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Sulforaphane, Anabolic

Roman Thaler, Antonio Maurizi, Paul Roschger, Ines Sturmlechner, Farzaneh Khani, Silvia Spitzer, Monika Rumpler, Jochen Zwerina, Heidrun Karlic, Amel Dudakovic, Klaus Klaushofer, Anna Teti, Nadia Rucci, Franz Varga, Andre J van Wijnen
Bone degenerative pathologies like osteoporosis may be initiated by age-related shifts in anabolic and catabolic responses that control bone homeostasis. Here we show that sulforaphane (SFN), a naturally occurring isothiocyanate, promotes osteoblast differentiation by epigenetic mechanisms. SFN enhances active DNA demethylation viaTet1andTet2and promotes preosteoblast differentiation by enhancing extracellular matrix mineralization and the expression of osteoblastic markers (Runx2,Col1a1,Bglap2,Sp7,Atf4, andAlpl)...
March 25, 2016: Journal of Biological Chemistry
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