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Medications linked to causing crohn’s disease

Rahoma E Saad, Rima Shobar, Ece A Mutlu
Collagenous colitis is a relatively rare disorder affecting mainly middle-aged women where they present with chronic non-bloody diarrhea. Both with lymphocytic colitis they compose microscopic colitis. The exact cause of collagenous colitis is still unknown however; many potential pathophysiologic mechanisms have been proposed but no convincing mechanism has been identified. Collagenous colitis has been linked to medications mainly NSAIDs, SSRIs, and PPIs. It is also believed that collagenous colitis is autoimmune disease and there are weak believe it could have some genetic inheritance...
February 2019: Medical Hypotheses
Frida Danielsson, McKenzie Kirsten Peterson, Helena Caldeira Araújo, Franziska Lautenschläger, Annica Karin Britt Gad
Vimentin is a protein that has been linked to a large variety of pathophysiological conditions, including cataracts, Crohn's disease, rheumatoid arthritis, HIV and cancer. Vimentin has also been shown to regulate a wide spectrum of basic cellular functions. In cells, vimentin assembles into a network of filaments that spans the cytoplasm. It can also be found in smaller, non-filamentous forms that can localise both within cells and within the extracellular microenvironment. The vimentin structure can be altered by subunit exchange, cleavage into different sizes, re-annealing, post-translational modifications and interacting proteins...
September 21, 2018: Cells
Mark Bounthavong, Meng Li, Jonathan H Watanabe
BACKGROUND: Previous estimates of the economic burden of Crohn's disease (CD) varied widely from $2.0 to $18.2 billion per year (adjusted to 2015 $US). However, these estimates do not reflect recent changes in pharmaceutical treatment options and guidelines. OBJECTIVE: The goal of this study was to update cost estimates of Crohn's disease based on a representative sample of the US population from the most recent 11 years (2003-2013) of the Medical Expenditure Panel Survey (MEPS)...
May 2017: Research in Social & Administrative Pharmacy: RSAP
Coad Thomas Dow
Genetic linkage studies and genome wide analysis have provided insights into complex medical diseases. Mycobacterium avium ss. paratuberculosis (MAP) causes Johne's disease, an important enteric inflammatory disease mostly studied in ruminant animals. MAP is also the putative cause of Crohn's disease. Moreover, MAP has been linked to other inflammatory diseases: sarcoidosis, Blau syndrome, autoimmune diabetes, autoimmune thyroiditis and multiple sclerosis. Genetic studies reveal an association between Parkinson's disease (PD), leprosy and Crohn's disease and since discovered, these findings have been considered "surprising"...
December 2014: Medical Hypotheses
Jennifer Devlen, Kathleen Beusterien, Linnette Yen, Awais Ahmed, Adam S Cheifetz, Alan C Moss
BACKGROUND: The causes for nonadherence to mesalamine in patients with inflammatory bowel disease (IBD) have been characterized using mostly indirect methods. Patient-reported barriers are lacking in this population. OBJECTIVE: To identify patient-reported barriers to mesalamine adherence through direct interviews. METHODS: Focus groups and one-on-one interviews were undertaken in adult patients with IBD. Transcripts from the focus groups and interviews were analyzed to identify themes and links between these themes, assisted by qualitative data software MaxQDA...
March 2014: Journal of Managed Care & Specialty Pharmacy
Jennifer Devlen, Kathleen Beusterien, Linnette Yen, Awais Ahmed, Adam S Cheifetz, Alan C Moss
BACKGROUND: The aim of this study was to describe the impacts of inflammatory bowel disease (IBD) from the patients' perspective and to inform the development of a conceptual model. METHODS: Focus groups and one-on-one interviews were undertaken in adult patients with IBD. Transcripts from the focus groups and interviews were analyzed to identify themes and links between themes, assisted by qualitative data software MaxQDA. Themes from the qualitative research were supplemented with those reported in the literature and concepts included in IBD-specific patient-reported outcome measures...
March 2014: Inflammatory Bowel Diseases
Sreeram V Ramagopalan, Julia Pakpoor, Olena Seminog, Raph Goldacre, Lee Graham, Michael J Goldacre
BACKGROUND: Subarachnoid hemorrhage (SAH) is a devastating cause of stroke, occurring in relatively young people. It has been suggested that some immune-mediated diseases may be associated with an increased risk of SAH. METHODS: We analysed a database of linked statistical records of hospital admissions and death certificates for the whole of England (1999-2011). Rate ratios for SAH were determined, comparing immune-mediated disease cohorts with comparison cohorts...
2013: BMC Neurology
Chao Li, Robert S Flynn, John R Grider, Karnam S Murthy, John M Kellum, Homayoon Akbari, John F Kuemmerle
BACKGROUND: Strictures develop in >30% of patients affected with Crohn's disease. No available medication prevents stricture development in susceptible patients. In Crohn's strictures, but not adjacent normal intestine, TGF-β1 increases in muscularis smooth muscle, increasing collagen I production and strictures. Muscle cells express αVβ3 integrin containing an Arg-Gly-Asp (RGD) binding domain. The aim was to determine whether increased TGF-β1 levels in strictures were the result of latent TGF-β1, which contains an RGD sequence, binding to and activation by αVβ3; and whether cilengitide, which is an RGD-containing αVβ3 integrin inhibitor, decreases TGF-β1 activation and development of fibrosis in chronic 2,4,6 trinitrobenzene sulfonic acid (TNBS)-induced colitis...
December 2013: Inflammatory Bowel Diseases
Saranya A Selvaraj, Elizabeth Chairez, Lisa M Wilson, Mark Lazarev, Eric B Bass, Susan Hutfless
BACKGROUND: To identify demographic and clinical characteristics associated with cases of hepatosplenic T-cell lymphoma (HSTCL) in patients with Crohn's disease, and to assess strength of evidence for a causal relationship between medications and HSTCL in Crohn's disease. METHODS: We identified cases of HSTCL in Crohn's disease in studies included in a comparative effectiveness review of Crohn's disease medications, through a separate search of PubMed and Embase for published case reports, and from the Food and Drug Administration (FDA) Adverse Event Reporting System (AERS)...
2013: Systematic Reviews
Clare J Wotton, Michael J Goldacre
BACKGROUND: Invasive pneumococcal disease is a serious infection, and it is an important cause of morbidity and mortality in certain groups of 'at-risk' people. Those considered 'at-risk' in the UK include very young children, people aged 65 years and older and people with certain serious chronic diseases, asplenia or immunosuppression. There is little evidence about whether people with immune-mediated diseases are at increased risk of pneumococcal disease and therefore may benefit from pneumococcal vaccination...
December 2012: Journal of Epidemiology and Community Health
N A Kennedy, D N Clark, J Bauer, A M Crowe, A D Knight, R J Nicholls, J Satsangi
BACKGROUND: Although population-based studies of patients with Crohn's disease (CD) suggest only a modestly increased mortality, recent data have raised concerns regarding the outcome of CD patients requiring hospitalisation. AIM: To determine the mortality and contributory factors in 1595 patients hospitalised for CD in Scotland between 1998 and 2000. METHODS: The Scottish Morbidity Records database and linked datasets were used to assess longitudinal patient outcome, and to explore associations between 3-year mortality and age, sex, comorbidity, admission type and social deprivation...
January 2012: Alimentary Pharmacology & Therapeutics
A Pronio, A Di Filippo, F Pitasi, D Caporilli, A Vestri, C Montesani
OBJECTIVE: The pouch-related fistulas range in literature from 2% to 16% and they can be cause of failure of the intervention of restorative proctocolectomy. Aim of this study was to examine factors associated with theirs development and to identify theirs possible etiology and pathogenesis. MATERIALS AND METHODS: Retrospective study focusing on 100 consecutive patients who underwent restorative proctocolectomy with pouch-anal anastomosis (IPAA). Patients with fistula and patients without fistula have been identified and the fistula type, the time from surgery and the site relative to IPAA have been recorded...
2011: La Clinica Terapeutica
Elizabeth A Worthey, Alan N Mayer, Grant D Syverson, Daniel Helbling, Benedetta B Bonacci, Brennan Decker, Jaime M Serpe, Trivikram Dasu, Michael R Tschannen, Regan L Veith, Monica J Basehore, Ulrich Broeckel, Aoy Tomita-Mitchell, Marjorie J Arca, James T Casper, David A Margolis, David P Bick, Martin J Hessner, John M Routes, James W Verbsky, Howard J Jacob, David P Dimmock
PURPOSE: We report a male child who presented at 15 months with perianal abscesses and proctitis, progressing to transmural pancolitis with colocutaneous fistulae, consistent with a Crohn disease-like illness. The age and severity of the presentation suggested an underlying immune defect; however, despite comprehensive clinical evaluation, we were unable to arrive at a definitive diagnosis, thereby restricting clinical management. METHODS: We sought to identify the causative mutation(s) through exome sequencing to provide the necessary additional information required for clinical management...
March 2011: Genetics in Medicine: Official Journal of the American College of Medical Genetics
María J Etchevers, Ingrid Ordás Jiménez
Smoking is a chronic disease that causes a wide variety of health problems, especially respiratory and cardiovascular diseases. Tobacco smoking is the main environmental factor linked to the pathogenesis and clinical course of Crohn's disease. However, smoking cessation is often not included as part of the treatment of this disease. In the last decade, major advances have been made in our understanding of the physiopathology and treatment of nicotine addiction. Several medical resources are currently available, ranging from a brief warning in the consulting room out patient clinic to drug therapies aimed at nicotine receptors to achieve smoking cessation...
October 2009: Gastroenterología y Hepatología
H M Al Freihi
Refractory or intractable ulcer is defined as an ulcer that fails to heal completely after eight to twelve weeks, despite appropriate treatment with a modern antiulcer therapy in a compliant patient. Refractory ulcer should be suspected in individuals diagnosed to have peptic ulcer if their symptoms persist longer than usual: occurrence of complications or simply their ulcers fail to heal, since up to 25% of such patients remain asymptomatic. Conditions associated with refractory ulcer include noncompliance, continuous consumption of nonsteroidal anti-inflammatory drugs, acid hypersecretion, smoking...
May 1995: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
G Van Assche
Despite the progress in the treatment of Crohn's disease and ulcerative colitis, there is a dire need to improve the benefit to risk ration of clinical care for young patients with chronic diseases. Most of the effective therapies for IBD are immunosuppressants and carry a burden of toxicity. The present work has focused on improving the tolerance of medical therapy while preserving efficacy. We have demonstrated that a reduction of the i.v. cyclosporine dose to 2 mg/kg preserves clinical efficacy and opens the perspective to a reduced toxicity...
2008: Verhandelingen—Koninklijke Academie Voor Geneeskunde Van België
Robert Heuschkel, Camilla Salvestrini, R Mark Beattie, Hans Hildebrand, Thomas Walters, Anne Griffiths
Around 1 in 4 patients with inflammatory bowel disease (IBD) present in childhood, the majority around the time of their pubertal growth spurt. This presents challenges over and above those of managing IBD in adults as this period is a time of dramatic psychological and physical transition for a child. Growth and nutrition are key priorities in the management of adolescents and young adults with IBD. Growth failure in IBD is characterized by delayed skeletal maturation and a delayed onset of puberty, and is best described in terms of height-for-age standard deviation score (Z score) or by variations in growth velocity over a period of 3-4 months...
June 2008: Inflammatory Bowel Diseases
Alain M Schoepfer, Michael Trummler, Petra Seeholzer, Dominique H Criblez, Frank Seibold
PURPOSE: This study was designed to evaluate the accuracy of four different fecal markers in discriminating between irritable bowel syndrome, inflammatory bowel disease, and other forms of colitis and to examine the feasibility of collecting fecal samples in outpatients. METHODS: We prospectively included 20 patients with irritable bowel syndrome, 36 with inflammatory bowel disease (24 Crohn's disease, 12 ulcerative colitis), and 18 with other forms of colitis (8 infectious colitis, 5 ischemic colitis, 5 medication-induced colitis)...
October 2007: Diseases of the Colon and Rectum
David A van Heel, Karen A Hunt, Kathy King, Subrata Ghosh, Simon M Gabe, Christopher G Mathew, Alastair Forbes, Raymond J Playford
BACKGROUND AND AIMS: Crohn's disease is strongly associated with double mutations in NOD2/CARD15. Three common mutations (Arg702Trp, Gly908Arg, Leu1007fs) impair innate immune responses to bacterial muramyl dipeptide. Rare NOD2 variants occur, but it is difficult to both identify them and assess their functional effect. We assessed the true frequency of defective muramyl dipeptide sensing in Crohn's disease and developed a rapid diagnostic assay. MATERIALS AND METHODS: An ex vivo assay was established and validated based on muramyl dipeptide stimulation of peripheral blood mononuclear cell cytokine production...
July 2006: Inflammatory Bowel Diseases
J De Quatrebarbes, N Cordel, P Bravard, B Lenormand, P Joly
INTRODUCTION: Melkersson Rosenthal's syndrome is a rare disease that classically combines: orofacial edema, peripheral facial paralysis and a plicated tongue. Miescher's cheilitis represents the monosymptomatic form of the disease. Its etiopathogenesis is unknown. We report 2 cases of Miescher's cheilitis during which the discovery of a monoclonal lymphocyte expansion raised the question of an eventual link between these two diseases. CASE REPORTS: CASE No 1. A 30 Year-old man, without medical past history, had been followed up for 3 Years for Miescher's cheilitis...
January 2004: Annales de Dermatologie et de Vénéréologie
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