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Myocardial infarction type 2

Luyu Yang, Hui Dong, Huizhi Lu, Youxia Liao, Hao Zhang, Lingwen Xu, Yun Tan, Song Cao, Jinhui Tan, Shouzhi Fu
Serum YKL-40, a potential inflammatory marker, is greatly increased at the early stage of ST-segment elevation myocardial infarction (STEMI). Here, we hypothesized that YKL-40 levels at admission could predict the long-term outcomes after STEMI.A total of 324 patients with acute STEMI undergoing primary percutaneous coronary intervention (PCI) were consecutively enrolled and followed for 24 months. The baseline clinical and procedural data were recorded, and serum YKL-40 levels at admission were measured using ELISA method...
March 2019: Medicine (Baltimore)
Nathan D Wong, Michael D Shapiro
The recent development of monoclonal antibodies targeted to proprotein convertase subtilisin/kexin type 9 (PCSK9), e.g., PCSK9 inhibitors has revolutionized the landscape of lipid management. Many clinical trials assessing this class have demonstrated remarkable and consistent reductions in low-density lipoprotein-cholesterol. Moreover, the GLAGOV trial demonstrated the efficacy of evolocumab, when added to statin therapy, in reducing the progression of atherosclerosis measured by serial intravascular ultrasound, with the first suggestion of continued benefit down to LDL-C levels of 0...
2019: Frontiers in Cardiovascular Medicine
Mee Kyoung Kim, Kyungdo Han, Eun Sil Koh, Eun Sook Kim, Min-Kyung Lee, Ga Eun Nam, Hyuk-Sang Kwon
BACKGROUND: Because weight control is a cornerstone of diabetes management, it is important to understand the relationship of weight change to risk of cardiovascular disease (CVD) among patients with type 2 diabetes mellitus (DM). We aimed to investigate whether changes in weight early after diagnosis influence the incidence of CVD and all-cause mortality in patients with type 2 DM. METHODS: Using nationally representative data from the Korean National Health Insurance System, 173,246 subjects with new-onset DM who underwent health examinations during 2007-2012 were included...
March 19, 2019: Cardiovascular Diabetology
Patrick W Serruys, Mariusz Tomaniak, Ply Chichareon, Rodrigo Modolo, Norihiro Kogame, Kuniaki Takahashi, Chun-Chin Chang, Ernest Spitzer, Simon J Walsh, David Adlam, David Hildick-Smith, István Édes, Pim van de Harst, Florian Krackhardt, Jan G P Tijssen, Tessa Rademaker-Havinga, Scot Garg, Philippe Gabriel Steg, Christian Hamm, Peter Jüni, Pascal Vranckx, Yoshinobu Onuma, Freek W A Verheugt
AIMS: To evaluate the impact of 23-month ticagrelor monotherapy following one-month dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) on the rates of patient-oriented composite endpoints (POCE) and net adverse clinical events (NACE). METHODS AND RESULTS: The rates of site-reported Academic Research Consortium (ARC)-2 defined POCE (all-cause death, any stroke, any myocardial infarction or any revascularization) and NACE (POCE or bleeding type 3 or 5 according to the Bleeding ARC [BARC]) were reported up to two-years by intention-to-treat principle in the randomized, multi-centre, open-label GLOBAL LEADERS study comparing two antiplatelet strategies in 15,991 patients undergoing PCI...
March 19, 2019: EuroIntervention
Viktor Rotbain Curovic, Simone Theilade, Signe A Winther, Nete Tofte, Jesper Eugen-Olsen, Frederik Persson, Tine W Hansen, Jørgen Jeppesen, Peter Rossing
OBJECTIVE: Soluble urokinase plasminogen activator receptor (suPAR) is an important inflammatory biomarker implicated in endothelial and podocyte dysfunction. However, suPAR's predictive qualities for complications in type 1 diabetes have yet to be determined. We investigated the prognostic value of suPAR for the development of cardiovascular events, decline in renal function, and mortality in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS: We included 667 patients with type 1 diabetes with various degrees of albuminuria in a prospective study...
March 18, 2019: Diabetes Care
Cian McCarthy, Sean Murphy, Joshua A Cohen, Saad Rehman, Maeve Jones-O'Connor, David S Olshan, Avinainder Singh, Muthiah Vaduganathan, James L Januzzi, Jason H Wasfy
Importance: Similar to other patients with acute myocardial infarction, patients with type 2 myocardial infarction (T2MI) are included in several value-based programs, including the Hospital Readmissions Reduction Program and the Hospital Value-Based Purchasing Program. To our knowledge, whether nonischemic myocardial injury is being misclassified as T2MI is unknown and may have implications for these programs. Objective: To determine whether patients with nonischemic myocardial injury are being miscoded as having T2MI and if this has implications for 30-day readmission and mortality rates...
March 17, 2019: JAMA Cardiology
Miriam Pikkemaat, Tobias Andersson, Olle Melander, John Chalmers, Karin Rådholm, Kristina Bengtsson Boström
AIMS: To study the association between baseline level of C-peptide and all-cause death, cardiovascular death and cardiovascular complications among persons with newly diagnosed type 2 diabetes. METHODS: The Skaraborg Diabetes Register contains data on baseline C-peptide concentrations among 398 persons <65 years with newly diagnosed type 2 diabetes 1996-1998. National registries were used to determine all-cause death, cardiovascular death and incidence of myocardial infarction and ischemic stroke until 31 December 2014...
March 13, 2019: Diabetes Research and Clinical Practice
Christina Tiller, Martin Reindl, Magdalena Holzknecht, Maximilian Klapfer, Alexander Beck, Benjamin Henninger, Agnes Mayr, Gert Klug, Sebastian Johannes Reinstadler, Bernhard Metzler
BACKGROUND: High-sensitivity cardiac troponin T (hs-cTnT) represents the biomarker of choice for infarct size (IS) estimation in patients with acute ST-elevation myocardial infarction (STEMI). However, admission values of hs-cTnT are only weakly associated with IS. The aim of this study was to investigate the incremental value of different biomarkers measured on admission for IS estimation in STEMI patients. METHODS: In this prospective observational study, we included 161 consecutive STEMI patients treated with primary percutaneous coronary intervention (pPCI)...
March 14, 2019: European Journal of Internal Medicine
Homare Okamura, Naoyuki Kimura, Makiko Mieno, Harunobu Matsumoto, Koichi Yuri, Atsushi Yamaguchi
OBJECTIVE: Left ventricular free wall rupture is a catastrophic complication of acute myocardial infarction. Sutureless repair has been reported to be an effective surgical procedure for left ventricular free wall rupture. However, the outcomes of sutureless repair remain unclear. METHODS: Between January 2001 and December 2016, 42 patients were treated for left ventricular free wall rupture at Jichi Medical University. Of them, 35 consecutive patients undergoing sutureless repair using the TachoComb (CSL Behring, Tokyo, Japan) or TachoSil (Nycomed, Zurich, Switzerland) patches were included in this study...
February 14, 2019: Journal of Thoracic and Cardiovascular Surgery
Christos V Bourantas, Thomas Zanchin, Antonis Sakellarios, Alexios Karagiannis, Anantharaman Ramasamy, Kyohei Yamaji, Masanori Taniwaki, Dik Heg, Aris Moschovitis, Dimitrios Fotiadis, Lampros Mihalis, Andreas Baumbach, Ryo Torii, Patrick Serruys, Hector M Garcia-Garcia, Stephan Windecker, Lorenz Räber
AIM: To examine the effect of endothelial shear stress (ESS) on the dynamic changes in plaque phenotype. METHODS: Patients with myocardial infarction that had intravascular ultrasound-virtual histology (IVUS-VH) and optical coherence tomography (OCT) at baseline and 13-month follow-up were studied. The IVUS-VH data were used to reconstruct the nonculprit vessels, and in the obtained models the ESS was estimated in 3 mm segments. Plaque morphology was derived in each segment from IVUS-VH and OCT...
March 15, 2019: Heart: Official Journal of the British Cardiac Society
Binayak Sinha, Samit Ghosal
INTRODUCTION: Although the positive effects of sodium-glucose cotransporter-2 inhibitors (SGLT-2i) on hospitalization for heart failure in type 2 diabetes (T2D) seem definite, some doubt exists about their effects on atherosclerotic cardiovascular disease (ASCVD). This study aims to shed light on this debatable issue. METHODS: An electronic database search (Cochrane Library, PubMed and Embase) was performed using two groups of terms ["sodium glucose cotransporter2 inhibitor", "dapagliflozin", "canagliflozin", "empagliflozin", "ertugliflozin"] AND ["major adverse cardiac events", "MACE", "cardiovascular death or hospitalization for heart failure", non-fatal myocardial infarction", "non-fatal stroke", "cardiovascular death", "hospitalization for heart failure"] and the cardiovascular outcome trials (CVOT) and pre-approval studies in phase 3 of all the SGLT2i analysed using comprehensive meta-analysis (CMA) software, version 3, Biostat Inc...
March 14, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Marion Laudette, Antonio Coluccia, Yannis Sainte-Marie, Andrea Solari, Loubina Fazal, Pierre Sicard, Romano Silvestri, Jeanne Mialet-Perez, Sandrine Pons, Bijan Ghaleh, Jean-Paul Blondeau, Frank Lezoualc'h
AIMS: Recent studies reported that cAMP-binding protein Epac1-deficient mice were protected against various forms of cardiac stress, suggesting that pharmacological inhibition of Epac1 could be beneficial for the treatment of cardiac diseases. To test this assumption, we characterized an Epac1-selective inhibitory compound and investigated its potential cardioprotective properties. METHODS AND RESULTS: We used the Epac1-BRET (bioluminescence resonance energy transfer) for searching for non-cyclic nucleotide Epac1 modulators...
March 14, 2019: Cardiovascular Research
Youngwon Kim, Stephen Sharp, Semi Hwang, Sun Ha Jee
OBJECTIVE: The objective of this study was to examine the longitudinal associations of exercise frequency with the incidence of myocardial infarction, stroke, hypertension, type 2 diabetes and 10 different cancer outcomes. DESIGN: A prospective cohort study. SETTING: Physical examination data linked with the entire South Korean population's health insurance system: from 2002 to 2015. PARTICIPANTS: 257 854 South Korean adults who provided up to 7 repeat measures of exercise (defined as exercises causing sweat) and confounders...
March 13, 2019: BMJ Open
Cian P McCarthy
No abstract text is available yet for this article.
March 11, 2019: American Journal of Medicine
Aslak Harbo Poulsen, Ole Raaschou-Nielsen, Alfredo Peña, Andrea N Hahmann, Rikke Baastrup Nordsborg, Matthias Ketzel, Jørgen Brandt, Mette Sørensen
BACKGROUND: Noise from wind turbines (WTs) is reported as more annoying than traffic noise at similar levels, raising concerns as to whether WT noise (WTN) increases risk for cardiovascular disease, as observed for traffic noise. OBJECTIVES: We aimed to investigate whether long-term exposure to WTN increases risk of myocardial infarction (MI) and stroke. METHODS: We identified all Danish dwellings within a radius 20 times the height of the closest WT and 25% of the dwellings within [Formula: see text] the height of the closest WT...
March 2019: Environmental Health Perspectives
Zhenhua Xing, Junyu Pei, Jiabing Huang, Xiaofan Peng, Pengfei Chen, Xinqun Hu, Shan Gao
BACKGROUND: It is unclear whether changes in weight affect subsequent adverse events in patients with type 2 diabetes mellitus (T2DM) already at high risk of cardiovascular disease (CVD). METHODS AND RESULTS: This is a post hoc analysis of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study data to examine the relationship between changes in weight and adverse events. Patients were divided into groups based on changes in body mass index (BMI): stable weight, gain or loss of BMI ≤1...
March 12, 2019: Endocrine
Aksam Yassin, Ahmad Haider, Karim S Haider, Monica Caliber, Gheorghe Doros, Farid Saad, W Timothy Garvey
OBJECTIVE: Type 2 diabetes (T2D) is a public health threat. Prediabetes represents a window of opportunity for intervention to prevent T2D. Men with T2D and prediabetes often have low testosterone. Since testosterone improves glycemic control in T2D, we investigated whether testosterone therapy (TTh) in men with hypogonadism and prediabetes prevents progression to T2D. RESEARCH DESIGN AND METHODS: Three hundred sixteen men with prediabetes (defined as HbA1c 5.7-6...
March 12, 2019: Diabetes Care
Carlos O Heras-Bautista, Nelly Mikhael, Jennifer Lam, Vaibhav Shinde, Alisa Katsen-Globa, Sabine Dieluweit, Marek Molcanyi, Vladimir Uvarov, Peter Jütten, Raja G A Sahito, Francisco Mederos-Henry, Alexander Piechot, Konrad Brockmeier, Jürgen Hescheler, Agapios Sachinidis, Kurt Pfannkuche
Pathophysiological conditions, such as myocardial infarction and mechanical overload affect the mammalian heart integrity, leading to a stiffened fibrotic tissue. With respect to the pathophysiology of cardiac fibrosis but also in the limelight of upcoming approaches of cardiac cell therapy it is of interest to decipher the interaction of cardiomyocytes with fibrotic matrix. Therefore, we designed a hydrogel-based model to engineer fibrotic tissue in vitro as an approach to predict the behavior of cardiomyocytes facing increased matrix rigidity...
March 9, 2019: Acta Biomaterialia
Theresa Winhusen, Jeff Theobald, David C Kaelber, Daniel Lewis
BACKGROUND AND AIMS: Screening for substance use disorder (SUD) in general medical settings may be particularly important in patients with comorbid health conditions exacerbated by SUD. This study evaluated whether SUD is associated with type 2 diabetes mellitus (T2DM)-complications in patients with co-occurring T2DM and hypertension. DESIGN: Analysis of a limited data set obtained through IBM Watson Health Explorys, a platform integrating data from electronic health records...
March 9, 2019: Addiction
Lorenz Räber, Kyohei Yamaji, Henning Kelbæk, Thomas Engstrøm, Andreas Baumbach, Marco Roffi, Clemens von Birgelen, Masanori Taniwaki, Aris Moschovitis, Serge Zaugg, Miodrag Ostojic, Giovanni Pedrazzini, Dimitrios-Alexios Karagiannis-Voules, Thomas F Lüscher, Ran Kornowski, David Tüller, Vladan Vukcevic, Dik Heg, Stephan Windecker
AIMS: The long-term outcomes of biolimus-eluting stents (BESs) with biodegradable polymer as compared with bare-metal stent (BMS) in patients with ST-segment elevation myocardial infarction (STEMI) remain unknown. METHODS AND RESULTS: We performed a 5-year clinical follow-up of 1157 patients (BES: N = 575 and BMS: N = 582) included in the randomized COMFORTABLE AMI trial. Serial intracoronary imaging of stented segments using both intravascular ultrasound (IVUS) and optical coherence tomography performed at baseline and 13 months follow-up were analysed in 103 patients...
March 9, 2019: European Heart Journal
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