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Correlation to antipsychotics medications and dementia

Leandro Boson Gambogi, Henrique Cerqueira Guimarães, Leonardo Cruz de Souza, Paulo Caramelli
BACKGROUND: The behavioral variant frontotemporal dementia (bvFTD) shares some clinical features with severe mental disorders, such as bipolar affective disorder (BAD), schizophrenia (SCZ), and schizoaffective disorder (SZA), and at least for a small subgroup of patients, these conditions may share similar pathological genetic mutations. OBJECTIVES: To investigate the frequency of a past medical history satisfying diagnostic criteria for BAD, SCZ, and SZA in a bvFTD outpatient sample, and to compare the clinical profile of patients with and without a positive history...
2018: Journal of Alzheimer's Disease: JAD
Tim Fleiner, Marleen Gersie, Sayantan Ghosh, Sabato Mellone, Wiebren Zijlstra, Peter Haeussermann
INTRODUCTION: To objectively quantify patients' physical activity and analyze the relationships between physical activity levels, psychopathology and sedative medication in acute hospital dementia care. MATERIALS AND METHODS: In this cross-sectional study we assessed the patients' physical activity based on data collection by hybrid motion sensors attached on their lower back. Daily doses of antipsychotics have been converted to olanzapine-equivalents and daily benzodiazepine medication is reported as diazepam-equivalents...
November 7, 2018: International Journal of Geriatric Psychiatry
Tracy Wharton, Daniel Paulson, Kimberly Burcher, Heather Lesch
For individuals with dementia, disorientation and both external and internal stimuli may trigger behaviors that are difficult to manage or dangerous to health-care providers. Identification of correlational risk factors to aggressive behavior in patients who are unknown to the hospital can allow providers to adapt patient care quickly. Records for patients aged 60+ who spent at least 24 hours at the hospital other than in the psychiatric unit were used (N = 14 080). The first 4000 records and every 10th person who met criteria (N = 5008) were searched for documentation of dementia (n = 505)...
November 1, 2018: American Journal of Alzheimer's Disease and Other Dementias
Rachel Kester, Jürgen Unützer, Diane Hogan, Hsiang Huang
BACKGROUND: Antipsychotic medications are widely used to treat behavioral symptoms of dementia. However, studies have shown that antipsychotic use in patients with dementia is associated with risk of side effects. AIMS: The aim of this study is to examine antipsychotic prescribing patterns for beneficiaries with dementia enrolled in a Medicare Advantage program and identify opportunities to improve prescribing practices. METHODS: This study includes Medicare Advantage beneficiaries who were 65 years of age or older with dementia...
April 2017: Journal of Mental Health
Niyatee Samudra, Neepa Patel, Kyle B Womack, Pravin Khemani, Shilpa Chitnis
Parkinson disease psychosis (PDP) is a common phenomenon in Parkinson disease (PD) patients treated with dopaminergic drugs, and is associated with high morbidity and mortality. It also correlates with depression and dementia, and can contribute to considerable caregiver stress and burnout. While symptoms can be relieved by decreasing doses or number of anti-PD medications, this may lead to an unacceptable worsening of motor function. When general medical or psychiatric conditions have been ruled out, and decreasing dopaminergic agents is not effective in treating psychosis, therapies include atypical antipsychotics, primarily clozapine and quetiapine...
December 2016: Drugs & Aging
Andrea Foebel, Anna Ballokova, Nathalie I H Wellens, Daniela Fialova, Koen Milisen, Rosa Liperoti, John P Hirdes
BACKGROUND: Use of antipsychotic (AP) medications is high and often inappropriate among institutionalized populations. Little is known about the correlates of new AP drug use following admission to long-term care (LTC) settings. This study investigated the frequency and correlates of new AP drug use among newly admitted LTC residents. METHODS: This longitudinal, retrospective study used data from the interRAI - Nursing Home Minimum Data Set version 2.0 (MDS 2.0) instrument...
October 19, 2015: BMC Geriatrics
Yi-Ting Lin, Tzung-Jeng Hwang, Jia-Chi Shan, Huey-Ling Chiang, Yi-Han Sheu, Hai-Gwo Hwu
BACKGROUND/PURPOSE: The USA Food and Drug Administration (FDA) issued warnings regarding the use of antipsychotics in patients with dementia in 2003 and 2005. We aimed to study the dose and duration of antipsychotic treatment in dementia, and to examine whether physicians' prescription behaviors changed after the FDA warnings. METHODS: Medical charts of outpatients who had Alzheimer's disease, vascular dementia, or mixed dementia were reviewed. Patients must have achieved a clinically stable state for at least 4 weeks after receiving antipsychotic treatment for agitation or psychosis...
February 2015: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Christoph U Correll, Benjamin I Joffe, Lisa M Rosen, Timothy B Sullivan, Russell T Joffe
This is a study of the metabolic and distal cardiovascular/cerebrovascular outcomes associated with the use of second-generation antipsychotics (SGAs) compared to antidepressants (ADs) in adults aged 18-65 years, based on data from Thomson Reuters MarketScan® Research Databases 2006-2010, a commercial U.S. claims database. Interventions included clinicians' choice treatment with SGAs (allowing any comedications) versus ADs (not allowing SGAs). The primary outcomes of interest were time to inpatient or outpatient claims for the following diagnoses within one year of SGA or AD discontinuation: hypertension, ischemic and hypertensive heart disease, cerebrovascular disease, diabetes mellitus, hyperlipidemia, and obesity...
February 2015: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
Lu-Wen Chi, Shu-Chin Lin, Shu-Hua Chang, Hua-Shan Wu
OBJECTIVE: To investigate the prevalence and patterns of and factors associated with hyperphagic behavior in Taiwanese patients with dementia living at home. METHODS: A cross-sectional and correlational design was used. A total of 104 patients with dementia and their primary caregivers were recruited from the geriatric, neurology, and memory clinics of a regional hospital, a medical center and two day-care centers in central Taiwan. The data related to hyperphagic behavior, functional abilities, medical conditions, body weight, and demographic characteristics of patients as well as the demographic characteristics of their primary caregivers were collected between January and May 2013...
October 2015: Biological Research for Nursing
Andrea D Foebel, Rosa Liperoti, Graziano Onder, Harriet Finne-Soveri, Jean Claude Henrard, Albert Lukas, Michael D Denkinger, Giovanni Gambassi, Roberto Bernabei
BACKGROUND: Behavioral and psychological symptoms of dementia (BPSD) are common reasons for use of antipsychotic drugs among older individuals with dementia. These drugs are not approved for such use and both the Food and Drug Administration and European Medicines Agency have issued warnings to limit such use. OBJECTIVES: This study aimed to describe patterns of antipsychotic drug use in a sample of nursing home residents with dementia in 7 European countries and Israel...
December 2014: Journal of the American Medical Directors Association
Claudio Bilotta, Carlotta Franchi, Alessandro Nobili, Paola Nicolini, Codjo Djignefa Djade, Mauro Tettamanti, Luca Pasina, Ida Fortino, Angela Bortolotti, Luca Merlino, Carlo Vergani
PURPOSE: The aims of this study are to analyse, in community-dwelling people aged 65+ living in Italy's Lombardy Region, electrocardiographic (ECG) monitoring for new users of the atypical antipsychotic quetiapine co-prescribed with acetylcholinesterase inhibitors (AChEIs) or memantine and to find independent predictors of ECG monitoring before and after the starting of this prescription. METHODS: The Lombardy Region's administrative health database was used to retrieve prescriptions of ECG exams as well as prevalence rates of subjects aged 65+ who were prescribed such psychotropic drugs from 2005 to 2009...
December 2014: European Journal of Clinical Pharmacology
Lucía del Rio-Casanova, Eduardo Paz-Silva, Ignacio Requena-Caballero, Francisco Diaz-Llenderrozas, Jesús Gomez-Trigo Baldominos, Alberto de la Cruz-Davila, Mario Paramo-Fernandez
INTRODUCTION: Antiphospholipid syndrome (APS) is an autoimmune disorder which causes an hypercoagulation state characterized by thrombotic events, repetitive miscarriages and the presence of antiphospholipid antibodies. APS may be an isolated disease (primary APS) or associated to systemic lupus erythematous or another autoimmune conditions (secondary APS). Neuropsychiatric manifestations accompanying APS include migraine, epilepsy, chorea, dementia or psychosis. Detailed descriptions of clinical cases are lacking, and correlations between clinical and analytical findings are far from being well known...
June 1, 2014: Revista de Neurologia
Aaron M Koenig, Meryl A Butters, Amy Begley, Semhar Ogbagaber, Abdus S Wahed, Charles F Reynolds
OBJECTIVE: Late-life depression frequently co-occurs with cognitive impairment. To inform clinical management of these conditions, we examined the hypotheses that, relative to cognitively normal elders meeting DSM-IV criteria for major depressive disorder, those with cognitive impairment would require greater intensity of pharmacotherapy to reach criteria for antidepressant response and would take longer to respond. METHOD: Using data from the MTLD-3 study, we conducted a series of secondary analyses examining the implications of cognitive impairment for short-term, open-trial pharmacotherapy of late-life depression (major depressive disorder in individuals 65 years and older)...
February 2014: Journal of Clinical Psychiatry
Sarah Kittel-Schneider, Johannes Weigl, Julia Volkert, Alexandra Geßner, Brigitte Schmidt, Susanne Hempel, Tilman Kiel, David G Olmes, Jasmin Bartl, Heike Weber, Juliane Kopf, Andreas Reif
BACKGROUND: A recent study suggested that progranulin (encoded by the fronto-temporal dementia risk gene GRN) plasma levels are decreased in bipolar disorder (BD). Replication of this finding is however lacking. METHODS: Progranulin plasma levels of bipolar patients (n=104) and healthy controls (n=80) were measured by enzyme-linked immunosorbent assay (ELISA). Participants were also genotyped for three single nucleotide polymorphisms (SNPs) in the GRN gene (rs2879096, rs4792938 and rs5848), and the effect of genetic variation on progranulin levels was examined...
March 2014: Journal of Affective Disorders
Tobias Gerhard, Ayse Akincigil, Christoph U Correll, Neil J Foglio, Stephen Crystal, Mark Olfson
OBJECTIVE: This study estimates national trends and patterns in use of second-generation antipsychotics (SGAs) for adjunctive treatment of nonpsychotic adult depression in office-based practice. METHOD: Twelve consecutive years (1999-2010) of the National Ambulatory Medical Care Survey were analyzed to estimate trends and patterns of adjunctive SGA treatment for adult (≥ 18 years) nonpsychotic depression in office-based visits. Adjunctive SGA use was examined among all office visits in which depression was diagnosed (N = 7,767), excluding visits with diagnoses for alternative SGA indications (schizophrenia, bipolar disorder, pervasive development disorder, psychotic depression, dementia) and those without an active antidepressant prescription...
May 2014: Journal of Clinical Psychiatry
Fabricio Ferreira de Oliveira, Paulo Henrique Ferreira Bertolucci, Elizabeth Suchi Chen, Marilia de Arruda Cardoso Smith
To evaluate correlations of pharmacological treatment with cognitive and behavioral symptoms in patients with dementia due to Alzheimer's disease with low schooling, subjects were assessed for demographic features, neuropsychiatric symptoms, cognitive decline, functionality, caregiver burden, APOE haplotypes and pharmacological treatment. Among 217 patients, use of cholinesterase inhibitors with or without Memantine was associated with less neuropsychiatric symptoms, while anti-psychotics and/or anti-epileptic drugs were associated with lower instrumental functionality...
January 15, 2014: Journal of the Neurological Sciences
R Colombo, A Corona, F Praga, C Minari, C Giannotti, A Castelli, F Raimondi
BACKGROUND: A wide variability in the approach towards delirium prevention and treatment in the critically ill results from the dearth of prospective randomised studies. METHODS: We launched a two-stage prospective observational study to assess delirium epidemiology, risk factors and impact on patient outcome, by enrolling all patients admitted to our Intensive Care Unit (ICU) over a year. The first step - from January to June 2008 was the observational phase, whereas the second one from July to December 2008 was interventional...
September 2012: Minerva Anestesiologica
Carole Parsons, Sarah Johnston, Elspeth Mathie, Natasha Baron, Ina Machen, Sarah Amador, Claire Goodman
BACKGROUND: Older people in general and care home residents in particular are at high risk of suboptimal or inappropriate prescribing. To date, research into potentially inappropriate prescribing (PIP) has not focused on care home residents and/or has not utilized the recently developed and validated Screening Tool of Older Persons' potentially inappropriate Prescriptions (STOPP) criteria. OBJECTIVE: The aim of this study was to estimate the prevalence of PIP in older people with dementia living in six residential care homes in England, using the STOPP criteria...
February 1, 2012: Drugs & Aging
Krista F Huybrechts, Kenneth J Rothman, M Alan Brookhart, Rebecca A Silliman, Stephen Crystal, Tobias Gerhard, Sebastian Schneeweiss
OBJECTIVE: Despite serious safety concerns, antipsychotic medications continue to be used widely in US nursing homes. The objective of this study was to quantify the variation in antipsychotic treatment choice across US nursing homes, and to characterize its correlates. METHODS: Prescribing practices were assessed in a cohort of 65,618 patients 65 years or older in 45 states who initiated treatment with an antipsychotic medication after nursing home admission between 2001 and 2005, using merged Medicaid; Medicare; Minimum Data Set; and Online Survey, Certification, and Reporting data...
February 2012: Journal of Clinical Psychopharmacology
Gabriele Cipriani, Marcella Vedovello, Angelo Nuti, Mario Di Fiorino
AIM: To consider the phenomenon of aggressive behavior perpetrated by people with dementia. METHODS: We searched electronic databases and key journals using the search terms: aggressive behavior; dementia; behavioral and psychological symptoms. RESULTS: Aggressive behavior (AB) is probably one of the principal problems in dementia. Aggression is linked to internal factors (depression, psychosis, pain) and external determinants (caregiver burden, social stimulation, quality of caregiver-patient relationship)...
October 2011: Geriatrics & Gerontology International
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