Raquel Gil Laborda, Edgard Rodríguez de Frías, Nabil Subhi-Issa, Elena Carrillo de Albornoz, Elena Meliá, Marcos Órdenes, Victoria Verdú, Juan Vidal, Esther Suárez, Isabel Santillán, Daniel Ordóñez, David Pintado-Vera, Victoria González Villafáñez, Ángel Lorenzo, Manuel Fariñas, Mario Rodríguez-Paíno, María Núñez Beltrán, Áurea García Segovia, Ainhoa Del Olmo, Fernando Martín Cañadas, Rosa Daurelio, Alfonso de la Fuente, José Manuel González Casbas, Vega Cabezuelo, Francisco Ros Berruezo, Miguel Ángel Moreno Hidalgo, Silvia Iniesta, Beatriz Bueno, Álvaro Martínez Acera, Alexandra Izquierdo, José Luis Vicario, Miguel Fernández-Arquero, Silvia Sánchez-Ramón
Throughout pregnancy, the decidua is predominantly populated by NK lymphocytes expressing Killer immunoglobulin-like receptors (KIR) that recognize human leukocyte antigen-C (HLA-C) ligands from trophoblast cells. This study aims to investigate the association of KIR-HLA-C phenotypes in couples facing infertility, particularly recurrent pregnancy loss (RPL) and recurrent implantation failure (RIF), in comparison to a reference population and fertile controls. This observational, non-interventional retrospective case-control study included patients consecutively referred to our Reproductive Immunology Unit from 2015 to 2019...
February 9, 2024: Scientific Reports