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recurrent ivf failure

Zhenhong Shuai, Xuemei Li, Xuelian Tang, Fang Lian, Zhengao Sun
OBJECTIVE: To evaluate the effect of transcutaneous electrical acupuncture stimulation (TEAS) on pregnancy outcomes in patients with recurrent implantation failure (RIF) undergoing in vitro fertilisation (IVF). METHODS: A total of 122 women with RIF undergoing fresh embryo transfer cycle IVF were randomly allocated to a TEAS or mock TEAS (MTEAS) group. Gonadotrophin therapy using a long protocol was provided in both groups. TEAS consisted of 30 min of stimulation (9-25 mA, 2 Hz) at SP6, CV3, CV4 and Zigong from day 5 of the ovarian stimulation cycle once every other day until the day of embryo transfer...
March 13, 2019: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
Mahvash Zargar, Mehri Ghafourian, Roshan Nikbakht, Vahideh Mir Hosseini, Parastoo Moradi Choghakabodi
STUDY OBJECTIVE: The identification of less invasive methods with acceptable diagnostic value for evaluating the intrauterine abnormalities can improve patients and physician satisfaction. Although, hysteroscopy plus biopsy have favorable predictive and diagnostic values, limited studies have evaluated its value, and the exact value of this method is not completely understood. So, this study is aimed at evaluating the prevalence of chronic endometritis in patients with RIF and RPL by hysteroscopy and Immunohistochemistry...
March 6, 2019: Journal of Minimally Invasive Gynecology
Fuminori Kimura, Akie Takebayashi, Mitsuaki Ishida, Akiko Nakamura, Jun Kitazawa, Aina Morimune, Kimiko Hirata, Akimasa Takahashi, Shoko Tsuji, Akiko Takashima, Tsukuru Amano, Shunichiro Tsuji, Tetsuo Ono, Shoji Kaku, Kyoko Kasahara, Suzuko Moritani, Ryoji Kushima, Takashi Murakami
AIM: Chronic endometritis (CE) is a disease of continuous and subtle inflammation characterized by the infiltration of plasma cells in the endometrial stromal area. Although the clinical significance of CE has been thought in clinical practice for a long time because it is either asymptomatic or presents with subtle symptoms, recent studies have shown the potential adverse effects of CE on fertility. In the present review, we focus on the concept, diagnosis, etiology, pathophysiology, diagnosis, impact on reproduction and treatment for it to understand CE...
March 6, 2019: Journal of Obstetrics and Gynaecology Research
Hounyoung Kim, Ji Eun Shin, Hwa Seon Koo, Hwang Kwon, Dong Hee Choi, Ji Hyang Kim
Objective: Thin or damaged endometrium remains to be an unsolved problem in the treatment of patients with infertility. The empirical preference for endometrial thickness (EMT) among clinicians is >7 mm, and the refractory thin endometrium, which doesn't respond to standard medical therapies, can be the etiology of recurrent implantation failure (RIF). Autologous platelet-rich plasma (PRP) is known to help tissue regeneration and is widely used in various fields. In the present study, we conducted PRP treatment and investigated its effect on the refractory thin endometrium...
2019: Frontiers in Endocrinology
Xiaoyan Mao, Ling Wu, Qiuju Chen, Yanping Kuang, Shaozhen Zhang
OBJECTIVE: To study if hysteroscopy (HSC) before starting an in-vitro fertilization (IVF) cycle improves IVF outcomes in women with recurrent implantation failure (RIF). METHODS: The Medline, Cochrane, EMBASE, and Google Scholar databases were searched using the following keywords until March 31, 2017: in-vitro fertilization; infertility; hysteroscopy; recurrence; embryo implantation; and pregnancy. Randomized controlled trials (RCTs), two-arm prospective studies, and retrospective studies were included...
February 2019: Medicine (Baltimore)
Natali Schachter-Safrai, Gilad Karavani, Adi Reuveni-Salzman, Moran Gil, Assaf Ben-Meir
OBJECTIVE: To assess whether a correlation exists between different sperm pathologies and Intracytoplasmic morphologically selected sperm injection (IMSI) outcomes. STUDY DESIGN: A retrospective cohort study which included couples with recurrent implantation failures (2 or more unsuccessful IVF-ICSI cycles) undergoing their first IVF-IMSI cycle in Hebrew-University Hadassah Medical Center between January 2008 and May 2017. RESULTS: A total of 170 couples with at least two IVF failures attempting their first IVF-IMSI cycle were included, of them 56 (32...
January 14, 2019: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Katrin Mikolaiczik, Marc Praetner, Michael Rüth, Karlheinz Mark
BACKGROUND: For the past decades the mean age of primiparae in Western societies is constantly increasing. At the same time, there is a growing demand for assisted reproductive technologies such as in vitro fertilization and intracytoplasmic sperm injection. Subsequently, a higher prevalence of pregnancy-associated diseases such as gestational hypertension and preeclampsia is observed. To improve pregnancy rates after in vitro fertilization/intracytoplasmic sperm injection and to reduce the risk of pregnancy-associated diseases with a cardiovascular pathophysiology, two anticoagulants are the focus of current research: low molecular weight heparin and acetylsalicylic acid (aspirin)...
January 19, 2019: Journal of Medical Case Reports
Laura Diniz Vagnini, Adriana Renzi, Bruna Petersen, Maria do Carmo Tomitão Canas, Claudia Guilhermino Petersen, Ana Lucia Mauri, Mariana Coltri Mattila, Juliana Ricci, Felipe Dieamant, João Batista Alcantara Oliveira, Ricardo Luiz Razera Baruffi, José Gonçalves Franco
OBJECTIVE: To investigate an association between polymorphisms related to the implantation process that together could help in the prediction of recurrent implantation failure (RIF). DESIGN: Cohort study. SETTING: Private fertility center and reproductive genetics laboratory. PATIENT(S): Forty-four women presenting RIF, who were included in study group (RIF group), and two control groups, one with 63 women who were attended at our service and became pregnant after the first IVF/intracytoplasmic sperm injection attempt (control group I) and other with 65 fertile women who had at least two children without any treatment and no history of miscarriage (control group II)...
January 2, 2019: Fertility and Sterility
Yasmin M Vasquez, Xiaoqiu Wang, Margeaux Wetendorf, Heather L Franco, Qianxing Mo, Tianyuan Wang, Rainer B Lanz, Steven L Young, Bruce A Lessey, Thomas E Spencer, John P Lydon, Francesco J DeMayo
Successful embryo implantation requires a receptive endometrium. Poor uterine receptivity can account for implantation failure in women who experience recurrent pregnancy loss or multiple rounds of unsuccessful in vitro fertilization cycles. Here, we demonstrate that the transcription factor Forkhead Box O1 (FOXO1) is a critical regulator of endometrial receptivity in vivo. Uterine ablation of Foxo1 using the progesterone receptor Cre (PgrCre) mouse model resulted in infertility due to altered epithelial cell polarity and apoptosis, preventing the embryo from penetrating the luminal epithelium...
November 19, 2018: PLoS Genetics
Jihyun Kim, Jaewang Lee, Jin Hyun Jun
Recurrent implantation failure (RIF) is one of the main causes for the repeated failure of IVF, and the major reason for RIF is thought to be a miscommunication between the embryo and uterus. However, the exact mechanism underlying embryo-uterus cross-talk is not fully understood. The aim of the present study was to identify differentially expressed microRNAs (miRNAs) among blastocysts, non-outgrowth and outgrowth embryos in mice using microarray analysis. A bioinformatics analysis was performed to predict the potential mechanisms of implantation...
November 15, 2018: Reproduction, Fertility, and Development
Chiara Achilli, Montserrat Duran-Retamal, Wael Saab, Paul Serhal, Srividya Seshadri
OBJECTIVE: To study the current evidence on the role of immunotherapy in IVF and in the management of recurrent pregnancy loss (RPL). DESIGN: Systematic review and meta-analysis. SETTING: A literature search was performed using MEDLINE, PUBMED, CINAHL, and EMBASE until May 2017. Only randomized controlled trials were included, and a meta-analysis was carried out where appropriate. PATIENT(S): Women undergoing IVF treatment with or without a history of recurrent implantation failure and women with idiopathic RPL...
November 2018: Fertility and Sterility
Sophie Cooper, Susan M Laird, Najat Mariee, Tin Chiu Li, Mostafa Metwally
This retrospective study of prospectively collected data examines the effect of prednisolone therapy on raised uterine Natural Killer cell (uNK) concentrations and pregnancy outcomes in women with recurrent miscarriage (RM) and recurrent implantation failure (RIF) after IVF/ICSI treatment. 136 women diagnosed with RRF who had a timed midluteal endometrial biopsy taken for uNK cell analysis were included. Women with high uNK cell concentrations (n = 45) were treated with prednisolone (10 mg/day) for one month, after which a second biopsy was taken for repeat uNK cell analysis...
October 25, 2018: Journal of Reproductive Immunology
Tarek K Al-Hussaini, Ali H Yosef, Ihab H El-Nashar, Omar M Shaaban
The empty follicle syndrome (EFS) is defined as a failure to aspirate any oocyte (s) from the follicles after ovarian hyperstimulation in preparation for IVF/ICSI. It is a frustrating and vague syndrome; and a controversial one concerning its existence, causes and possible treatment. Recurrent EFS or the recovery of immature oocytes thereafter is a more challenging problem. Delayed injection after leaving the immature oocytes for in vitro -maturation (IVM) has been suggested to be a possible option if immature oocytes are retrieved...
October 30, 2018: JBRA Assisted Reproduction
Azahara Turienzo, Belén Lledó, José A Ortiz, Ruth Morales, Juan Sanz, Joaquín Llácer, Rafael Bernabeu
Recurrent pregnancy loss (RPL; defined as the loss of three or more consecutive pregnancies) and recurrent implantation failure (RIF; when implantation is not achieved after at least three cycles of IVF) are two of the major challenges that reproductive medicine faces. Some polymorphisms have been identified as possible causes of an increased risk of these diseases. This paper studies the prevalence of the polymorphisms in p53, VEGF, IL-10, IL-11 and APOE in RIF and RPL patients that determines the risk for these pathologies...
October 18, 2018: Human Fertility: Journal of the British Fertility Society
Carol Coughlan
Recurrent implantation failure (RIF) is very distressing for couples and frustrating for their clinicians who seek to find a solution. RIF is defined as the failure to achieve a clinical pregnancy following the transfer of at least four good-quality embryos in a minimum of three fresh or frozen cycles in a woman of age below 40 years. An agreed local protocol regarding how couples with RIF should be further investigated and managed should be in place. Ovarian function should be assessed by measuring antral follicle count, FSH, and AMH...
August 2, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
Magdalena Pasińska, Ewelina Łazarczyk, Katarzyna Jułga, Magdalena Bartnik-Głaska, Beata Nowakowska, Olga Haus
BACKGROUND: Balanced reciprocal chromosomal translocations (RCTs) are the ones of the most common structural aberrations in the population, with an incidence of 1:625. RCT carriers usually do not demonstrate changes in phenotype, except when the translocation results in gene interruption. However, these people are at risk of production of unbalanced gametes during meiosis, as a result of various forms of chromosome segregation. This may cause infertility, non-implantation of the embryo, shorter embryo or foetus survival, as well as congenital defects and developmental disorders in children after birth...
August 20, 2018: BMC Medical Genomics
(no author information available yet)
Adjuvant immunotherapy treatments in in vitro fertilization (IVF) aim to improve the outcome of assisted reproductive technology (ART) in both the general ART population as well as subgroups such as patients with recurrent miscarriage or implantation failure. The purpose of this guideline is to evaluate the role of immunomodulating therapy in ART. Unfortunately, many of the evaluated therapies lack robust evidence from well-designed adequately powered randomized controlled trials to support their use. Immunotherapies reviewed in the present document are either not associated with improved live-birth outcome in IVF or have been insufficiently studied to make definitive recommendations...
August 2018: Fertility and Sterility
Ercan Bastu, Irem Demiral, Tuba Gunel, Ege Ulgen, Ece Gumusoglu, Mohammad Kazem Hosseini, Ugur Sezerman, Faruk Buyru, John Yeh
The aim of this prospective cohort study was to identify altered biologic processes in the endometrium that may be potential markers of receptive endometrium in patients with repeated implantation failure (RIF) as compared with fertile controls. The study was conducted in a university-affiliated in vitro fertilization (IVF) gynecology clinic and molecular biology and genetics laboratory. Healthy fertile controls (n = 24) and patients with RIF (n = 24) were recruited. Window of implantation gene profiling associated with RIF was performed...
August 6, 2018: Reproductive Sciences
Zakaria Hindi, Mosa Hussein, Abdallah Gad, Abdallah A Khaled, Talal Zahoor
Catastrophic antiphospholipid syndrome is a rare disorder that remains under-recognized causing a high mortality rate even with treatment. Factors such as infections and systemic lupus erythematosus flare play as an inciting event in the thrombotic crisis which underlies catastrophic antiphospholipid syndrome. The use of plasmapheresis has improved the outcome of such cases with a reduction in mortality rate from over 50% to less than 30%, according to some studies. However, the definitive treatment of this disabling and fatal condition remains an area warranting research...
2018: SAGE Open Medical Case Reports
Soheila Arefi, Elham Fazeli, Manijeh Esfahani, Nasim Borhani, Nazila Yamini, Ahmad Hosseini, Fattaneh Farifteh
Background: Family of colony-stimulating factors (CSF) have an essential role on early cross talk between embryo and uterine endometrium. Objective: The aim of this study was to evaluate the effects of the single dose of Granulocyte-CSF (G-CSF) injection on clinical outcome of assisted reproductive technology cycle in patients with repeated implantation failures. Materials and Methods: This randomized control trial study was performed on 52 infertile women who referred to the clinic with the history of more than three previous In vitro fertilization/Intracytoplasmic sperm injection-embryo transfer failures...
May 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
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