Peng Xiao, Xuechun Cai, Zhou Zhang, Ke Guo, Yuehai Ke, Ziwei Hu, Zhangfa Song, Yuening Zhao, Lingya Yao, Manlu Shen, Jingyun Li, Youling Huang, Lingna Ye, Lingjie Huang, Yu Zhang, Rongbei Liu, Mengque Xu, Xutao Xu, Yuan Zhao, Qian Cao
Most patients with inflammatory bowel disease (IBD) develop anemia, which is attributed to the dysregulation of iron metabolism. Reciprocally, impaired iron homeostasis also aggravates inflammation. How this iron-mediated, pathogenic anemia-inflammation crosstalk is regulated in the gut remains elusive. Herein, it is for the first time revealed that anemic IBD patients exhibit impaired production of short-chain fatty acids (SCFAs), particularly butyrate. Butyrate supplementation restores iron metabolism in multiple anemia models...
January 18, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)