Pouya Goleij, Mohammad Rahimi, Motahareh Pourshahroudi, Mohammad Amin Khazeei Tabari, Syed Muhammad, Richard Christian Suteja, Maria Daglia, Pantea Majma Sanaye, Mahboube Hadipour, Haroon Khan, Parniyan Sadeghi
BACKGROUND: The interleukin-2 (IL-2) family of cytokines, including IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21, are pivotal regulators of the immune response, impacting both innate and adaptive immunity. Understanding their molecular characteristics, receptor interactions, and signalling pathways is essential for elucidating their roles in health and disease. OBJECTIVES: This review provides a comprehensive overview of the IL-2 family of cytokines, highlighting their molecular biology, receptor interactions, and signalling mechanisms...
May 17, 2024: Cytokine