keyword
https://read.qxmd.com/read/38277086/comparison-of-histological-skin-changes-after-massive-weight-loss-in-post-bariatric-and-non-bariatric-patients
#21
JOURNAL ARTICLE
Mohamed Hany, Ahmed Zidan, Nasser A Ghozlan, Mohamed N Ghozlan, Anwar Ashraf Abouelnasr, Eman Sheta, Yasser Hamed, Hassan Kholosy, Mohammed Soffar, Walid M El Midany, Bart Torensma
BACKGROUND: Changes in the skin structure, including the collagen and elastin content, have been reported with massive weight loss (MWL) following bariatric metabolic surgery (BMS) and have been correlated to a higher risk of complications after body-contouring surgery (BCS). This study aimed at comparing the histological characteristics of the skin of patients having surgical MWL (SMWL) post-BMS to those with non-surgical massive weight loss (NSMWL). METHODS: This prospective study compared the epidermal thickness, and collagen and elastin fibers content in 80 skin biopsies obtained from BCS procedures performed to patients who experienced MWL defined more than 50% of excess weight loss (%EWL) either SMWL (40 biopsies) or NSMWL (40 biopsies)...
January 26, 2024: Obesity Surgery
https://read.qxmd.com/read/38276139/effect-of-ultraviolet-radiation-on-the-enzymolytic-and-biomechanical-profiles-of-abdominal-aortic-adventitia-tissue
#22
JOURNAL ARTICLE
Emil-Marian Arbănaşi, Eliza Russu, Eliza-Mihaela Arbănaşi, Constantin Claudiu Ciucanu, Adrian Vasile Mureșan, Shuko Suzuki, Traian V Chirilă
BACKGROUND: The abdominal aortic aneurysm (AAA) is defined as an increase in aortic diameter by more than 50% and is associated with a high risk of rupture and mortality without treatment. The aim of this study is to analyze the role of aortic adventitial collagen photocrosslinking by UV-A irradiation on the biomechanical profile of the aortic wall. METHODS: This experimental study is structured in two parts: the first part includes in vitro uniaxial biomechanical evaluation of porcine adventitial tissue subjected to either short-term elastolysis or long-term collagenolysis in an attempt to duplicate two extreme situations as putative stages of aneurysmal degeneration...
January 22, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38248682/biomimetic-coatings-in-implant-dentistry-a-quick-update
#23
REVIEW
Mohammed Aso Abdulghafor, Mohammed Khalid Mahmood, Herve Tassery, Delphine Tardivo, Arthur Falguiere, Romain Lan
Biomimetic dental implants are regarded as one of the recent clinical advancements in implant surface modification. Coatings with varying thicknesses and roughness may affect the dental implant surface's chemical inertness, cell adhesion, and antibacterial characteristics. Different surface coatings and mechanical surface changes have been studied to improve osseointegration and decrease peri-implantitis. The surface medication increases surface energy, leading to enhanced cell proliferation and growth factors, and, consequently, to a rise in the osseointegration process...
December 30, 2023: Journal of Functional Biomaterials
https://read.qxmd.com/read/38244675/sirt1-dependent-pgc-1%C3%AE-deacetylation-by-srt1720-rescues-progression-of-atherosclerosis-by-enhancing-mitochondrial-function
#24
JOURNAL ARTICLE
Jin Young Sung, Seul Gi Kim, Young Jin Kang, So-Young Park, Hyoung Chul Choi
Vascular smooth muscle cell (VSMC) senescence promotes atherosclerosis via lipid-mediated mitochondrial dysfunction and oxidative stress. However, the mechanisms of mitochondrial dysfunction and VSMC senescence in atherosclerosis have not been established. Here, we investigated the mechanisms whereby signaling pathways regulated by SRT1720 enhance or regulate mitochondrial functions in atherosclerotic VSMCs to suppress atherosclerosis. Initially, we examined the effect of SRT1720 on oleic acid (OA)-induced atherosclerosis...
January 18, 2024: Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids
https://read.qxmd.com/read/38237712/contributions-of-collagen-and-elastin-to-elastic-behaviours-of-tendon-fascicle
#25
JOURNAL ARTICLE
Yusei Ishizaki, Junfeng Wang, Jeonghyun Kim, Takeo Matsumoto, Eijiro Maeda
Tendon exhibits the capacity to be stretched and to return to its original length without suffering structural damage in vivo, a capacity known as elastic recoil. Collagen fibres are aligned longitudinally and elastin fibres mostly run parallel to collagen fibres in tendon. However, their interactions and contributions to tendon elastic behaviours are not well understood. The present study examined functional roles of collagen and elastin in tendon elastic behaviours using a variety of mechanical tests. We prepared three types of fascicle specimens from mouse tail tendon: fascicles freshly isolated, those digested with elastase in PBS to selectively remove elastin, and those incubated in PBS without elastase...
January 16, 2024: Acta Biomaterialia
https://read.qxmd.com/read/38229336/-socs3-transcriptionally-activated-by-nr4a1-induces-apoptosis-and-extracellular-matrix-degradation-of-vaginal-fibroblasts-in-pelvic-organ-prolapse
#26
JOURNAL ARTICLE
Xin Jin, Qing Hu, Meiying Qin, Yitong Yin, Zhijun Xia
BACKGROUND: Pelvic organ prolapse (POP) is a common gynecological chronic disorder. Human vaginal fibroblasts (HVFs) that maintain the integrity of vaginal wall tissues are essential for keeping pelvic organs in place. Apoptosis and the degradation of the extracellular matrix (ECM) in HVFs contribute to the progression of POP. The cytokine signal transduction inhibitor 3 ( SOCS3 ) exerts significant regulatory effects on cell signal transduction pathways, thereby affecting various pathological processes...
January 17, 2024: Balkan Medical Journal
https://read.qxmd.com/read/38227601/morphological-and-ultrastructural-investigation-of-the-posterior-atlanto-occipital-membrane-comparing-children-with-chiari-malformation-type-i-and-controls
#27
JOURNAL ARTICLE
Vijay M Ravindra, Lorraina Robinson, Hailey Jensen, Elena Kurudza, Evan Joyce, Allison Ludwick, Russell Telford, Osama Youssef, Justin Ryan, Robert J Bollo, Rajiv R Iyer, John R W Kestle, Samuel H Cheshier, Daniel S Ikeda, Qinwen Mao, Douglas L Brockmeyer
INTRODUCTION: The fibrous posterior atlanto-occipital membrane (PAOM) at the craniocervical junction is typically removed during decompression surgery for Chiari malformation type I (CM-I); however, its importance and ultrastructural architecture have not been investigated in children. We hypothesized that there are structural differences in the PAOM of patients with CM-I and those without. METHODS: In this prospective study, blinded pathological analysis was performed on PAOM specimens from children who had surgery for CM-I and children who had surgery for posterior fossa tumors (controls)...
2024: PloS One
https://read.qxmd.com/read/38227167/a-systematic-comparison-of-normal-structure-and-function-of-the-greater-thoracic-vessels
#28
JOURNAL ARTICLE
Abhay B Ramachandra, Cristina Cavinato, Jay D Humphrey
The greater thoracic vessels are central to a well-functioning circulatory system and are often targeted in congenital heart surgeries, yet the structure and function of these vessels have not been well studied. Here we use consistent methods to quantify and compare microstructural features and biaxial biomechanical properties of the following six greater thoracic vessels in wild-type mice: ascending thoracic aorta, descending thoracic aorta, right subclavian artery, right pulmonary artery, thoracic inferior vena cava, and superior vena cava...
January 16, 2024: Annals of Biomedical Engineering
https://read.qxmd.com/read/38219051/an-improved-understanding-of-the-pathophysiology-of-pelvic-organ-prolapse-a-3d-in-vitro-model-under-static-and-mechanical-loading-conditions
#29
JOURNAL ARTICLE
Melissa J J van Velthoven, Aksel N Gudde, Marit van der Kruit, Malou P C van Loon, Lissy Rasing, Frank A D T G Wagener, Jan-Paul Roovers, Zeliha Guler, Paul H J Kouwer
The suboptimal outcomes of pelvic organ prolapse (POP) surgery illustrate the demand for improved therapies. However, their development is hampered by the limited knowledge on the cellular pathophysiology of POP. Current investigations, that are limited to tissues and 2D in vitro models, provide highly inconclusive results on how the extracellular matrix (ECM) metabolism and fibroblasts are affected in POP. This study uses a physiologically relevant 3D in vitro model to investigate the cellular pathophysiology of POP by determining the differences between POP and non-POP fibroblasts on ECM metabolism, proliferation and fibroblast-to-myofibroblast (FMT) transition...
January 14, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38217034/exosomes-in-skin-photoaging-biological-functions-and-therapeutic-opportunity
#30
REVIEW
Amirhossein Hajialiasgary Najafabadi, Mohammad Hasan Soheilifar, Nastaran Masoudi-Khoram
Exosomes are tiny extracellular vesicles secreted by most cell types, which are filled with proteins, lipids, and nucleic acids (non-coding RNAs, mRNA, DNA), can be released by donor cells to subsequently modulate the function of recipient cells. Skin photoaging is the premature aging of the skin structures over time due to repeated exposure to ultraviolet (UV) which is evidenced by dyspigmentation, telangiectasias, roughness, rhytides, elastosis, and precancerous changes. Exosomes are associated with aging-related processes including, oxidative stress, inflammation, and senescence...
January 12, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38214099/application-and-reduction-of-a-nonlinear-hyperelastic-wall-model-capturing-ex-vivo-relationships-between-fluid-pressure-area-and-wall-thickness-in-normal-and-hypertensive-murine-left-pulmonary-arteries
#31
JOURNAL ARTICLE
Mansoor A Haider, Katherine J Pearce, Naomi C Chesler, Nicholas A Hill, Mette S Olufsen
Pulmonary hypertension is a cardiovascular disorder manifested by elevated mean arterial blood pressure (>20 mmHg) together with vessel wall stiffening and thickening due to alterations in collagen, elastin, and smooth muscle cells. Hypoxia-induced (type 3) pulmonary hypertension can be studied in animals exposed to a low oxygen environment for prolonged time periods leading to biomechanical alterations in vessel wall structure. This study introduces a novel approach to formulating a reduced order nonlinear elastic structural wall model for a large pulmonary artery...
January 12, 2024: International Journal for Numerical Methods in Biomedical Engineering
https://read.qxmd.com/read/38201803/inhibition-of-pro-fibrotic-molecules-expression-in-idiopathic-pulmonary-fibrosis-derived-lung-fibroblasts-by-lactose-modified-hyaluronic-acid-compounds
#32
JOURNAL ARTICLE
Alice Donato, Antonino Di Stefano, Nadia Freato, Laura Bertocchi, Paola Brun
Idiopathic pulmonary fibrosis (IPF) is a chronic inflammatory and fibrotic pathological condition with undefined effective therapies and a poor prognosis, partly due to the lack of specific and effective therapies. Galectin 3 (Gal-3), a pro-fibrotic ß-galactoside binding lectin, was upregulated in the early stages of the pathology, suggesting that it may be considered a marker of active fibrosis. In the present in vitro study, we use Hylach® , a lactose-modified hyaluronic acid able to bind Gal-3, to prevent the activation of lung myofibroblast and the consequent excessive ECM protein cell expression...
December 31, 2023: Polymers
https://read.qxmd.com/read/38197274/use-of-a-collagen-elastin-matrix-with-split-thickness-skin-graft-for-defect-coverage-in-complex-wounds
#33
JOURNAL ARTICLE
Seyed Arash Alawi, Feras Taqatqeh, Jan Matschke, Olimpiu Bota, Adrian Dragu
OBJECTIVE: Severe soft tissue damage with destruction of the dermis requires plastic reconstructive treatment. For multimorbid patients or patients unable to undergo major reconstructive surgery, use of dermal substitutes, such as a collagen-elastin matrix (CEM) with a split-thickness skin graft (STSG), instead of local or free flap surgery, may be a valid and easy treatment option. We aimed to investigate and compare the outcomes and rate of successful defect reconstruction using CEM plus STSG, using either a one-step approach (simultaneous CEM and STSG) or a two-step approach (CEM and negative wound pressure therapy (NPWT), with secondary STSG transplantation)...
January 2, 2024: Journal of Wound Care
https://read.qxmd.com/read/38183742/inhibiting-lysyl-oxidases-prevents-pathologic-cartilage-calcification
#34
JOURNAL ARTICLE
Ilaria Bernabei, Elodie Faure, Mario Romani, Julien Wegrzyn, Jürgen Brinckmann, Véronique Chobaz, Alexander So, Thomas Hugle, Nathalie Busso, Sonia Nasi
Lysyl oxidases (LOX(L)) are enzymes that catalyze the formation of cross-links in collagen and elastin fibers during physiologic calcification of bone. However, it remains unknown whether they may promote pathologic calcification of articular cartilage, an important hallmark of debilitating arthropathies. Here, we have studied the possible roles of LOX(L) in cartilage calcification, related and not related to their cross-linking activity. We first demonstrated that inhibition of LOX(L) by β-aminoproprionitrile (BAPN) significantly reduced calcification in murine and human chondrocytes, and in joint of meniscectomized mice...
February 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38183136/dysregulation-of-extracellular-matrix-and-lysyl-oxidase-in-ehlers-danlos-syndrome-type-iv-skin-fibroblasts
#35
JOURNAL ARTICLE
Reece Foehr, Keith Anderson, Owen Dombrowski, Anna Foehr, Erik D Foehr
BACKGROUND: Ehlers-Danlos syndrome Type IV (aka Vascular Ehlers Danlos, or vEDS) is a dominantly inherited mutation in the Collagen 3A1 gene (COL3A1). The disease is characterized by tissue friability and age-related susceptibility to arterial aneurysm, dissection and rupture as well as uterine and bowl tears. These clinical manifestations result in major surgical intervention and decreased life expectancy. Understanding how mutations in COL3A1 impact the structure and function of the extracellular matrix (ECM) is important to managing the disease and finding treatments...
January 5, 2024: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/38170063/insights-into-ascending-aortic-aneurysm-interactions-between-biomechanical-properties-of-the-aortic-wall-and-tissue-biomarkers
#36
JOURNAL ARTICLE
Svetlana I Sazonova, Viktor V Saushkin, Dmitriy S Panfilov, Ivan V Stepanov, Anna M Gusakova, Anatoliy B Skosyrsky, Alexander V Vrublevsky, Ayas O Uvanchikov, Boris N Kozlov
BACKGROUND: It remains difficult to understand the association between the local mechanical properties of ascending thoracic aorta aneurysm (asTAA), its tissue, and its cellular and molecular changes. The purpose of our study was to investigate the relationship between biomechanical properties, histopathological findings, and tissue biomarkers of asTAA. METHODS: Intraoperative asTAA samples from 30 patients were studied. All samples were examined histologically and underwent a tensile test...
January 15, 2024: Heliyon
https://read.qxmd.com/read/38162102/evaluation-of-aortic-wall-strength-in-human-immunodeficiency-virus-associated-thoracic-ascending-aortic-aneurysm-a-pilot-study
#37
JOURNAL ARTICLE
Moleboheng Mokotjo, Angela J Woodiwiss, Shungu Mogaladi, J Michael Hasenkam, Ruchika Meel
BACKGROUND: Human immunodeficiency virus (HIV) associated aortopathy is associated with considerable morbidity and mortality. The pathophysiology of aortic wall strength in HIV thoracic aortic aneurysm has not been studied. METHODS: The patients with HIV associated thoracic ascending aortic aneurysm (TAAA) were enrolled in the study and underwent surgery as part of their routine management. We compared collagen quantity in aneurysmal and non-aneurysmal aortic tissue in TAAA with regards to hydroxyproline concentration as a surrogate measure for collagen content and sent aneurysmal aorta for routine clinical histological assessment...
December 15, 2023: Cardiovascular Diagnosis and Therapy
https://read.qxmd.com/read/38154490/a-novel-method-for-the-rat-model-of-abdominal-aortic-aneurysm-induced-by-retroperitoneal-implantation-of-an-osmotic-pump-system-with-lipopolysaccharide
#38
JOURNAL ARTICLE
Jiang-Ping Gao, Hong-Peng Zhang, Ren Wei, Wei Guo
OBJECTIVE: This study tested a novel method for the abdominal aortic aneurysm (AAA) rat model induced by retroperitoneal implantation of an osmotic pump system with lipopolysaccharide (LPS) based on the hypothesis that chronic inflammation of perivascular adipose tissue directly influenced the development and progression of AAAs. METHODS: 20 Male Sprague-Dawley rats (10-month-old) fed with the Paigen diet were randomly divided into four groups: the blank group ×2, the sham group ×4, the empty capsule group ×4, and the lipopolysaccharide (LPS) capsule group ×10...
December 26, 2023: Annals of Vascular Surgery
https://read.qxmd.com/read/38151614/multiscale-insights-into-postnatal-aortic-development
#39
JOURNAL ARTICLE
Bruno V Rego, Sae-Il Murtada, Guangxin Li, George Tellides, Jay D Humphrey
Despite its vital importance for establishing proper cardiovascular function, the process through which the vasculature develops and matures postnatally remains poorly understood. From a clinical perspective, an ability to mechanistically model the developmental time course in arteries and veins, as well as to predict how various pathologies and therapeutic interventions alter the affected vessels, promises to improve treatment strategies and long-term clinical outcomes, particularly in pediatric patients suffering from congenital heart defects...
December 27, 2023: Biomechanics and Modeling in Mechanobiology
https://read.qxmd.com/read/38146723/acquired-perforating-dermatosis-a-disorder-treatable-with-mycophenolate-mofetil
#40
JOURNAL ARTICLE
Shaima Al-Bader, Kamel El-Reshaid, John Madda
Acquired perforating dermatosis (APD) is an adult skin disease characterized by an umbilicated papulonodular rash with transepidermal elimination of dermal components such as collagen and/or elastin. It is frequently associated with multiple medications and diseases such as diabetes and chronic renal failure. It is a disabling disease with severe pruritus in 83.3% of cases and generalized ulcerating lesions that are associated with infections and scarring. Nearly 10% of renal patients are affected. Supportive measurements of disease activity and previous medications failed to halt its natural progression...
March 1, 2023: Saudi Journal of Kidney Diseases and Transplantation
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