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Keywords Quality of life in schizophren...

Quality of life in schizophrenia patients

https://read.qxmd.com/read/38532916/evaluation-of-oral-health-education-programs-among-patients-with-schizophrenia-in-india-an-interventional-study
#1
JOURNAL ARTICLE
Binu Purushothaman, Karishma, Akriti Agrawal, Jazib Nazeer, Basanta K Choudhury, Jagadish Prasad Rajguru, Irfanula Huda, Indrani Das
BACKGROUND: Schizophrenia is a mental disease that can drastically affect oral health. Hence, this remains a significant factor that affects oral health-related quality of life (OHRQoL). Assessing the OHRQoLin schizophrenic patients is one of the primary needs. The oral health impact profile is an impressive range of instruments that assesses the impact of oral conditions on well-being and quality of life. MATERIALS AND METHODS: A 100 schizophrenic individuals were randomly selected from the Psychiatry Department of Government Hospital, Patna, Bihar, India, and grouped into two groups: (a) Group I with...
2024: Journal of Education and Health Promotion
https://read.qxmd.com/read/38531159/insomnia-and-aggression-in-stable-schizophrenic-patients-the-mediating-role-of-quality-of-life
#2
JOURNAL ARTICLE
Ruochen Zhou, Mengting Ye, Xu OuYang, ShaoFei Zhang, SiYuan Zheng, Ruoqi Wang, Panpan Cao, Kefei Yang, Xiaoqin Zhou
UNLABELLED: Aggression in schizophrenia patients is an issue of concern. Previous studies have shown that aggression in schizophrenia patients may be related to insomnia and quality of life to different extents. This study aimed to explore the potential mediating role of quality of life in the relationship between aggression and insomnia among schizophrenia patients. Demographic factors affecting aggression in schizophrenia patients were also explored. PATIENTS AND METHODS: A total of 781 stable patients aged 18-75 who met the ICD10 diagnosis of "schizophrenia" completed the completed questionnaire...
March 25, 2024: Schizophrenia Research
https://read.qxmd.com/read/38525604/early-intervention-in-psychosis-and-management-of-first-episode-psychosis-in-low-and-lower-middle-income-countries-a-systematic-review
#3
JOURNAL ARTICLE
Saeed Farooq, Nishani Fonseka, Malik Wajid Ali, Abbie Milner, Shumaila Hamid, Saima Sheikh, Muhammad Firaz Khan, Mian Mukhtar-Ul-Haq Azeemi, Gayan Ariyadasa, Abdul Jalil Khan, Muhammad Ayub
BACKGROUND AND HYPOTHESIS: People with first-episode psychosis (FEP) in low- and lower-middle-income countries (LMIC) experience delays in receiving treatment, resulting in poorer outcomes and higher mortality. There is robust evidence for effective and cost-effective early intervention in psychosis (EIP) services for FEP, but the evidence for EIP in LMIC has not been reviewed. We aim to review the evidence on early intervention for the management of FEP in LMIC. STUDY DESIGN: We searched 4 electronic databases (Medline, Embase, PsycINFO, and CINAHL) to identify studies describing EIP services and interventions to treat FEP in LMIC published from 1980 onward...
March 25, 2024: Schizophrenia Bulletin
https://read.qxmd.com/read/38512459/identification-of-important-gene-signatures-in-schizophrenia-through-feature-fusion-and-genetic-algorithm
#4
JOURNAL ARTICLE
Zhixiong Chen, Ruiquan Ge, Changmiao Wang, Ahmed Elazab, Xianjun Fu, Wenwen Min, Feiwei Qin, Gangyong Jia, Xiaopeng Fan
Schizophrenia is a debilitating psychiatric disorder that can significantly affect a patient's quality of life and lead to permanent brain damage. Although medical research has identified certain genetic risk factors, the specific pathogenesis of the disorder remains unclear. Despite the prevalence of research employing magnetic resonance imaging, few studies have focused on the gene level and gene expression profile involving a large number of screened genes. However, the high dimensionality of genetic data presents a great challenge to accurately modeling the data...
March 21, 2024: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://read.qxmd.com/read/38509645/palliative-psychiatry-for-a-patient-with-treatment-refractory-schizophrenia-and-severe-chronic-malignant-catatonia-case-report
#5
JOURNAL ARTICLE
Junona Elgudin, Clark Johnsen, Anna Lisa Westermair, Manuel Trachsel
BACKGROUND: Palliative psychiatry is an emerging field that suggests a role for palliative interventions in the management of severe and persistent mental illness (SPMI). Current literature describes using a palliative approach for patients with severe anorexia nervosa. To our knowledge, this is the first case report describing end-of-life care in a patient with treatment-refractory catatonic schizophrenia. CASE DESCRIPTION: We describe the case of a 49-year-old man with schizophrenia and severe chronic agitated/malignant catatonia who was hospitalized for ten months...
March 19, 2024: Annals of Palliative Medicine
https://read.qxmd.com/read/38506057/longitudinal-association-of-social-isolation-and-loneliness-with-physical-function-among-in-patients-living-with-schizophrenia
#6
JOURNAL ARTICLE
Li-Jung Chen, Andrew Steptoe, I-Chia Chien, Po-Wen Ku
UNLABELLED: WHAT IS KNOWN ON THE SUBJECT?: People living with schizophrenia have reduced physical function and are more likely to experience loneliness than those without condition. Low physical function is associated with greater loneliness in people with psychosis. However, it is unclear whether social isolation and loneliness contribute to impaired physical function in this population. Loneliness is linked to an increased risk of physical function impairment among older individuals, but research on patients living with schizophrenia is limited...
March 20, 2024: Journal of Psychiatric and Mental Health Nursing
https://read.qxmd.com/read/38503415/home-based-intervention-with-semaglutide-treatment-of-neuroleptic-related-prediabetes-histori-protocol-describing-a-prospective-randomised-placebo-controlled-and-double-blinded-multicentre-trial
#7
JOURNAL ARTICLE
Ashok Ainkaran Ganeshalingam, Nicolai Gundtoft Uhrenholt, Sidse Arnfred, Peter Haulund Gæde, Niels Bilenberg, Jan Frystyk
INTRODUCTION: Subjects with schizophrenia have a 2-3 fold higher mortality rate than the general population and a reduced life expectancy of 10-20 years. Approximately one-third of this excess mortality has been attributed to obesity-related type 2 diabetes (T2D) and to cardiovascular disease. Glucagon-like peptide-1 (GLP-1) analogues increase satiety and delay gastric emptying, thereby reducing food intake and weight. GLP-1 analogues also exert beneficial effects on cardiovascular outcomes in high-risk patients with T2D...
March 18, 2024: BMJ Open
https://read.qxmd.com/read/38492329/identification-and-treatment-of-individuals-with-childhood-onset-and-early-onset-schizophrenia
#8
REVIEW
Christoph U Correll, Celso Arango, Birgitte Fagerlund, Silvana Galderisi, Martien J Kas, Stefan Leucht
Approximately 8 % of patients with schizophrenia are diagnosed before age 18, and 18 % experience their first symptoms before age 18. This narrative review explores the management of patients with early-onset schizophrenia (EOS) and childhood-onset schizophrenia (COS) from diagnosis to their transition to adult care settings. Early diagnosis of schizophrenia in children and adolescents is essential for improving outcomes, but delays are common due to overlapping of symptoms with developmental phenomena and other psychiatric conditions, including substance use, and lack of clinicians' awareness...
March 15, 2024: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/38470162/cognitive-behavioural-therapy-added-to-standard-care-for-first-episode-and-recent-onset-psychosis
#9
REVIEW
Susanna Franziska Mayer, Ciaran Corcoran, Liam Kennedy, Stefan Leucht, Irene Bighelli
BACKGROUND: Cognitive behavioural therapy (CBT) can be effective in the general population of people with schizophrenia. It is still unclear whether CBT can be effectively used in the population of people with a first-episode or recent-onset psychosis. OBJECTIVES: To assess the effects of adding cognitive behavioural therapy to standard care for people with a first-episode or recent-onset psychosis. SEARCH METHODS: We conducted a systematic search on 6 March 2022 in the Cochrane Schizophrenia Group's Study-Based Register of Trials, which is based on CENTRAL, MEDLINE, Embase, CINAHL, PsycINFO, PubMed, ClinicalTrials...
March 12, 2024: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38469291/brain-imaging-derived-phenotypes-a-biomarker-for-the-onset-of-inflammatory-bowel-disease-and-a-potential-mediator-of-mental-complications
#10
JOURNAL ARTICLE
Fan Li, Qi Zhao, Tongyu Tang, Yuyuan Liu, Zhaodi Wang, Zhi Wang, Xiaoping Han, Zifeng Xu, Yu Chang, Yuqin Li
BACKGROUND AND AIMS: Inflammatory bowel disease (IBD), mainly categorized into Crohn's disease (CD) and ulcerative colitis (UC), is a chronic relapsing gastrointestinal disorder that significantly impairs patients' quality of life. IBD patients often experience comorbidities such as anxiety and depression, and the underlying mechanisms and treatment strategies remain areas of investigation. METHODS: We conducted a Mendelian randomization(MR) analysis utilizing brain image derived phenotypes (IDP) from the UK Biobank database to investigate the causal relationships between IBD and alterations in brain structural morphology and connectivity of neural tracts...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38463408/changes-in-psychosocial-variables-among-caregivers-of-patients-with-schizophrenia-a-short-term-follow-up-study
#11
JOURNAL ARTICLE
Sanimar S Kochhar, Ashwani K Mishra, Rakesh K Chadda, Mamta Sood, Rachna Bhargava
BACKGROUND AND AIMS: Caring for a person with schizophrenia entails considerable effort. The caregiving experience while caring for a person with schizophrenia has been described as both stressful and enriching. The literature on changes in caregiving experience with time has been fairly limited. The present analysis looks at the change in the caregiving experience of caregivers of patients with schizophrenia. METHOD: This study had a sample of 50 caregivers of patients with schizophrenia who were followed up after a period of 6 to 10 months...
March 2024: Curēus
https://read.qxmd.com/read/38456932/shaping-tomorrow-s-support-baseline-clinical-characteristics-predict-later-social-functioning-and-quality-of-life-in-schizophrenia-spectrum-disorder
#12
JOURNAL ARTICLE
Jiasi Hao, Natalia Tiles-Sar, Tesfa Dejenie Habtewold, Edith J Liemburg, Richard Bruggeman, Lisette van der Meer, Behrooz Z Alizadeh
PURPOSE: We aimed to explore the multidimensional nature of social inclusion (mSI) among patients diagnosed with schizophrenia spectrum disorder (SSD), and to identify the predictors of 3-year mSI and the mSI prediction using traditional and data-driven approaches. METHODS: We used the baseline and 3-year follow-up data of 1119 patients from the Genetic Risk and Outcome in Psychosis (GROUP) cohort in the Netherlands. The outcome mSI was defined as clusters derived from combined analyses of thirteen subscales from the Social Functioning Scale and the brief version of World Health Organization Quality of Life questionnaires through K-means clustering...
March 8, 2024: Social Psychiatry and Psychiatric Epidemiology
https://read.qxmd.com/read/38439651/auricular-acupressure-improve-constipation-of-patients-with-schizophrenia-a-pilot-randomized-controlled-study
#13
JOURNAL ARTICLE
Ciao-Min Gong, Hui-Chuan Huang, Ju-Han Liu, Shiou-Shiun Yu, Yu-Ting Chen
Backgroun d. Constipation is a common distressing problem in patients with schizophrenia that can cause complications and impair quality of life. Objective . The objective of this study was to investigate the efficacy of applying auricular acupressure (AA) treatment in improving constipation in patients with schizophrenia. Metho ds. A crossover randomized controlled trial design was performed from April 2022 to December 2023 at four psychiatric rehabilitation care centers. A total of 23 patients with schizophrenia received an AA intervention or usual care according to the designated treatment sequences...
March 4, 2024: Biological Research for Nursing
https://read.qxmd.com/read/38439517/investigating-gender-differences-in-quality-of-life-and-social-support-in-patients-with-severe-mental-illnesses
#14
JOURNAL ARTICLE
Somayeh Shokrgozar, Elahe Abdollahi, Morvarid Abedrad, Parham Asadi, Vida Rouzbehan, Zahra Nazari, Roghayeh Zare
BACKGROUND: Severe mental illnesses (SMIs), including schizophrenia and bipolar disorder affect patients significantly. Gender has been identified as a key factor influencing the experience of SMIs with notable disparities in prevalence, symptoms, and treatment outcomes. Additionally, the quality of life (QoL) and social support for patients with SMIs can vary based on gender. AIMS: This study examined gender differences in QoL and social support of patients with SMIs...
March 4, 2024: International Journal of Social Psychiatry
https://read.qxmd.com/read/38435916/a-scoping-review-is-yoga-an-effective-intervention-for-erectile-dysfunction-and-premature-ejaculation
#15
REVIEW
Subrahmanaya Bhat, Manoj K Pandey, Udayakumar K, Nikunj Gokani, T S Sathyanarayana Rao
There is increasing concern among both healthcare professionals and the general public about the long-term effectiveness and possible adverse effects of medicines used to treat premature ejaculation (PE) and erectile dysfunction (ED). There is also a growing recognition of the advantages of incorporating alternative or traditional approaches into healthcare systems. Yoga is gaining popularity globally and has emerged as a viable adjunct and alternative to add value to patient care and prevention of illnesses, which requires further investigation...
January 2024: Curēus
https://read.qxmd.com/read/38394386/systematic-review-and-meta-analysis-of-exercise-interventions-for-psychotic-disorders-the-impact-of-exercise-intensity-mindfulness-components-and-other-moderators-on-symptoms-functioning-and-cardiometabolic-health
#16
JOURNAL ARTICLE
Matthias Rißmayer, Joseph Kambeitz, Florian Javelle, Theresa Katharina Lichtenstein
BACKGROUND AND HYPOTHESIS: Exercise therapy has been shown to be an effective complementary treatment for patients with psychotic disorders. However, the specific impacts of different training modalities remain poorly understood. This article aims to quantitatively review the moderating influence of different exercise modalities, hypothesizing that higher exercise intensity as well as utilization of mindfulness-based exercise (MBE) components, will improve intervention outcomes. STUDY DESIGN: PubMed, Web of Science, and PsycINFO were searched from 2010 to March 2022 for randomized controlled trials investigating exercise interventions in patients with psychotic disorders (preregistration: https://doi...
February 23, 2024: Schizophrenia Bulletin
https://read.qxmd.com/read/38388986/an-open-label-study-to-assess-monthly-risperidone-injections-180-mg-following-switch-from-daily-oral-risperidone-6-mg-in-stable-schizophrenic-patients
#17
JOURNAL ARTICLE
David P Walling, Sunita N Shinde, Janice M Pogoda, Jahnavi Kharidia, Celine M Laffont
BACKGROUND AND OBJECTIVE: Long-acting injectable antipsychotics have shown benefits over oral medications with reduced hospitalization rates and improved health-related quality of life. RBP-7000 (PERSERIS® ) is a monthly risperidone formulation (90 or 120 mg) for the treatment of schizophrenia administered by subcutaneous abdominal injection. The objective of this study was to assess a higher dose of 180 mg RBP-7000 and an alternate injection site. METHODS: Following stabilization on 6 mg/day (3 mg twice daily) oral risperidone, clinically stable schizophrenic participants received 3 monthly doses of 180 mg RBP-7000 in the abdomen followed by a fourth monthly dose of 180 mg RBP-7000 in the upper arm (each dose administered as two 90-mg injections)...
February 22, 2024: Clinical Drug Investigation
https://read.qxmd.com/read/38368745/transcriptome-profiling-as-a-biological-marker-for-bipolar-disorder-sub-phenotypes
#18
JOURNAL ARTICLE
Joanna Pawlak, Aleksandra Szczepankiewicz, Maria Skibińska, Beata Narożna, Paweł Kapelski, Przemysław Zakowicz, Karolina Gattner, Dominik Spałek, Łukasz Mech, Monika Dmitrzak-Węglarz
PURPOSE: Bipolar affective disorder (BP) causes major functional impairment and reduced quality of life not only for patients, but also for many close relatives. We aimed to investigate mRNA levels in BP patients to find differentially expressed genes linked to specific clinical course variants; assuming that several gene expression alterations might indicate vulnerability pathways for specific course and severity of the disease. MATERIALS: We searched for up- and down-regulated genes comparing patients with diagnosis of BP type I (BPI) vs type II (BPII), history of suicide attempts, psychotic symptoms, predominance of manic/hypomanic episodes, and history of numerous episodes and comorbidity of substance use disorders or anxiety disorders...
February 17, 2024: Advances in Medical Sciences
https://read.qxmd.com/read/38367610/personal-recovery-in-first-episode-psychosis-beyond-clinical-and-functional-recovery
#19
JOURNAL ARTICLE
Isolde L Maas, Marc M Bohlken, Shiral S Gangadin, Bram-Sieben Rosema, Wim Veling, Nynke Boonstra, Lieuwe de Haan, Marieke J H Begemann, Sanne Koops
BACKGROUND: The concept of personal recovery after psychotic illness focuses more on patients' social and existential needs compared to traditional outcome measures including clinical and functional recovery. This research aims to contribute to a broad framework on (personal) recovery and associated factors. METHODS: Data from 203 persons with symptomatic remission of their first-episode psychosis from the ongoing HAMLETT study were analyzed. To determine the relative importance of several biological, clinical, psychological, and social factors in explaining personal recovery as measured by the Recovery Assessment Scale (RAS), partial Spearman correlations (controlling for clinical recovery (PANSS) and functional recovery (WHODAS 2...
April 2024: Schizophrenia Research
https://read.qxmd.com/read/38364700/clinical-implementation-of-preemptive-pharmacogenomics-in-psychiatry
#20
JOURNAL ARTICLE
Maria Skokou, Kariofyllis Karamperis, Margarita-Ioanna Koufaki, Evangelia-Eirini Tsermpini, Maria-Theodora Pandi, Stavroula Siamoglou, Panagiotis Ferentinos, Marina Bartsakoulia, Theodora Katsila, Christina Mitropoulou, George P Patrinos
BACKGROUND: Pharmacogenomics (PGx) holds promise to revolutionize modern healthcare. Although there are several prospective clinical studies in oncology and cardiology, demonstrating a beneficial effect of PGx-guided treatment in reducing adverse drug reactions, there are very few such studies in psychiatry, none of which spans across all main psychiatric indications, namely schizophrenia, major depressive disorder and bipolar disorder. In this study we aim to investigate the clinical effectiveness of PGx-guided treatment (occurrence of adverse drug reactions, hospitalisations and re-admissions, polypharmacy) and perform a cost analysis of the intervention...
February 15, 2024: EBioMedicine
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