keyword
https://read.qxmd.com/read/38393529/embryo-transfer-strategies-for-women-with-recurrent-implantation-failure-during-the-frozen-thawed-embryo-transfer-cycles-sequential-embryo-transfer-or-double-blastocyst-transfer
#21
JOURNAL ARTICLE
Qiao-Hang Zhao, Yu-Wei Song, Jian Chen, Xiang Zhou, Ji-Lai Xie, Qiu-Ping Yao, Qi-Yin Dong, Chun Feng, Li-Ming Zhou, Wei-Ping Fu, Min Jin
OBJECTIVE: Both sequential embryo transfer (SeET) and double-blastocyst transfer (DBT) can serve as embryo transfer strategies for women with recurrent implantation failure (RIF). This study aims to compare the effects of SeET and DBT on pregnancy outcomes. METHODS: Totally, 261 frozen-thawed embryo transfer cycles of 243 RIF women were included in this multicenter retrospective analysis. According to different embryo quality and transfer strategies, they were divided into four groups: group A, good-quality SeET (GQ-SeET, n=38 cycles); group B, poor-quality or mixed-quality SeET (PQ/MQ-SeET, n=31 cycles); group C, good-quality DBT (GQ-DBT, n=121 cycles); and group D, poor-quality or mixed-quality DBT (PQ/MQ-DBT, n=71 cycles)...
February 2024: Current Medical Science
https://read.qxmd.com/read/38385050/zona-pellucida-removal-resulted-in-a-successful-live-birth-report-on-a-case-with-recurrent-implantation-failure-due-to-embryonic-bacteria-contamination
#22
Son Truong Dang, Huy Phuong Tran, Tuong Nguyen Ho, Loc Thai Ly, Tuyet Thi-Diem Hoang, Trang Nguyen-Khanh Huynh, Anh Tuan Do, Thuan Duc Nguyen, Phuong Thi Dao
KEY CLINICAL MESSAGE: In in vitro fertilization (IVF), laser offers several advantages. In this study, we employed laser to eliminate the zona pellucida of a contaminated embryo. This approach helps to rescue embryo with bacterial contamination, and improve embryo-endometrium interaction. ABSTRACT: To present a case report on the removal of a contaminated zona pellucida from an embryo of patient with a history of recurrent implantation failure (RIF), which was followed by a successful live birth...
February 2024: Clinical Case Reports
https://read.qxmd.com/read/38384848/upregulated-%C3%AE-actinin-1-impairs-endometrial-epithelial-cell-adhesion-by-downregulating-nebl-in-recurrent-implantation-failure
#23
JOURNAL ARTICLE
Xiaowei Zhou, Jingru Duan, Wenjie Zhou, Aijun Zhang, Qian Chen
Poor endometrial receptivity results in embryo implantation failure. Acquisition of endometrial receptivity involves substantial structural alterations in the cytoskeleton and plasma membrane of epithelial cells, which facilitate embryo adhesion. However, the underlying molecular mechanism remains largely unknown. In this study, we identified that α-actinin-1 (ACTN1) was significantly downregulated in the mid-secretory phase of the endometrium compared with other phases; however, ACTN1 significantly increased in women with recurrent implantation failure (RIF)...
March 15, 2024: IScience
https://read.qxmd.com/read/38384413/preimplantation-genetic-testing-for-aneuploidy-optimizes-reproductive-outcomes-in-recurrent-reproductive-failure-a-systematic-review
#24
Youwen Mei, Yonghong Lin, Ying Chen, Jiafeng Zheng, Xue Ke, Xuefei Liang, Fang Wang
INTRODUCTION: Recurrent reproductive failure (RRF) is a common pregnancy complication, imposing great physical, emotional and financial burden for the suffered couples. The leading cause of RRF is believed to be aneuploid embryo, which could be solved by preimplantation genetic testing for aneuploidy (PGT-A) in theory. With molecular genetic development, PGT-A based on comprehensive chromosomal screening (CCS) procedures and blastocyst biopsy is widely applied in clinical practice. However, its effects in RRF were not defined yet...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38365988/intravenous-immunoglobulin-for-patients-with-unexplained-recurrent-implantation-failure-a-6-year-single-center-retrospective-review-of-clinical-outcomes
#25
JOURNAL ARTICLE
Einav Kadour Peero, Shorooq Banjar, Rabea Khoudja, Shaonie Ton-Leclerc, Coralie Beauchamp, Joanne Benoit, Marc Beltempo, Michael H Dahan, Phil Gold, Isaac Jacques Kadoch, Wael Jamal, Carl Laskin, Neal Mahutte, Simon Phillips, Camille Sylvestre, Shauna Reinblatt, Bruce D Mazer, William Buckett, Genevieve Genest
The effectiveness of intravenous immunoglobulin (IVIg) for patients with unexplained recurrent implantation failure (uRIF) remains debated. We retrospectively analysed outcomes of uRIF patients treated with IVIg compared to a separate control uRIF cohort within our center (01/2014-12/2021). Primary outcomes included live birth, miscarriage, or transfer failure. We documented IVIg side effects and maternal/fetal outcomes. Logistic regression analysis was used to assess for association of IVIg exposure with outcomes and adjust for confounders...
February 16, 2024: Scientific Reports
https://read.qxmd.com/read/38365686/sequential-embryo-transfer-combined-with-intrauterine-perfusion-improved-pregnancy-outcomes-in-patients-with-recurrent-implantation-failure
#26
JOURNAL ARTICLE
Wenda Zou, Dan Liu, Juan Peng, Zhijing Tang, Yukun Li, Juan Zhang, Ziwei Liu
OBJECTIVE: To compare the application of sequential embryo transfer, cleavage embryo transfer, and blastocyst transfer combined with intrauterine perfusion in frozen-thawed embryo transfer cycles in patients with recurrent implantation failure to provide a reference for reproductive clinicians. METHODS: The 166 patients who underwent frozen-thawed embryo transfer due to recurrent implantation failure in the reproductive center from January 2021 to March 2022 were retrospectively analyzed...
February 16, 2024: BMC Women's Health
https://read.qxmd.com/read/38350949/the-reproductive-potential-of-vitrified-warmed-euploid-embryos-declines-following-repeated-uterine-transfers
#27
JOURNAL ARTICLE
A Almohammadi, F Choucair, L El Taha, H Burjaq, M Albader, A B Cavanillas, Johnny T Awwad
BACKGROUND: Recurrent implantation failure (RIF) represents a vague clinical condition with an unclear diagnostic challenge that lacks solid scientific underpinning. Although euploid embryos have demonstrated consistent implantation capabilities across various age groups, a unanimous agreement regarding the advantages of preimplantation genetic testing for aneuploidy (PGT-A) in managing RIF is absent. The ongoing discussion about whether chromosomal aneuploidy in embryos significantly contributes to recurrent implantation failure remains unsettled...
February 13, 2024: Reproductive Biology and Endocrinology: RB&E
https://read.qxmd.com/read/38348954/the-use-of-immunomodulation-therapy-in-women-with-recurrent-implantation-failure-undergoing-assisted-conception-a-multicentre-cohort-study
#28
MULTICENTER STUDY
Mohammed Khairy, Hoda Harb, Abey Eapen, Pedro Melo, Rahnuma Kazem, Madhurima Rajkhowa, George Ndukuwe, Arri Coomarasamy
PROBLEM: Recurrent implantation failure (RIF) after multiple embryo transfers remains a vexing problem and immunomodulators have been used with conflicting results. This study aims to assess the effect of immunomodulation therapy on live birth rate (LBR) in women with RIF undergoing assisted reproduction treatment (ART). METHOD OF STUDY DESIGN: This is a retrospective cohort study in multicentre network of private assisted conception units in the UK. The study included women who had at least two failed attempts of embryo transfers at CARE fertility network in the period from 1997 to 2018...
February 2024: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/38348012/correction-assessing-the-impact-of-genratest-on-women-with-recurrent-implantation-failure-a-single-center-study
#29
Huy Phuong Tran, Loc Thai Ly, Vy Nguyen-Thao Do, Tuyet Thi-Diem Hoang, Thuy Thi-Thanh Tran, Hien Nguyen-Trong Le, Phuong Thi-Vy Nguyen, Ngoc Anh Nguyen, Trang Nguyen-Khanh Huynh
[This corrects the article DOI: 10.7759/cureus.52256.].
January 2024: Curēus
https://read.qxmd.com/read/38347968/assessing-the-impact-of-genratest-on-women-with-recurrent-implantation-failure-a-single-center-study
#30
JOURNAL ARTICLE
Huy Phuong Tran, Loc Thai Ly, Vy Nguyen-Thao Do, Tuyet Thi-Diem Hoang, Thuy Thi-Thanh Tran, Hien Nguyen-Trong Le, Phuong Thi-Vy Nguyen, Ngoc Anh Nguyen, Trang Nguyen-Khanh Huynh
Objective Recurrent implantation failure (RIF) is a significant challenge in assisted reproduction. Genratest has emerged as a potential tool to identify the displaced window of implantation (WOI). This study aimed to evaluate the impact of this test on the pregnancy outcomes of RIF patients. Methods A retrospective analysis was conducted on 143 RIF patients who were categorized into two groups: the personalized embryo transfer (pET, n=69) group and standard embryo transfer (sET, n=74) group. The main measured outcomes were clinical pregnancy, ongoing pregnancy, miscarriage, and live birth rates...
January 2024: Curēus
https://read.qxmd.com/read/38336826/centromeric-aa-motif-in-kir-as-an-optimal-surrogate-marker-for-precision-definition-of-alloimmune-reproductive-failure
#31
JOURNAL ARTICLE
Raquel Gil Laborda, Edgard Rodríguez de Frías, Nabil Subhi-Issa, Elena Carrillo de Albornoz, Elena Meliá, Marcos Órdenes, Victoria Verdú, Juan Vidal, Esther Suárez, Isabel Santillán, Daniel Ordóñez, David Pintado-Vera, Victoria González Villafáñez, Ángel Lorenzo, Manuel Fariñas, Mario Rodríguez-Paíno, María Núñez Beltrán, Áurea García Segovia, Ainhoa Del Olmo, Fernando Martín Cañadas, Rosa Daurelio, Alfonso de la Fuente, José Manuel González Casbas, Vega Cabezuelo, Francisco Ros Berruezo, Miguel Ángel Moreno Hidalgo, Silvia Iniesta, Beatriz Bueno, Álvaro Martínez Acera, Alexandra Izquierdo, José Luis Vicario, Miguel Fernández-Arquero, Silvia Sánchez-Ramón
Throughout pregnancy, the decidua is predominantly populated by NK lymphocytes expressing Killer immunoglobulin-like receptors (KIR) that recognize human leukocyte antigen-C (HLA-C) ligands from trophoblast cells. This study aims to investigate the association of KIR-HLA-C phenotypes in couples facing infertility, particularly recurrent pregnancy loss (RPL) and recurrent implantation failure (RIF), in comparison to a reference population and fertile controls. This observational, non-interventional retrospective case-control study included patients consecutively referred to our Reproductive Immunology Unit from 2015 to 2019...
February 9, 2024: Scientific Reports
https://read.qxmd.com/read/38324178/exosomes-as-modulators-of-embryo-implantation
#32
REVIEW
Zeinab Dehghan, Delsuz Rezaee, Effat Noori, Tayyebeh Pilehchi, Fatemeh Saberi, Zahra Taheri, Gholamhossein Darya, Shayesteh Mehdinejadiani
Exosomes, known as extracellular vehicles (EVs), are found in biological fluids. They have the capability to carry and transfer signaling molecules, such as nucleic acids and proteins, facilitating intercellular communication and regulating the gene expression profile in target cells. EVs have the potential to be used as biomarkers in diagnosis, prognosis and also as feasible therapeutic targets. The available evidence suggests that exosomes play critical roles in the reproductive system, particularly during implantation, which is widely recognized as a crucial step in early pregnancy...
February 7, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38322806/preimplantation-genetic-testing-for-aneuploidy-could-not-improve-cumulative-live-birth-rate-among-705-couples-with-unexplained-recurrent-implantation-failure
#33
JOURNAL ARTICLE
Yang Liu, Xiangxin Lan, Juanjuan Lu, Qian Zhang, Tingting Zhou, Tianxiang Ni, Junhao Yan
OBJECTIVE: We evaluate whether next-generation sequencing (NGS)-based preimplantation genetic testing for aneuploidy (PGT-A) improves the cumulative pregnancy outcomes of patients with unexplained recurrent implantation failure (uRIF) as compared to conventional in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI). PATIENTS AND METHODS: This was a retrospective cohort study (2015-2022). A total of 705 couples diagnosed with uRIF were included in the study...
2024: Application of Clinical Genetics
https://read.qxmd.com/read/38310681/recurrent-implantation-failure-and-inflammatory-markers-in-serum-and-follicle-fluid-of-women-undergoing-assisted-reproduction
#34
JOURNAL ARTICLE
Hannah Nenonen, Alexandra Kondic, Emir Henic, Ida Hjelmér
It has been shown previously that the immune system plays a role in implantation and embryo development. The objective was therefore to evaluate cytokine levels and Th1/Th2 ratio in women with recurrent implantation failure in this nested case-control study. Women with no implantation after ≥ 3 embryo transfers were included in the recurrent implantation failure group (n = 29) and were compared with women with successful pregnancy after the first embryo transfer, with an indication of male factor (n = 26)...
January 30, 2024: Journal of Reproductive Immunology
https://read.qxmd.com/read/38283774/management-of-recurrent-implantation-failure-and-hereditary-thrombophilia-a-case-report
#35
Tamar Barbakadze, Tengiz Zhorzholadze, Nino Kutchukhidze, Mariam Shervashidze, Tea Charkviani
Recurrent implantation failure (RIF) is one of the core problems for assisted reproductive technology (ART). High-quality, euploid embryos and synchronization between the embryonic stage and the uterine endometrial lining are crucial for positive outcomes. Molecular biology techniques have significantly transformed assisted reproductive technology (ART). Numerous couples facing infertility issues have successfully achieved the birth of healthy infants through the application of molecular biology methods: preimplantation genetic testing for aneuploidy (PGT-A) and endometrial receptivity analysis (ERA)...
January 2024: Curēus
https://read.qxmd.com/read/38263588/prevalence-and-confounders-of-chronic-endometritis-diagnosed-using-cd138-in-patients-with-recurrent-implantation-failure
#36
JOURNAL ARTICLE
Hye Jeong Hue, Hyunji Choi, Hyun Kyoung Lee, Jung Ryeol Lee, Byung Chul Jee, Chang Woo Choo, Seul Ki Kim
OBJECTIVE: This retrospective study aimed to investigate the prevalence of chronic endometritis, diagnosed using CD138 immunohistochemistry, among infertile women and to assess the association between chronic endometritis and recurrent implantation failure (RIF). METHODS: In total, 266 patients who underwent hysteroscopy due to infertility between 2019 and 2020 were included in the analysis. Of these, 136 patients with RIF and 130 non-RIF patients were included in the study...
January 24, 2024: Clinical and Experimental Reproductive Medicine
https://read.qxmd.com/read/38255823/effects-of-melatonin-gm-csf-igf-1-and-lif-in-culture-media-on-embryonic-development-potential-benefits-of-individualization
#37
REVIEW
Jung-Won Choi, Sung-Woo Kim, Hee-Sun Kim, Moon-Joo Kang, Sung-Ah Kim, Ji-Yeon Han, Hoon Kim, Seung-Yup Ku
The implantation of good-quality embryos to the receptive endometrium is essential for successful live birth through in vitro fertilization (IVF). The higher the quality of embryos, the higher the live birth rate per cycle, and so efforts have been made to obtain as many high-quality embryos as possible after fertilization. In addition to an effective controlled ovarian stimulation process to obtain high-quality embryos, the composition of the embryo culture medium in direct contact with embryos in vitro is also important...
January 6, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38249354/a-review-of-the-optimization-of-thyroid-function-thrombophilia-immunity-and-uterine-milieu-treatment-strategy-for-recurrent-implantation-failure-and-recurrent-pregnancy-loss
#38
REVIEW
Keiji Kuroda
BACKGROUND: Aside from embryonic factors, various factors can intricately interfere with embryo implantation and maintenance of pregnancy, causing recurrent implantation failure (RIF) or recurrent pregnancy loss (RPL). This review focuses the optimization of thyroid function, thrombophilia, immunity, and uterine milieu (OPTIMUM) treatment strategy on RIF and RPL. METHODS: Three studies employing the OPTIMUM treatment strategy for patients with RIF and/or RPL were reviewed...
2024: Reproductive Medicine and Biology
https://read.qxmd.com/read/38237738/nsun2-mediated-m-5-c-methylation-impairs-endometrial-receptivity
#39
JOURNAL ARTICLE
Jiafeng Lu, Ming Zhang, Zhenxing Liu, Ling Guo, Peng Huang, Wenjuan Xia, Jincheng Li, Jinghuan Lv, Hoi-Hung Cheung, Chenyue Ding, Hong Li, Boxian Huang
Impaired endometrial decidualization is the primary cause of recurrent implantation failure (RIF). RNA methylation modification, especially NSUN family mediated m5 C, is crucial for various physiological events, such as maternal-to-zygotic transition, gametogenesis, embryonic development, organismal lifespan, and cell cycle. However, the regulatory mechanisms between NSUN family mediated m5 C modification and RIF remain unknown. We acquired NSUN2 expression data of 15 human endometrium samples at proliferative and secretory stages from reproductive cell atlas...
January 17, 2024: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://read.qxmd.com/read/38236723/decreased-nsd2-impairs-stromal-cell-proliferation-in-human-endometrium-via-reprogramming-h3k36me2
#40
JOURNAL ARTICLE
Chuan-Mei Qin, Xiao-Wei Wei, Jia-Yi Wu, Xue-Qing Liu, Yi Lin
Recurrent implantation failure (RIF) is a formidable challenge in assisted reproductive technology because of its unclear molecular mechanism. Impaired human endometrial stromal cell (HESC) proliferation disrupts the rhythm of the menstrual cycle, resulting in devastating disorders between the embryo and the endometrium. The molecular function of histone methylation enzymes in modulating HESC proliferation remains largely uncharacterized. Herein, we found that the levels of histone methyltransferase nuclear receptor binding SET domain protein 2 (NSD2) and the di-methylation of lysine 36 on histone H3 are decreased significantly in the proliferative-phase endometrium of patients with RIF...
January 1, 2024: Reproduction
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