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thalassaemia malaysia

Khian Aun Tan, Su Han Lum, Abqariyah Yahya, Shekhar Krishnan, Muhammad Yazid Jalaludin, Way Seah Lee
INTRODUCTION: Endocrine dysfunction due to iron overload secondary to frequent blood transfusions is a common complication in children with transfusion-dependent thalassaemia (TDT). We ascertained the prevalence of endocrine dysfunction in children with TDT seen in a hospital setting in Malaysia. METHODS: We reviewed all patients with TDT who had ≥ 8 blood transfusions per year. Patients who had a history of stem cell transplantation, concurrent autoimmune diseases or were newly diagnosed to have TDT were excluded...
December 17, 2018: Singapore Medical Journal
Danny Xuan Rong Koh, Raja Zahratul Azma Raja Sabudin, Malisa Mohd Yusoff, Noor Hamidah Hussin, Rahimah Ahmad, Ainoon Othman, Endom Ismail
Thalassaemia is a public health problem in Malaysia, with each ethnic group having their own common mutations. However, there is a lack on data on the prevalence and common mutations among the indigenous people. This cross-sectional study was performed to determine the common mutations of α- and β-thalassaemia among the subethnic groups of Senoi, the largest Orang Asli group in Peninsular Malaysia. Blood samples collected from six Senoi subethnic groups were analysed for full blood count and haemoglobin analysis (HbAn)...
September 2017: Annals of Human Genetics
Elspeth M Bird, Uma Parameswaran, Timothy William, Tien Meng Khoo, Matthew J Grigg, Ammar Aziz, Jutta Marfurt, Tsin W Yeo, Sarah Auburn, Nicholas M Anstey, Bridget E Barber
BACKGROUND: Transfusion-transmitted malaria (TTM) is a well-recognized risk of receiving blood transfusions, and has occurred with Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, and Plasmodium malariae. The simian parasite Plasmodium knowlesi is also known to be transmissible through inoculation of infected blood, and this species is now the most common cause of malaria in Malaysia with a high rate of severity and fatal cases reported. No confirmed case of accidental transfusion-transmitted P...
July 12, 2016: Malaria Journal
T-Y Lee, M-I Lai, V Ramachandran, J A M A Tan, L-K Teh, R Othman, N H Hussein, E George
INTRODUCTION: Alpha thalassaemia is a highly prevalent disease globally and is a well-known public health problem in Malaysia. The deletional forms of the mutation are the most common forms found in alpha thalassaemia. The three most common deletional alpha thalassaemia found in this region include --(SEA) deletion, -α(3.7) rightward and -α(4.2) leftward deletions. The prevalence rate of triplication alpha cases such as ααα(anti3.7) and ααα(anti4.2) is not known in Malaysia although it plays a role in exacerbating the clinical phenotypes in beta thalassaemia carriers...
August 2016: International Journal of Laboratory Hematology
Hafiza Alauddin, Suziana Mohamad Nasir, Madzlifah Ahadon, Raja Zahratul Azma Raja Sabudin, Azlin Ithnin, Noor Hamidah Hussin, Hamidah Alias, C-Khai Loh, Zarina Abdul Latiff, Nor Azian Abdul Murad, Ainoon Othman
Haemoglobin (Hb) Lepore is a variant Hb consisting of two α-globin and two δβ-globin chains. In a heterozygote, it is associated with clinical findings of thalassaemia minor, but interactions with other haemoglobinopathies can lead to various clinical phenotypes and pose diagnostic challenges. We reported a pair of siblings from a Malay family, who presented with pallor and hepatosplenomegaly at the ages of 21 months and 14 months old. The red cell indices and peripheral blood smears of both patients showed features of thalassaemia intermedia...
December 2015: Malaysian Journal of Pathology
N Z Zainal, H Alauddin, S Ahmad, N H Hussin
Thalassaemia carriers are common in the Asian region including Malaysia. Asymptomatic patients can be undiagnosed until they present for their antenatal visits. Devastating obstetric outcome may further complicate the pregnancy if both parents are thalassaemia carriers leading to hydrophic fetus due to haemoglobin Bart's disease. However in certain cases where unexplained hydrops fetalis occur in parents with heterozygous thalassaemia carrier,mutated α genes should be suspected. We report a twenty-nine year old woman in her third pregnancy with two previous pregnancies complicated by early neonatal death at 21 and 28 weeks of gestation due to hydrops fetalis...
December 2014: Malaysian Journal of Pathology
C F Ngim, H Ibrahim, N M Lai, C S Ng
OBJECTIVE: We aimed to identify factors contributing to ineffective prevention of thalassaemia in Malaysia by studying events leading to the births of children with transfusion-dependent thalassaemia (TDT) including their parents' reproductive choices. METHODS: Thirty children with TDT born in the year 2005 to 2012 were included. Their parents underwent a semi-structured, face-to-face interview in 2012 and were followed up until 2014 to evaluate the actual decisions made during subsequent pregnancy...
January 2015: Prenatal Diagnosis
Nur Fatihah Mohd Yatim, Masitah Abd Rahim, Kavitha Menon, Faisal Muti Al-Hassan, Rahimah Ahmad, Anita Bhajan Manocha, Mohamed Saleem, Badrul Hisham Yahaya
Both α- and β-thalassaemia syndromes are public health problems in the multi-ethnic population of Malaysia. To molecularly characterise the α- and β-thalassaemia deletions and mutations among Malays from Penang, Gap-PCR and multiplexed amplification refractory mutation systems were used to study 13 α-thalassaemia determinants and 20 β-thalassaemia mutations in 28 and 40 unrelated Malays, respectively. Four α-thalassaemia deletions and mutations were demonstrated. --SEA deletion and αCSα accounted for more than 70% of the α-thalassaemia alleles...
2014: International Journal of Molecular Sciences
Raja Zahratul Azma, Othman Ainoon, Alauddin Hafiza, Ithnin Azlin, Abudul Razak Noor Farisah, Sardi Nor Hidayati, Hussin Noor Hamidah
Alpha (Α) thalassaemia is the most common inherited disorder in Malaysia. The clinical severity is dependant on the number of Α genes involved. Full blood count (FBC) and haemoglobin (Hb) analysis using either gel electrophoresis, high performance liquid chromatography (HPLC) or capillary zone electrophoresis (CE) are unable to detect definitively alpha thalassaemia carriers. Definitive diagnosis of Α-thalassaemias requires molecular analysis and methods of detecting both common deletional and non-deletional molecular abnormailities are easily performed in any laboratory involved in molecular diagnostics...
April 2014: Malaysian Journal of Pathology
L-K Teh, T-Y Lee, J A M A Tan, M-I Lai, E George
INTRODUCTION: In Malaysia, β-thalassaemia is a common inherited blood disorder in haemoglobin synthesis with a carrier rate of 4.5%. Currently, PCR-incorporating techniques such as amplification refractory mutation system (ARMS) or reverse dot blot hybridization (RDBH) are used in β-thalassaemia mutation detection. ARMS allows single-mutation identification using two reactions, one for wild type and another for mutant alleles. RDBH requires probe immobilization and optimization of hybridization and washing temperatures which is time consuming...
February 2015: International Journal of Laboratory Hematology
Rahimah Ahmad, Mohamed Saleem, Nisha Sabrina Aloysious, Punithawathy Yelumalai, Nurul Mohamed, Syahzuwan Hassan
Alpha thalassaemia is highly prevalent in the plural society of Malaysia and is a public health problem. Haematological and molecular data from 5016 unrelated patients referred from various hospitals to the Institute for Medical Research for α thalassaemia screening from 2007 to 2010 were retrieved. The aims of this retrospective analysis were to describe the distribution of various alpha thalassaemia alleles in different ethnic groups, along with their genotypic interactions, and to illustrate the haematological changes associated with each phenotype...
2013: International Journal of Molecular Sciences
A N Rahimah, S Nisha, B Safiah, H Roshida, Y Punithawathy, H Nurul, H Syahzuwan, Z Zubaidah
OBJECTIVES: Alpha thalassaemia is wide spread in Malaysia and is a public health problem. This study aimed to describe the carrier frequencies of α‒thalassaemia and its distribution among major ethnic groups in three states of Malaysia. METHODS: Educational forums were organised and study was explained to students from three schools. Students were invited to take part in the screening with parent consent. A total of 8420 adolescent students aged 16 years volunteered to participate in the study...
December 2012: Medical Journal of Malaysia
Syahzuwan Hassan, Rahimah Ahmad, Zubaidah Zakaria, Zefarina Zulkafli, Wan Zaidah Abdullah
BACKGROUND: β-thalassaemia is one of the most common single-gene disorders worldwide. Each ethnic population has its own common mutations, accounting for the majority of cases, with a small number of mutations for the rarer alleles. Due to the heterogeneity of β-thalassaemia and the multi-ethnicity of Malaysians, molecular diagnostics may be expensive and time consuming. METHODS: A simple polymerase chain reaction (PCR) approach involving a multiplex amplification refractory mutation system (MARMS) and one amplification refractory mutation system (ARMS), consisting of 20 β-globin gene mutations, were designed and employed to investigate β-thalassaemia patients and carriers...
January 2013: Malaysian Journal of Medical Sciences: MJMS
Alauddin Hafiza, Mohd Yusoff Malisa, R D Aidifitrina Khirotdin, Ithnin Azlin, Zahratul Azma, Matthew Chong Kwok Thong, Irwan Mohamad Ali, Zi-Ning Yeoh, Lailyvia Mohd Ishak, Nur Rabiatuladawiah Mohd Radzi, Noor Hamidah Hussin
OBJECTIVE: The capillary electrophoresis (CE) is a new system that utilizes the principle of electrokinetic separation of molecules in eight electrolyte buffer-filled silica capillaries. In this study, we established the normal ranges of haemoglobin A2 (HbA2) and haemoglobin F (HbF) levels for normal individuals using this system and also the HbA2 level in beta thalassaemia and haemoglobin E (HbE) individuals. MATERIALS AND METHODS: 154 samples from normal individuals, 218 samples from beta thalassaemia heterozygotes and 91 samples from HbE heterozygotes were subjected to high performance liquid chromatography (HPLC) and CE analysis...
December 2012: Malaysian Journal of Pathology
Chin Fang Ngim, Nai Ming Lai, Hishamshah Ibrahim, Vanassa Ratnasingam
Thalassaemia is a public health problem in multi-ethnic Malaysia which mainly affects the Malays, Kadazan-Dusuns and Chinese. This study, the first in Malaysia, aims to evaluate the acceptability of prenatal diagnosis and abortion among Malaysian parents who have a child or children with thalassaemia major and the socio-demographic factors affecting their decision-making. A pre-structured questionnaire was distributed to parents of children with thalassaemia major. Response rate for completed surveys was 99...
April 2013: Journal of Community Genetics
E George, Lai Kuan Teh, Jama Tan, Mei I Lai, Lily Wong
AIMS: Classical carriers of β-thalassaemia are identified by a raised HbA2 level. Earlier studies indicated that the Filipino β-deletion has high raised HbA2 levels. The introduction of automated high performance liquid chromatography (HPLC) for thalassaemia screening is an important advance in technology for haematology laboratories. The BioRad Variant II Hb analyser is a common instrument used to quantify HbA2 levels in thalassaemia screening. This study aimed to determine HbA2 levels in carriers of Filipino β-mutation using the BioRad Variant II Hb analyser...
January 2013: Pathology
R Z Azma, O Ainoon, I Azlin, H Hamenuddin, N A Hadi, W K Tatt, I N Syazana, A M Asmaliza, S Das, N H Hamidah
BACKGROUND: Anaemia is a global health problem including Malaysia. In adults, anaemia may affect work productivity. Iron deficiency anaemia and thalassaemia are common causes of anaemia in Malaysia. However, there is scarcity of data on national prevalence of iron deficiency anaemia and thalassaemia, especially in young adults. This cross sectional study was performed to determine the prevalence of iron deficiency anaemia and thalassaemia among medical students of Universiti Kebangsaan Malaysia Medical Centre (UKMMC)...
July 2012: La Clinica Terapeutica
E George, A R Jamal, F Khalid, K A Osman
UNLABELLED: Beta-thalassaemia is characterized by a decrease (β(+)) or absence (β(0)) in the synthesis of β-globin chains of human haemoglobin. The heterozygous state for β(+) or β(0) result in β-thalassaemia trait in which the hallmark is the presence of an elevated level of Haemoglobin (Hb) A(2) (α(2)δ(2)). In the past, the traditional methods such as cellulose acetate electrophoresis with elution and microcolumn chromatrography have been the techniques used by the majority of the laboratories in Malaysia for the estimation of (Hb) A(2) levels...
July 2001: Malaysian Journal of Medical Sciences: MJMS
S Jameela, S O Sharifah Sabirah, J Babam, C L Phan, P Visalachy, K M Chang, M A Salwana, A Zuraidah, Y Subramanian, A Rahimah
Thalassaemia is a common disorder in Malaysia. It is estimated that 4.5% of the population are carriers for beta- or alpha- thalassaemias. We set out to screen Form 4 students aged between 15 and 16 years old in a national school, for thalassaemia in March 2008. Written consent was obtained from 310 students. The carrier rate for the common thalassaemia syndromes was 6.8% (2.9% for beta-thalassaemia, 2.6% for HbE and 1.3% for two-gene deletion for alpha-thalassaemia). Carriers for beta-thalassaemia and two-gene deletion for alpha-thalassaemia were more common in the Chinese (4...
December 2011: Medical Journal of Malaysia
I Abdul Wahab, M Naznin, M Z Nora, A R Suzanah, M Zulaiho, A R Aidl Faszrul, W S Kamaruzaman
Marked improvement in the management of thalassaemia has not been matched by progress in psychosocial rehabilitation as thalassaemia continues to pose challenges to patients and their family members. Few studies have been carried out in Malaysia to look at such issues. This study is therefore to explore the concerns, beliefs and feelings about thalassaemia. It was conducted in the year 2009 over 7 months on "focus groups", in patients aged 8-22 years and parents attending Paediatric Clinic of Tengku Ampuan Afzan Hospital, Kuantan, Pahang...
October 2011: Medical Journal of Malaysia
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