxylic acid and/or 4-hydroxy-3,5-dimethoxybenzoic acid...
December 5, 2003: Journal of Chromatography. A
Boris Zanolari, David Guilet, Andrew Marston, Emerson F Queiroz, Marçal de Q Paulo, Kurt Hostettmann
Eight new tropane alkaloids (1-8) were isolated from the bark of "catuaba", a Brazilian endemic plant Erythroxylum vacciniifolium Martius. Their structures were determined by high-resolution mass spectrometry and multidimensional NMR spectroscopy.
April 2003: Journal of Natural Products
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