Read by QxMD icon Read

Knee platelet rich plasma

Brendan O'Connell, Nicholas Martin Wragg, Samantha Louise Wilson
Osteoarthritis (OA) is a degenerative disease involving joint damage, an inadequate healing response and progressive deterioration of the joint architecture that commonly affects the knee and/or hip joints. It is a major world public health problem and is predicted to increase rapidly with an ageing population and escalating rate of obesity. Autologous blood-derived products possess much promise in the repair and regeneration of tissue and have important roles in inflammation, angiogenesis, cell migration and metabolism in pathological conditions, including OA...
February 13, 2019: Cell and Tissue Research
Elizabeth Vinod, Deepak Vinod Francis, Soosai Manickam Amirtham, Solomon Sathishkumar, P R J V C Boopalan
Limited self-restorative ability of the cartilage has necessitated the use of cell and tissue engineering based therapies. Recent advances in the isolation, expansion and characterization of articular cartilage derived chondroprogenitors(CPs) has gained popularity in its role for cartilage repair. Platelet rich plasma (PRP) is a reliable biological scaffold for in-vitro and in-vivo studies with reported therapeutic applications in cartilage and bone pathologies. The aim of this study was to evaluate whether human allogeneic PRP could serve as a biological scaffold for chondroprogenitors (CPs) in cartilage repair...
February 2019: Tissue & Cell
Volkan Subaşı, Timur Ekiz
This paper presents the cases of 3 females with knee osteoarthritis. All 3 received a single bone marrow aspiration concentrate (BMAC) injection followed one month later by a platelet-rich plasma (PRP) injection. Compared with the baseline values, pain and functionality scores improved in all the patients. The aim of presenting these cases is to highlight that the combined use of intra-articular BMAC and PRP treatments may have positive effects on pain, functional status and quality of life in patients with knee osteoarthritis...
February 2019: Complementary Therapies in Clinical Practice
G Dwivedi, A Chevrier, C D Hoemann, M D Buschmann
Bone Marrow Stimulation (BMS) improves knee joint function but elicits incomplete repair. Liquid chitosan (CS)-glycerol phosphate/blood clots have been shown to improve BMS-based cartilage repair. Platelet-rich-plasma (PRP) - a rich source of growth factors and cytokines - improves recruitment and chondrogenic potential of subchondral mesenchymal stem cells. We hypothesized that repair response in a rabbit chronic defect model will improve when freeze-dried chitosan/PRP is used to augment BMS. Bilateral trochlear defects created in New Zealand White rabbits were allowed to progress to a chronic stage over 4 weeks...
February 1, 2019: Journal of Tissue Engineering and Regenerative Medicine
Janine McKay, Kristian Frantzen, Neeltje Vercruyssen, Kholoud Hafsi, Tyler Opitz, Amelia Davis, William Murrell
The purpose of this manuscript is to provide a current concept review for the rehabilitative management of knee osteoarthritis (KOA) following regenerative medicine intervention. A proposed comprehensive regenerative rehabilitative program has been created, based on a literature review of the current best practices of rehabilitative methods and non-operative management in KOA patients with an emphasis on the goals of regenerative medicine: to optimize self-healing and functional tissue recovery. Regenerative medicine promotes regeneration and joint restoration by using blood-based procedures such as platelet rich plasma, stem cell and cell-based or tissue engineering...
January 2019: Journal of Clinical Orthopaedics and Trauma
Maimuna Marenah, Jinjie Li, Ashok Kumar, William Murrell
The economic and human cost of knee osteoarthritis is forecast to increase. This will impact not only aging individuals, but also the working age members of emerging economies. The current treatment pathways are often costly, time-consuming, and insufficient to manage the degeneration of the knee over the ever-increasing lifespan of patients around the world. In response to the shortcomings of a focus on symptom management, international and high-impact regulators, researchers, clinicians, and most importantly patients, are increasingly interested in the possible management of knee osteoarthritis with novel therapies in the field of regenerative medicine treatments...
January 2019: Journal of Clinical Orthopaedics and Trauma
Diego Delgado, Ane Garate, Hunter Vincent, Ane Miren Bilbao, Rikin Patel, Nicolás Fiz, Steve Sampson, Mikel Sánchez
Knee osteoarthritis (OA) is a degenerative process that slowly destroys the joints producing pain and loss of function, and diminishes the quality of life. Current treatments alleviate this symptomatology but do not stop the disease, being total knee arthroplasty the only definitive solution. Among the emerging treatments, Platelet-Rich Plasma (PRP) has shown promising results in the treatment of OA. However, to improve its effectiveness, it is necessary to approach this pathology targeting the whole joint, not only the cartilage, but including other tissues such as subchondral bone...
January 2019: Journal of Clinical Orthopaedics and Trauma
Mandeep S Dhillon, Sandeep Patel, Tungish Bansal
Platelet rich plasma (PRP) has clearly emerged offering a possible solution that could modify the disease process and offer symptomatic relief in early osteoarthritis of knee. Great efforts are underway to improve PRP products for use in knee osteoarthritis (OA). Upcoming research is focused on the ideal PRP type, dose, frequency of injection and mode of injection. The combination of PRP with biocompatible carriers/scaffolds like gelatin hydrogel and chitosan appear to be promising based on early in vitro and animal studies...
January 2019: Journal of Clinical Orthopaedics and Trauma
Pedro Iván Arias-Vázquez, Carlos Alfonso Tovilla-Zárate, Yazmín Hernández-Díaz, Thelma Beatriz González-Castro, Isela Esther Juárez-Rojop, María Lilia López-Narváez, Deysi Yadira Bermudez-Ocaña, Hugo Adrián Barjau-Madrígal, Gabriela Legorreta-Ramírez
BACKGROUND: Ozone therapy has been widely used to decrease pain related to osteoarthritis, but the effectiveness of this treatment has not been evaluated. OBJECTIVE: To evaluate the effectiveness of ozone therapy in the reduction of pain in patients with knee OA, according to the type of intervention and duration of the effect. TYPE: Meta-analysis LITERATURE SURVEY: We performed an online search using PUBMED, DIALNET, SCIELO, MEDIGRAPHIC and ISCO3 databases. We searched for articles published up to January 2018...
January 28, 2019: PM & R: the Journal of Injury, Function, and Rehabilitation
Carl P C Chen, Jean-Lon Chen, Chih-Chin Hsu, Yu-Cheng Pei, Wei-Han Chang, Hsueh-Chih Lu
Knee pain caused by osteoarthritis (OA) is commonly seen in geriatric patients. Patients with knee OA are often complicated with joint pain, soreness, and weakness. The injection of autologous platelet rich plasma (aPRP) has been proven to be effective in treating mild knee OA. The effect of injecting aPRP in treating moderate to severe degrees of knee OA remains controversial. This study aimed to evaluate the effectiveness of aPRP in treating patients with at least grade 2 on the Kellgren and Lawrence system for the classification of knee OA using a proteomic approach and clinical evaluation tool of Lequesne index...
January 18, 2019: Experimental Gerontology
Ziming Chen, Zhantao Deng, Yuanchen Ma, Junxing Liao, Qingtian Li, Mengyuan Li, Hua Liu, Ganghong Chen, Chaoming Zeng, Qiujian Zheng
Knee osteoarthritis (KOA) is one of the most frequently encountered diseases in the orthopedic department. Existing non-surgical treatments have a limited effect on the repair of cartilage and on bone regeneration. Platelet-rich plasma (PRP) is an autologous bioactive substance that can repair cartilage injury and accelerate bone regeneration effectively. However, reporting of PRP preparation protocols in clinical studies is highly inconsistent, with the majority of studies providing insufficient information to allow the protocol to be reproduced...
January 4, 2019: Journal of Visualized Experiments: JoVE
Serkan Sözkesen, Huseyin Gokhan Karahan, Ahmet Kurtulmus, Cemil Kayali, Taskin Altay
BACKGROUND: The purpose of this study is to describe the role of Platelet Rich Plasma in preventing tunnel enlargement in anterior cruciate ligament reconstruction with a hamstring autograft Material and methods. Forty-four patients who underwent transtibial reconstructive surgery with a hamstring tendon autograft between March 2014 and July 2015 were included in this study. This study involved two groups. Group A consisted of 18 patients who underwent PRPadministration into the femoral and tibial tunnel...
August 30, 2018: Ortopedia, Traumatologia, Rehabilitacja
Ece Uslu Güvendi, Ayhan Aşkin, Güven Güvendi, Hikmet Koçyiğit
Objectives: This study aims to assess whether platelet rich plasma (PRP) is an effective treatment for knee osteoarthritis, and compare its efficiency with corticosteroid treatment in terms of pain control, physical function, and quality of life. Patients and methods: The study included 50 patients (4 males, 46 females; mean age 61.6±6.9 years; range 50 to 75 years) who were diagnosed as grade 3 knee osteoarthritis. Patients were randomized into three groups as corticosteroid group (receiving one corticosteroid injection), single PRP group (receiving one PRP injection), and three PRP group (receiving three PRP injections with one week interval)...
September 2018: Archives of rheumatology
Yong Huang, Xiaolu Liu, Xinliang Xu, Junbin Liu
BACKGROUND: Knee osteoarthritis (KOA) is a degenerative joint disease leading to pain and disability for which no curative treatment exists. Intra-articular (IA) therapies are part of this multimodal approach and are approved by the Food and Drug Administration (FDA) and European Medicines Agency (EMA). Platelet-rich plasma (PRP), hyaluronic acid (HA), and corticosteroids (CS) have been increasingly used in recent years to treat KOA. PURPOSE: To determine whether IA-PRP was superior to IA-HA or IA-CS administration routes in these patients...
January 8, 2019: Der Orthopäde
Ronald E Delanois, Jennifer I Etcheson, Nipun Sodhi, Ralph F Henn, Chukwuweike U Gwam, Nicole E George, Michael A Mont
BACKGROUND: The use of biologic therapies for the management of knee osteoarthritis has increased, despite insufficient evidence of efficacy. Our aim was to complete a systematic review and analysis of reports utilizing the highest level-of-evidence evaluating: (1) platelet-rich plasma injections (PRPs); (2) bone marrow-derived mesenchymal stem cells (BMSCs); (3) adipose-derived mesenchymal stem cells (ADSCs); and (4) amnion-derived mesenchymal stem cells (AMSCs). METHODS: PubMed, Embase, and Cochrane Library databases were queried for studies evaluating PRP injections, BMSCs, ADSCs, and AMSCs in patients with knee osteoarthritis...
December 17, 2018: Journal of Arthroplasty
Jorge Chahla, Brian J Cole
Osteoarthritis (OA) constitutes a significant cause of disability, and it is now recognized as a source of increased mortality. Thus, several therapeutic approaches have been reported in the literature in an attempt to mitigate the symptoms of OA with varying degrees of success. Platelet-rich plasma (PRP) is being increasingly accepted as one of the most efficacious approaches for the symptomatic treatment of mild to moderate OA. Several confounding factors can affect the outcome of PRP such as age, grade of OA, PRP processing technique, and number and timing of these injections...
January 2019: Arthroscopy: the Journal of Arthroscopic & related Surgery
Kuan-Yu Lin, Chia-Chi Yang, Chien-Jen Hsu, Ming-Long Yeh, Jenn-Huei Renn
PURPOSE: To prospectively compare the efficacy of intra-articular injections of platelet-rich plasma (PRP) and hyaluronic acid (HA) with a sham control group (normal saline solution [NS]) for knee osteoarthritis in a randomized, dose-controlled, placebo-controlled, double-blind, triple-parallel clinical trial. METHODS: A total of 87 osteoarthritic knees (53 patients) were randomly assigned to 1 of 3 groups receiving 3 weekly injections of either leukocyte-poor PRP (31 knees), HA (29 knees), or NS (27 knees)...
January 2019: Arthroscopy: the Journal of Arthroscopic & related Surgery
Alessandro Di Martino, Berardo Di Matteo, Tiziana Papio, Francesco Tentoni, Filippo Selleri, Annarita Cenacchi, Elizaveta Kon, Giuseppe Filardo
BACKGROUND: Platelet-rich plasma (PRP) injections have been proposed as a new conservative option for knee degeneration to provide symptomatic relief and delay surgical intervention. Although the current literature provides some evidence on the benefits of this technique compared with viscosupplementation, no studies have been performed to compare their long-term effects. PURPOSE: To compare the long-term clinical outcomes provided by intra-articular injections of either PRP or hyaluronic acid (HA) to treat knee degenerative disease...
December 13, 2018: American Journal of Sports Medicine
Shiqiang Ruan, Jiang Deng, Ling Yan, Wenliang Huang
Articular cartilage is avascular and aneural, and has limited capacity for self-regeneration when injured. Tissue engineering has emerged as a promising approach in repairing cartilage defects. To improve the therapy of cartilage healing, the present study investigated the efficacy of the combination of lentivirus-mediated bone morphogenetic protein-2 (BMP2) in bone marrow-derived stromal cells (BMSCs) and platelet-rich plasma (PRP) on cartilage and bone healing in a cartilage defect model using the rabbit knee...
December 2018: Experimental and Therapeutic Medicine
Jorge Chahla, Mark E Cinque, Bert R Mandelbaum
Anterior cruciate ligament (ACL) reconstruction is one of the most common procedures studied in the orthopaedic literature. In this regard, graft preparation is a key factor for successful outcomes. Although current methods to reconstruct the ACL are generally perceived to be successful, recent studies indicate that normal structure and function of the knee are fully restored in less than half of the patients. Therefore, biologically augmenting these scaffolds could provide a potential solution for improving healing times and biomechanical properties of the graft...
November 2018: Arthroscopy Techniques
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"