keyword
https://read.qxmd.com/read/38525703/recurrent-intracerebral-haematomas-due-to-amyloid-angyopathy-after-lyodura-transplantation-in-childhood
#1
Maša Fabjan, Ana Jurečič, Miha Jerala, Janja Pretnar Oblak, Senta Frol
The number of published cases of presumed iatrogenic cerebral amyloid angiopathy (iCAA) due to the transmission of amyloid β during neurosurgery is slowly rising. One of the potential ways of transmission is through a cadaveric dura mater graft (LYODURA) exposure during neurosurgery. This is a case of a 46-year-old female patient with no chronic conditions who presented with recurrent intracerebral haemorrhages (ICHs) without underlying vessel pathology. Four decades prior, the patient had a neurosurgical procedure with documented LYODURA transplantation...
March 4, 2024: Neurology International
https://read.qxmd.com/read/38508150/computed-tomography-perfusion-in-acute-stroke-assessment
#2
REVIEW
Anthony Pereira, Vafa Alakbarzade, Deborah Lowe, David Hargroves
BACKGROUND: Traditionally, non-contrast computed tomography (CT) alone was used in the initial assessment of acute ischaemic stroke patients mainly to exclude haemorrhage or alternative pathology. SUMMARY: Late-window (beyond 6 hours) and recent large-volume endovascular mechanical thrombectomy (MT) trials integrated CT Perfusion (CTP) imaging to guide MT and/or intravenous thrombolysis (IVT) decision-making in stroke patients. KEY MESSAGES: In current clinical practice, many patients are being excluded from reperfusion therapy due to a lack of data from urgent investigations to assess cerebral vasculature and perfusion...
March 20, 2024: Cerebrovascular Diseases
https://read.qxmd.com/read/38501882/mri-hypoperfusion-as-a-determinant-of-cognitive-impairment-in-adults-with-moyamoya-angiopathy
#3
JOURNAL ARTICLE
Marine Giroud, Mélanie Planton, Jean Darcourt, Nicolas Raposo, Pierre Brandicourt, Hélène Mirabel, Dominique Hervé, Alain Viguier, Jean-François Albucher, Jérémie Pariente, Jean Marc Olivot, Fabrice Bonneville, Patrice Péran, Lionel Calviere
INTRODUCTION: In Moyamoya angiopathy (MMA), mechanisms underlying cognitive impairment remain debated. We aimed to assess the association of cognitive impairment with the degree and the topography of cerebral hypoperfusion in MMA. METHODS: A retrospective analysis of neuropsychological and perfusion MRI data from adults with MMA was performed. Ischemic and haemorrhagic lesion masks were created to account for cerebral lesions in the analysis of cerebral perfusion...
March 19, 2024: European Stroke Journal
https://read.qxmd.com/read/38501129/re-open-randomised-trial-of-biosimilar-tnk-versus-tpa-during-endovascular-therapy-for-acute-ischaemic-stroke-due-to-large-vessel-occlusions
#4
JOURNAL ARTICLE
Rohit Bhatia, Mv Padma Srivastava, Saman Fatima, Risha Sarkar, Imnameren Longkumer, Shailesh Gaikwad, Leve S Joseph Devaranjan, Ajay Garg, Jeyaraj Durai Pandian, Dheeraj Khurana, P N Sylaja, Shweta Jain, Deepti Arora, Aneesh Dhasan, Sanjith Aaron, Angel T Miraclin, Pamidimukkala Vijaya, Srijithesh P Rajendran, Jayanta Roy, Biman Kanti Ray, Vivek Nambiar, Paul J Alapatt, Meenakshi Sharma
RATIONALE: Rapid and timely treatment with intravenous thrombolysis and endovascular treatment (EVT) in patients with acute ischaemic stroke (AIS) and large vessel occlusion (LVO) significantly improves patient outcomes. Bridging therapy is the current standard of care in these patients. However, an incompletely answered question is whether one thrombolytic agent is better than another during bridging therapy. AIM: The current study aims to understand if one thrombolytic agent is superior to the other during bridging therapy in the treatment of AIS and LVO...
2024: BMJ neurology open
https://read.qxmd.com/read/38501127/stenosis-long-term-single-versus-dual-antiplatelet-therapy-in-patients-with-ischaemic-stroke-due-to-intracranial-atherosclerotic-disease-a-randomised-trial
#5
JOURNAL ARTICLE
Rohit Bhatia, M V Padma Srivastava, Risha Sarkar, Saman Fatima, Imnameren Longkumer, Ajay Garg, Pooja Gupta, Jeyaraj Durai Pandian, Dheeraj Khurana, P N Sylaja, Shweta Jain, Deepti Arora, Aneesh Dhasan, Meenakshi Sharma
RATIONALE: Intracranial atherosclerotic disease (ICAD) is a pathological process that causes progressive stenosis and cerebral hypoperfusion, leading to stroke occurrence and recurrence around the world. The exact duration of dual antiplatelet therapy (DAPT) for ICAD is unclear in view of long-term risk of bleeding complications. AIM: The current study aims to study the efficacy and safety of long-term DAPT (up to 12 months) in patients with ICAD. SAMPLE SIZE: Using 80% power and an alpha error of 5 %, presuming a 10%-15% drop-out rate, a total of 2200 patients will be recruited for the study...
2024: BMJ neurology open
https://read.qxmd.com/read/38496025/correlation-of-levels-of-lactic-acid-and-glucose-in-cerebrospinal-fluid-of-cerebral-hemorrhage-patients-with-the-occurrence-of-postoperative-intracranial-infection-and-clinical-prognosis
#6
JOURNAL ARTICLE
Lei Zhang, Yan Zhang, Xiaotian Wang, Yun Zhao
BACKGROUND: Cerebral haemorrhage is a critical condition that often requires surgical treatment, and postoperative intracranial infection can significantly impact patient outcomes. The aim of the study was to examine the relationship between the levels of lactic acid and glucose in cerebrospinal fluid (CSF) of patients with cerebral haemorrhage and their postoperative intracranial infection and clinical prognosis. METHODS: The study selected the clinical data of 324 patients with cerebral haemorrhage who underwent surgical treatment in our hospital from March 2020 to March 2022 for retrospective analysis and divided these patients into the intracranial infection group (Group A, n=22, leukocyte values in CSF>5×106/L) and the non-intracranial infection group (Group B, n=302, leukocyte values in CSF 5×106/L) according to the occurrence of postoperative intracranial infection in patients to detect the levels of lactic acid and glucose in CSF at different times in the two groups...
January 25, 2024: Journal of Medical Biochemistry
https://read.qxmd.com/read/38490104/female-mice-display-sex-specific-differences-in-cerebrovascular-function-and-subarachnoid-haemorrhage-induced-injury
#7
JOURNAL ARTICLE
Danny D Dinh, Hoyee Wan, Darcy Lidington, Steffen-Sebastian Bolz
BACKGROUND: In male mice, a circadian rhythm in myogenic reactivity influences the extent of brain injury following subarachnoid haemorrhage (SAH). We hypothesized that female mice have a different cerebrovascular phenotype and consequently, a distinct SAH-induced injury phenotype. METHODS: SAH was modelled by pre-chiasmatic blood injection. Olfactory cerebral resistance arteries were functionally assessed by pressure myography; these functional assessments were related to brain histology and neurobehavioral assessments...
March 14, 2024: EBioMedicine
https://read.qxmd.com/read/38487357/thrombolytic-therapy-for-central-retinal-artery-occlusion-in-an-academic-multi-site-stroke-centre
#8
JOURNAL ARTICLE
Nour Alhayek, Jacob M Sobczak, Aimen Vanood, Cumara B O'Carroll, Bart M Demaerschalk, John Chen, Oana M Dumitrascu
Central retinal artery occlusion (CRAO) is a subtype of acute ischaemic stroke leading to severe visual loss. A recent American Heart Association scientific statement proposed time-windows for thrombolysis in CRAO similar to acute ischaemic cerebral strokes. We aimed to review our academic multi-site stroke centre experience with intravenous (IVT) and intra-arterial thrombolysis (IAT) in CRAO between 1997 and 2022. Demographic, clinical characteristics, thrombolysis timeline, concurrent therapies, complications, and 3-month follow-up visual acuity (VA) were collected...
2024: Neuro-ophthalmology
https://read.qxmd.com/read/38482623/infratentorial-cerebral-cavernous-malformation-may-be-a-risk-factor-for-symptomatic-bleeding-and-precocity-of-symptoms-a-multicenter-propensity-score-matched-case-control-study
#9
JOURNAL ARTICLE
Gustavo da Fontoura Galvão, Ricardo Castro Filho, Alexandre Alexandre Martins Cunha, Andre André Guimarães Soares, Marcos Antônio Dellaretti Filho, Jorge Marcondes de Souza
BACKGROUND: Cerebral Cavernous Malformation (CCM) is one of the most common types of vascular malformation of the central nervous system. Intracerebral hemorrhage, seizures, and lesional growth are the main clinical manifestations. Natural history studies have tried to identify many risk factors; however, the clinical course remains highly unpredictable. OBJECTIVE: Here, we have analyzed a multicenter CCM cohort looking for the differential clinical data regarding the patients harboring supra and/or infratentorial cavernous malformations in order to better understand risk factors involved in the anatomical location of the unique neurosurgical disease...
March 13, 2024: Current Neurovascular Research
https://read.qxmd.com/read/38477418/influence-of-isolated-low-grade-intracranial-haemorrhages-on-the-neurodevelopmental-outcome-of-infants-born-very-low-birthweight
#10
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 13, 2024: Developmental Medicine and Child Neurology
https://read.qxmd.com/read/38471987/monitoring-of-cerebral-blood-flow-autoregulation-physiologic-basis-measurement-and-clinical-implications
#11
REVIEW
Eric L Vu, Charles H Brown, Kenneth M Brady, Charles W Hogue
Cerebral blood flow (CBF) autoregulation is the physiologic process whereby blood supply to the brain is kept constant over a range of cerebral perfusion pressures ensuring a constant supply of metabolic substrate. Clinical methods for monitoring CBF autoregulation were first developed for neurocritically ill patients and have been extended to surgical patients. These methods are based on measuring the relationship between cerebral perfusion pressure and surrogates of CBF or cerebral blood volume (CBV) at low frequencies (<0...
March 11, 2024: British Journal of Anaesthesia
https://read.qxmd.com/read/38471459/temporal-trends-in-severe-brain-injury-and-associated-outcomes-in-very-preterm-infants
#12
JOURNAL ARTICLE
Abdul Razak, Emily Johnston, Alice Stewart, Marissa A T Clark, Penelope Stevens, Margaret Charlton, Flora Wong, C McDonald, Rod W Hunt, Suzanne Miller, Atul Malhotra
INTRODUCTION: Severe brain injury (SBI), including severe intraventricular haemorrhage (sIVH) and cystic periventricular leukomalacia, poses significant challenges for preterm infants, yet recent data and trends are limited. METHODS: Analyses were conducted using the Australian and New Zealand Neonatal Network data on preterm infants born &lt;32 weeks' gestation admitted at Monash Children's Hospital, Australia, from January 2014 to April 2021. The occurrence and trends of SBI and sIVH among preterm infants, along with the rates and trends of death and neurodevelopmental impairment (NDI) in SBI infants were assessed...
March 12, 2024: Neonatology
https://read.qxmd.com/read/38470001/frequency-of-ischaemic-stroke-and-intracranial-haemorrhage-in-patients-with-reversible-cerebral-vasoconstriction-syndrome-rcvs-and-posterior-reversible-encephalopathy-syndrome-pres-a-systematic-review
#13
JOURNAL ARTICLE
Jana Kaufmann, Philipp Buecke, Thomas Meinel, Morin Beyeler, Adrian Scutelnic, Johannes Kaesmacher, Adnan Mujanović, Thomas Dobrocky, Hakim Arsany, Nils Peters, Werner Z'Graggen, Simon Jung, David Seiffge
BACKGROUND: Posterior reversible encephalopathy syndrome (PRES) and reversible cerebral vasoconstriction syndrome (RCVS) may cause ischaemic stroke and intracranial haemorrhage. The aim of our study was to assess the frequency of the afore-mentioned outcomes. METHODS: We performed a PROSPERO-registered (CRD42022355704) systematic review and meta-analysis accessing PubMed until 7 November 2022. The inclusion criteria were: (1) original publication, (2) adult patients (≥18 years), (3) enrolling patients with PRES and/or RCVS, (4) English language and (5) outcome information...
March 12, 2024: European Journal of Neurology
https://read.qxmd.com/read/38440097/stress-cardiomyopathy-in-the-paediatric-population-a-case-series
#14
Nadine Annino, Aymeric Cantais, Etienne Javouhey, Florent Baudin
BACKGROUND: Stress cardiomyopathy (Takotsubo syndrome) defined as Takotsubo syndrome is defined as a reversible acute myocardial syndrome with myocardial injury with regional wall motion abnormality and no coronary explanations in the context of stress. The pathophysiology remains partially unknown, and these cases are probably underestimated in paediatrics. We report six cases of Takotsubo probably secondary to neurological damage. CASE SUMMARY: Six patients (10, 13, 16, 10, and 9 years and 5 months) presented with haemodynamic lability with echocardiography data leading to suspicion of Takotsubo syndrome...
March 2024: European Heart Journal. Case Reports
https://read.qxmd.com/read/38435656/cerebral-oxygenation-monitoring-for-early-detection-of-subarachnoid-haemorrhage-in-infratentorial-arteriovenous-malformation-undergoing-embolisation-a-case-study
#15
JOURNAL ARTICLE
Kunal K Sharma, Prachi Sharma, Rohini M Surve
No abstract text is available yet for this article.
February 2024: Indian Journal of Anaesthesia
https://read.qxmd.com/read/38430071/bi-allelic-nit1-variants-cause-a-brain-small-vessel-disease-characterized-by-movement-disorders-massively-dilated-perivascular-spaces-and-intracerebral-hemorrhage
#16
JOURNAL ARTICLE
Julie W Rutten, Minne N Cerfontaine, Kyra L Dijkstra, Aat A Mulder, Jeroen Vreijling, Mark Kruit, Roman I Koning, Susanne T de Bot, Koen M van Nieuwenhuizen, Hans J Baelde, Henk W Berendse, Leon H Mei, George J G Ruijter, Frank Baas, Carolina R Jost, Sjoerd G van Duinen, Esther A R Nibbeling, Gido Gravesteijn, Saskia A J Lesnik Oberstein
PURPOSE: To describe a recessively inherited cerebral small vessel disease, caused by loss-of-function variants in Nitrilase1 (NIT1). METHODS: We performed exome sequencing, brain MRI, neuropathology, electron microscopy, Western Blotting and transcriptomic and metabolic analyses in seven NIT1-small vessel disease patients from five unrelated pedigrees. RESULTS: The first identified patients were three siblings, compound heterozygous for the NIT1 c...
February 27, 2024: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://read.qxmd.com/read/38424037/diagnosis-and-management-of-subarachnoid-haemorrhage
#17
REVIEW
Suneesh Thilak, Poppy Brown, Tony Whitehouse, Nandan Gautam, Errin Lawrence, Zubair Ahmed, Tonny Veenith
Aneurysmal subarachnoid haemorrhage (aSAH) presents a challenge to clinicians because of its multisystem effects. Advancements in computed tomography (CT), endovascular treatments, and neurocritical care have contributed to declining mortality rates. The critical care of aSAH prioritises cerebral perfusion, early aneurysm securement, and the prevention of secondary brain injury and systemic complications. Early interventions to mitigate cardiopulmonary complications, dyselectrolytemia and treatment of culprit aneurysm require a multidisciplinary approach...
February 29, 2024: Nature Communications
https://read.qxmd.com/read/38418755/red-blood-cells-in-the-cerebrospinal-fluid-compartment-after-subarachnoid-haemorrhage-significance-and-emerging-therapeutic-strategies
#18
REVIEW
Soham Bandyopadhyay, Nina Schwendinger, Behnam Rezai Jahromi, Shivanand P Lad, Spiros Blackburn, Stefan Wolf, Diederik Bulters, Ian Galea, Michael Hugelshofer
Subarachnoid haemorrhage (SAH) is a subtype of stroke that predominantly impacts younger individuals. It is associated with high mortality rates and can cause long-term disabilities. This review examines the contribution of the initial blood load and the dynamics of clot clearance to the pathophysiology of SAH and the risk of adverse outcomes. These outcomes include hydrocephalus and delayed cerebral ischaemia (DCI), with a particular focus on the impact of blood located in the cisternal spaces, as opposed to ventricular blood, in the development of DCI...
February 29, 2024: Translational Stroke Research
https://read.qxmd.com/read/38404631/cerebrovascular-responses-in-a-patient-with-lundberg-b-waves-following-subarachnoid-haemorrhage-assessed-with-a-novel-non-invasive-brain-pulse-monitor-a-case-report
#19
Elliot John Teo, Sigrid Petautschnig, Jack Hellerstedt, Sally A Grace, Jacqui S Savage, Brendan Fafiani, Paul Daniel Smith, Ashu Jhamb, Timothy Haydon, Barry Dixon
Subarachnoid haemorrhage (SAH) can trigger a range of poorly understood cerebrovascular responses that may play a role in delayed cerebral ischemia. The brain pulse monitor is a novel non-invasive device that detects a brain photoplethysmography signal that provides information on intracranial pressure (ICP), compliance, blood flow and tissue oxygen saturation. We monitored the cerebrovascular responses in a patient with Lundberg B waves following a SAH. The patient presented with a Fischer grade 4 SAH that required urgent left posterior communicating artery aneurysm coiling and ventricular drain insertion...
2024: Medical Devices: Evidence and Research
https://read.qxmd.com/read/38387502/tranexamic-acid-in-patients-with-traumatic-brain-injury-a-meta-analysis
#20
JOURNAL ARTICLE
R M Sarhan, M S Boshra, M E A Abdelrahim, H Osama
BACKGROUND: We performed a meta-analysis to assess the effectiveness and safety of tranexamic acid in patients with traumatic brain injury (TBI). METHODS: We searched the literature for articles evaluating the effectiveness and safety of tranexamic acid (TXA) in TBI published between January 2012 and January 2021, and identified 8 studies with a total of 10860 patients: 5660 received TXA and 5200 served as controls. We used a dichotomous or continuous approach with a random or fixed-effect model to assess the efficacy and safety of TXA in TBI, and calculated the mean difference (MD) and odds ratio (OR) with the corresponding 95% confidence interval...
February 20, 2024: Revista española de anestesiología y reanimación
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