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W M Dong, J M Lu, J G Zhu, J H Ye, Y F Feng, H C He
Objective: To investigate the effect of G protein-coupled estrogen receptor (GPER) on proliferation and autophagy in prostatic epithelial cells. Methods: Cell Counting Kit-8 (CCK8) assay was used to observe the growth of BPH-1 and RWPE-1 cells after treating with or not with estradiol or GPER selective agonist G1. Autophagy was quantified with Western blot and Cyto-ID autophagy detection kit after treating with estradiol, G1 or both G1 and G15 in the same cells. Results: The OD value in estrogen group and G1 group was significantly lower than those in control group ( P< 0...
February 12, 2019: Zhonghua Yi Xue za Zhi [Chinese medical journal]
A Makvandi, R Kowsar, M Hajian, A H Mahdavi, N Tanhaei Vash, M H Nasr-Esfahani
BACKGROUND: Reproductive toxicity of lipopolysaccharide (LPS) on spermatozoa is well established. OBJECTIVE: The aim of the present study was to show the potential benefits of alpha lipoic acid (ALA) as a strong antioxidant in alleviating the reproductive toxicity of LPS. MATERIALS AND METHODS: Sperm cells and cumulus-oocyte complexes (COCs) were collected from healthy NMRI mice (body weights ranged from 25 to 35 g, 100 females and 200 males)...
February 20, 2019: Andrology
Kai Yao, Zhanwei Xu, Jianfeng Huang, Meng Ma, Licai Fu, Xuetao Shen, Jia Li, Maosen Fu
Molybdenum disulfide (MoS2 ), a 2D-layered compound, is regarded as a promising anode for sodium-ion batteries (SIBs) due to its attractive theoretical capacity and low cost. The main challenges associated with MoS2 are the low rate capability suffering from the sluggish kinetics of Na+ intercalation and the poor cycling stability owning to the stack of MoS2 sheets. In this work, a unique architecture of bundled defect-rich MoS2 (BD-MoS2 ) that consists of MoS2 with large vacancies bundled by ultrathin MoO3 is achieved via a facile quenching process...
February 20, 2019: Small
Rafael Rodríguez, Emilio Quiñoá, Ricardo Riguera, Félix Freire
Interconversion between extended and bent structures at the pendant groups of a chiral polyene framework [poly(phenylacetylene) with (R)-(2-methoxy-2-phenylacetyl)glycine residues linked to 4-vinylanilines] allows the reversible colorimetric transformation from stretched to compressed helical cis-transoid polyenic structures through manipulation of the flexible spacer. This transformation generates either organogels (stretched helical form) or nanoparticles (compressed helical form) under the control of polar/low polar stimuli respectively and opens the way to the development of new sensors and stimuli-sensitive materials based on these concepts...
February 20, 2019: Small
Dana Kaizerman-Kane, Maya Hadar, Noam Tal, Roman Dobtovetsky, Yossi Zafrani, Yoram Cohen
We describe the preparation of the first water-soluble pH-responsive supramolecular hexagonal boxes (SHBs) based on multiple charge-assisted hydrogen bonds between peramino-pillar[6]arenes 2 with the molecular "lid" mellitic acid (1a). The interaction between 2 and 1a, as well as the other "lids" pyromellitic and trimesic acids (1b and 1c, respecively) were studied by a combination of experimental and computational methods. Interestingly, the addition of 1a to the complexes of the protonated form of pillar[6]arene 2, i...
February 20, 2019: Angewandte Chemie
Xiaolan Liu, Wenwen Fan, Zhixiang Lu, Yu Qin, Shaoxiong Yang, Yuan Li, Yanxiong Liu, Qiue Cao, Li-Yan Zheng
During the last decade, the controllable reversible phase transition of functional materials has received growing interest, showing unique performances for various technological applications. Although many metal-organic frameworks (MOFs) possess lamellar structure, the reversible structural transformation of MOFs between three-dimensional (3D) phase and two-dimensional (2D) phase remains a largely unexplored area. Herein, we report for the first time a europium MOFs with unprecedented reversible morphology in the different solvent at room temperature...
February 20, 2019: Chemistry: a European Journal
Mingxing Chen, Hui Shen, Linlin Zhu, Hongfeng Yang, Peng Ye, Pengfei Liu, Yue Gu, Shaoliang Chen
Hypoxia-induced excessive pulmonary artery smooth muscle cell (PASMC) proliferation plays an important role in the pathology of pulmonary arterial hypertension (PAH). Berberine (BBR) is reported as an effective antiproliferative properties applied in clinical. However, the effect of BBR on PAH remains unclear. In the present study, we elucidated the protective effects of BBR against abnormal PASMC proliferation and vascular remodeling in chronic hypoxia-induced hearts. Furthermore, the potential mechanisms of BBR were investigated...
February 20, 2019: Journal of Cellular Physiology
David S Schade, R Philip Eaton
CLINICAL ISSUE: Cardiovascular disease remains the number one cause of morbidity and mortality in the United States despite major advances in our understanding of its pathogenesis and prevention. One reason for this continued epidemic is the poor adherence to treatment guidelines by caregivers and the lack of understanding by patients relative to its reversibility with treatment. Current guidelines are complex and often contradictory as there are at least 21 organizations publishing guidelines...
February 20, 2019: Journal of Clinical Endocrinology and Metabolism
Daniel Vigo, Laura Jones, Daniel E Maidana, Michael Krausz, Devora Kestel
The objective of this study is to provide an estimate of the burden of disease related to mental health in Argentina, in order to provide elements for the rational prioritization of resource allocation and the development of services. Based on the estimations made by the Study of the Global Burden of Disease (1) we add an analysis of the load product of: a) self-injuries and suicide; b) common neurological disorders with severe psychological and behavioral manifestations; c) somatic consequences of alcohol use disorder; and iv) an estimate of the disorder by somatic symptoms with prominent pain...
November 2018: Vertex: Revista Argentina de Psiquiatriá
Victor Simon, Carole Hyacinthe, Sylvie Rétaux
Fish reproductive patterns are very diverse in terms of breeding frequency, mating system, sexual dimorphisms and selection, mate choice, spawning site choice, courtship patterns, spawning behaviors and parental care. Here we have compared the breeding behavior of the surface-dwelling and cave-dwelling morphs of the characiform A. mexicanus, with the goals of documenting the spawning behavior in this emerging model organism, its possible evolution after cave colonization, and the sensory modalities involved...
2019: PloS One
Yuan Qiu, Suchun Wang, Baoxu Huang, Huanxiang Zhong, Zihao Pan, Qingye Zhuang, Cheng Peng, Guangyu Hou, Kaicheng Wang
With rapidly increasing animal pathogen surveillance requirements, new technologies are needed for a comprehensive understanding of the roles of pathogens in the occurrence and development of animal diseases. We applied metagenomic technology to avian virus surveillance to study the main viruses infecting six poultry farms in two provinces in eastern China. Cloacal/throat double swabs were collected from 60 birds at each farm according to a random sampling method. The results showed that the method could simultaneously detect major viruses infecting farms, including avian influenza virus, infectious bronchitis virus, Newcastle disease virus, rotavirus G, duck hepatitis B virus, and avian leukemia virus subgroup J in several farms...
2019: PloS One
Meng Wang, Ji Hu, Linling Yan, Yeping Yang, Min He, Meng Wu, Qin Li, Wei Gong, Yang Yang, Yi Wang, Diane E Handy, Bin Lu, Chuanming Hao, Qinghua Wang, Yiming Li, Ronggui Hu, Robert C Stanton, Zhaoyun Zhang
Oxidative stress contributes substantially to podocyte injury, which plays an important role in the development of diabetic kidney disease. The mechanism of hyperglycemia-induced oxidative stress in podocytes is not fully understood. Glucose-6-phosphate dehydrogenase (G6PD) is critical in maintaining NADPH, which is an important cofactor for the antioxidant system. Here, we hypothesized that high glucose induced ubiquitination and degradation of G6PD, which injured podocytes by reactive oxygen species (ROS) accumulation...
February 20, 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Latarsha J Carithers, Rachana Agarwal, Ping Guan, Hana Odeh, Michael C Sachs, Kelly B Engel, Sarah R Greytak, Mary Barcus, Conrado Soria, Chih-Jian Jason Lih, P Mickey Williams, Philip A Branton, Leslie Sobin, Benjamin Fombonne, Therese Bocklage, Chris Andry, Elizabeth R Duffy, Gabriel Sica, Rajiv Dhir, Scott Jewell, Nancy Roche, Helen M Moore
CONTEXT.—: Despite widespread use of formalin-fixed, paraffin-embedded (FFPE) tissue in clinical and research settings, potential effects of variable tissue processing remain largely unknown. OBJECTIVE.—: To elucidate molecular effects associated with clinically relevant preanalytical variability, the National Cancer Institute initiated the Biospecimen Preanalytical Variables (BPV) program. DESIGN.—: The BPV program, a well-controlled series of systematic, blind and randomized studies, investigated whether a delay to fixation (DTF) or time in fixative (TIF) affects the quantity and quality of DNA and RNA isolated from FFPE colon, kidney, and ovarian tumors in comparison to case-matched snap-frozen controls...
February 20, 2019: Archives of Pathology & Laboratory Medicine
Robert G T Blokpoel, Diana W Wolthuis, Alette A Koopman, Martin C J Kneyber
No abstract text is available yet for this article.
February 20, 2019: American Journal of Respiratory and Critical Care Medicine
Mayuko Isomura, David A Petrone, Erick M Carreira
The inherent difficulty in eliciting facial control over carbocations has limited their utility as intermediates in asymmetric catalysis. We have now shown that a docking strategy involving the reversible coordination of a substrate to a chiral transition metal catalyst can be used to enable highly stereoselective nucleophilic attack on intermediate tertiary carbocations. This approach has been implemented to achieve the first example of enantioselective reductive deoxygenation of tertiary alcohols. This reduction occurs with high enantio- (up to 96% ee) and regioselectivity (up to >50:1 rr) by applying a novel Hantzsch ester analog as a convenient hydride source...
February 20, 2019: Journal of the American Chemical Society
Xueyun Li, Bo Li, Mingchen Liu, Yufeng Zhou, Liyuan Zhang, Xiaoqiang Qiao
Stationary phases with mixed-mode mechanisms emerge as a hot research topic. In the present research, monodisperse core-shell UiO-67@SiO2 materials were prepared and further served as the packed column for mixed-mode hydrophilic interaction liquid chromatography/reversed-phase liquid chromatography. The developed UiO-67@SiO2 materials were characterized via thermogravimetric analysis, scanning electron microscopy, X Ray Powder diffraction as well as FT-IR techniques. The developed UiO-67@SiO2 column shows flexible selectivity for separation of both hydrophobic (anilines, alkylbenzenes, polycyclic aromatic hydrocarbons) and hydrophilic (thioureas) compounds...
February 20, 2019: ACS Applied Materials & Interfaces
Xing Ou, Liang Cao, Xinghui Liang, Fenghua Zheng, Hong-Sheng Zheng, Xianfeng Yang, Jeng-Han Wang, Chenghao Yang, Meilin Liu
SnS2 has been extensive studied as an anode material for sodium storage owing to its high theoretical specific capacity, whereas, the unsatisfied initial coulombic efficiency (ICE) caused by the partial irreversible conversion reaction during the charge/discharge process is one of the critical issues that hamper its practical applications. Hence, heterostructured SnS2/Mn2SnS4/carbon nanoboxes (SMS/C NBs) have been developed by a facial wet-chemical method and utilized as the anode material of SIBs. SMS/C NBs can deliver an initial capacity of 841...
February 20, 2019: ACS Nano
Juliana Arrais Guerra, Kátia Cristina Kampa, Maurício Zapparoli, Venâncio Af Alves, Cláudia Alexandra Pontes Ivantes
The disease and the case reported here are relevant especially because of their varied clinical presentation, possibility of being associated with other disorders affecting several organs and possible differential diagnoses. Congenital Hepatic Fibrosis is an autosomal recessive disease due to mutation in the PKHD1 gene, which encodes the fibrocystin/polyductine protein. It is a cholangiopathy, characterized by varying degrees of periportal fibrosis and irregular proliferation of bile ducts. Affected patients are typically diagnosed in childhood, but in some cases the disease may remain asymptomatic for many years...
October 2018: Arquivos de Gastroenterologia
Qingwen Li, Shanshan Cui, Guoqing Jing, Huang Ding, Zhongyuan Xia, Xianghu He
PURPOSE: To investigate the role of PI3k/Akt signal pathway in the protective effects of propofol on intestinal and lung injury induced by intestinal ischemia/reperfusion(I/R). METHODS: Male Sprague-Dawley rats were subjected to 45 min of ischemia by occluding the superior mesenteric artery and to 2h of reperfusion to establish the model of I/R. Twenty four rats were randomly divided into four groups: Sham, intestinal I/R (II/R), propofol (P), wortmannin (W). In groups P, W, propofol was injected intravenously and continuously at the onset of reperfusion via infusion pump...
February 14, 2019: Acta Cirúrgica Brasileira
Yayi Huang, Fang Zhou, Chen Shen, Huaxin Wang, Yeda Xiao
PURPOSE: To investigate the influence of lycium barbarum polysaccharides (LBP), a functional derivative from lycium barbarum, on septic kidney injury. METHODS: The SD male rats were randomly divided into 8 groups. The concentration of IL-1β, IL-6, IL-8, TNF-α, NF-κB and ROS, in kidney cortex homogenates after 12 h treatments were determined by enzyme-linked immunosorbent assay and ROS test kit, respectively. Morphology observation of kidney tissue was conducted with HE staining...
February 14, 2019: Acta Cirúrgica Brasileira
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