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Keywords Osteoarthritis platelet rich p...

Osteoarthritis platelet rich plasma

https://read.qxmd.com/read/38410168/comparison-of-conventional-dose-versus-superdose-platelet-rich-plasma-for-knee-osteoarthritis-a-prospective-triple-blind-randomized-clinical-trial
#21
JOURNAL ARTICLE
Sandeep Patel, Shivam Gahlaut, Tarkik Thami, Devendra Kumar Chouhan, Ashish Jain, Mandeep Singh Dhillon
BACKGROUND: Confusion persists regarding the ideal dosage of platelet-rich plasma (PRP) injection for knee osteoarthritis (OA). PURPOSE/HYPOTHESIS: The purpose of the study was to compare the efficacy of 2 different single-injection PRP dosages in patients with early knee OA-a conventional 4 mL dose and a superdose of 8 mL. It was hypothesized that 8 mL of PRP would be superior to 4 mL of PRP in this patient population. STUDY DESIGN: Randomized clinical trial; Level of evidence, 1...
February 2024: Orthopaedic Journal of Sports Medicine
https://read.qxmd.com/read/38406632/use-of-quantitative-mass-spectrometry-based-proteomics-and-elisa-to-compare-the-alpha-2-macroglobulin-concentration-in-equine-blood-based-products-processed-by-three-different-orthobiologic-devices
#22
JOURNAL ARTICLE
Kyla F Ortved, Larry Alward, Bobby Cowles, Renata Linardi, Dhvani Barot, Alex Usimaki, Joseph R Fedie, Deb Amodie, Laurie R Goodrich
INTRODUCTION: Alpha 2 macroglobulin (A2M), a multi-functional protein in the plasma protease inhibitor class, regulates proinflammatory cytokines and the clearance of chondrodestructive enzymes in cases of joint injury and osteoarthritis (OA). The purpose of this study was to compare A2M concentrations in equine plasma samples processed by three commercial devices developed for stall-side regenerative joint therapy. METHODS: Plasma samples were obtained from healthy adult horses ( N  = 13)...
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38402426/photo-polymerizable-autologous-growth-factor-loaded-silk-based-biomaterial-inks-toward-3d-printing-based-regeneration-of-meniscus-tears
#23
JOURNAL ARTICLE
Ashutosh Bandyopadhyay, Baishali Ghibhela, Sayanti Shome, Samsamul Hoque, Samit K Nandi, Biman B Mandal
Meniscus tears in the avascular region undergoing partial or full meniscectomy lead to knee osteoarthritis and concurrent lifestyle hindrances in the young and aged alike. Here they reported ingenious photo-polymerizable autologous growth factor loaded 3D printed scaffolds to potentially treat meniscal defects . A shear-thinning photo-crosslinkable silk fibroin methacrylate-gelatin methacrylate-polyethylene glycol dimethacrylate biomaterial-ink is formulated and loaded with freeze-dried growth factor rich plasma (GFRP) ...
February 25, 2024: Advanced biology
https://read.qxmd.com/read/38393452/comparison-of-efficacy-of-ultrasound-guided-platelet-rich-plasma-injection-versus-dry-needling-in-lateral-epicondylitis-a-randomised-controlled-trial
#24
JOURNAL ARTICLE
G K Sharma, A Patil, P Kaur, S Rajesh, Elena Drakonaki, Rajesh Botchu
PURPOSE: To assess whether Ultrasound guided dry needling is adequate for both common extensor tendon tears and tendinosis or whether ultrasound guided platelet rich plasma (PRP) has a superior outcome when compared to dry needling when there are tears of the common extensor tendon. MATERIALS AND METHODS: This is a single-centre, single-blinded, randomised controlled trial conducted between November 2018 and April 2020. 40 patients diagnosed with lateral epicondylitis based on clinical and sonographic features and having comparable baseline characteristics were randomly assigned to the two study groups (dry needling and PRP)...
February 23, 2024: Journal of Ultrasound
https://read.qxmd.com/read/38392616/clinical-outcome-of-multiple-platelet-rich-plasma-injection-and-correlation-with-pdgf-bb-in-the-treatment-of-knee-osteoarthritis
#25
JOURNAL ARTICLE
Radiyati Umi Partan, Khoirun Mukhsinin Putra, Hafizzanovian Hafizzanovian, Surya Darma, Muhammad Reagan, Putri Muthia, Afifah Salshabila Radiandina, Eny Rahmawati
(1) Background: Current treatments for knee osteoarthritis (KOA), such as intra-articular corticosteroids or hyaluronic acid (HA) injections, are controversial due to their ineffectiveness in preventing disease progression. Platelet-rich plasma (PRP) has become a promising and possible treatment for KOA. It is thought to enhance articular cartilage regeneration and reduce OA-related impairment. PRP contains growth factors such as PDGF-BB, which stimulates growth and inhibits joint damage. Based on numerous studies, after a certain amount of time, it was found that multiple PRP treatments reduced pain more than a single injection...
February 7, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38384614/autologous-conditioned-plasma-acp-and-osteoarthritis-of-the-knee-a-review-of-current-clinical-evidence
#26
REVIEW
Ashim Gupta, Vijay Jain
The primary objective of this study is to record the clinical outcomes of autologous conditioned plasma (ACP) for the treatment of knee osteoarthritis (OA) based on published literature. Multiple databases (PubMed, Embase, Web of Science and Scopus) were searched using terms for "knee OA" and the intervention "ACP" for articles published in English to January 4, 2024. All clinical studies using ACP for knee OA were included. Studies not utilizing ACP alone, i.e. used as an adjunct with other modalities or not focusing on the management of knee OA, were excluded...
January 2024: Curēus
https://read.qxmd.com/read/38382202/literature-review-details-and-supports-the-application-of-platelet-rich-plasma-products-in-canine-medicine-particularly-as-an-orthobiologic-agent-for-osteoarthritis
#27
JOURNAL ARTICLE
Brittany J Carr, Allison V Miller, Aimee C Colbath, Santiago Peralta, Christopher W Frye
Platelet-rich plasma (PRP) and other platelet-derived products represent a subset of regenerative medicine and have been researched in the veterinary community for the treatment of osteoarthritis, soft tissue wounds, tendinopathies, periodontitis, and fracture repairs. PRP is simple to produce, relatively affordable, safe, and can be delivered on site, making it an appealing therapeutic agent in veterinary medicine. As an orthobiologic for the treatment of osteoarthritis, it is one of few interventions with clinical study support that possess anabolic potential...
February 24, 2024: Journal of the American Veterinary Medical Association
https://read.qxmd.com/read/38371711/intra-articular-injection-of-platelet-lysate-derived-extracellular-vesicles-recovers-from-knee-osteoarthritis-in-an-in-vivo-rat-model
#28
JOURNAL ARTICLE
Maria Antònia Forteza-Genestra, Miquel Antich-Rosselló, Carmen Ráez-Meseguer, Anna Tomàs Sangenís, Javier Calvo, Antoni Gayà, Marta Monjo, Joana Maria Ramis
OBJECTIVE: MSCs and Platelet-Rich Plasma are the main focus in the study of new regenerative treatments aimed to reverse Osteoarthritis (OA). However, extracellular vesicles (EVs) present several advantages to cell-based treatments. Thus, the aim of this study was to compare and evaluate the regenerative potential of MSC-derived EVs (cEVs) and platelet-derived EVs (pEVs) in an OA cartilage rat model. DESIGN: OA in vivo model was established through injection of 6 mg MIA in the rat knee joints...
March 2024: Journal of Orthopaedic Translation
https://read.qxmd.com/read/38363024/women-show-a-positive-response-to-platelet-rich-plasma-despite-presenting-more-painful-knee-osteoarthritis-than-men
#29
JOURNAL ARTICLE
Mikel Sánchez, Cristina Jorquera, Leonor López de Dicastillo, Nina Martínez, João Espregueira-Mendes, Josep Vergés, Juan Azofra, Diego Delgado
PURPOSE: The purpose of this study was to evaluate the impact of gender on the efficacy of platelet-rich plasma (PRP) in patients with knee osteoarthritis (KOA), comparing their short-term response between men and women. METHODS: Four hundred-eighteen patients (529 knees) were included. Patients were treated with three injections of PRP on a weekly basis. Blood and PRP samples were randomly tested. Patients were asked to complete the knee injury and osteoarthritis outcome score (KOOS) and 12-item short form survey (SF-12), at baseline and 6 months...
February 16, 2024: Knee Surgery, Sports Traumatology, Arthroscopy
https://read.qxmd.com/read/38361943/infrapatellar-fat-pad-adipose-tissue-derived-macrophages-display-a-predominant-cd11c-cd206-phenotype-and-express-genotypes-attributable-to-key-features-of-oa-pathogenesis
#30
JOURNAL ARTICLE
Patchanika Hengtrakool, Nitigorn Leearamwat, Panjana Sengprasert, Jutamas Wongphoom, Thiamjit Chaichana, Mana Taweevisit, Srihatach Ngarmukos, Aree Tanavalee, Tanapat Palaga, Rangsima Reantragoon
OBJECTIVES: In knee osteoarthritis (OA), macrophages are the most predominant immune cells that infiltrate synovial tissues and infrapatellar fat pads (IPFPs). Both M1 and M2 macrophages have been described, but their role in OA has not been fully investigated. Therefore, we investigated macrophage subpopulations in IPFPs and synovial tissues of knee OA patients and their correlation with disease severity, examined their transcriptomics, and tested for factors that influenced their polarization...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38356839/the-efficacy-of-extracorporeal-shock-wave-combined-with-platelet-rich-plasma-in-the-treatment-of-knee-osteoarthritis-with-meniscus-injury-a-retrospective-analysis
#31
JOURNAL ARTICLE
Jin Li, Jie Li, Dan Li, Xi Jin, Sheng Liu, Liheng Zhang
OBJECTIVE: To determine the efficacy of extracorporeal shock wave (ESW) combined with autologous platelet-rich plasma (PRP) therapy on knee osteoarthritis (KOA) with meniscus injury in terms of pain relief, functional outcome and complications. METHODS: This is a retrospective observational study. Clinical data of 144 patients with KOA accompanied by medial meniscus injury, who received treatment in Jilin Provincial People's Hospital from March 2021 to December 2022, were retrospectively evaluated...
2024: Pakistan Journal of Medical Sciences Quarterly
https://read.qxmd.com/read/38339913/effect-of-intra-articular-platelet-rich-plasma-or-hyaluronic-acid-on-limb-function-recovery-in-dogs-with-tplo-for-cranial-cruciate-ligament-rupture-a-randomised-controlled-trial
#32
JOURNAL ARTICLE
F Volz, D Eberle, M Kornmayer, Y Zablotski, A Meyer-Lindenberg
OBJECTIVES: This study aimed to investigate the recovery of limb function following a single intra-articular injection of platelet-rich plasma or hyaluronic acid in dogs with cranial cruciate ligament rupture treated with tibial plateau levelling osteotomy compared to dogs receiving no injection intraoperatively. MATERIALS AND METHODS: Sixty-two dogs with cranial cruciate ligament rupture, body weights of 20 to 40 kg, and no other orthopaedic conditions were enrolled in this prospective, randomised, double-blind, controlled study at the small animal clinic at LMU Munich...
February 10, 2024: Journal of Small Animal Practice
https://read.qxmd.com/read/38331363/platelet-rich-plasma-bone-marrow-aspirate-concentrate-and-hyaluronic-acid-injections-outperform-corticosteroids-in-pain-and-function-scores-at-a-minimum-of-6-months-as-intra-articular-injections-for-knee-osteoarthritis-a-systematic-review-and-network-meta-analysis
#33
JOURNAL ARTICLE
Harkirat Jawanda, Zeeshan A Khan, Alec A Warrier, Alexander J Acuña, Sachin Allahabadi, Daniel J Kaplan, Ethan Ritz, Garrett R Jackson, Enzo S Mameri, Anjay Batra, Grant Dornan, Jennifer Westrick, Nikhil N Verma, Jorge Chahla
PURPOSE: To compare the efficacy of common intra-articular injections used in the treatment of knee osteoarthritis, including corticosteroid (CS), hyaluronic acid (HA), platelet-rich plasma (PRP), and bone marrow aspirate concentrate (BMAC), with a minimum follow-up of 6-months. METHODS: A literature search was conducted using the 2020 PRISMA guidelines in August 2022 in the following databases: PubMed/MEDLINE, Scopus, Cochrane Database of Controlled Trials and the Cochrane Database of Systematic Reviews...
February 6, 2024: Arthroscopy
https://read.qxmd.com/read/38323999/does-the-combination-of-platelet-rich-plasma-and-supervised-exercise-yield-better-pain-relief-and-enhanced-function-in-knee-osteoarthritis-a-randomized-controlled-trial
#34
JOURNAL ARTICLE
Sezen Karaborklu Argut, Derya Celik, Omer Naci Ergin, Onder Ismet Kilicoglu
BACKGROUND: Knee osteoarthritis is a leading cause of disability with substantial healthcare costs, and efficient nonsurgical treatment methods are still needed. Platelet-rich plasma (PRP) injections and exercise therapy are used frequently in clinical practice. Whether PRP or PRP combined with exercise is more effective than exercise alone is unclear. QUESTIONS/PURPOSES: (1) Which treatment relieves knee osteoarthritis pain better: PRP alone, exercise, or PRP combined with exercise? (2) Does PRP alone, exercise, or PRP combined with exercise yield better results in terms of the WOMAC score, performance on the 40-m fast-paced walk test and stair climbing test, and the SF-12 health-related quality of life score? METHODS: In this randomized, controlled, three-arm clinical trial, we recruited patients with mild-to-moderate (Kellgren-Lawrence Grade II or III) knee osteoarthritis with a minimum of 3 points on the 11-point numeric rating scale for pain...
February 6, 2024: Clinical Orthopaedics and related Research
https://read.qxmd.com/read/38309989/arthroscopic-microfracture-and-associated-techniques-in-the-treatment-of-osteochondral-lesions-of-the-talus-a-systematic-review-and-metanalysis
#35
REVIEW
Susanna Basciani, Umile Giuseppe Longo, Giuseppe Francesco Papalia, Rocco Papalia, Andrea Marinozzi
BACKGROUND: Osteochondral lesions of the talus are common in patients suffering even minor trauma; timely diagnosis and treatment can prevent the development of early osteoarthritis. The objectives of this systematic review and meta-analysis were to evaluate the effects of additional procedures on arthroscopic ankle microperforations for osteochondral lesions. METHODS: A systematic literature search was conducted using PubMed-Medline, Cochrane Central, and Google Scholar to select clinical studies analyzing the efficacy of platelet-rich plasma (PRP), hyaluronic acid (HA), and bone marrow concentrate (BMC) procedures...
January 11, 2024: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://read.qxmd.com/read/38305236/platelet-rich-plasma-injections-for-the-treatment-of-ankle-osteoarthritis-response
#36
COMMENT
Liam D A Paget, Gustaaf Reurink, Gino M M J Kerkhoffs, Johannes L Tol
No abstract text is available yet for this article.
February 2024: American Journal of Sports Medicine
https://read.qxmd.com/read/38302491/intra-articular-injection-of-bone-marrow-aspirate-concentrate-mesenchymal-stem-cells-%C3%A2-in-kl-grade-iii-and-iv-knee-osteoarthritis-4-year-results-of-37-knees
#37
JOURNAL ARTICLE
Christof Pabinger, Harald Lothaller, Georg Stefan Kobinia
Cell based therapies are increasingly used and results of bone marrow aspirate concentrate (BMAC) show encouraging short- to middle term results, superior to hyaluronic acid and platelet rich plasma (PRP). Most studies describe patients with mild to moderate arthritis and results of patients with KL III and IV osteoarthritis of the knee are limited to short term evaluations. Hence, the aim of this prospective study was to investigate the mid-term outcome of BMAC injections in patients with severe osteoarthritis of the knee...
February 1, 2024: Scientific Reports
https://read.qxmd.com/read/38299047/reporting-bias-is-highly-prevalent-in-systematic-reviews-and-meta-analyses-of-platelet-rich-plasma-injections-for-hip-osteoarthritis
#38
REVIEW
Daniel Kim, Bryan S Bashrum, Jacob L Kotlier, Cory K Mayfield, Ashley A Thompson, Maya Abu-Zahra, Mina Hwang, Ioanna K Bolia, Frank A Petrigliano, Joseph N Liu
PURPOSE: To describe the incidence and types of spin in systematic reviews of platelet-rich plasma (PRP) injections for hip osteoarthritis (OA) and to determine whether patterns in study characteristics could be identified among studies with identifiable spin. METHODS: The PubMed, Scopus, and SPORTDiscus databases were queried. Inclusion criteria were systematic reviews or meta-analyses that included an assessment of intra-articular PRP injections as a stand-alone treatment for hip OA...
February 2024: Arthroscopy, sports medicine, and rehabilitation
https://read.qxmd.com/read/38296448/editorial-commentary-platelet-rich-plasma-for-musculoskeletal-conditions-is-supported-by-a-large-number-of-clinical-studies-particularly-for-knee-osteoarthritis
#39
EDITORIAL
Erik Hohmann
Platelet-rich plasma (PRP) represents a biological treatment for various musculoskeletal conditions. Over the past 20 years, publications regarding the treatment of orthopaedic conditions with PRP have shown a 4-fold increase. Several systematic reviews and meta-analyses have demonstrated that PRP is effective and often superior to other treatment modalities. However, the value of these studies is somehow limited as high risk of bias, study heterogeneity, and low levels of certainty compromise the validity of their conclusions...
February 2024: Arthroscopy
https://read.qxmd.com/read/38295392/academy-of-orthopaedic-surgeons-technology-overview-summary-concentrated-bone-marrow-aspirate-for-knee-osteoarthritis
#40
JOURNAL ARTICLE
Jonathan Dubin, Philipp Leucht, Martha Murray, Ryan Pezold
The Platelet-Rich Plasma (PRP) for Knee Osteoarthritis Technology Overview is based on a systematic review of current scientific and clinical research. Through analysis of the current best evidence, this technology overview seeks to evaluate the efficacy of PRP for patients with knee osteoarthritis. The systematic literature review resulted in 54 articles: 36 high-quality and 18 moderate-quality. The findings of these studies were summarized to present findings on PRP versus control/placebo, acetaminophen, non-steroidal anti-inflammatory drugs, corticosteroids, exercise, prolotherapy, autologous conditioned serum, bone marrow aspirate concentrate, hyaluronic acid, and ozone therapy...
January 30, 2024: Journal of the American Academy of Orthopaedic Surgeons
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