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Pediatrics metabolic syndrome

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https://read.qxmd.com/read/30747351/collapsing-glomerulopathy-in-a-child-with-lchad-deficiency-a-rare-association
#1
Gurinder Kumar, Rajendran Nair, Bassem Soliman Hendawy, Omar Ahmed AlShkeili, Ahmed Abdulla Alabdouli, Adnan Mohamed Al Ali, Amal Mohamed Jasem AlTenaiji
Metabolic disorders, although rare, can involve multiple organ systems and have a varied presentation. Renal involvement has been reported in several metabolic disorders in the pediatric age group. We report a rare metabolic disorder, long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency, in a child who developed steroid-resistant nephrotic syndrome at the age of 5 years. Renal biopsy showed features of collapsing glomerulopathy. The child had progressive chronic kidney disease. Alternative immunosuppressants including tacrolimus failed to show any clinical improvement...
February 12, 2019: CEN Case Reports
https://read.qxmd.com/read/30736978/laparoscopic-living-donor-hepatectomy-for-pediatric-liver-transplantation-the-first-7-cases-in-spain
#2
J Briceno, R Ciria, P López, A Luque, A Arjona-Sanchez, J M Sánchez-Hidalgo, M D Ayllón, I Gómez-Luque, J Gomez
Herein we report on laparoscopic donor hepatectomy (left lateral sectionectomy) for pediatric living donor liver transplantation by using a pure laparoscopic approach. Seven laparoscopic living donor procedures were performed during the period March 2016 to February 2017 at our institution. The average age of donors was 33.3 years. Preoperative liver function was normal in all donors. Four donors required 1 or more Pringle maneuver(s). The etiology was biliary atresia (n = 3), metabolic disorders (n = 2) (OTC deficiency), Alagille syndrome (n = 1), and neonatal ductopenia (n = 1)...
January 2019: Transplantation Proceedings
https://read.qxmd.com/read/30725017/-high-prevalence-of-overweight-obesity-insulin-resistance-and-metabolic-syndrome-in-rural-children-and-adolescents
#3
Jorge Sapunar, Nicolás Aguilar-Farías, Juan Navarro, Gustavo Araneda, Damian Chandia-Poblete, Víctor Manríquez, Roberto Brito, Alvaro Cerda
BACKGROUND: Childhood and adolescent obesity is a major public health problem in Chile. AIM: To characterize cardiometabolic risk factors in a population of schoolchildren from Carahue, Chile. MATERIAL AND METHODS: Cross-sectional assessment of 208 children aged 10.4 ± 1.0 years (106 women). A clinical evaluation was carried out including pubertal development according to Tanner and anthropometric parameters. A fasting blood sample was obtained to measure glucose, insulin and lipid profile...
September 2018: Revista Médica de Chile
https://read.qxmd.com/read/30710625/metabolic-syndrome-in-adolescents-with-polycystic-ovary-syndrome-prevalence-based-on-different-diagnostic-criteria
#4
Sinem Akgül, Andrea E Bonny
STUDY OBJECTIVE: Existing literature on the prevalence of metabolic syndrome (MBS) in adolescents with polycystic ovary syndrome (PCOS) is inconsistent, likely due to the application of differing diagnostic criteria. The objective was to assess the prevalence of MBS in adolescents with PCOS depending on the PCOS diagnostic criteria utilized. DESIGN, SETTING, AND PARTICIPANTS: A retrospective chart review of female patients (N=37), ages 11-22 years, diagnosed with PCOS between 01/2013-12/2017...
January 30, 2019: Journal of Pediatric and Adolescent Gynecology
https://read.qxmd.com/read/30701372/loss-of-control-eating-and-obesity-among-children-and-adolescents
#5
REVIEW
Meghan E Byrne, Sarah LeMay-Russell, Marian Tanofsky-Kraff
PURPOSE OF REVIEW: This review summarizes findings on pediatric loss-of-control (LOC) eating and obesity published since 2013 in relation to physiological, socioenvironmental, and psychological factors. RECENT FINDINGS: LOC eating and obesity are highly comorbid in youth. Genetic and physiological risk factors are associated with the development of LOC eating. Adverse physiological outcomes of LOC eating include increased risk for overweight and obesity and greater dysfunction in components of metabolic syndrome...
January 30, 2019: Current Obesity Reports
https://read.qxmd.com/read/30693370/metabolic-liver-diseases-presenting-with-neonatal-cholestasis-at-the-crossroad-between-old-and-new-paradigms
#6
Helena Moreira-Silva, Inês Maio, Anabela Bandeira, Esmeralda Gomes-Martins, Ermelinda Santos-Silva
Metabolic liver diseases (MLD) are an important group of disorders presenting with neonatal cholestasis (NC). The spectrum of liver involvement is wide and the presumptive diagnosis is traditionally based on clinical and laboratory findings. Recently, next-generation sequencing (NGS) panels have emerged as an appealing tool to diagnose neonatal/infantile cholestatic disorders. The aim of this study was to identify clinical phenotypes of liver injury and contribute to find a diagnostic methodology that integrates new molecular diagnostic tools...
January 28, 2019: European Journal of Pediatrics
https://read.qxmd.com/read/30691143/metabolomic-salivary-signature-of-pediatric-obesity-related-liver-disease-and-metabolic-syndrome
#7
Jacopo Troisi, Federica Belmonte, Antonella Bisogno, Luca Pierri, Angelo Colucci, Giovanni Scala, Pierpaolo Cavallo, Claudia Mandato, Antonella Di Nuzzi, Laura Di Michele, Anna Pia Delli Bovi, Salvatore Guercio Nuzio, Pietro Vajro
Pediatric obesity-related metabolic syndrome (MetS) and nonalcoholic fatty liver disease (NAFLD) are increasingly frequent conditions with a still-elusive diagnosis and low-efficacy treatment and monitoring options. In this study, we investigated the salivary metabolomic signature, which has been uncharacterized to date. In this pilot-nested case-control study over a transversal design, 41 subjects (23 obese patients and 18 normal weight (NW) healthy controls), characterized based on medical history, clinical, anthropometric, and laboratory data, were recruited...
January 26, 2019: Nutrients
https://read.qxmd.com/read/30685742/hepatopathies-in-children-and-adolescents-with-type-1-diabetes
#8
Firdevs Aydın, Nelgin Gerenli, Fatma Dursun, Tülay Öztürk Atasoy, Sevinç Kalın, Heves Kırmızıbekmez
Background Diabetes and hepatosteatosis are dramatically increasing in childhood. Non-alcoholic fatty liver disease (NAFLD) is defined as a common disorder in adulthood, especially with type-2 diabetes and metabolic syndrome, while very few studies are available on liver health in children with type-1 diabetes. Patients and methods One hundred and ten (52 males and 58 females) patients with type-1 diabetes aged between 8 and 18 years were examined. The lipid profile, liver enzymes and hepatobiliary ultrasound findings of patients were investigated in terms of hepatopathies...
January 26, 2019: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://read.qxmd.com/read/30676437/metabolic-changes-in-children-that-received-chemotherapy
#9
Elena Soto-Vega, Luis S Carrillo-Vicente, Juan C Vázquez, María C Pérez de Celis Herrero, María J Muñoz-Pérez
Cancer treatments are associated with short and long-effects. Epidemiological reports have revealed clinical features of metabolic syndrome (MS), obesity or overweight in young cancer survivors. The aim of the study was to examine the prevalence of unhealthy weight status and risk factors associated with MS related to chemotherapy. We study 52 pediatric cancer patients and analyze cholesterol, triglycerides, glycosylated hemoglobin, body mass index, waist circumference (WC), FINDRISC test. All the parameters were analyzed according to the percentile corresponding to sex and age of each child...
January 22, 2019: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/30664821/center-variation-in-screening-for-and-management-of-metabolic-syndrome-in-pediatric-liver-transplant-recipients-a-survey-of-split-centers
#10
Kelly Hilk, Melissa Zerofsky, Sue Rhee, Philip Rosenthal, Emily R Perito
INTRODUCTION: PTMS-a clustering of hypertension, dyslipidemia, glucose intolerance/diabetes, and obesity-is increasingly recognized as a contributor to long-term morbidity after transplant. We sought to describe pediatric liver transplant center protocols and provider practices in screening for and managing these conditions. METHODS: Cross-sectional survey of pediatric liver transplant providers from centers that participate in Studies of Liver Transplantation (SPLIT)...
January 21, 2019: Pediatric Transplantation
https://read.qxmd.com/read/30657467/a-recurrent-de-novo-mutation-in-atp1a3-gene-in-a-mexican-patient-with-alternating-hemiplegia-of-childhood-detected-by-massively-parallel-sequencing
#11
Carolina I Galaz-Montoya, Sofia Alcaraz-Estrada, Leopoldo A García-Montaño, Juan C Zenteno, Raul E Piña-Aguilar
Background: Pediatric movement disorders represent a diagnostic challenge for pediatricians and pediatric neurologists due to their high clinical heterogeneity and shared common features. Therefore, specific diagnoses require different approaches including metabolic work-up and specific tests for frequent genetic conditions. Alternating hemiplegia of childhood (AHC) is an ultra-rare pediatric movement disorder, characterized by paroxysmal alternating hemiplegia, dystonia, and seizure-like episodes that can be misleading during the evaluation of a child with a movement disorder...
2019: Boletín Médico del Hospital Infantil de México
https://read.qxmd.com/read/30654153/pediatric-endocrinology-through-syndromes
#12
REVIEW
Gianluca Tornese, Maria Chiara Pellegrin, Egidio Barbi, Alessandro Ventura
In everyday practice, a pediatric endocrinologist will face a variety of different endocrine issues (such as short or tall stature, dysthyroidism, abnormal pubertal timing or impaired glucose metabolism), which relevantly contribute to the global care of a number of syndromic conditions. On the other hand, the presence of endocrine features may assist in the diagnostic process, leading to final diagnosis of a syndromic disorder. The intention of this review is to provide a referenced overview of different genetic syndromes characterized by endocrine features, and to present a possible classification, based on whether the endocrinopathy or the syndrome is typically recognized first...
January 14, 2019: European Journal of Medical Genetics
https://read.qxmd.com/read/30616577/hepatomegaly-and-type-1-diabetes-a-clinical-case-of-mauriac-s-syndrome
#13
Fortunato Lombardo, Stefano Passanisi, Albino Gasbarro, Giovanni Tuccari, Antonio Ieni, Giuseppina Salzano
BACKGROUND: Hepatic glycogenosis is characterized by excessive glycogen accumulation in hepatocytes and represents a complication of poor controlled type 1 diabetes. It can be caused by excessive insulin doses or recurrent ketoacidosis episodes. Mauriac's syndrome is a rare disease, which includes short stature, growth maturation delay, dyslipidemia, moon facies, protuberant abdomen, hepatomegaly with transaminase elevation. It has become even less common after the emergence of advances on diabetes treatment, but still exists...
January 7, 2019: Italian Journal of Pediatrics
https://read.qxmd.com/read/30606251/host-immunoglobulin-g-selectively-identifies-pathobionts-in-pediatric-inflammatory-bowel-diseases
#14
Heather Armstrong, Misagh Alipour, Rosica Valcheva, Michael Bording-Jorgensen, Juan Jovel, Deenaz Zaidi, Prachi Shah, Yuefei Lou, Cory Ebeling, Andrew L Mason, Dawson Lafleur, Jeremy Jerasi, Gane K-S Wong, Karen Madsen, Matthew W Carroll, Hien Q Huynh, Levinus A Dieleman, Eytan Wine
BACKGROUND: Inflammatory bowel diseases (IBD) are a group of complex and multifactorial disorders with unknown etiology. Chronic intestinal inflammation develops against resident intestinal bacteria in genetically susceptible hosts. We hypothesized that host intestinal immunoglobulin (Ig) G can be used to identify bacteria involved in IBD pathogenesis. RESULTS: IgG-bound and -unbound microorganisms were collected from 32 pediatric terminal ileum aspirate washes during colonoscopy [non-IBD (n = 10), Crohn disease (n = 15), and ulcerative colitis (n = 7)], and composition was assessed using the Illumina MiSeq platform...
January 3, 2019: Microbiome
https://read.qxmd.com/read/30599480/association-between-hemoglobin-glycation-index-and-cardiometabolic-risk-factors-in-korean-pediatric-nondiabetic-population
#15
Bora Lee, You Jung Heo, Young Ah Lee, Jieun Lee, Jae Hyun Kim, Seong Yong Lee, Choong Ho Shin, Sei Won Yang
PURPOSE: The hemoglobin glycation index (HGI) represents the degree of nonenzymatic glycation and has been positively associated with cardiometabolic risk factors (CMRFs) and cardiovascular disease in adults. This study aimed to investigate the association between HGI, components of metabolic syndrome (MS), and alanine aminotransferase (ALT) in a pediatric nondiabetic population. METHODS: Data from 3,885 subjects aged 10-18 years from the Korea National Health and Nutrition Examination Survey (2011-2016) were included...
December 2018: Annals of Pediatric Endocrinology & Metabolism
https://read.qxmd.com/read/30592949/-application-value-of-continuous-blood-purification-in-pediatric-intensive-care-unit-analysis-of-203-cases
#16
Shaodong Zhao, Xuhua Ge, Penghong Xu, Yong Liu, Jun Shi, Hongjun Miao
OBJECTIVE: To explore the clinical application value of the continuous blood purification (CBP) technology in pediatric intensive care unit (ICU). METHODS: A retrospective study was conducted. All CBP patients admitted to pediatric ICU of Children's Hospital of Nanjing Medical University from 2015 to 2017 were enrolled. The disease diagnosis, CBP treatment mode, catheter placement, anticoagulation way, treatment time and adverse reactions were summarized and analyzed...
December 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/30582317/evaluation-of-unfavorable-cardiovascular-and-metabolic-risk-factors-in-children-and-young-adults-with-haemophilia
#17
Melek Yıldız, Nihal Özdemir, Hasan Önal, Başak Koç, Beyza Eliuz Tipici, Bülent Zülfikar
Objective: Increased risk of unfavorable cardiovascular risk factors has been defined in the aging population of haemophilia however they were less investigated in young patients. The purpose of this study was to assess obesity, hypertension, metabolic variables, insulin resistance and metabolic syndrome in young patients with haemophilia (PwH). Methods: Forty-eight haemophilia A and B patients and 35 age and sex matched healthy controls were included. Anthropometric measurements, blood pressure, fasting glucose and insulin levels, serum lipids and dietary intakes were evaluated...
December 24, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/30549264/waist-circumference-and-abdominal-volume-index-are-the-strongest-anthropometric-discriminators-of-metabolic-syndrome-in-spanish-adolescents
#18
Javier S Perona, Jacqueline Schmidt Rio-Valle, Robinson Ramírez-Vélez, María Correa-Rodríguez, Ángel Fernández-Aparicio, Emilio González-Jiménez
BACKGROUND: Waist circumference has been suggested as predictor for metabolic syndrome (MetS) in adolescents but it has not been compared with newly proposed anthropometric indexes. This study aimed to disclose the capacity of ten classic and novel anthropometric indexes to discriminate by the presence of MetS in this young population. MATERIALS AND METHODS: A cross-sectional study was performed on 981 adolescents (13.2±1.2 y) randomly recruited from eighteen schools in south-east Spain...
December 14, 2018: European Journal of Clinical Investigation
https://read.qxmd.com/read/30540704/fecal-microbiota-transplantation-for-recurrent-clostridium-difficile-infection-and-other-conditions-in-children-a-joint-position-paper-from-the-north-american-society-for-pediatric-gastroenterology-hepatology-and-nutrition-and-the-european-society-for-pediatric
#19
Zev H Davidovics, Sonia Michail, Maribeth R Nicholson, Larry K Kociolek, Nikhil Pai, Richard Hansen, Tobias Schwerd, Aldo Maspons, Raanan Shamir, Hania Szajewska, Nikhil Thapar, Tim de Meij, Alexis Mosca, Yvan Vandenplas, Stacy A Kahn, Richard Kellermayer
Fecal microbiota transplantation (FMT) is becoming part of the treatment algorithms against recurrent Clostridium difficile infection (rCDI) both in adult and pediatric gastroenterology practice. With our increasing recognition of the critical role the microbiome plays in human health and disease, FMT is also being considered as a potential therapy for other disorders, including inflammatory bowel disease (Crohn disease, ulcerative colitis), graft versus host disease, neuropsychiatric diseases, and metabolic syndrome...
January 2019: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/30532105/-efectos-sobre-el-perfil-metab%C3%A3-lico-el-%C3%A3-ndice-de-masa-corporal-la-composici%C3%A3-n-corporal-y-la-comorbilidad-en-adolescentes-con-obesidad-m%C3%A3-rbida-que-han-fallado-al-manejo-conservador-para-bajar-de-peso-operados-de-manga-g%C3%A3-strica-laparosc%C3%A3-pica-reporte-del
#20
Jaime Nieto-Zermeño, Ricardo Ordorica Flores, Blanca Del Río-Navarro, Betzabé Salgado-Arroyo, Jorge Mario Molina-Díaz
Introduction: Obesity is a world pandemic; in Mexico 3 out of 10 adolescents suffer from it. Conservative management of morbid obesity is not effective and bariatric surgery is the only useful therapy. International pediatric bariatric surgery series are scarce and in Mexico there is limited experience. Method: We analyze the metabolic repercussions, comorbidities and complications in our series of Mexican adolescents with morbid obesity who underwent a gastric sleeve between 2011 and 2015...
2018: Gaceta Médica de México
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