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"recurrent implantation failure"

Greene Donald Royster, Justine C Harris, Amanda Nelson, Yessenia Castro, R Patrick Weitzel, John Tisdale, Ryan J Heitmann, Alan H DeCherney, Erin F Wolff
There are few treatments for patients with recurrent pregnancy loss (RPL) or recurrent implantation failure (RIF). Women with RPL and unexplained infertility have lower T regulatory cell (Treg ) expression when compared to fertile controls. A murine model has been developed with depletion of regulatory T cells (DEREG) after administration of diphtheria toxin (DT), resulting in smaller litter sizes, secondary to embryo implantation failure. Numerous murine studies have shown that adoptive transfer of CD4+ CD25+ FoxP3+ Tregs from donors improves litter sizes in DEREG mice with depleted Tregs ...
February 19, 2019: Reproductive Sciences
Xiaoyan Mao, Ling Wu, Qiuju Chen, Yanping Kuang, Shaozhen Zhang
OBJECTIVE: To study if hysteroscopy (HSC) before starting an in-vitro fertilization (IVF) cycle improves IVF outcomes in women with recurrent implantation failure (RIF). METHODS: The Medline, Cochrane, EMBASE, and Google Scholar databases were searched using the following keywords until March 31, 2017: in-vitro fertilization; infertility; hysteroscopy; recurrence; embryo implantation; and pregnancy. Randomized controlled trials (RCTs), two-arm prospective studies, and retrospective studies were included...
February 2019: Medicine (Baltimore)
Maria M Szwarc, Lan Hai, William E Gibbons, Qianxing Mo, Rainer B Lanz, Francesco J DeMayo, John P Lydon
Mouse studies support a role for endometrial early growth response 1 (EGR1) in uterine receptivity and decidualization, which are processes controlled by estrogen and progesterone. However, the importance of this transcription factor in similar cellular processes in human is unclear. Analysis of clinical samples indicate that endometrial EGR1 levels are decreased in the endometrium of women with recurrent implantation failure, suggesting tight control of EGR1 levels are necessary for normal endometrial function...
January 31, 2019: Journal of Steroid Biochemistry and Molecular Biology
Arezoo Maleki-Hajiagha, Maryam Razavi, Mahroo Rezaeinejad, Safoura Rouholamin, Amir Almasi-Hashiani, Reihaneh Pirjani, Mahdi Sepidarkish
Intrauterine administration of autologous peripheral blood mononuclear cells (PBMC) has been proposed to improve implantation rates in women with recurrent implantation failure (RIF). The objective of this study was to evaluate whether intrauterine administration of PBMC improves clinical pregnancy and live birth in couples with RIF. Various databases were searched including Medline, Embase, Scopus, Web of Science and Cochrane Central Register of Controlled Trials up to April 2018. This review included all studies that compared intervention of PBMC in infertile women undergoing any form of assisted reproductive technology (ART)...
February 2019: Journal of Reproductive Immunology
Natali Schachter-Safrai, Gilad Karavani, Adi Reuveni-Salzman, Moran Gil, Assaf Ben-Meir
OBJECTIVE: To assess whether a correlation exists between different sperm pathologies and Intracytoplasmic morphologically selected sperm injection (IMSI) outcomes. STUDY DESIGN: A retrospective cohort study which included couples with recurrent implantation failures (2 or more unsuccessful IVF-ICSI cycles) undergoing their first IVF-IMSI cycle in Hebrew-University Hadassah Medical Center between January 2008 and May 2017. RESULTS: A total of 170 couples with at least two IVF failures attempting their first IVF-IMSI cycle were included, of them 56 (32...
January 14, 2019: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Dong Li, Weihua Jiang, Yiqun Jiang, Shanshan Wang, Junshun Fang, Lihua Zhu, Yinchun Zhu, Guijun Yan, Haixiang Sun, Linjun Chen, Ningyuan Zhang
Long non-coding RNAs (lncRNAs), a class of non-coding RNA, have been shown to be essential in many diseases, such as infertility. Here, we found three candidate lncRNAs, ENST00000414116, ENST00000433673, and ENST00000448179, that are highly expressed in the uterus endometrial tissues of normal patients compared to the tissues of patients with adenomyosis, endometriosis, and recurrent implantation failure. lncRNAs ENST00000414116 and ENST00000433673 showed high expression in endometrial stromal cells (ESCs) and endometrial epithelial cells (EECs), respectively, and lncRNA ENST00000448179 was specifically expressed in ESCs...
January 16, 2019: Systems Biology in Reproductive Medicine
Laura Diniz Vagnini, Adriana Renzi, Bruna Petersen, Maria do Carmo Tomitão Canas, Claudia Guilhermino Petersen, Ana Lucia Mauri, Mariana Coltri Mattila, Juliana Ricci, Felipe Dieamant, João Batista Alcantara Oliveira, Ricardo Luiz Razera Baruffi, José Gonçalves Franco
OBJECTIVE: To investigate an association between polymorphisms related to the implantation process that together could help in the prediction of recurrent implantation failure (RIF). DESIGN: Cohort study. SETTING: Private fertility center and reproductive genetics laboratory. PATIENT(S): Forty-four women presenting RIF, who were included in study group (RIF group), and two control groups, one with 63 women who were attended at our service and became pregnant after the first IVF/intracytoplasmic sperm injection attempt (control group I) and other with 65 fertile women who had at least two children without any treatment and no history of miscarriage (control group II)...
January 2, 2019: Fertility and Sterility
Wen-Juan Wang, Hong Zhang, Zhong-Quan Chen, Wei Zhang, Xue-Mei Liu, Jiang-Ye Fang, Fu-Jun Liu, Joanne Kwak-Kim
BACKGROUND: Chronic endometritis (CE) is a condition which results in reduced receptivity of embryos by dysregulated lymphocyte subsets, abnormal expression of cytokines, chemokines and other regulatory molecules in the endometrium (EM). Macroautophagy (autophagy), the highly conserved cellular homeostasis pathway, plays an essential role in the development and function of T lymphocytes, and supports T cell lineage stability and survival fitness. The possible relationships between autophagy and local cytokine milieus in repeated implantation failure (RIF) with CE have not been elucidated yet...
January 3, 2019: Reproductive Biology and Endocrinology: RB&E
Anne E Martini, Sue Jasulaitis, Louis F Fogg, Meike L Uhler, Jennifer E Hirshfeld-Cytron
Context: Intralipid is used to improve clinical outcomes in patients with recurrent pregnancy loss (RPL) or recurrent implantation failure (RIF) with elevated natural killer (NK) cells. Data supporting this practice is conflicting but suggestive of minimal benefit. Aims: The aims of this study are to determine if intralipid infusion improves live birth rates and if is a cost-effective therapy in the RPL/RIF population. Settings and Design: This was a large REI private practice, retrospective cohort study...
July 2018: Journal of Human Reproductive Sciences
Kadri Rekker, Signe Altmäe, Marina Suhorutshenko, Maire Peters, Juan F Martinez-Blanch, Francisco M Codoñer, Felipe Vilella, Carlos Simón, Andres Salumets, Agne Velthut-Meikas
The endometrium undergoes extensive changes to prepare for embryo implantation and microRNAs (miRNAs) have been described as playing a significant role in the regulation of endometrial receptivity. However, there is no consensus about the miRNAs involved in mid-secretory endometrial functions. We analysed the complete endometrial miRNome from early secretory (pre-receptive) and mid-secretory (receptive) phases from fertile women and from patients with recurrent implantation failure (RIF) to reveal differentially expressed (DE) miRNAs in the mid-secretory endometrium...
November 23, 2018: Genes
Mahnaz Ghaebi, Samaneh Abdolmohammadi-Vahid, Majid Ahmadi, Shadi Eghbal-Fard, Sanam Dolati, Mohammad Nouri, Mehdi Talebi, Kobra Hamdi, Faroogh Marofi, Leili Aghebati-Maleki, Farhad Jadidi-Niaragh, Masoume Dopour, Mehdi Yousefi
The objective of this study was to determine whether there are any differences in the T cell composition and the expression of specific factors (i.e., IRF4, TBX21, GATA3, and GITR) of T cells between women with Repeated Implantation Failure (RIF) and fertile women. We observed a decrease in circulating Tregs and exhausted CD8 + T cells in RIF patients when compared to the controls whereas exhausted Treg and Th17 cells were more frequent. Using real-time PCR, we determined that the expression of IRF-4 and TBX21 was significantly elevated in the cases...
November 8, 2018: Journal of Reproductive Immunology
Jihyun Kim, Jaewang Lee, Jin Hyun Jun
Recurrent implantation failure (RIF) is one of the main causes for the repeated failure of IVF, and the major reason for RIF is thought to be a miscommunication between the embryo and uterus. However, the exact mechanism underlying embryo-uterus cross-talk is not fully understood. The aim of the present study was to identify differentially expressed microRNAs (miRNAs) among blastocysts, non-outgrowth and outgrowth embryos in mice using microarray analysis. A bioinformatics analysis was performed to predict the potential mechanisms of implantation...
November 15, 2018: Reproduction, Fertility, and Development
Chiara Achilli, Montserrat Duran-Retamal, Wael Saab, Paul Serhal, Srividya Seshadri
OBJECTIVE: To study the current evidence on the role of immunotherapy in IVF and in the management of recurrent pregnancy loss (RPL). DESIGN: Systematic review and meta-analysis. SETTING: A literature search was performed using MEDLINE, PUBMED, CINAHL, and EMBASE until May 2017. Only randomized controlled trials were included, and a meta-analysis was carried out where appropriate. PATIENT(S): Women undergoing IVF treatment with or without a history of recurrent implantation failure and women with idiopathic RPL...
November 2018: Fertility and Sterility
Sophie Cooper, Susan M Laird, Najat Mariee, Tin Chiu Li, Mostafa Metwally
This retrospective study of prospectively collected data examines the effect of prednisolone therapy on raised uterine Natural Killer cell (uNK) concentrations and pregnancy outcomes in women with recurrent miscarriage (RM) and recurrent implantation failure (RIF) after IVF/ICSI treatment. 136 women diagnosed with RRF who had a timed midluteal endometrial biopsy taken for uNK cell analysis were included. Women with high uNK cell concentrations (n = 45) were treated with prednisolone (10 mg/day) for one month, after which a second biopsy was taken for repeat uNK cell analysis...
October 25, 2018: Journal of Reproductive Immunology
Aysen Boza, Oznur Dundar Akin, Sule Yildiz Oguz, Selim Misirlioglu, Bulent Urman
OBJECTIVE: To evaluate the long term anatomical and reproductive outcomes of hysteroscopic treatment for T shaped uterus in patients presenting with reproductive failure. METHODS: This prospective cohort study included 56 patients with a history of long-standing unexplained infertility, recurrent implantation failure (RIF), and/or recurrent pregnancy loss (RPL) who were eligible for metroplasty by office hysteroscopy. Office hysteroscopy under conscious sedation was performed...
October 22, 2018: Journal of Gynecology Obstetrics and Human Reproduction
Diana Alecsandru, Ana Barrio, Victor Andia, Edgar Cruz, Pilar Aparicio, Jose Serna, Maria Cruz, Antonio Pellicer, Juan Antonio Garcia-Velasco
Pancreatic Autoimmunity is defined as the presence of autoantibodies and more frequent need for insulin treatment. Affected women presenting recurrent implantation failure (RIF) or recurrent miscarriage (RM) are often misdiagnosed. The objective of thestudy was to describe clinical and metabolic profiles suggestive of Pancreatic Autoimmunity and therapeutic strategy in patients with RIF/RM. We analyzed retrospectively 735 patients, and have identified a subset (N = 20) with similar metabolic characteristics...
2018: PloS One
Azahara Turienzo, Belén Lledó, José A Ortiz, Ruth Morales, Juan Sanz, Joaquín Llácer, Rafael Bernabeu
Recurrent pregnancy loss (RPL; defined as the loss of three or more consecutive pregnancies) and recurrent implantation failure (RIF; when implantation is not achieved after at least three cycles of IVF) are two of the major challenges that reproductive medicine faces. Some polymorphisms have been identified as possible causes of an increased risk of these diseases. This paper studies the prevalence of the polymorphisms in p53, VEGF, IL-10, IL-11 and APOE in RIF and RPL patients that determines the risk for these pathologies...
October 18, 2018: Human Fertility: Journal of the British Fertility Society
S Khayat, B Elliott, M H Dahan
Endometriosis is common among those with infertility, although many cases go undiagnosed. This study was performed to determine whether empiric treatment with two months of depo-leuprolide 3.75 mg monthly (dep-GnRH-ag) and letrozole 5 mg daily improves pregnancy outcomes in patients with at least two unexplained failed embryo transfers (ETs) but without a previous diagnosis of endometriosis. A retrospective cohort study was performed with subjects who failed at least two good quality ET. The study excluded women with a known history of endometriosis or ovarian cysts (possible endometriomas)...
October 17, 2018: Gynecological Endocrinology
Anthea B M Paul, Seifeldin T Sadek, Arnold M Mahesan
MicroRNAs (miRNAs) are emerging as important in human embryo implantation, and we present here a review of the literature from a clinical perspective. Implantation involves complex interactions between the blastocyst and endometrium. miRNAs have been shown to be differentially expressed in implanted compared with non-implanted blastocysts and euploid compared with aneuploid blastocysts. Further, miRNAs are differentially expressed in proliferative compared with decidualized endometrium, and in receptive compared with pre-receptive endometrium...
October 12, 2018: Journal of Assisted Reproduction and Genetics
Carol Coughlan
Recurrent implantation failure (RIF) is very distressing for couples and frustrating for their clinicians who seek to find a solution. RIF is defined as the failure to achieve a clinical pregnancy following the transfer of at least four good-quality embryos in a minimum of three fresh or frozen cycles in a woman of age below 40 years. An agreed local protocol regarding how couples with RIF should be further investigated and managed should be in place. Ovarian function should be assessed by measuring antral follicle count, FSH, and AMH...
August 2, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
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