keyword
https://read.qxmd.com/read/38488566/relative-energy-deficiency-in-sport-reds-endocrine-manifestations-pathophysiology-and-treatments
#21
JOURNAL ARTICLE
Angeliki M Angelidi, Konstantinos Stefanakis, Sharon H Chou, Laura Valenzuela-Vallejo, Konstantina Dipla, Chrysoula Boutari, Konstantinos Ntoskas, Panagiotis Tokmakidis, Alexander Kokkinos, Dimitrios G Goulis, Helen A Papadaki, Christos S Mantzoros
Research on lean, energy-deficient athletic and military cohorts has broadened the concept of the Female Athlete Triad into the Relative Energy Deficiency in Sport (REDs) syndrome. REDs represents a spectrum of abnormalities induced by low energy availability (LEA), which serves as the underlying cause of all symptoms described within the REDs concept, affecting exercising populations of either biological sex. Both short- and long-term LEA, in conjunction with other moderating factors, may produce a multitude of maladaptive changes that impair various physiological systems and adversely affect health, well-being, and sport performance...
March 15, 2024: Endocrine Reviews
https://read.qxmd.com/read/38477252/nuclear-localization-signal-enhances-the-targeting-and-therapeutic-efficacy-of-a-porphyrin-based-molecular-cargo-a-systemic-in-vitro-and-ex-vivo-evaluation
#22
JOURNAL ARTICLE
Naveen Kumar, Amit K Sharma, Mohini Guleria, Sandeep B Shelar, Avik Chakraborty, Sutapa Rakshit, Soumi Kolay, Drishty Satpati, Tapas Das
The objective of the present work was to evaluate the potential of a nuclear localization signal (NLS) toward facilitating intracellular delivery and enhancement in the therapeutic efficacy of the molecular cargo. Toward this, an in-house synthesized porphyrin derivative, namely, 5-carboxymethyelene-oxyphenyl-10,15,20- tris (4-methoxyphenyl) porphyrin (UTriMA), was utilized for conjugation with the NLS sequence [PKKKRKV]. The three compounds synthesized during the course of the present work, namely DOTA-Lys-NLS, DOTA-UTriMA-Lys-NLS, and DOTA-Lys-UTriMA, were evaluated for cellular toxicity in cancer cell lines (HT1080), wherein all exhibited minimal dark toxicity...
March 13, 2024: Molecular Pharmaceutics
https://read.qxmd.com/read/38476959/the-roles-of-sex-hormones-in-the-pathophysiology-of-age-related-sarcopenia-and-frailty
#23
REVIEW
Tatsuya Hosoi, Mitsutaka Yakabe, Seiji Hashimoto, Masahiro Akishita, Sumito Ogawa
BACKGROUND: Sarcopenia is an age-related condition characterized by a progressive and systemic decline in skeletal muscle mass, quality, and strength. The incidence of sarcopenia contains sex-specific aspects, indicating the contribution of sex hormones to its pathophysiology. This review focuses on changing trends in sarcopenia, discusses alterations in definitions and diagnostic criteria, and emphasizes the association between sarcopenia and sex hormones. METHODS: A literature search was performed on PubMed for related articles published between 1997 and December 2023 using appropriate keywords...
2024: Reproductive Medicine and Biology
https://read.qxmd.com/read/38476877/opioid-use-disorder-a-qualitative-exploratory-analysis-of-potential-misunderstandings-in-patients-with-chronic-non-cancer-pain
#24
JOURNAL ARTICLE
Neele Kufeld, Klaus Weckbecker, Johannes Michalak, Winfried Häuser, Frank Petzke, Norbert Scherbaum, Michael Specka, Alexandra Schmidt, Alexandra Piotrowski, Christine Kersting, Johannes Maximilian Just
PURPOSE: Substance use disorders (SUD) are a challenging comorbidity in patients with chronic non-cancer pain (CNCP) as they complicate diagnosis and therapy, especially when opioids are part of the therapeutic regimen. A definite diagnosis of opioid use disorder (OUD) in patients with CNCP on long-term opioid therapy (LTOT) is a prerequisite for effective and targeted therapy but may be complicated as some criteria of OUD might be attributed to the desire of the patient to relieve the pain...
2024: Journal of Pain Research
https://read.qxmd.com/read/38476783/exploring-esketamine-s-therapeutic-outcomes-as-an-fda-designated-breakthrough-for-treatment-resistant-depression-and-major-depressive-disorder-with-suicidal-intent-a-narrative-review
#25
REVIEW
Suneeta Kumari, Hassan A Chaudhry, Adam Sagot, Stacy Doumas, Hussain Abdullah, Eric Alcera, Ramon Solhkhah, Saba Afzal
The expansive spectrum of major depressive disorder (MDD) continues to pose challenges for psychiatrists to treat effectively. Oral antidepressant (OAD) medications that alter monoamine neurotransmitters, mainly selective serotonin reuptake inhibitors (SSRIs) and selective norepinephrine reuptake inhibitors (SNRIs), have been the mainstay of therapy for decades. Although these drugs have been largely beneficial, a considerable subset of patients do not respond adequately to multiple conventional therapies administered for an appropriate length of time, leading to a diagnosis of treatment-resistant depression (TRD)...
February 2024: Curēus
https://read.qxmd.com/read/38476652/anti-ulcerative-colitis-effects-of-chemically-characterized-extracts-from-c-alliandra-haematocephala-in-acetic-acid-induced-ulcerative-colitis
#26
JOURNAL ARTICLE
Inaam Ur Rehman, Mohammad Saleem, Syed Atif Raza, Saher Bashir, Taha Muhammad, Shahzad Asghar, Muhammad Usman Qamar, Tawaf Ali Shah, Yousef A Bin Jardan, Amare Bitew Mekonnen, Mohammed Bourhia
Background: Ulcerative colitis is a chronic immune-mediated inflammatory bowel disease that involves inflammation and ulcers of the colon and rectum. To date, no definite cure for this disease is available. Objective: The objective of the current study was to assess the effect of Calliandra haematocephala on inflammatory mediators and oxidative stress markers for the exploration of its anti-ulcerative colitis activity in rat models of acetic acid-induced ulcerative colitis. Methods: Methanolic and n-hexane extracts of areal parts of the plant were prepared by cold extraction method...
2024: Frontiers in Chemistry
https://read.qxmd.com/read/38474369/pronecroptotic-therapy-using-ceramide-nanoliposomes-is-effective-for-triple-negative-breast-cancer-cells
#27
JOURNAL ARTICLE
Yuki Ohya, Yuri Ogiso, Masaya Matsuda, Harumi Sakae, Kentaro Nishida, Yasuhiro Miki, Todd E Fox, Mark Kester, Wataru Sakamoto, Takeshi Nabe, Kazuyuki Kitatani
Regulated necrosis, termed necroptosis, represents a potential therapeutic target for refractory cancer. Ceramide nanoliposomes (CNLs), considered potential chemotherapeutic agents, induce necroptosis by targeting the activating protein mixed lineage kinase domain-like protein (MLKL). In the present study, we examined the potential of pronecroptotic therapy using CNLs for refractory triple-negative breast cancer (TNBC), for which there is a lack of definite and effective therapeutic targets among the various immunohistological subtypes of breast cancer...
February 26, 2024: Cells
https://read.qxmd.com/read/38473734/sphingosine-prevents-rhinoviral-infections
#28
JOURNAL ARTICLE
Judith Lang, Matthias Soddemann, Michael J Edwards, Gregory C Wilson, Karl S Lang, Erich Gulbins
Rhinoviral infections cause approximately 50% of upper respiratory tract infections and novel treatment options are urgently required. We tested the effects of 10 μM to 20 μM sphingosine on the infection of cultured and freshly isolated human cells with minor and major group rhinovirus in vitro. We also performed in vivo studies on mice that were treated with an intranasal application of 10 μL of either a 10 μM or a 100 μM sphingosine prior and after infection with rhinovirus strains 1 and 2 and determined the infection of nasal epithelial cells in the presence or absence of sphingosine...
February 20, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473256/effect-of-clinical-complete-remission-following-neoadjuvant-pembrolizumab-or-chemotherapy-in-bladder-preservation-strategy-in-patients-with-muscle-invasive-bladder-cancer-declining-definitive-local-therapy
#29
JOURNAL ARTICLE
Pei-Hung Chang, Hung-Yi Chen, Yueh-Shih Chang, Po-Jung Su, Wen-Kuan Huang, Cheng-Feng Lin, Jason Chia-Hsun Hsieh, Chun-Te Wu
This study aimed to evaluate the outcomes and identify the predictive factors of a bladder-preservation approach incorporating maximal transurethral resection of bladder tumor (TURBT) coupled with either pembrolizumab or chemotherapy for patients diagnosed with muscle-invasive bladder cancer (MIBC) who opted against definitive local therapy. We conducted a retrospective analysis on 53 MIBC (cT2-T3N0M0) patients who initially planned for neoadjuvant pembrolizumab or chemotherapy after maximal TURBT but later declined radical cystectomy and radiotherapy...
February 23, 2024: Cancers
https://read.qxmd.com/read/38467922/-177-lu-lu-psma-617-as-first-line-systemic-therapy-in-patients-with-metastatic-castration-resistant-prostate-cancer-a-real-world-study
#30
JOURNAL ARTICLE
Swayamjeet Satapathy, Madhav Prasad Yadav, Sanjana Ballal, Ranjit Kumar Sahoo, Chandrasekhar Bal
PURPOSE: The use of [177 Lu]Lu-PSMA-617 radioligand therapy has become increasingly recognized as a viable therapeutic approach for patients in the advanced stages of metastatic castration-resistant prostate cancer (mCRPC). However, there is limited data regarding its effectiveness and safety in earlier lines. This study aims to present our institution's experience with [177 Lu]Lu-PSMA-617 as a first-line systemic therapy for mCRPC. METHODS: We collected and analyzed data from consecutive mCRPC patients who underwent first-line treatment with [177 Lu]Lu-PSMA-617 at our center from 2015 to 2023...
March 12, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38465266/integrated-network-pharmacology-and-in-vivo-experimental-validation-approach-to-explore-the-potential-antioxidant-effects-of-annao-pingchong-decoction-in-intracerebral-hemorrhage-rats
#31
JOURNAL ARTICLE
Xuqing Zhou, Xu Wang, Jiaqi Li, Mengxue Zhang, Yi Yang, Shihui Lei, Ying He, Hua Yang, Desheng Zhou, Chun Guo
BACKGROUND: Annao Pingchong decoction (ANPCD) is a traditional Chinese decoction which has definite effects on treating intracerebral hemorrhage (ICH) validated through clinical and experimental studies. However, the impact of ANPCD on oxidative stress (OS) after ICH remains unclear and is worth further investigating. AIM: To investigate whether the therapeutic effects of ANPCD on ICH are related to alleviating OS damage and seek potential targets for its antioxidant effects...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38459984/assessing-the-effect-of-absorbable-steroid-sinus-implant-a-state-of-the-art-systematic-review
#32
REVIEW
Christian Calvo-Henriquez, Ainhoa García-Lliberós, Serafin Sánchez-Gómez, Isam Alobid
OBJECTIVES: Endoscopic sinus surgery is not a definitive treatment for chronic rhinosinusitis (CRS). The use of sinus stents after surgery to maintain sinus patency and deliver local steroids has gained popularity. The first steroid-eluting bioabsorbable implant (SEBI) approved for this indication, later Propel, was developed in 2011. This state-of-the-art review aims to summarize the available evidence, as well as to point out potential pitfalls and lack of specific analyses to guide future research on this new therapeutic option...
March 9, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38459381/role-of-hyperbaric-oxygen-in-filler-induced-vascular-occlusion
#33
REVIEW
Javier Madero, Manolo Salvador, Jonathan Kadouch, Cristina Muñoz-Gonzalez, Nabil Fakih-Gomez
INTRODUCTION: The rising incidence of filler-induced vascular complications in the context of aesthetic procedures necessitates a thorough assessment of therapeutic options. Hyperbaric oxygen therapy (HBOT) has emerged as a potential intervention for filler-induced vascular occlusion (FIVO), although optimal dosing and timing remain undefined. METHODS: This review explores the pathophysiology of FIVO and elucidates HBOT's multifaceted role in salvaging ischemic tissue...
March 8, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38457424/five-year-clinical-outcomes-of-scanning-carbon-ion-radiotherapy-for-prostate-cancer
#34
JOURNAL ARTICLE
Yosuke Takakusagi, Hiroaki Koge, Kio Kano, Satoshi Shima, Keisuke Tsuchida, Nobutaka Mizoguchi, Daisaku Yoshida, Tadashi Kamada, Hiroyuki Katoh
BACKGROUND: Carbon-ion radiotherapy (CIRT) has been associated with favorable clinical outcomes in patients with prostate cancer. At our facility, all patients are treated using scanning CIRT (sCIRT). We retrospectively analyzed five-year clinical outcomes of prostate cancer treated with sCIRT to investigate treatment efficacy and toxicity. METHODS: In this study, we included 253 consecutive prostate cancer patients treated with sCIRT at the Kanagawa Cancer Center from December 2015 to December 2017...
2024: PloS One
https://read.qxmd.com/read/38450517/next-generation-strategies-to-improve-safety-and-efficacy-of-adeno-associated-virus-based-gene-therapy-for-hemophilia-lessons-from-clinical-trials-in-other-gene-therapies
#35
JOURNAL ARTICLE
Giovanni Di Minno, Wolfgang Miesbach, Giancarlo Castaman, Flora Peyvandi
Three major directions for the global progress of adeno-associated virus (AAV) vectors for gene therapies (GT) are analyzed: a) engineering vectors to increase transgene expression; b) aligning interests of the health system with costs and challenges for pharmaceutical industry; c) refining patient eligibility criteria, and endpoints definition. Currently employed AAV vectors may cause toxicity and adverse events. Furthermore, studies in animals do not fully predict risks and clinical benefits of AAV-based GT, and animal models reflecting the heterogeneity of certain clinical settings (e...
March 7, 2024: Haematologica
https://read.qxmd.com/read/38449295/abflex-designing-antibody-complementarity-determining-regions-with-flexible-cdr-definition
#36
JOURNAL ARTICLE
Woosung Jeon, Dongsup Kim
MOTIVATION: Antibodies are proteins that the immune system produces in response to foreign pathogens. Designing antibodies that specifically bind to antigens is a key step in developing antibody therapeutics. The complementarity determining regions (CDRs) of the antibody are mainly responsible for binding to the target antigen, and therefore must be designed to recognize the antigen. RESULTS: We develop an antibody design model, AbFlex, that exhibits state-of-the-art performance in terms of structure prediction accuracy and amino acid recovery rate...
March 6, 2024: Bioinformatics
https://read.qxmd.com/read/38448389/discovery-of-6-acylamino-sulfonamido-benzoxazolone-with-il-6-inhibitory-activity-as-promising-therapeutic-agents-for-ulcerative-colitis
#37
JOURNAL ARTICLE
Re Ge, Jiaqi Song, Zhen Cao, Shurong Ban, Li Tang, Qingshan Li
Ulcerative colitis has been widely concerned for its persistent upward trend and sustained overproduction of pro-inflammatory cytokines such as IL-6 remains a crucial factor in UC development. Therefore, identification of new effective drugs to block inflammatory responses is an urgent and viable strategy for UC. In our research, twenty-three 6-acylamino/sulfonamido benzoxazolone derivatives were synthesized, characterized, and evaluated for anti-inflammatory activity against NO and IL-6 in LPS-induced RAW264...
March 6, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38446584/mir-26a-5p-inhibits-the-proliferation-of-psoriasis-like-keratinocytes-in-vitro-and-in-vivo-by-dual-interference-with-the-cdc6-ccne1-axis
#38
JOURNAL ARTICLE
Jianing Li, Daxin Pang, Lin Zhou, Hongsheng Ouyang, Yaping Tian, Hao Yu
Psoriasis is a chronic inflammatory proliferative dermatological ailment that currently lacks a definitive cure. Employing data mining techniques, this study identified a collection of substantially downregulated miRNAs (top 10). Notably, 32 targets were implicated in both the activation of the IL-17 signaling pathway and cell cycle dysregulation. In silico analysis revealed that one of these miRNAs, miR-26a-5p, is a highly conserved cross-species miRNA. Strikingly, the miR-26a-5p sequences in humans and mice are identical, and mmu-miR-26a-5p was found to target the same 7 cell cycle targets as its human counterpart, hsa-miR-26a-5p...
March 5, 2024: Aging
https://read.qxmd.com/read/38445118/small-bowel-obstruction-due-to-abdominal-cocoon-syndrome-in-post-covid-19-patients
#39
JOURNAL ARTICLE
Mohammad Aboelnaga, Mohamed S Elkadi, Islam E Abdelhady, Yomna H Elwan
BACKGROUND: Abdominal cocoon syndrome, also recognized as encapsulating peritoneal sclerosis, is an exceedingly rare medical condition characterized by an anomalous membranous envelopment of the small bowel. Despite its clinical rarity, the precise etiology and pathogenic mechanisms of this syndrome remain elusive. METHODS: This comprehensive discussion presents a case series encompassing six patients who sought medical attention in the Emergency Room, all sharing a common presentation: severe abdominal distension and persistent constipation...
February 2024: Curēus
https://read.qxmd.com/read/38444673/connecting-atrial-fibrillation-to-digestive-neoplasms-exploring-mediation-via-ischemic-stroke-and-heart-failure-in-mendelian-randomization-studies
#40
JOURNAL ARTICLE
Zhijie Xu, Xuezhi Rao, Yaxuan Xing, Zhiwei Zhu, Longmei Yan, Jian Huang, Jingchun Zhang, Ruwen Zheng
BACKGROUND: Notwithstanding the acknowledged interplay between atrial fibrillation (AF) and the emergence of digestive system neoplasms, the intricacies of this relationship remain ambiguous. By capitalizing univariable Mendelian Randomization (MR) complemented by a mediated MR tactic, our pursuit was to elucidate the causative roles of AF in precipitating digestive system malignancies and potential intermediary pathways. METHOD: This research endeavor seeks to scrutinize the causal clinical implications of whether genetic predispositions to AF correlate with an increased risk of digestive system malignancies, employing MR analytical techniques...
2024: Frontiers in Oncology
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