keyword
https://read.qxmd.com/read/35019942/treatment-of-familial-benign-chronic-pemphigus-with-superficial-radiotherapy
#21
JOURNAL ARTICLE
Hans Christian Wulf, Stine Regin Wiegell
IMPORTANCE: Hailey-Hailey disease (HHD) is a chronic genodermatosis with recurrent vesicles and erosions mainly in the intertriginous areas. Hailey-Hailey disease severely affects patient quality of life. Standard treatments attempt to control the flares, but often do not result in long-term remission of the disease. OBJECTIVE: To describe outcomes of treatment with superficial radiotherapy (SR) for severe treatment-refractory HHD. DESIGN, SETTING, AND PARTICIPANTS: This retrospective case-series included 13 patients with severe HHD with a mean (SD) duration of 24 (14) years whose treatments with SR and follow-up were conducted at the Department of Dermatology at Bispebjerg University Hospital (Copenhagen, Denmark) from January 2015 to April 2021...
March 1, 2022: JAMA Dermatology
https://read.qxmd.com/read/34993571/dietary-carbohydrate-restriction-augments-weight-loss-induced-improvements-in-glycaemic-control-and-liver-fat-in-individuals-with-type-2-diabetes-a-randomised-controlled-trial
#22
RANDOMIZED CONTROLLED TRIAL
Mads N Thomsen, Mads J Skytte, Amirsalar Samkani, Martin H Carl, Philip Weber, Arne Astrup, Elizaveta Chabanova, Mogens Fenger, Jan Frystyk, Bolette Hartmann, Jens J Holst, Thomas M Larsen, Sten Madsbad, Faidon Magkos, Henrik S Thomsen, Steen B Haugaard, Thure Krarup
AIMS/HYPOTHESIS: Lifestyle modification and weight loss are cornerstones of type 2 diabetes management. However, carbohydrate restriction may have weight-independent beneficial effects on glycaemic control. This has been difficult to demonstrate because low-carbohydrate diets readily decrease body weight. We hypothesised that carbohydrate restriction enhances the beneficial metabolic effects of weight loss in type 2 diabetes. METHODS: This open-label, parallel RCT included adults with type 2 diabetes, HbA1c 48-97 mmol/mol (6...
March 2022: Diabetologia
https://read.qxmd.com/read/34557856/socioeconomic-inequalities-in-the-incidence-of-alcohol-related-liver-disease-a-nationwide-danish-study
#23
JOURNAL ARTICLE
Gro Askgaard, Kate M Fleming, Colin Crooks, Frederik Kraglund, Camilla B Jensen, Joe West, Peter Jepsen
Background: There is socio-economic inequality in total alcohol-related harm, but knowledge of inequality in the incidence of specific alcohol-related diseases would be beneficial for prevention. Registry-based studies with nationwide coverage may reveal the full burden of socioeconomic inequality compared to what can be captured in questionnaire-based studies. We examined the incidence of alcohol-related liver disease (ALD) according to socioeconomic status and age. Methods: We used national registries to identify patients with an incident diagnosis of ALD and their socioeconomic status in 2009-2018 in Denmark...
September 2021: The Lancet regional health. Europe
https://read.qxmd.com/read/34491861/substantial-decrease-in-vancomycin-resistant-enterococcus-faecium-outbreak-duration-and-number-of-patients-during-the-danish-covid-19-lockdown-a-prospective-observational-study
#24
JOURNAL ARTICLE
Katrine Lauridsen Gisselø, Ingrid Maria Cecilia Rubin, Maja Søndergaard Knudsen, Michelle From-Hansen, Marie Stangerup, Christiane Pahl Kavalaris, Mette Pinholt, Sarah Mollerup, Henrik Westh, Mette Damkjær Bartels, Andreas Munk Petersen
Vancomycin-resistant Enterococcus faecium (VREfm) is a globally significant nosocomial pathogen with a rapidly increasing prevalence. The objectives were to investigate VREfm outbreak duration and study the additional impact that infection control bundle strategies (ICBSs) set up to curb coronavirus disease 2019 (COVID-19) spreading had on VREfm outbreaks. Outbreak data set were collected prospectively from April 2, 2014 to August 13, 2020 at Copenhagen University Hospital Bispebjerg, Denmark. All VREfm samples had polymerase chain reaction performed for vanA / vanB genes before whole genome sequencing using the Illumina MiSeq platform...
January 2022: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://read.qxmd.com/read/33913417/medication-errors-in-residential-facilities-based-on-danish-poison-information-center-inquiries
#25
JOURNAL ARTICLE
Catrine Bakkedal, Karen Reenberg Eriksen, Nete Brandt Hansen, Tonny Studsgaard Petersen, Kim Peder Dalhoff, Søren Bøgevig, Maarten Pieter Rizing, Mikkel Bring Christensen
INTRODUCTION: This study describes the types and health consequences of medication errors in residential facilities for which the Danish Poison Information Center (DPIC) was contacted. METHODS: This study is based on all inquiries made by residential facilities to the DPIC during a 13-month period. Information about inquirers and residents, data related to the medication error, symptoms, risk assessments and recommendations was collected, and a follow-up phone call was made to evaluate the clinical outcomes, preferably within one week...
April 28, 2021: Danish Medical Journal
https://read.qxmd.com/read/33881573/fistula-laser-closure-filac%C3%A2-for-fistula-in-ano-yet-another-technique-with-50-healing-rates
#26
JOURNAL ARTICLE
Andreas Nordholm-Carstensen, Helene Perregaard, Kikke Bartholin Hagen, Peter-Martin Krarup
PURPOSE: Treatment of ano-cutaneous fistulas remains a therapeutic challenge. Fistula Laser Closure (FiLaC™) is a relatively new technique for the treatment of ano-cutaneous fistulas. This study aimed to determine the success rate of fistula closure using FiLaC™. Secondary endpoints included adverse events and patient characteristics associated with treatment success. METHODS: This was a retrospective cohort study of consecutive patients subjected to FiLaC™ at Digestive Disease Center, Bispebjerg University Hospital, Copenhagen, between March 2017 and July 2019...
September 2021: International Journal of Colorectal Disease
https://read.qxmd.com/read/33823427/cognitive-impairments-four-months-after-covid-19-hospital-discharge-pattern-severity-and-association-with-illness-variables
#27
JOURNAL ARTICLE
K W Miskowiak, S Johnsen, S M Sattler, S Nielsen, K Kunalan, J Rungby, T Lapperre, C M Porsberg
The ongoing Coronavirus Disease 2019 (COVID-19) pandemic has affected more than 100 million people and clinics are being established for diagnosing and treating lingering symptoms, so called long-COVID. A key concern are neurological and long-term cognitive complications. At the same time, the prevalence and nature of the cognitive sequalae of COVID-19 are unclear. The present study aimed to investigate the frequency, pattern and severity of cognitive impairments 3-4 months after COVID-19 hospital discharge, their relation to subjective cognitive complaints, quality of life and illness variables...
May 2021: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/33730733/immunoinflammatory-biomarkers-in-serum-are-associated-with-disease-severity-in-atopic-dermatitis
#28
JOURNAL ARTICLE
Jesper Grønlund Holm, Guillem Hurault, Tove Agner, Maja Lisa Clausen, Sanja Kezic, Reiko J Tanaka, Simon Francis Thomsen
BACKGROUND: A growing body of evidence links various biomarkers to atopic dermatitis (AD). Still, little is known about the association of specific biomarkers to disease characteristics and severity in AD. OBJECTIVE: To explore the relationship between various immunological markers in the serum and disease severity in a hospital cohort of AD patients. METHODS: Outpatients with AD referred to the Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark, were divided into groups based on disease severity (SCORAD)...
March 17, 2021: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/33543698/injuries-following-accidents-with-electric-scooters
#29
JOURNAL ARTICLE
Kristin Ingstrup Nielsen, Finn Erland Nielsen, Søren Wistisen Rasmussen
INTRODUCTION: Since the introduction of electric scooter (e-scooter) rental services in Denmark in January 2019, injuries following accidents involving e-scooters have increased. Internationally, a few studies have been published examining patient and injury characteristics following accidents involving e-scooters. However, data are limited. The purpose of this study was to describe the injuries, treatment and hospital course following accidents involving e-scooters. METHODS: Prospective collection of data on all persons involved in accidents related to e-scooters who were examined and treated at the Emergency Department of Bispebjerg and Frederiksberg, Denmark, during the period from 30 June 2019 to 30 September 2019...
January 20, 2021: Danish Medical Journal
https://read.qxmd.com/read/33376179/biomarkers-for-length-of-hospital-stay-changes-in-muscle-mass-strength-and-physical-function-in-older-medical-patients-protocol-for-the-copenhagen-protect-study-a-prospective-cohort-study
#30
JOURNAL ARTICLE
Rikke S Kamper, Martin Schultz, Sofie K Hansen, Helle Andersen, Anette Ekmann, Hanne Nygaard, Fredrik Helland, Miriam R Wejse, Camilla B Rahbek, Tim Noerst, Eckart Pressel, Finn Erland Nielsen, Charlotte Suetta
INTRODUCTION: Sarcopenia is generally used to describe the age-related loss of muscle mass and strength believed to play a major role in the pathogenesis of physical frailty and functional impairment that may occur with old age. The knowledge surrounding the prevalence and determinants of sarcopenia in older medical patients is scarce, and it is unknown whether specific biomarkers can predict physical deconditioning during hospitalisation. We hypothesise that a combination of clinical, functional and circulating biomarkers can serve as a risk stratification tool and can (i) identify older acutely ill medical patients at risk of prolonged hospital stays and (ii) predict changes in muscle mass, muscle strength and function during hospitalisation...
December 29, 2020: BMJ Open
https://read.qxmd.com/read/33199307/screening-for-potential-familial-hypercholesterolaemia-in-general-practice-management-and-potentials
#31
JOURNAL ARTICLE
Stefan Mülverstedt, Per Rossen Hildebrandt, Eva Prescott, Merete Heitmann
BACKGROUND: Familial Hypercholesterolaemia (FH) is a common genetic disorder causing premature cardiovascular disease (CVD). The estimated prevalence of probable or definite FH according to the Dutch Lipid Clinic Network (DLCN) Criteria for FH is 1:200-250 individuals. In Denmark approximately 12% are identified. AIM: To provide knowledge of the prevalence and management of FH in general practice. DESIGN AND SETTING: A collaboration between six General Practitioners and the department of cardiology, Bispebjerg hospital...
November 16, 2020: BJGP Open
https://read.qxmd.com/read/32489532/elevated-blood-eosinophils-in-acute-copd-exacerbations-better-short-and-long-term-prognosis
#32
JOURNAL ARTICLE
Ajmal Jabarkhil, Mia Moberg, Julie Janner, Mie Nymann Petersen, Camilla Bjørn Jensen, Lars Henrik Äangquist, Jørgen Vestbo, Tine Jess, Celeste Porsbjerg
Background : Elevated eosinophils in COPD is recognized as a potential risk factor for exacerbations, but the prognostic role of elevated eosinophils during exacerbations of COPD is unclear. We investigated short-term and long-term outcomes in patients with exacerbations of eosinophilic phenotype, compared with patients with low blood eosinophils. Methods : A single-centre retrospective study of all patients admitted for a COPD exacerbation to Bispebjerg University Hospital in 2010-2011 was established by linking inpatient data with national patient and prescription registries, with a three-year follow-up period...
2020: European Clinical Respiratory Journal
https://read.qxmd.com/read/32392360/introducing-the-hip-call-to-facilitate-early-surgical-treatment-of-hip-fractures-a-feasibility-study
#33
JOURNAL ARTICLE
Thomas G Jensen, Louise Ø Vinstrup, Simone Dalskov, Martin Aasbrenn, Henrik Palm, Søren A Rugolo, Merete T Vendelø, Signe Dollerup, Sine A N Eriksen, Troels H Lunn
INTRODUCTION: Surgical treatment of hip fractures within 24-48 hours decreases morbidity and mortality, but goals for early surgery have not been widely achieved so far. The primary aim of this study was to investigate the feasibility of implementation of a hip call, and the secondary aim was to investigate the effect of the hip call on time for pre-operative preparation and surgery compared to a historical control cohort. MATERIALS AND METHODS: From March 4, 2019 until June 30, 2019, admission of patients at Copenhagen University Hospital, Bispebjerg, Denmark, with a suspected hip fracture triggered an acute hip call...
September 2020: Acta Anaesthesiologica Scandinavica
https://read.qxmd.com/read/32323017/correction-to-consensus-on-international-guidelines-for-management-of-groin-hernias
#34
JOURNAL ARTICLE
Nadine van Veenendaal, Maarten Simons, William Hope, Sathien Tumtavitikul, Jaap Bonjer
In the Acknowledgments, Lars N. Jorgensen of the HerniaSurge Group was incorrectly listed as: "Lars Jorgensen, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark." The correct listing should have read: "Lars N. Jorgensen, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark."
June 2020: Surgical Endoscopy
https://read.qxmd.com/read/32313715/predictors-of-acute-kidney-injury-after-hip-fracture-in-older-adults
#35
JOURNAL ARTICLE
Julie Braüner Christensen, Martin Aasbrenn, Luana Sandoval Castillo, Anette Ekmann, Thomas Giver Jensen, Eckart Pressel, Troels Haxholdt Lunn, Charlotte Suetta, Henrik Palm
Introduction: This study aimed to investigate the prevalence of acute kidney injury (AKI) following hip fracture surgery in geriatric patients and to identify predictors for development of AKI with a focus on possible preventable risk factors. Methods: In this retrospective cohort study, we reviewed electronic medical records of all patients above 65 years of age who underwent hip fracture surgery at Copenhagen University Hospital, Bispebjerg, Denmark, in 2018. Acute kidney injury was assessed according to the Kidney Disease Improving Global Outcomes guidelines...
2020: Geriatric Orthopaedic Surgery & Rehabilitation
https://read.qxmd.com/read/31696265/thyroid-stimulating-hormone-tsh-is-associated-with-30-day-mortality-in-hip-fracture-patients
#36
JOURNAL ARTICLE
Etienne Rapacki, Jes B Lauritzen, Christian M Madsen, Henrik L Jørgensen, Debbie Norring-Agerskov
PURPOSE: The aim of this study is to assess the possible association between thyroid-stimulating hormone (TSH) and mortality in hip fracture patients. PATIENTS AND METHODS: The study is based on a hip fracture database from Bispebjerg University Hospital (Copenhagen, Denmark). This database includes all hip fracture patients (ICD-10 codes DS720 (femoral neck), DS721 (pertrochanteric), and DS722 (subtrochanteric)) admitted to Bispebjerg Hospital from 1996 to 2012...
November 6, 2019: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://read.qxmd.com/read/31583251/healing-of-diabetic-foot-ulcers-in-patients-treated-at-the-copenhagen-wound-healing-center-in-1999-2000-and-in-2011-2012
#37
JOURNAL ARTICLE
Marie Louise Buhl Sørensen, Rasmus Bo Jansen, Therese Wilbek Fabricius, Bo Jørgensen, Ole Lander Svendsen
Aim: To describe differences in healing time of diabetic foot ulcers for patients treated at the Copenhagen Wound Healing Center, Bispebjerg Hospital, between the years 1999/2000 and 2011/2012. The Center is highly specialized and receives diabetes patients with hard-to-heal foot ulcers. A further aim is to attempt to find predictors of healing time of diabetic foot ulcers. Methods: A retrospective descriptive study of records from patients with diabetic foot ulcer treated at the Copenhagen Wound Healing Center in 1999, 2000, 2011, or 2012...
2019: Journal of Diabetes Research
https://read.qxmd.com/read/31338545/a-carbohydrate-reduced-high-protein-diet-improves-hba-1c-and-liver-fat-content-in-weight-stable-participants-with-type-2-diabetes-a-randomised-controlled-trial
#38
RANDOMIZED CONTROLLED TRIAL
Mads J Skytte, Amirsalar Samkani, Amy D Petersen, Mads N Thomsen, Arne Astrup, Elizaveta Chabanova, Jan Frystyk, Jens J Holst, Henrik S Thomsen, Sten Madsbad, Thomas M Larsen, Steen B Haugaard, Thure Krarup
AIMS/HYPOTHESIS: Dietary recommendations for treating type 2 diabetes are unclear but a trend towards recommending a diet reduced in carbohydrate content is acknowledged. We compared a carbohydrate-reduced high-protein (CRHP) diet with an iso-energetic conventional diabetes (CD) diet to elucidate the effects on glycaemic control and selected cardiovascular risk markers during 6 weeks of full food provision of each diet. METHODS: The primary outcome of the study was change in HbA1c ...
November 2019: Diabetologia
https://read.qxmd.com/read/30959559/treatment-of-atopic-dermatitis-with-dupilumab-experience-from-a-tertiary-referral-centre
#39
JOURNAL ARTICLE
C M Olesen, J G Holm, L B Nørreslet, J V Serup, S F Thomsen, T Agner
BACKGROUND: Management of moderate-to-severe atopic dermatitis (AD) frequently requires treatment with systemic therapies. Dupilumab is the first biological agent approved for treatment of moderate-to-severe AD. Although promising results have appeared in clinical trials, real-life data on efficacy and safety are lacking. OBJECTIVES: To assess effectiveness and safety of treatment with dupilumab in the real-life clinical setting at a Danish tertiary referral centre...
April 8, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/30887182/visceral-obesity-and-short-term-outcomes-after-laparoscopic-rectal-cancer-resection
#40
JOURNAL ARTICLE
Niklas Nygaard Baastrup, Jan Kim Christensen, Kristian Kiim Jensen, Lars Nannestad Jørgensen
BACKGROUND: Complications after rectal resection are frequent. Recently, methods to assess visceral obesity (VO) have become available as an alternative to measurement of body mass index (BMI). The aim of this study was to examine the association between visceral fat volume (VFV) and the short-term outcomes after laparoscopic low anterior resection (LLAR) in patients with rectal cancer. METHODS: We studied a consecutive series of patients undergoing LLAR at Bispebjerg University Hospital from 01...
March 18, 2019: Surgical Endoscopy
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