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Navin Cooray, Fernando Andreotti, Christine Lo, Mkael Symmonds, Michele T M Hu, Maarten De Vos
OBJECTIVE: Evidence suggests Rapid-Eye-Movement (REM) Sleep Behaviour Disorder (RBD) is an early predictor of Parkinson's disease. This study proposes a fully-automated framework for RBD detection consisting of automated sleep staging followed by RBD identification. METHODS: Analysis was assessed using a limited polysomnography montage from 53 participants with RBD and 53 age-matched healthy controls. Sleep stage classification was achieved using a Random Forest (RF) classifier and 156 features extracted from electroencephalogram (EEG), electrooculogram (EOG) and electromyogram (EMG) channels...
February 6, 2019: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Paulo Bugalho, Manuel Salavisa, João Pedro Marto, Claudia Borbinha, Luísa Alves
INTRODUCTION: Sleep dysfunction is frequent in Dementia with Lewy Bodies (DLB), but polysomnographic (PSG) data is scarce. Our objectives were to: (1) compare PSG data between DLB patients and age normative values (NV), Parkinson's Disease (PD) and idiopathic REM sleep behavior disorder (iRBD) patients; (2) evaluate the relation between of OSA, Fluctuations and Hypersomnolence and PSG data. METHODS: We selected all consecutive patients with DLB, PD and iRBD that underwent video-PSG during a two year period...
December 18, 2018: Sleep Medicine
Luca Baldelli, Olga Addimanda, Marco Burattini, Giacomo Chiaro, Veronica Brusi, Elettra Pignotti, Riccardo Meliconi, Federica Provini
OBJECTIVES: To investigate the prevalence of REM sleep behavior disorder (RBD) in patients with inflammatory arthritis (IA) to ascertain if RBD could be an internal red flag signaling a fluctuating state of inflammation based on the theory of "protoconsciousness". MATERIALS & METHODS: One hundred and three patients with a confirmed diagnosis of IA were consecutively recruited. The patients underwent general (IA activity, functional status, laboratory tests) and neurological evaluations...
February 15, 2019: Brain and Behavior
Ryuji Sakakibara, Fuyuki Tateno, Yosuke Aiba, Tsuyoshi Ogata, Masahiko Kishi, Hitoshi Terada, Tsutomu Inaoka, Tomoya Nakatsuka, Katsuyoshi Matsuoka
Objectives: Neuroimaging markers for Parkinson's disease (PD)/dementia with Lewy bodies (DLB) include dopamine transporter (DAT) scanning and metaiodobenzylguanidine (MIBG) myocardial scintigraphy. It is unknown which marker is useful to identify the premotor phase PD/DLB. We reported four patients who, during a negative DAT scan period, had a positive MIBG result that suggested premotor PD/DLB. Here we report 18 additional patients. Methods: This study was a prospective cohort study...
January 2019: Movement Disorders Clinical Practice
David Weise, Clemens Pargac, Johann Otto Pelz, Jost-Julian Rumpf, Christopher Fricke, Joseph Classen
OBJECTIVE: Degeneration of nuclei of the brainstem, especially parts of the vagal nuclei complex and the reticular formation, in Parkinson's disease (PD) may in part be responsible for nonmotor signs like obstipation, cardiac dysfunction and rapid eye movement sleep behavior disorder (RBD). The aim of the study was to establish a new blink reflex (BR) variant involving the vagal nuclei complex and the reticular formation and to investigate BR comprehensively using 3 different afferent routes in PD...
January 19, 2019: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Linda A Hershey, Rhonda Coleman-Jackson
Dementia with Lewy bodies (DLB) is a complex disease that involves a variety of cognitive, behavioral and neurological symptoms, including progressive memory loss, visual hallucinations, parkinsonism, cognitive fluctuations and rapid eye movement sleep behavior disorder (RBD). These symptoms may appear in varying combinations and levels of severity in each patient who is seen in the clinic, making diagnosis and treatment a challenge. DLB is the third most common of all the neurodegenerative diseases behind both Alzheimer's disease and Parkinson's disease (PD)...
January 25, 2019: Drugs & Aging
Kazumasa Shindo, Tohko Sato, Hiroaki Murata, Yuta Ichinose, Takanori Hata, Yoshihisa Takiyama
BACKGROUND: Spinocerebellar ataxia type 31 (SCA 31) is a slowly progressive neurodegenerative disorder characterized by pure cerebellar ataxia. Unlike other CAG repeat diseases, sleep-related problems have not been reported in patients with SCA 31 so far. CASE PRESENTATION: A 67-year-old woman was admitted to our hospital with dysarthria and gait disturbance after onset age of 62 years. Neurological examination revealed pure cerebellar ataxia. Genetic analysis detected expansion of a TGGAA repeat in the coding region of the BEAN/TK2 gene on chromosome 16p22...
January 11, 2019: BMC Neurology
Chun Yao, Seyed-Mohammad Fereshtehnejad, Mark R Keezer, Christina Wolfson, Amélie Pelletier, Ronald B Postuma
OBJECTIVE: To assess sociodemographic, socioeconomic, and clinical correlates of idiopathic REM sleep behavior disorder (RBD) in a 30,097-person national cohort. METHODS: Participants 45 to 85 years of age in Canada were collected as part of the Canadian Longitudinal Study on Aging. Possible RBD (pRBD) was screened with the REM Sleep Behavior Disorder Single-Question Screen, a questionnaire with 94% specificity and 87% sensitivity. To improve diagnostic accuracy, those screening positive for apnea or non-REM parasomnia (young-onset pRBD) and those self-reporting dementia or Parkinson disease were excluded...
December 26, 2018: Neurology
Gilad Yahalom, Lior Greenbaum, Simon Israeli-Korn, Tsvia Fay-Karmon, Vered Livneh, Jennifer A Ruskey, Léanne Roncière, Armaghan Alam, Ziv Gan-Or, Sharon Hassin-Baer
INTRODUCTION: The clinical characteristics of Parkinson's disease (PD) associated with both the LRRK2 p.G2019S mutation and a GBA variant (LRRK2-GBA-PD) have not yet been determined. METHODS: In this retrospective observational study of Ashkenazi-Jewish (AJ) PD patients, we describe the clinical course and characteristics of LRRK2-GBA-PD and estimate the risk to develop PD for the double mutation carriers. Odds ratios (OR) were estimated using published data on frequencies of GBA and LRRK2 mutations...
December 13, 2018: Parkinsonism & related Disorders
Sungyang Jo, Hyun-Woo Kim, Ji Ye Jeon, Sang-Ahm Lee
BACKGROUND: This study investigated the protective effect of rapid eye movement (REM) sleep without atonia against obstructive sleep apnea (OSA) in patients with idiopathic REM sleep behavior disorder (RBD). METHODS: In this case-control study, patients with idiopathic RBD and OSA (RBD-OSA) were consecutively enrolled and OSA controls without RBD were matched for age, sex, and apnea-hypopnea index (AHI). Clinical and polysomnographic characteristics were compared between RBD-OSA patients and OSA controls...
November 19, 2018: Sleep Medicine
Roberta Ronchi, Irene Rossi, Elena Calzolari, Nadia Bolognini, Giuseppe Vallar
Prism adaptation is a well-known method used to investigate brain plasticity, and a promising technique for the rehabilitation of unilateral spatial neglect (USN). Only little evidence about the mechanisms of prism adaptation (PA) in patients with left-brain damage is on record, and about putative differences of PA, and the aftereffects (AEs), between patients with left and right brain damage. In the present study, PA and the AEs were assessed in 30 brain-damaged patients, 20 with right-sided lesions (10 with and 10 without USN), and 10 with left-sided lesions without USN, as well as in a control group of 24 age-matched participants...
November 1, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Navin Cooray, Fernando Andreotti, Christine Lo, Mkael Symmonds, Michele T M Hu, Maarten De Vos
This study aims to develop automated diagnostic tools to aid in the identification of rapid-eye-movement (REM) sleep behaviour disorder (RBD). Those diagnosed with RBD enact their dreams and therefore present an abnormal characteristic of movement during REM sleep. Several methods have been proposed for RBD detection that use electromyogram (EMG) recordings and manually annotated sleep stages to objectively quantify abnormal REM movement. In this work we further develop these proven techniques with additional features that incorporate the relationship of muscle movement between sleep stages and general sleep architecture...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Hossein Sanjari Moghaddam, Mahsa Dolatshahi, Elaheh Salardini, Mohammad Hadi Aarabi
OBJECTIVE: Although olfaction dysfunction is now considered as an established clinical marker of prodromal Parkinson disease (PD), little is known about the neural underpinnings of olfaction dysfunction in the prodromal phase of PD. The aim of this study was to examine the microstructural association of olfaction in prodromal PD compared to early stage drug-naïve PD patients. METHODS: Diffusion MRI connectometry was conducted on 18 early PD and 17 prodromal PD patients to investigate the differences in group in terms of altered connectivity, i...
November 1, 2018: Neurological Sciences
Alberto Romagnolo, Maurizio Zibetti, Aristide Merola, Daniela Canova, Marianna Sarchioto, Elisa Montanaro, Carlo Alberto Artusi, Fabrizio Vallelonga, Simona Maule, Leonardo Lopiano
BACKGROUND: Falls represent one of the main complications of Parkinson's disease (PD), significantly lowering quality of life. Cardiovascular autonomic neuropathy (cAN) is one of the key contributing factors to PD-associated falls. However, a direct quantification of its impact on the risk of falling in PD is still lacking. In this 12-month prospective study, we sought to evaluate the association between cAN and falls. METHODS: Fifty consecutive patients were evaluated with a standardized battery of autonomic testing, Unified Parkinson's Disease Rating Scale, push and release (P&R) test, timed up and go test, freezing of gait (FOG) questionnaire, Montreal cognitive assessment (MoCA)...
October 31, 2018: Journal of Neurology
Chaoran Ma, Milena Pavlova, Junjuan Li, Ying Liu, Yujie Sun, Zhe Huang, Shouling Wu, Xiang Gao
Objective: To systematically examine the association between alcohol intake and likelihood of having probable rapid eye movement sleep behavior disorder (pRBD) 6 years later. Methods: The study included 11,905 participants (mean age: 47.7 years) of the Kailuan Study, free of stroke, cancer, Parkinson disease, dementia, and head injury in 2006. We determined pRBD using a validated RBD questionnaire-Hong Kong in 2012. Amounts and types of alcohol intake were collected with questionnaire...
October 2018: Annals of Clinical and Translational Neurology
Raffaele Ferri, Debora Aricò, Filomena I I Cosentino, Bartolo Lanuzza, Giacomo Chiaro, Mauro Manconi
Objective: To assess the presence of increased REM-related motor activity during sleep, by questionnaires for REM sleep behavior disorder (RBD), in subjects with "isolated" REM sleep without atonia (RWA). Subjects and Methods: Two-hundred-and-forty-nine patients were consecutively enrolled, with age ≥18 years, sharing bedroom with a roommate, and without a severe health, neurologic or cognitive problem. Motor activity during sleep was assessed by means of the RBD Screening Questionnaire (RBDSQ) and the RBD questionnaire-Hong Kong (RBDQ-HK)...
September 15, 2018: Sleep
Shuangwu Liu, Dongchao Shen, Hongfei Tai, Ning Su, Qingyun Ding, Hanhui Fu, Kang Zhang, Zhili Wang, Mingsheng Liu, Yan Huang, Liying Cui
Objective: To evaluate the frequency and clinical features of restless legs syndrome (RLS) in a group of Chinese patients with amyotrophic lateral sclerosis (ALS). Methods: 109 Patients included in this study fulfilled the revised El Escorial diagnostic criteria for clinically definite, probable and lab-supported probable ALS, and a group of 109 control subjects was matched for age and sex to the ALS group. Disease severity was assessed by the revised ALS functional rating scale (ALSFRS-R). The diagnosis of RLS was made according to the criteria of the International RLS Study Group...
2018: Frontiers in Neurology
Kamila Weissová, Jitka Škrabalová, Kateřina Skálová, Kateřina Červená, Zdeňka Bendová, Eva Miletínová, Jana Kopřivová, Karel Šonka, Daniela Dudysová, Aleš Bartoš, Jitka Bušková
OBJECTIVE: To evaluate changes in the expression of clock genes and melatonin levels in patients with idiopathic REM sleep behavior disorder (RBD) as a potential early stage of synucleinopathies. METHODS: We assessed the rhythmicity of circadian clock genes using real time-quantitative polymerase chain reaction and 24-h blood melatonin profiles using radio-immunoassay in 10 RBD patients and nine age-matched controls. RESULTS: The RBD patients did not show circadian rhythmicity for clock genes Per2, Bmal1, and Nr1d1 but the rhythmicity of Per 1 remained, and the amplitude of Per3 was diminished...
August 9, 2018: Sleep Medicine
Lana M Chahine, Liz Urbe, Chelsea Caspell-Garcia, Dag Aarsland, Roy Alcalay, Paolo Barone, David Burn, Alberto J Espay, Jamie L Hamilton, Keith A Hawkins, Shirley Lasch, James B Leverenz, Irene Litvan, Irene Richard, Andrew Siderowf, Christopher S Coffey, Tanya Simuni, Daniel Weintraub
INTRODUCTION: Several characteristics associated with increased risk for Parkinson's disease (PD) have been identified, including specific genotypes and various non-motor symptoms. Characterizing non-motor features, such as cognitive abilities, among individuals considered at-risk for PD is essential to improving prediction of future neurodegeneration. METHODS: Participants belonging to the following cohorts of the Parkinson Progression Markers Initiative (PPMI) study were included: de novo PD with dopamine transporter binding deficit (n = 423), idiopathic REM sleep behavior disorder (RBD, n = 39), hyposmia (n = 26) and non-PD mutation carrier (NMC; Leucine-rich repeat kinase 2 (LRRK2) G2019S (n = 88) and glucocerebrosidase (GBA) gene (n = 38) mutations))...
2018: PloS One
Katherine C Hughes, Xiang Gao, Jessica M Baker, Christopher Stephen, Iris Y Kim, Linda Valeri, Michael A Schwarzschild, Alberto Ascherio
BACKGROUND: Several non-motor features may individually contribute to identify prodromal Parkinson's disease (PD), but little is known on how they interact. METHODS: We conducted a case-control study nested within the Health Professionals Follow-up Study in a large cohort of men age 40-75 at recruitment in 1986. Cases (n=120) had confirmed PD, were <85 in January 2012, returned a 2012 questionnaire with questions on probable rapid eye movement sleep behaviour disorder (RBD) and constipation sent to all cohort participants and completed in 2014 the Brief Smell Identification Test and a questionnaire assessing parkinsonism and other non-motor PD features (including depressive symptoms, excessive daytime sleepiness, impaired colour vision and body pain)...
August 3, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
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