Ellen Vercalsteren, Dimitra Karampatsi, Doortje Dekens, Aikaterini Letsiou, Alexander Zabala, Mihaela Romanitan, Thomas Klein, Thomas Nyström, Vladimer Darsalia, Cesare Patrone
Type 2 diabetes (T2D) impairs post-stroke recovery, and the underlying mechanisms are unknown. Insulin resistance (IR), a T2D hallmark that is also closely linked to aging, has been associated with impaired post-stroke recovery. However, whether IR worsens stroke recovery is unknown. We addressed this question in mouse models where early IR, with or without hyperglycemia, was induced by chronic high-fat diet feeding or sucrose supplementation in the drinking water, respectively. Furthermore, we used 10-month-old mice, spontaneously developing IR but not hyperglycemia, where IR was normalized pharmacologically pre-stroke with Rosiglitazone...
February 16, 2023: International Journal of Molecular Sciences