keyword
https://read.qxmd.com/read/27320547/predictive-risk-factors-in-the-development-of-intraoperative-hyperkalemia-in-adult-living-donor-liver-transplantation
#21
JOURNAL ARTICLE
S-E Juang, C-E Huang, C-L Chen, C-H Wang, C-J Huang, K-W Cheng, S-C Wu, T-H Shih, S-C Yang, Z-W Wong, B Jawan, Y-E Lee
BACKGROUND: Hyperkalemia, defined as a serum potassium level higher than 5 mEq/L, is common in the liver transplantation setting. Severe hyperkalemia may induce fatal cardiac arrhythmias; therefore, it should be monitored and treated accordingly. The aim of the current retrospective study is to evaluate and indentify the predictive risk factors of hyperkalemia during living-donor liver transplantation (LDLT). METHODS AND PATIENTS: Four hundred eighty-seven adult LDLT patients were included in the study...
May 2016: Transplantation Proceedings
https://read.qxmd.com/read/26345674/renal-tubular-acidosis-type-iv-as-a-complication-of-lupus-nephritis
#22
JOURNAL ARTICLE
C Sánchez-Marcos, V Hoffman, S Prieto-González, J Hernández-Rodríguez, G Espinosa
Renal tubular acidosis (RTA) is a rare complication of renal involvement of systemic lupus erythematosus (SLE). We describe a 24-year-old male with type IV lupus nephropathy as a presenting manifestation of SLE. He presented with improvement of renal function following induction therapy with three pulses of methylprednisolone and 500 mg biweekly pulses of cyclophosphamide. However, a week after the first pulse of cyclophosphamide, the patient presented with a significant increase in legs edema and severe hyperkalemia...
March 2016: Lupus
https://read.qxmd.com/read/26036654/-the-most-frequent-electrolyte-disorders-in-the-emergency-department-what-must-be-done-immediately
#23
JOURNAL ARTICLE
B M W Schmidt
Hyponatremia is the most common form of electrolyte disorder in the emergency room. The symptoms are unspecific and include nausea, dizziness and often falls. Typical symptoms of severe hypernatremia are vomiting, cerebral seizures, somnolence and even coma. The specific initial laboratory diagnostics include measurement of serum electrolytes, serum glucose, serum and urine osmolarity and sodium in urine. The main aim of the clinical examination is to estimate the volume status. If a patient has hypovolemia an infusion of isotonic sodium chloride solution (0...
July 2015: Der Internist
https://read.qxmd.com/read/25843460/-tumor-lysis-syndrome-after-folfiri-cetuximab-for-ascending-colon-cancer
#24
JOURNAL ARTICLE
Satoru Matsuyama, Takako Kuramoto, Ryosuke Tanaka, Kazutoshi Hashiguchi
We report a case of an 83-year-old woman who developed tumor lysis syndrome (TLS) 5 days after FOLFIRI+cetuximab (Cmab) therapy. A huge ascending colon cancer measuring 10 cm in diameter and with peritoneal dissemination was diagnosed. Following successful therapy with FOLFIRI alone, FOLFIRI+Cmab was administered. On day 5, TLS was diagnosed with hyperuricemia, hyperkalemia, hyperphosphatemia, and an increase in serum creatinine. Intravenous furosemide, volume loading, and glucose-insulin therapy resulted in improvement of laboratory data in 2 days...
April 2015: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://read.qxmd.com/read/25377117/effect-of-mineralocorticoids-on-acid-base-balance
#25
REVIEW
Carsten A Wagner
Aldosterone is classically associated with the regulation of salt and potassium homeostasis but has also profound effects on acid-base balance. During acidosis, circulating aldosterone levels are increased and the hormone acts in concert with angiotensin II and other factors to stimulate renal acid excretion. Pharmacological blockade of aldosterone action as well as inherited or acquired syndromes of impaired aldosterone release or action impair the renal response to acid loading and cause hyperkalemic renal tubular acidosis...
2014: Nephron. Physiology
https://read.qxmd.com/read/24842358/a-complication-to-be-aware-of-hyperkalaemia-following-propranolol-therapy-for-an-infant-with-intestinal-haemangiomatozis
#26
JOURNAL ARTICLE
Burcu Belen, Aynur Oguz, Arzu Okur, Buket Dalgic
Infantile haemangiomas, benign vascular tumours seen in 4-10% of infants are characterised by their spontaneous remission following a 3-9 month period of dynamic growth. Propranolol has been reported to be used as a successful treatment of severe symptomatic infantile haemangiomas. Hyperkalaemia has not been recognised as a serious effect of propranolol since recently. Here, we would like to portray a 2-year-old male patient with intestinal haemangiomatosis who presented with severe hyperkalaemia and was successfully managed with hydration, loop diuretics, potassium binding granules, inhaler β-2 agonists and insulin...
May 19, 2014: BMJ Case Reports
https://read.qxmd.com/read/23869534/safety-of-spironolactone-in-dogs-with-chronic-heart-failure-because-of-degenerative-valvular-disease-a-population-based-longitudinal-study
#27
RANDOMIZED CONTROLLED TRIAL
H P Lefebvre, E Ollivier, C E Atkins, B Combes, D Concordet, V Kaltsatos, L Baduel
BACKGROUND: Spironolactone treatment in humans is associated with an increased risk of hyperkalemia and renal dysfunction. HYPOTHESIS: Dogs with cardiac disease treated with spironolactone, in addition to conventional therapy, are not at higher risk for adverse events (AEs) than those receiving solely conventional therapy. ANIMALS: One hundred and ninety-six client-owned dogs with naturally occurring myxomatous mitral valve disease. METHODS: Prospective, double-blinded field study with dogs randomized to receive either spironolactone (2 mg/kg once a day) or placebo in addition to conventional therapy (angiotensin-converting enzyme inhibitor, plus furosemide and digoxin if needed)...
September 2013: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/23760292/partial-genetic-deficiency-in-tissue-kallikrein-impairs-adaptation-to-high-potassium-intake-in-humans
#28
RANDOMIZED CONTROLLED TRIAL
Joana S Monteiro, Anne Blanchard, Emmanuel Curis, Régine Chambrey, Xavier Jeunemaitre, Michel Azizi
Inactivation of the tissue kallikrein gene in mice impairs renal handling of potassium due to enhanced H, K-ATPase activity, and induces hyperkalemia. We investigated whether the R53H loss-of-function polymorphism of the human tissue kallikrein gene affects renal potassium handling. In a crossover study, 30 R53R homozygous and 10 R53H heterozygous healthy males were randomly assigned to a low-sodium/high-potassium or a high-sodium/low-potassium diet to modulate tissue kallikrein synthesis. On the seventh day of each diet, participants were studied before and during a 2-h infusion of furosemide to stimulate distal potassium secretion...
December 2013: Kidney International
https://read.qxmd.com/read/22129317/pharmacovigilance-and-the-cardiovascular-system-two-sides-to-every-story
#29
JOURNAL ARTICLE
Guillermo Alberto Keller, Guillermo Di Girolamo, Paulino Antonio Alvarez
PURPOSE: The objective of the present study was to quantify the reported cardiovascular adverse reactions and adverse reactions to cardiovascular drugs to help to design and implement monitoring and prevention strategies. METHODS: The pharmacovigilance unit (PU) is a peripheral effector of National Pharmacovigilance Center and receives adverse drug reactions notifications from 10 teaching hospitals. Data on adverse reactions beginning in 2004 and notified to the PU were extracted from the database...
September 1, 2011: Current Drug Safety
https://read.qxmd.com/read/21661096/four-nephrology-myths-debunked
#30
REVIEW
Jean-Sebastien Rachoin, Elizabeth A Cerceo
There are many controversial topics relating to renal disease in hospitalized patients. The aim of this review is to shed light on some important and often debated issues. Hypothyroidism, unlike myxedema, is not a cause of hyponatremia (although it can be sometimes seen in conjunction with the latter) and additional investigations should be done to determine its etiology. Sodium bicarbonate is effective for treatment of hyperkalemia primarily by enhancing renal potassium elimination rather than by translocating potassium into cells...
May 2011: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://read.qxmd.com/read/21553088/effect-of-amino-acid-infusion-on-potassium-serum-levels-in-neuroendocrine-tumour-patients-treated-with-targeted-radiopeptide-therapy
#31
JOURNAL ARTICLE
Giampiero Giovacchini, Guillaume Nicolas, Heike Freidank, Thomas L Mindt, Flavio Forrer
PURPOSE: Administration of positively charged amino acids has been introduced to reduce the nephrotoxicity of targeted radiopeptide therapy (TRT). However, the amino acid solution may have side effects, including hyperkalaemia. The aim of this study was to evaluate the frequency and the magnitude of hyperkalaemia in neuroendocrine tumour (NET) patients undergoing TRT. METHODS: Enrolled in the study were 31 patients with NET eligible for TRT with [(90)Y-DOTA(0),Tyr(3)]octreotide ((90)Y-DOTATOC)...
September 2011: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/21492039/ecg-of-the-month-hyperkalemia
#32
JOURNAL ARTICLE
Sara M Johns, Joshua A Stern, O Lynne Nelson
No abstract text is available yet for this article.
April 15, 2011: Journal of the American Veterinary Medical Association
https://read.qxmd.com/read/21192246/management-of-refractory-ascites
#33
REVIEW
Shashideep Singhal, Kiran K Baikati, Ibrahim I Jabbour, Sury Anand
Ascites that does not respond or recurs after high-dose diuresis and sodium restriction should be considered refractory ascites. As cirrhosis advances, the escaping fluid overwhelms the lymphatic return. Decrease in renal plasma flow leads to increased sodium reabsorption at the proximal tubule leading to decreased responsiveness to loop diuretics and mineralocorticoid antagonists, which work distally. These complex hemodynamic alterations lead to refractory ascites. In refractory ascites, high-dose diuresis (400 mg of spironolactone and 160 mg of furosemide) and sodium restriction (<90 mmol/d) result in inadequate weight loss and sub optimal sodium excretion (<78 mmol/d)...
March 2012: American Journal of Therapeutics
https://read.qxmd.com/read/20298139/rhabdomyolysis-historical-background-clinical-diagnostic-and-therapeutic-features
#34
REVIEW
Gianfranco Cervellin, Ivan Comelli, Giuseppe Lippi
Rhabdomyolysis, a term used to describe the rapid breakdown of striated muscle, is characterized by rupture and necrosis of muscle fibers. This process results in the release of cell breakdown products into the bloodstream and extracellular space. Although direct muscle injury remains the most common cause of muscle injury, additional causes include hereditary enzyme disorders, drugs, toxins, endocrinopathies, malignant hyperthermia, neuroleptic malignant syndrome, heatstroke, hypothermia, electrolyte alterations, diabetic ketoacidosis and non-ketotic hyperosmolar coma, severe hypo- or hyperthyroidism and bacterial or viral infections...
June 2010: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/20219947/osmoregulation-of-ceroid-neuronal-lipofuscinosis-type-3-in-the-renal-medulla
#35
JOURNAL ARTICLE
Colleen S Stein, Paul H Yancey, Inês Martins, Rita D Sigmund, John B Stokes, Beverly L Davidson
Recessive inheritance of mutations in ceroid neuronal lipofuscinosis type 3 (CLN3) results in juvenile neuronal ceroid lipofuscinosis (JNCL), a childhood neurodegenerative disease with symptoms including loss of vision, seizures, and motor and mental decline. CLN3p is a transmembrane protein with undefined function. Using a Cln3 reporter mouse harboring a nuclear-localized bacterial beta-galactosidase (beta-Gal) gene driven by the native Cln3 promoter, we detected beta-Gal most prominently in epithelial cells of skin, colon, lung, and kidney...
June 2010: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/20030530/renin-angiotensin-system-blockade-is-not-associated-with-hyperkalemia-in-chronic-hemodialysis-patients
#36
JOURNAL ARTICLE
Hsin-Hung Lin, Ya-Fei Yang, Ju-Kuang Chang, I-Wen Ting, Huey-Liang Kuo, I-Kuan Wang, Chiu-Ching Huang
BACKGROUND: Serious hyperkalemia was reported in 10% of chronic hemodialysis (HD) patients that could lead to arrhythmia and death. Angiotensin-converting enzyme inhibitors (ACE-I) and angiotensin II receptor blockers (ARB) are well accepted for cardio-protective benefits. The relationship between renin-angiotensin system blockade (RASB) and hyperkalemia in chronic HD patients remains controversial. The aim of this study was to find the relationship between RASB and hyperkalemia in these patients...
2009: Renal Failure
https://read.qxmd.com/read/19702222/-case-of-unexpected-intraoperative-hyperkalemia
#37
JOURNAL ARTICLE
Satomi Suzuki, Go Kashiwagi, Yoshiki Nakasone, Akihiro Tomioka, Shigeru Saito
We experienced a case of unexpected ECG abnormality with hyperkalemia. A 65-year-old man was suffering from maxillary sinus cyst and Caldwell-Luc procedure was scheduled. He had diabetes mellitus and hypertension for 15 years, and was taking oral hypoglycemic agent and hypotensive drug (angiotensin converting enzyme and angiotensin receptor blockers : ARB). Abnormal findings were HbA1c 7.7% and glycosuria over 1,000 mg x dl(-1). ECG and other laboratory tests were within normal limits. The patient was monitored with 3 leads ECG during the operation...
August 2009: Masui. the Japanese Journal of Anesthesiology
https://read.qxmd.com/read/19247762/salbutamol-to-facilitate-management-of-acute-hyperkalemia-in-liver-transplantation-a-case-report
#38
JOURNAL ARTICLE
Duk-Kyung Kim, Seong-Hwan Chang, Ik-Jin Yun, Won-Kyoung Kwon, Nam-Sik Woo
PURPOSE: Acute hyperkalemia is a frequent, potentially life-threatening complication in orthotopic liver transplantation (OLT). We describe a case of acute hyperkalemia during the pre-anhepatic stage that remained persistent despite conventional treatment, including calcium salts, insulin and glucose, sodium bicarbonate, and furosemide. CLINICAL FEATURES: A 50-yr-old man with end-stage hepatitis B liver cirrhosis underwent living donor liver transplantation, receiving a right lobe graft donated by his son...
February 2009: Canadian Journal of Anaesthesia
https://read.qxmd.com/read/18751643/the-silence-of-the-atria
#39
JOURNAL ARTICLE
Avraham Unterman, Samuel D Moscavitch
No abstract text is available yet for this article.
July 2008: Israel Medical Association Journal: IMAJ
https://read.qxmd.com/read/17176359/carvedilol-accelerate-elevation-of-serum-potassium-in-chronic-heart-failure-patients-administered-spironolactone-plus-furosemide-and-either-enalapril-maleate-or-candesartan-cilexetil
#40
JOURNAL ARTICLE
M Saito, D Nakayama, M Takada, K Hirooka, Y Yasumura
OBJECTIVE: To retrospectively investigate the effect of carvedilol and spironolactone plus furosemide, administered concomitantly with an angiotensin II converting enzyme inhibitor (ACE-I) or an angiotensin II receptor blocker (ARB) to patients with chronic heart failure (CHF). METHODS: Patients with CHF, who visited Departments of Cardiovascular Internal Medicine at the National Hospital Organization Osaka Medical Center, were enrolled for this study. Serum potassium, blood urea nitrogen (BUN), serum creatinine (Scr) and serum sodium were measured in every patient at the time of start of treatment and after 3 and 12 months of treatment...
December 2006: Journal of Clinical Pharmacy and Therapeutics
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