keyword
https://read.qxmd.com/read/38536048/mixed-connective-tissue-disease-presenting-with-psychosis-a-case-report
#1
JOURNAL ARTICLE
Nikhil Tondehal, Arnab Sengupta, Kavya Mohankumar, Chintan Trivedi, Zeeshan Mansuri, Shailesh Jain
Mixed connective tissue disease (MCTD) is a systemic autoimmune disease with features overlapping multiple autoimmune disorders. One study found that over 55% of patients with MCTD experienced neuropsychiatric symptoms, the most common of which was an "aseptic meningitis-like syndrome." We present a case of a 17-year-old adolescent girl presenting with abnormal speech and behavior, auditory hallucinations, and paranoid delusions after an isolated episode of fever. She was treated for her psychotic symptoms but later developed symptoms resembling neuroleptic malignant syndrome...
April 1, 2024: Journal of Nervous and Mental Disease
https://read.qxmd.com/read/38515990/globus-pallidus-lesion-with-iron-deposition-and-dopaminergic-denervation-in-a-patient-with-a-pathogenic-slc6a1-variant-a-case-report
#2
JOURNAL ARTICLE
Victoire Leclert, Chloe Laurencin, Roxana Ameli, Marc Hermier, Anthime Flaus, Stephane Prange, Gaetan Lesca, Stephane Thobois
OBJECTIVES: SLC6A1 -related disorders encompass heterogeneous neuropsychiatric manifestations through GABAergic dysregulation, without any specific abnormalities on brain MRI, nor evidence of dopaminergic cell loss on I123 -FP-β-CIT SPECT. We report here a case of globus pallidus lesions and dopaminergic denervation in a patient with a pathogenic SLC6A1 variant. METHODS: A 26-year-old female patient with intellectual disability, behavioral, and psychiatric disorders treated by neuroleptics for many years developed a parkinsonian syndrome associated with mild hand dystonia and chorea...
April 2024: Neurology. Genetics
https://read.qxmd.com/read/38514109/-neuroleptic-intolerance-and-residual-mutism-in-a-young-woman-with-anti-n-methyl-d-aspartate-receptor-nmdar-encephalitis
#3
JOURNAL ARTICLE
Kazue Tajima, Toshio Fukutake
We report a case of anti-NMDAR encephalitis and residual mutism in a 23-year-old woman who presented with neuroleptic intolerance. Admission to our department for investigation of her abnormal behavior revealed cerebrospinal fluid (CSF) positivity for anti-NMDAR antibodies, and the patient underwent immunotherapy. However, generalized tonic seizures developed, requiring mechanical ventilation in the intensive care unit. Antipsychotic drugs were also administered for involuntary movements and insomnia. Thereafter, a malignant syndrome of severe hyperCKemia (Max: 191,120 IU/L) and shock developed, requiring resuscitation and three sessions of hemodialysis...
March 2024: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://read.qxmd.com/read/38503415/home-based-intervention-with-semaglutide-treatment-of-neuroleptic-related-prediabetes-histori-protocol-describing-a-prospective-randomised-placebo-controlled-and-double-blinded-multicentre-trial
#4
JOURNAL ARTICLE
Ashok Ainkaran Ganeshalingam, Nicolai Gundtoft Uhrenholt, Sidse Arnfred, Peter Haulund Gæde, Niels Bilenberg, Jan Frystyk
INTRODUCTION: Subjects with schizophrenia have a 2-3 fold higher mortality rate than the general population and a reduced life expectancy of 10-20 years. Approximately one-third of this excess mortality has been attributed to obesity-related type 2 diabetes (T2D) and to cardiovascular disease. Glucagon-like peptide-1 (GLP-1) analogues increase satiety and delay gastric emptying, thereby reducing food intake and weight. GLP-1 analogues also exert beneficial effects on cardiovascular outcomes in high-risk patients with T2D...
March 18, 2024: BMJ Open
https://read.qxmd.com/read/38502289/an-evidence-based-update-on-anticholinergic-use-for-drug-induced-movement-disorders
#5
JOURNAL ARTICLE
Nora Vanegas-Arroyave, Stanley N Caroff, Leslie Citrome, Jovita Crasta, Roger S McIntyre, Jonathan M Meyer, Amita Patel, J Michael Smith, Khody Farahmand, Rachel Manahan, Leslie Lundt, Samantha A Cicero
Drug-induced movement disorders (DIMDs) are associated with use of dopamine receptor blocking agents (DRBAs), including antipsychotics. The most common forms are drug-induced parkinsonism (DIP), dystonia, akathisia, and tardive dyskinesia (TD). Although rare, neuroleptic malignant syndrome (NMS) is a potentially life-threatening consequence of DRBA exposure. Recommendations for anticholinergic use in patients with DIMDs were developed on the basis of a roundtable discussion with healthcare professionals with extensive expertise in DIMD management, along with a comprehensive literature review...
March 19, 2024: CNS Drugs
https://read.qxmd.com/read/38444738/parkinsonism-hyperpyrexia-a-rare-consequence-of-deep-brain-stimulator-malfunction-in-advanced-parkinson-s-disease
#6
JOURNAL ARTICLE
Manuel Díaz Castela, Patricia Prendes Fernández, Sonia Heres Bruck, Esther Suárez San Martín, Ciara García Fernández, Javier Sol Álvarez, Beatriz Lozano Aragoneses, Antonio Sáiz Ayala, Elena Santamarta Liébana, Juan Álvarez Carriles, Lorena González Álvarez, Marta Blázquez Estrada
Parkinsonism-hyperpyrexia syndrome (PHS) is a rare neurological emergency that shares clinical features with neuroleptic malignant syndrome. It is usually due to sudden deprivation of dopaminergic treatment, although there are cases related to failure of the deep brain stimulation system.
2024: Clinical parkinsonism & related disorders
https://read.qxmd.com/read/38370948/neuroleptic-malignant-syndrome-after-abrupt-discontinuation-of-neuroleptic-and-anticholinergic-drugs
#7
JOURNAL ARTICLE
Sameer Bhargava, Khushboo Bairwa, Yogesh Motwani
No abstract text is available yet for this article.
November 2023: Industrial Psychiatry Journal
https://read.qxmd.com/read/38356424/-drug-induced-movement-disorders-nosology-and-treatment
#8
JOURNAL ARTICLE
Laurie Marten, Frédérique Depierreux
Movements disorders are frequently encountered in general practice and emergency departments and are in many cases of iatrogenic origin. Dopamine D2 receptor blocking agents (DRBA), mainly neuroleptics, are most often incriminated. These drug-induced movement disorders (DIMD) can be classified according to the kinetics of the manifestations (acute DIMD and tardive syndromes), the phenomenology of the abnormal movements observed or depending on the pharmacological agent involved. The diagnosis is based on the time course of the events, clinical examination and meticulous anamnesis of the patient's previous and current treatments...
February 2024: Revue Médicale de Liège
https://read.qxmd.com/read/38327911/atypical-neuroleptic-malignant-syndrome-with-type-2-respiratory-failure-treated-with-non-invasive-ventilation
#9
Simon Farrugia, Sarah Bonello, Yanika Gatt, Martin V Balzan
Neuroleptic malignant syndrome (NMS) is characterized by hyperthermia, severe rigidity, and autonomic instability that is life-threatening if not treated promptly by intensive supportive care. However, there have been numerous reports of "atypical NMS" where the diagnostic criteria of NMS are only partially satisfied. We present a case of an elderly male who presented with atypical NMS secondary to antidopaminergic drug administration which precipitated acute respiratory failure. Our patient exhibited features of severe rigidity and autonomic instability, without hyperthermia...
January 2024: Curēus
https://read.qxmd.com/read/38320820/atypical-neuroleptic-malignant-syndrome-in-an-incarcerated-patient-a-demographic-who-may-be-at-increased-risk
#10
JOURNAL ARTICLE
Matthew Zabel, Rajeev Kandukuri
An incarcerated male patient with a psychiatric history of schizoaffective disorder presented to the emergency department with muscle rigidity and mutism after receiving a 150 mg haloperidol decanoate injection. At the peak of his illness, symptoms included muscular rigidity, mutism, excessive drooling, an altered level of consciousness, tachycardia, diaphoresis and tremors. Atypical neuroleptic malignant syndrome (NMS) was diagnosed after discrediting similar illnesses through clinical reasoning, laboratory and imaging studies...
February 6, 2024: BMJ Case Reports
https://read.qxmd.com/read/38315306/first-generation-antipsychotic-associated-serious-adverse-events-in-women-a-retrospective-analysis-of-a-pharmacovigilance-database
#11
JOURNAL ARTICLE
Kenneth L McCall, Bennett J Doughty, Brian J Piper, Heeral Naik, Seraphine Bange, Emily E Leppien
BACKGROUND: Women have been under-represented in trials of antipsychotic medications. AIM: Our primary objective was to evaluate five adverse events (AE) associated with first-generation antipsychotics (FGAs) among women relative to men through an analysis of the FDA Adverse Event Reporting System (FAERS). METHOD: We queried 24.6 million AE reports from 2000 to 2023 involving FGAs. The study cohort consisted of chlorpromazine (n = 3317), fluphenazine (n = 1124), haloperidol (n = 16,709), loxapine (n = 3151), perphenazine (n = 816), thioridazine (n = 665), thiothixene (n = 244), and trifluoperazine (n = 360)...
February 5, 2024: International Journal of Clinical Pharmacy
https://read.qxmd.com/read/38312440/serotonin-syndrome-and-neuroleptic-malignant-syndrome-a-case-report-of-intersecting-symptomatology
#12
Loulwa Maktabi, Denver Shipman, Justin P Reinert
INTRODUCTION: Serotonin syndrome and neuroleptic malignant syndrome are caused by 2 distinct pathologies; however, the clinical presentation associated with both syndromes share many features. METHODS: We describe a 56-year-old male patient who presented to our facility with seizures, leukocytosis, fevers, extremity hyperreflexia, and signs of autonomic dysfunction as evidenced by cardiovascular instability. The patient was noted to be taking vortioxetine, trazodone, lamotrigine, lurasidone, and carbidopa-levodopa as outpatient medications for his depression, an unspecified mood disorder, and Parkinson disease...
February 2024: Mental Health Clinician
https://read.qxmd.com/read/38304856/catatonia-related-adverse-outcomes-after-long-acting-injectable-antipsychotics-case-series
#13
Joseph D Dragonetti, Jacqueline G Posada, Richard Garrett Key, Joseph L Kugler
Due to a lack of controlled, prospective trials examining the pathophysiology and treatment of catatonia, current guidelines vary regarding how and when to best use antipsychotics in the presence of catatonia and what factors to consider in a thorough risk-benefit analysis. The literature is especially limited in describing the risks and benefits of using long-acting injectable antipsychotics in the presence of catatonia. We describe four cases where patients with preexisting catatonia received long-acting injectable first generation antipsychotics and experienced severe adverse effects (three experienced worsening of catatonia and one experienced neuroleptic malignant syndrome)...
2024: SAGE Open Medical Case Reports
https://read.qxmd.com/read/38289687/anesthesia-management-for-electroconvulsive-therapy
#14
JOURNAL ARTICLE
Brian Czerwonka, Jake Johnston, Rachel Smith-Steinert
Electroconvulsive therapy (ECT) was first introduced in the late 1930s. In 2016, 1.4 million people worldwide were treated with ECT, a procedure that differs from any other. Indications for ECT include schizophrenia, schizoaffective disorder, catatonia, neuroleptic malignant syndrome, and bipolar disorder. Additionally, ECT can be beneficial for patients with autism spectrum disorder, specifically those with self-injurious behaviors and severe behaviors related to agitated or excited catatonia. As indications for ECT have grown, the results of therapy have proven beneficial...
February 2024: AANA Journal
https://read.qxmd.com/read/38253334/a-multicenter-single-arm-open-label-interventional-study-of-adherence-to-brexpiprazole-during-switching-from-previous-antipsychotic-drugs-in-patients-with-schizophrenia-or-schizoaffective-disorder
#15
JOURNAL ARTICLE
Kazuyuki Nakagome, Hisateru Tachimori, Shiro Endo, Ken Murakami, Takaharu Azekawa, Seiji Hongo, Kazunari Niidome, Yoshitsugu Kojima, Sakiko Yamada, Hideki Oi, Tomiki Sumiyoshi
The rate of medication persistence was examined in patients with schizophrenia or schizoaffective disorder during switching from previously administered antipsychotics to brexpiprazole, a new dopamine D2 receptor partial agonist. A multicenter, single-arm, open-label 24-week interventional study was conducted, consisting of two 12-week consecutive periods: an initial switch (by plateau cross-titration) with the subsequent period, followed by a second maintenance period. Prior antipsychotics were olanzapine or risperidone/paliperidone...
January 22, 2024: Neuropsychopharmacology Reports
https://read.qxmd.com/read/38190342/restless-legs-syndrome-neuroleptic-induced-akathisia-and-the-iron-opioid-dopamine-link
#16
EDITORIAL
Arthur S Walters
No abstract text is available yet for this article.
January 8, 2024: Sleep
https://read.qxmd.com/read/38164744/24-hours-urine-metanephrines-excretion-in-patients-diagnosed-with-adrenal-incidentaloma-impact-of-commonly-used-drugs-on-clinical-decision
#17
JOURNAL ARTICLE
Joanna Kokoszka, Marta Opalinska, Katarzyna Sitarz, Magdalena Kolasa, Monika Szewczyk, Jolanta Bugajska, Joanna Berska, Krystyna Sztefko, Alicja Hubalewska-Dydejczyk
INTRODUCTION: Incidentaloma is an adrenal tumor detected during diagnostic imaging performed for extra-adrenal causes. Evaluation of metanephrines concentrations in 24-hour urine collection can be a significant challenge in patients with multiple medications used and comorbidities. OBJECTIVES: The aim of this study was to evaluate the effect of commonly used groups of drugs on metanephrines in 24 h urine collection. PATIENTS AND METHODS: 1051 patients with adrenal mass  < 10 HU on unenhanced computed tomography were included in the study...
January 2, 2024: Polish Archives of Internal Medicine
https://read.qxmd.com/read/38152526/subthalamic-deep-brain-stimulation-in-parkinson-s-disease-a-boon-or-bane-a-single-centre-retrospective-observational-study-from-india
#18
JOURNAL ARTICLE
Darpanarayan Hazra, Gina Maryann Chandy, Amit Ghosh
Background  Subthalamic deep brain stimulation (STN-DBS) for refractory Parkinson's disease (PD) is more of a modality of treatment that is empirical, for which a physiological explanation is being sought. This study was done to determine the outcome and complications of patients undergoing STN-DBS for PD. Methods  This retrospective observational cohort study was conducted in an advanced neuromedicine facility in eastern India for 9 years (August 2013-August 2022), which included all patients undergoing STN-DBS...
September 2023: Asian Journal of Neurosurgery
https://read.qxmd.com/read/38151160/examining-the-features-of-neuroleptic-malignant-syndrome-in-anti-nmda-receptor-encephalitis-a-case-control-study
#19
JOURNAL ARTICLE
Jesus Ramirez-Bermudez, Miguel Restrepo-Martinez, Mariana Espinola-Nadurille, Victoria Martinez-Angeles, Juan Carlos Lopez-Hernandez, Laura E Hernandez-Vanegas, Francisco Martinez-Carrillo, Ramiro Ruiz-Garcia, Veronica Rivas-Alonso, Jose Flores-Rivera, Thomas A Pollak
BACKGROUND: Anti-N-methyl-D-aspartate receptor encephalitis (ANMDARE) is a neuroimmunological disorder that frequently improves with immunotherapy. Symptomatic treatment with antipsychotics is common in the early stages when psychiatric symptoms predominate, and their use has been associated with serious side effects including neuroleptic malignant syndrome (NMS). The observation of an adverse response to antipsychotics, raising the suspicion of NMS, has been included as a criterion for possible autoimmune psychosis...
December 25, 2023: Journal of the Academy of Consultation—Liaison Psychiatry
https://read.qxmd.com/read/38147393/-history-of-the-development-of-domestic-psychiatry-the-period-1940-1980
#20
JOURNAL ARTICLE
N Yu Pyatnitskiy, V G Kaleda
The article briefly presents an analysis of the development of domestic psychiatry (with an emphasis on research in the field of psychopathology and nosology) from the post-war period (the Great Patriotic War) to the era of "perestroika". With the founding of the Institute of Psychiatry of the USSR Academy of Medical Sciences under the leadership of V.A. Gilyarovsky, the study of endogenous diseases was based on a multidisciplinary approach, in which the clinical-psychopathological research method was combined with clinical/biological ones...
2023: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
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